nach oben

Virchows Archiv

Erschienen in:

17.08.2018 | Original Article

Association of HER2 gene amplification and tumor progression in early gastric cancer

verfasst von: Kazuki Kanayama, Hiroshi Imai, Eri Usugi, Taizo Shiraishi, Yoshifumi S. Hirokawa, Masatoshi Watanabe

Erschienen in: Virchows Archiv | Ausgabe 5/2018

Einloggen, um Zugang zu erhalten

Abstract

Overexpression of human epidermal growth factor receptor 2 (HER2) protein in association with HER2 gene amplification is found in 7–34% of gastric cancers. In breast cancer, HER2 overexpression is a prognostic factor in advanced cases and is associated with tumor progression in ductal carcinoma in situ. However, the biological and clinical significance of HER2 status in early gastric cancer is unknown. Here, we aimed to examine the correlation between HER2 gene amplification and tumor progression in early gastric cancer. The HER2 status was evaluated in 149 lesions from 141 consecutive patients with early gastric cancer who underwent endoscopic resection by immunohistochemistry and dual color in situ hybridization. HER2 gene amplification was detected in 35 (23.5%) of 149 lesions, and of those, 26 cases (74.3%) showed intratumoral heterogeneity. HER2 gene amplification was found in noninvasive carcinoma, and there was a significant correlation between HER2 status and T factor (P = 0.0290). Our study demonstrated that HER2 gene amplification occurred during the early stages of gastric cancer and showed heterogeneity in several cases. HER2 gene amplification may be involved in tumor progression in early gastric cancer.

Nur mit Berechtigung zugänglich

Bartkova J, Barnes DM, Millis RR, Gullick WJ (1990) Immunohistochemical demonstration of c-erbB-2 protein in mammary ductal carcinoma in situ. Hum Pathol 21:1164–1167CrossRef

Cassaro M, Rugge M, Tieppo C, Giacomelli L, Velo D, Nitti D, Farinati F (2007) Indefinite for non-invasive neoplasia lesions in gastric intestinal metaplasia: the immunophenotype. J Clin Pathol 60:615–621. https://doi.org/10.1136/jcp.2006.040386 CrossRefPubMed

Correa P, Piazuelo MB, Wilson KT (2010) Pathology of gastric intestinal metaplasia: clinical implications. Am J Gastroenterol 105:493–498. https://doi.org/10.1038/ajg.2009.728 CrossRefPubMedPubMedCentral

Diaz LA Jr, Williams RT, Wu J, Kinde I, Hecht JR, Berlin J, Allen B, Bozic I, Reiter JG, Nowak MA, Kinzler KW, Oliner KS, Vogelstein B (2012) The molecular evolution of acquired resistance to targeted EGFR blockade in colorectal cancers. Nature 486:537–540. https://doi.org/10.1038/nature11219 CrossRefPubMedPubMedCentral

Fassan M, Mastracci L, Grillo F, Zagonel V, Bruno S, Battaglia G, Pitto F, Nitti D, Celiento T, Zaninotto G, Fiocca R, Rugge M (2012) Early HER2 dysregulation in gastric and oesophageal carcinogenesis. Histopathology 61:769–776. https://doi.org/10.1111/j.1365-2559.2012.04272.x CrossRefPubMed

Fassan M, Pizzi M, Farinati F, Nitti D, Zagonel V, Genta RM, Rugge M (2012) Lesions indefinite for intraepithelial neoplasia and OLGA staging for gastric atrophy. Am J Clin Pathol 137:727–732. https://doi.org/10.1309/AJCPEU41HTGXSJDQ CrossRefPubMed

Garcia-Garcia E, Gomez-Martin C, Angulo B, Conde E, Suarez-Gauthier A, Adrados M, Perna C, Rodriguez-Peralto JL, Hidalgo M, Lopez-Rios F (2011) Hybridization for human epidermal growth factor receptor 2 testing in gastric carcinoma: a comparison of fluorescence in-situ hybridization with a novel fully automated dual-colour silver in-situ hybridization method. Histopathology 59:8–17. https://doi.org/10.1111/j.1365-2559.2011.03894.x CrossRefPubMedPubMedCentral

Hofmann M, Stoss O, Shi D, Buttner R, van de Vijver M, Kim W, Ochiai A, Ruschoff J, Henkel T (2008) Assessment of a HER2 scoring system for gastric cancer: results from a validation study. Histopathology 52:797–805. https://doi.org/10.1111/j.1365-2559.2008.03028.x CrossRefPubMed

Kadota K, Suzuki K, Colovos C, Sima CS, Rusch VW, Travis WD, Adusumilli PS (2012) A nuclear grading system is a strong predictor of survival in epitheloid diffuse malignant pleural mesothelioma. Mod Pathol 25:260–271. https://doi.org/10.1038/modpathol.2011.146 CrossRefPubMed

10.

