Introduction
Materials and methods
Case selection
Immunohistochemistry
Interpretation of immunohistochemical preparations
Statistical analysis
Results
Clinicopathologic features
Immunohistochemical findings
mtTFA expression
Variable | mtTFA in | mtTFA in | ||||
---|---|---|---|---|---|---|
Endometrioid adenocarcinomas | Nonendometroioid carcinomas | |||||
Positive | Negative | P value | Positive | Negative | P value | |
n = 123 | n = 122 | n = 17 | n = 14 | |||
Age | 0.376 | 0.608 | ||||
<60 years | 76 | 82 | 4 | 2 | ||
≥60 years | 47 | 40 | 13 | 12 | ||
Stage | 0.008 | 0.197 | ||||
I and II | 85 | 102 | 13 | 7 | ||
III and IV | 38 | 20 | 4 | 7 | ||
Grade | 0.050 | |||||
1 and 2 | 95 | 106 | ||||
3 | 28 | 16 | ||||
Myometrial invasion | <0.001 | 0.175 | ||||
≥1/2 | 78 | 103 | 11 | 5 | ||
>1/2 | 45 | 19 | 6 | 9 | ||
LVSI | 0.006 | 0.953 | ||||
− | 68 | 88 | 7 | 6 | ||
+ | 55 | 34 | 10 | 8 | ||
Cervical invasion | 0.015 | 0.983 | ||||
− | 97 | 110 | 12 | 10 | ||
+ | 26 | 12 | 5 | 4 | ||
Ovarian metastasis | 0.542 | 0.856 | ||||
− | 109 | 111 | 14 | 12 | ||
+ | 14 | 11 | 3 | 2 | ||
Lymph node metastasisa
| 0.003 | 0.672 | ||||
− | 87 | 100 | 8 | 7 | ||
+ | 19 | 5 | 2 | 3 | ||
LI ofp53 expression | 0.003 | 0.73 | ||||
<50% | 98 | 113 | 2 | 1 | ||
≥ 50% | 25 | 9 | 15 | 13 |
p53 expression
Prognosis
Variables | Univariate analysis | Multivariate analysis | ||||
---|---|---|---|---|---|---|
HR | 95%CI | P value | HR | 95%CI | P value | |
Age | ||||||
<60 vs. ≥60 years | 2.742 | 1.134–6.630 | 0.025 | 1.527 | 0.602–3.874 | 0.373 |
Grade | ||||||
1 and 2 vs. 3 | 3.476 | 1.419–8.513 | 0.006 | 1.235 | 0.339–4.505 | 0.749 |
Myometrial invasion | ||||||
≥1/2 vs. >1/2 | 17.997 | 5.272–61.438 | <0.001 | 6.545 | 1.517–28.246 | 0.012 |
LVSI | ||||||
Negative vs. positive | 5.876 | 2.133–16.183 | <0.001 | 0.969 | 0.232–4.037 | 0.965 |
Cervical invasion | ||||||
Negative vs. positive | 4.560 | 1.815–11.458 | 0.001 | 1.085 | 0.306–3.843 | 0.899 |
Ovarian metastasis | ||||||
Negative vs. positive | 5.955 | 2.373–14.941 | <0.001 | 3.065 | 0.988–9.504 | 0.052 |
Lymph node metastasis | ||||||
Negative vs. positive | 15.738 | 6.401–38.693 | <0.001 | 4.954 | 1.510–16.256 | 0.008 |
p53 | ||||||
LI < 50% vs. LI ≥ 50% | 2.921 | 1.117–7.638 | 0.029 | 0.960 | 0.254–3.821 | 0.952 |
mtTFA | ||||||
LI < 32% vs. LI ≥ 32% | 3.395 | 1.232–9.358 | 0.018 | 1.224 | 0.403–3.719 | 0.722 |