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Journal of Cancer Research and Clinical Oncology

Erschienen in:

28.12.2015 | Review – Clinical Oncology

ERG expression in prostate cancer: biological relevance and clinical implication

verfasst von: Hatem Abou-Ouf, Liena Zhao, Tarek A. Bismar

Erschienen in: Journal of Cancer Research and Clinical Oncology | Ausgabe 8/2016

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Abstract

Introduction

Screening for increased levels of prostate-specific antigen (PSA) has allowed early detection of a large majority of prostate cancer (PCa) cases. However, the relative lack of specificity of PSA has resulted in significant over-diagnosis and unnecessary treatment for indolent tumors. The fusion of the transmembrane protease serine 2 with E26 transformation-specific family genes, particularly ERG, is the most widespread genetic alteration in prostate cancer, and data suggest that it is more specific for neoplastic prostate disease and may be of added prognostic value and point toward molecular subtype of PCa.

Methods

In this review, retrospective studies and clinical trials were analyzed to highlight the recent advances in our understanding of the cellular consequence of ERG rearrangement, describe its interactions with other genetic and molecular pathways, and discuss its potential diagnostic and prognostic value.

Conclusion

ERG over-expression has an emerging role in the diagnosis of PCa pathology, although there is still debate about its prognostic value. Elucidation of the mechanisms of ERG gene rearrangements and expression promises novel therapeutic and diagnostic avenues for prostate cancer.

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Titel: ERG expression in prostate cancer: biological relevance and clinical implication
verfasst von: Hatem Abou-Ouf
Liena Zhao
Tarek A. Bismar
Publikationsdatum: 28.12.2015
Verlag: Springer Berlin Heidelberg
Erschienen in: Journal of Cancer Research and Clinical Oncology / Ausgabe 8/2016
Print ISSN: 0171-5216
Elektronische ISSN: 1432-1335
DOI: https://doi.org/10.1007/s00432-015-2096-x

Springer Medizin

ERG expression in prostate cancer: biological relevance and clinical implication

Abstract

Introduction

Methods

Conclusion

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Update Onkologie

Springer Medizin

Abstract

Introduction

Methods

Conclusion

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