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Virchows Archiv

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25.04.2016 | Brief Report

Primary pulmonary clear cell sarcoma—the first two reported cases

verfasst von: Giap Hean Goh, Ming Teh, Tomas Vanecek, Cesar Moran, Fredrik Petersson

Erschienen in: Virchows Archiv | Ausgabe 1/2016

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Abstract

We report two cases (male patients 50 and 55 years old) of clear cell sarcoma (“melanoma of soft parts”) arising in the lung, of which one case showed regional lymph node metastases. Histologically, both tumors displayed varying clear epithelioid and spindle neoplastic cells arranged in storiform and nested growth patterns, separated by thin fibrovascular septa. Immunohistochemical studies demonstrated positive expression of S-100 protein, HMB-45 and Melan-A in one case and S-100 protein only in the other. Fluorescence in situ hybridization showed positive EWSR1 gene rearrangement, and a presence of EWS-ATF1 fusion transcript was confirmed by RT-PCR and sequencing in one case.

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Titel: Primary pulmonary clear cell sarcoma—the first two reported cases
verfasst von: Giap Hean Goh
Ming Teh
Tomas Vanecek
Cesar Moran
Fredrik Petersson
Publikationsdatum: 25.04.2016
Verlag: Springer Berlin Heidelberg
Erschienen in: Virchows Archiv / Ausgabe 1/2016
Print ISSN: 0945-6317
Elektronische ISSN: 1432-2307
DOI: https://doi.org/10.1007/s00428-016-1943-8

Neu im Fachgebiet Pathologie

Open Access 15.04.2024 | Biomarker | Schwerpunkt: Next Generation Pathology

Springer Medizin

Primary pulmonary clear cell sarcoma—the first two reported cases

Abstract

Neu im Fachgebiet Pathologie

Molekularpathologische Untersuchungen im Wandel der Zeit

Vergleichende Pathologie in der onkologischen Forschung

Gastrointestinale Stromatumoren

Personalisierte Medizin in der Onkologie

Springer Medizin

Abstract

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