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Brain Structure and Function

Erschienen in:

01.03.2010 | Original article

Changes in dendritic complexity and spine morphology in transgenic mice expressing human wild-type tau

verfasst von: Dara L. Dickstein, Hannah Brautigam, Steven D. Stockton Jr., James Schmeidler, Patrick R. Hof

Erschienen in: Brain Structure and Function | Ausgabe 2-3/2010

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Abstract

Neurofibrillary tangles (NFTs) are composed of insoluble, hyperphosphorylated aggregates of the microtubule-associated protein tau and are present in various neurodegenerative diseases, including Alzheimer’s disease (AD). To investigate how tau affects neuronal function during NFT formation and subsequent neurodegeneration, we examined the morphology, spine density, spine type, and spine volume of layer III pyramidal neurons from the prefrontal cortex of mice expressing wild-type human tau (htau) over time. There were no significant alterations in apical dendritic arbor length in 3-, 6-, and 12-month-old htau mice; however, 12-month-old mice exhibited more complex arborization patterns. In addition, we observed a shift in spine morphology with fewer mushroom and more thin spines in both apical and basal dendrites as a function of htau accumulation. Interestingly, there was an overall decrease in volume of spines from 3 to 12 months. However, the volume of mushroom spines decreased from 3 to 6 months and increased from 6 to 12 months. This increase in complexity and branching in 12-month-old mice and the increase of volume of mushroom spines may represent compensatory mechanisms in the remaining intact neurons. As such, the accumulation of phosphorylated tau over time may contribute to the cognitive decline observed in AD by affecting neuronal structure and synaptic properties. Such alterations in dendrites and spines may result in the deterioration of neuronal function observed in AD, and provide a morphologic substrate for the relationship between synaptic integrity and cognitive decline.

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Titel: Changes in dendritic complexity and spine morphology in transgenic mice expressing human wild-type tau
verfasst von: Dara L. Dickstein
Hannah Brautigam
Steven D. Stockton Jr.
James Schmeidler
Patrick R. Hof
Publikationsdatum: 01.03.2010
Verlag: Springer-Verlag
Erschienen in: Brain Structure and Function / Ausgabe 2-3/2010
Print ISSN: 1863-2653
Elektronische ISSN: 1863-2661
DOI: https://doi.org/10.1007/s00429-010-0245-1

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