Kanayama K, Imai H, Yoneda M, Hirokawa YS, Shiraishi T (2016) Significant intratumoral heterogeneity of human epidermal growth factor receptor 2 status in gastric cancer: a comparative study of immunohistochemistry, FISH, and dual-color in situ hybridization. Cancer Sci 107:536–542. https://doi.org/10.1111/cas.12886 CrossRefPubMedPubMedCentral

11.

Kataoka Y, Okabe H, Yoshizawa A, Minamiguchi S, Yoshimura K, Haga H, Sakai Y (2013) HER2 expression and its clinicopathological features in resectable gastric cancer. Gastric Cancer 16:84–93. https://doi.org/10.1007/s10120-012-0150-9 CrossRefPubMed

12.

Kurozumi S, Padilla M, Kurosumi M, Matsumoto H, Inoue K, Horiguchi J, Takeyoshi I, Oyama T, Ranger-Moore J, Allred DC, Dennis E, Nitta H (2016) HER2 intratumoral heterogeneity analyses by concurrent HER2 gene and protein assessment for the prognosis of HER2 negative invasive breast cancer patients. Breast Cancer Res Treat 158:99–111. https://doi.org/10.1007/s10549-016-3856-2 CrossRefPubMedPubMedCentral

13.

Lee S, de Boer WB, Fermoyle S, Platten M, Kumarasinghe MP (2011) Human epidermal growth factor receptor 2 testing in gastric carcinoma: issues related to heterogeneity in biopsies and resections. Histopathology 59:832–840. https://doi.org/10.1111/j.1365-2559.2011.04017.x CrossRefPubMed

14.

Marusyk A, Tabassum DP, Altrock PM, Almendro V, Michor F, Polyak K (2014) Non-cell-autonomous driving of tumour growth supports sub-clonal heterogeneity. Nature 514:54–58. https://doi.org/10.1038/nature13556 CrossRefPubMedPubMedCentral

15.

Nakashima Y, Yao T, Hirahashi M, Aishima S, Kakeji Y, Maehara Y, Tsuneyoshi M (2011) Nuclear atypia grading score is a useful prognostic factor in papillary gastric adenocarcinoma. Histopathology 59:841–849. https://doi.org/10.1111/j.1365-2559.2011.04035.x CrossRefPubMed

16.

Roses RE, Paulson EC, Sharma A, Schueller JE, Nisenbaum H, Weinstein S, Fox KR, Zhang PJ, Czerniecki BJ (2009) HER-2/neu overexpression as a predictor for the transition from in situ to invasive breast cancer. Cancer Epidemiol Biomark Prev 18:1386–1389. https://doi.org/10.1158/1055-9965.EPI-08-1101 CrossRef

17.

Rugge M, de Boni M, Pennelli G, de Bona M, Giacomelli L, Fassan M, Basso D, Plebani M, Graham DY (2010) Gastritis OLGA-staging and gastric cancer risk: a twelve-year clinico-pathological follow-up study. Aliment Pharmacol Ther 31:1104–1111. https://doi.org/10.1111/j.1365-2036.2010.04277.x CrossRefPubMed

18.

Rugge M, Pennelli G, Pilozzi E, Fassan M, Ingravallo G, Russo VM, Di Mario F (2011) Gastritis: the histology report. Dig Liver Dis 43(Suppl 4):S373–S384. https://doi.org/10.1016/s1590-8658(11)60593-8 CrossRefPubMed

19.

Sawaki A, Ohashi Y, Omuro Y, Satoh T, Hamamoto Y, Boku N, Miyata Y, Takiuchi H, Yamaguchi K, Sasaki Y, Nishina T, Satoh A, Baba E, Tamura T, Abe T, Hatake K, Ohtsu A (2012) Efficacy of trastuzumab in Japanese patients with HER2-positive advanced gastric or gastroesophageal junction cancer: a subgroup analysis of the Trastuzumab for Gastric Cancer (ToGA) study. Gastric Cancer 15:313–322. https://doi.org/10.1007/s10120-011-0118-1 CrossRefPubMed

20.

