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Virchows Archiv

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01.07.2012 | Review and Perspectives

Teratoma with somatic-type malignant components of the testis. A review and an update

verfasst von: Gregor Mikuz, Maurizio Colecchia

Erschienen in: Virchows Archiv | Ausgabe 1/2012

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Abstract

Malignant transformation of germ cell tumors into somatic malignancy is uncommon. Its presentation differs from series to series, with 43 % of adult cases identified within the primary tumors and the remainder at the time of relapse or in the metastasis. Patients with stage I disease enjoy an excellent prognosis; whereas in metastatic sites when not completely resectable, the somatic type malignancies suffer a dismal prognosis. Radical surgery is significant for the prospects of cure and is standard chemotherapy for germ cell tumors; a transformation-oriented treatment can be effective for these patients. A deeper understanding of the biology of this phenomenon is essential for clinicians involved in such malignancies in order to permit a better control of the disease.

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Titel: Teratoma with somatic-type malignant components of the testis. A review and an update
verfasst von: Gregor Mikuz
Maurizio Colecchia
Publikationsdatum: 01.07.2012
Verlag: Springer-Verlag
Erschienen in: Virchows Archiv / Ausgabe 1/2012
Print ISSN: 0945-6317
Elektronische ISSN: 1432-2307
DOI: https://doi.org/10.1007/s00428-012-1251-x

Springer Medizin

Teratoma with somatic-type malignant components of the testis. A review and an update

Abstract

Neu im Fachgebiet Pathologie

Molekularpathologische Untersuchungen im Wandel der Zeit

Vergleichende Pathologie in der onkologischen Forschung

Gastrointestinale Stromatumoren

Personalisierte Medizin in der Onkologie

Springer Medizin

Abstract

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