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01.06.2007 | Original Article

Acute interstitial nephritis of HIV-positive patients under atazanavir and tenofovir therapy in a retrospective analysis of kidney biopsies

verfasst von: Simone Schmid, Milos Opravil, Michael Moddel, Milo Huber, Rahel Pfammatter, Gerald Keusch, Patrice Ambuhl, Rudolf P. Wuthrich, Holger Moch, Zsuzsanna Varga

Erschienen in: Virchows Archiv | Ausgabe 6/2007

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Abstract

We performed a retrospective analysis on kidney biopsies of 30 human immunodeficiency virus (HIV)-positive patients. Twenty-two of them received highly active antiretroviral therapy (HAART). Tenofovir containing HAART together with atazanavir, a new protease inhibitor, was administered to three patients. All of them developed acute renal failure. The kidney biopsies of these patients showed an acute interstitial nephritis or a chronic interstitial nephritis with an acute component. Withdrawal of atazanavir and tenofovir resulted in recovery of renal function in all three patients. Acute interstitial nephritis was observed only in 1 of 19 patients without atazanavir or tenofovir treatment. We conclude that acute interstitial nephritis and consecutive acute renal failure is a relevant side effect of atazanavir and tenofovir therapy in HIV-positive patients.

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Titel: Acute interstitial nephritis of HIV-positive patients under atazanavir and tenofovir therapy in a retrospective analysis of kidney biopsies
verfasst von: Simone Schmid
Milos Opravil
Michael Moddel
Milo Huber
Rahel Pfammatter
Gerald Keusch
Patrice Ambuhl
Rudolf P. Wuthrich
Holger Moch
Zsuzsanna Varga
Publikationsdatum: 01.06.2007
Verlag: Springer-Verlag
Erschienen in: Virchows Archiv / Ausgabe 6/2007
Print ISSN: 0945-6317
Elektronische ISSN: 1432-2307
DOI: https://doi.org/10.1007/s00428-007-0418-3

Springer Medizin

Acute interstitial nephritis of HIV-positive patients under atazanavir and tenofovir therapy in a retrospective analysis of kidney biopsies

Abstract

Neu im Fachgebiet Pathologie

Molekularpathologische Untersuchungen im Wandel der Zeit

Vergleichende Pathologie in der onkologischen Forschung

Gastrointestinale Stromatumoren

Personalisierte Medizin in der Onkologie

Springer Medizin

Abstract

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