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Journal of Cancer Research and Clinical Oncology

Erschienen in:

01.03.2008 | Original Paper

Nuclear to cytoplasmic shift of p33^ING1b protein from normal oral mucosa to oral squamous cell carcinoma in relation to clinicopathological variables

verfasst von: Jin-Ting Zhang, Da-Wei Wang, Qing-Xing Li, Zhen-Long Zhu, Ming-Wei Wang, Dong-Sheng Cui, Yan-Hong Yang, Yu-Xin Gu, Xiao-Feng Sun

Erschienen in: Journal of Cancer Research and Clinical Oncology | Ausgabe 3/2008

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Abstract

Purpose

p33^ING1b, as a candidate tumour suppressor gene, has been found to be expressed a proportion of oral squamous cell carcinomas (OSCCs), however, its clinicopathological significance is not studied yet. Our aim was to investigate association of p33^ING1b expression with clinicopathological variables and particularly interesting new cysteine–histidine rich protein (PINCH) in OSCCs.

Methods

p33^ING1b expression was immumohistochemically examined in 20 normal oral mucosa specimens and 49 OSCCs.

Results

Normal squamous cells showed only p33^ING1bnuclear expression (no cytoplasmic expression), with a rate of 90% positive cases. While 24% of OSCCs appeared cytoplasmic expression (11 of them with weak nuclear staining) and the rest tumours (76%) were negative for p33^ING1b. Furthermore, the cases having lymph node metastasis showed a higher frequency of positive cytoplasmic expression than those without metastasis (P = 0.03). The p33^ING1b cytoplasmic expression was positively related to PINCH expression (P = 0.04), the cases positive for both proteins had a high rate of the metastasis (P = 0.03).

Conclusions

The transfer of p33^ING1b protein from the nucleus to the cytoplasm may result in loss of normal cellular function of the protein, which might play a role in the tumourigenesis and metastasis of OSCCs.

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Titel: Nuclear to cytoplasmic shift of p33ING1b protein from normal oral mucosa to oral squamous cell carcinoma in relation to clinicopathological variables
verfasst von: Jin-Ting Zhang
Da-Wei Wang
Qing-Xing Li
Zhen-Long Zhu
Ming-Wei Wang
Dong-Sheng Cui
Yan-Hong Yang
Yu-Xin Gu
Xiao-Feng Sun
Publikationsdatum: 01.03.2008
Verlag: Springer-Verlag
Erschienen in: Journal of Cancer Research and Clinical Oncology / Ausgabe 3/2008
Print ISSN: 0171-5216
Elektronische ISSN: 1432-1335
DOI: https://doi.org/10.1007/s00432-007-0305-y

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Nuclear to cytoplasmic shift of p33^ING1b protein from normal oral mucosa to oral squamous cell carcinoma in relation to clinicopathological variables