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Virchows Archiv

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01.05.2010 | Original Article

Impact of podoplanin expression in oral squamous cell carcinoma: clinical and histopathologic correlations

verfasst von: Matthias Kreppel, Martin Scheer, Uta Drebber, Lutz Ritter, Joachim E. Zöller

Erschienen in: Virchows Archiv | Ausgabe 5/2010

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Abstract

Cervical lymph node metastases reduce the overall survival of patients with oral squamous cell carcinoma (OSCC) and require a neck dissection. However, elective management of a clinical N0 neck remains a controversial topic, as there are no reliable factors available predicting cervical lymph node metastases. Recent studies suggest an impact of podoplanin expression on metastatic spread to the cervical lymph nodes. Our aim was to investigate the influence of podoplanin expression on prognosis and metastatic lymphatic spread. In our retrospective study, podoplanin expression was examined in a set of 80 patients with OSCC by immunhistochemistry. We analysed associations between the level of podoplanin expression and various clinicopathologic parameters. In 67 patients (84%), podoplanin was expressed on the tumour cells. Nineteen patients (24%) showed high levels of expression. The 5-year overall survival (31%) for patients with high levels of podoplanin expression was significantly lower (p < 0.001) than for patients with low and moderate expression of podoplanin (93% and 65%, respectively). There was an association between podoplanin expression and the frequency of cervical lymph node metastases. Cervical lymph node metastases were found in 79% of the patients with high podoplanin expression, while patients with weak podoplanin expression had metastases in only 22% (p < 0.001). None of the 13 patients without podoplanin expression had cervical lymph node metastases. We concluded that podoplanin is expressed frequently in OSCC and that podoplanin expression correlates with cervical lymph node metastases and clinical outcome.

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Titel: Impact of podoplanin expression in oral squamous cell carcinoma: clinical and histopathologic correlations
verfasst von: Matthias Kreppel
Martin Scheer
Uta Drebber
Lutz Ritter
Joachim E. Zöller
Publikationsdatum: 01.05.2010
Verlag: Springer-Verlag
Erschienen in: Virchows Archiv / Ausgabe 5/2010
Print ISSN: 0945-6317
Elektronische ISSN: 1432-2307
DOI: https://doi.org/10.1007/s00428-010-0915-7

Neu im Fachgebiet Pathologie

Open Access 15.04.2024 | Biomarker | Schwerpunkt: Next Generation Pathology

Springer Medizin

Impact of podoplanin expression in oral squamous cell carcinoma: clinical and histopathologic correlations

Abstract

Neu im Fachgebiet Pathologie

Molekularpathologische Untersuchungen im Wandel der Zeit

Vergleichende Pathologie in der onkologischen Forschung

Gastrointestinale Stromatumoren

Personalisierte Medizin in der Onkologie

Springer Medizin

Abstract

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