Schlemper RJ, Riddell RH, Kato Y, Borchard F, Cooper HS, Dawsey SM, Dixon MF, Fenoglio-Preiser CM, Flejou JF, Geboes K, Hattori T, Hirota T, Itabashi M, Iwafuchi M, Iwashita A, Kim YI, Kirchner T, Klimpfinger M, Koike M, Lauwers GY, Lewin KJ, Oberhuber G, Offner F, Price AB, Rubio CA, Shimizu M, Shimoda T, Sipponen P, Solcia E, Stolte M, Watanabe H, Yamabe H (2000) The Vienna classification of gastrointestinal epithelial neoplasia. Gut 47:251–255CrossRef

21.

Seol H, Lee HJ, Choi Y, Lee HE, Kim YJ, Kim JH, Kang E, Kim SW, Park SY (2012) Intratumoral heterogeneity of HER2 gene amplification in breast cancer: its clinicopathological significance. Mod Pathol 25:938–948. https://doi.org/10.1038/modpathol.2012.36 CrossRefPubMed

22.

Silva TC, Leal MF, Calcagno DQ, de Souza CR, Khayat AS, dos Santos NP, Montenegro RC, Rabenhorst SH, Nascimento MQ, Assumpcao PP, de Arruda Cardoso Smith M, Burbano RR (2012) hTERT, MYC and TP53 deregulation in gastric preneoplastic lesions. BMC Gastroenterol 12:85. https://doi.org/10.1186/1471-230x-12-85 CrossRefPubMedPubMedCentral

23.

Sottoriva A, Kang H, Ma Z, Graham TA, Salomon MP, Zhao J, Marjoram P, Siegmund K, Press MF, Shibata D, Curtis C (2015) A Big Bang model of human colorectal tumor growth. Nat Genet 47:209–216. https://doi.org/10.1038/ng.3214 CrossRefPubMedPubMedCentral

24.

Yoshida H, Yamamoto N, Taniguchi H, Oda I, Katai H, Kushima R, Tsuda H (2014) Comparison of HER2 status between surgically resected specimens and matched biopsy specimens of gastric intestinal-type adenocarcinoma. Virchows Arch 465:145–154. https://doi.org/10.1007/s00428-014-1597-3 CrossRefPubMed

25.

Zheng Y (2010) Expression of p53, c-erbB-2 and Ki67 in intestinal metaplasia and gastric carcinoma. World J Gastroenterol 16:339–344. https://doi.org/10.3748/wjg.v16.i3.339 CrossRefPubMedPubMedCentral

Titel: Association of HER2 gene amplification and tumor progression in early gastric cancer
verfasst von: Kazuki Kanayama
Hiroshi Imai
Eri Usugi
Taizo Shiraishi
Yoshifumi S. Hirokawa
Masatoshi Watanabe
Publikationsdatum: 17.08.2018
Verlag: Springer Berlin Heidelberg
Erschienen in: Virchows Archiv / Ausgabe 5/2018
Print ISSN: 0945-6317
Elektronische ISSN: 1432-2307
DOI: https://doi.org/10.1007/s00428-018-2433-y

Neu im Fachgebiet Pathologie

Open Access 15.04.2024 | Biomarker | Schwerpunkt: Next Generation Pathology

Springer Medizin

Association of HER2 gene amplification and tumor progression in early gastric cancer

Abstract

Neu im Fachgebiet Pathologie

Molekularpathologische Untersuchungen im Wandel der Zeit

Vergleichende Pathologie in der onkologischen Forschung

Gastrointestinale Stromatumoren

Personalisierte Medizin in der Onkologie

Springer Medizin

Abstract

Bitte loggen Sie sich ein, um Zugang zu diesem Inhalt zu erhalten

Weitere Artikel der Ausgabe 5/2018

Carbonic anhydrases II, IX, and XII in Barrett’s esophagus and adenocarcinoma

Book Review—Practical cytopathology: a diagnostic approach to fine needle aspiration biopsy, 1st edition

TERT promoter mutational screening as a tool to predict malignant behaviour in follicular thyroid tumours—three examples from the clinical routine

Biphenotypic sinonasal sarcoma: demographics, clinicopathological characteristics, molecular features, and prognosis of a recently described entity

Nuclear loss and cytoplasmic expression of androgen receptor in penile carcinomas: role as a driver event and as a prognosis factor

Head and neck manifestations of an undiagnosed McCune-Albright syndrome: clinicopathological description and literature review

Neu im Fachgebiet Pathologie

Molekularpathologische Untersuchungen im Wandel der Zeit

Vergleichende Pathologie in der onkologischen Forschung

Gastrointestinale Stromatumoren

Personalisierte Medizin in der Onkologie