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Virchows Archiv

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01.08.2006 | Case Report

Extramammary myofibroblastoma is genetically related to spindle cell lipoma

verfasst von: Francesca Maggiani, Maria Debiec-Rychter, Guy Verbeeck, Raf Sciot

Erschienen in: Virchows Archiv | Ausgabe 2/2006

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Abstract

Extramammary-type myofibroblastoma is a rare, benign spindle cell lesion, strictly resembling the breast counterpart, but occurring in extramammary sites, mainly in the inguinal/groin area. In this paper, we describe an extramammary-type myofibroblastoma in the groin of a 37-year-old male patient. The tumor showed a typical morphological and immunophenotypical profile, including staining for both CD34 and desmin. Dual-color interphase florescent in situ hybridization analysis revealed losses of RB/13q14 and FKHR/13q14 loci within tumor cells. The chromosome 13 rearrangements associated with the loss of the 13q14 chromosomal region are typically seen in spindle cell lipoma, and have been previously recognized in mammary myofibroblastoma, providing strong evidence for a pathogenetic link between these lesions.

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Titel: Extramammary myofibroblastoma is genetically related to spindle cell lipoma
verfasst von: Francesca Maggiani
Maria Debiec-Rychter
Guy Verbeeck
Raf Sciot
Publikationsdatum: 01.08.2006
Verlag: Springer-Verlag
Erschienen in: Virchows Archiv / Ausgabe 2/2006
Print ISSN: 0945-6317
Elektronische ISSN: 1432-2307
DOI: https://doi.org/10.1007/s00428-006-0228-z

Springer Medizin

Extramammary myofibroblastoma is genetically related to spindle cell lipoma

Abstract

Neu im Fachgebiet Pathologie

Molekularpathologische Untersuchungen im Wandel der Zeit

Vergleichende Pathologie in der onkologischen Forschung

Gastrointestinale Stromatumoren

Personalisierte Medizin in der Onkologie

Springer Medizin

Abstract

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