Several analyses of hernia registries have demonstrated that patients older than 65 years have significantly higher perioperative complication rates compared with patients up to the age of 65. To date, no special analyses of endoscopic/laparoscopic inguinal hernia surgery or of the relevant additional influence factors have been carried out. Besides, there is no definition to determine whether 65 years should really be considered to be the age limit.
Methods
In the Herniamed Hernia Registry, it was possible to identify 24,571 patients with a primary inguinal hernia and aged at least 16 years who had been operated on between September 1, 2009, and April 15, 2013, using either the TAPP technique (n = 17,214) or TEP technique (n = 7,357). Patients in the age group up to and including 65 years (≤65 years) were compared with those older than 65 years (>65 years) in terms of their perioperative outcome. That was done first using unadjusted analysis and then multivariable analysis.
Results
Unadjusted analysis revealed significantly different results for the intraoperative (1.19 vs 1.60 %; p = 0,010), postoperative surgical (2.72 vs 4.59 %; p < 0.001) and postoperative general complications (0.85 vs 1.98 %; p < 0.001) as well as for complication-related reoperations (1.07 vs 1.37 %; p = 0,044), which were more favorable in the ≤65 years age group. However, in multivariable analysis, it was not possible to confirm that for the intraoperative complications or the reoperations. Reoperations were needed more often for bilateral procedures (p < 0.001; OR 2.154 [1.699; 2.730]), higher ASA classification (IV vs I: p = 0.004; OR 6.001 [1.786; 20.167]), larger hernia defect and scrotal hernias. The impact of these factors, in addition to that of age >65 years, was also reflected in the postoperative complication rates. The age limit for increased onset of perioperative complication rates tends to be more than 80 rather than 65 years.
Conclusion
The higher perioperative complication rate associated with endoscopic/laparoscopic inguinal hernia surgery in patients older than 65 years is of multifactorial genesis and is observed in particular as from the age of 80 years.
Hinweise
F. Mayer and M. Lechner contributed equally to the publication.
The demographics of western society are undergoing a significant change, with an increasingly elderly population. Inguinal hernia repair remains the most frequent surgical intervention in the west, and the impact of changing patient demographics means an increasing number of elderly patients require elective surgical repair. Incidence is also higher in the elderly, as loss of tissue strength leads to increased herniation [1‐3].
On the basis of the 2006 National Hospital Discharge Survey, patients aged 65 and older accounted for 35 % of all procedures [4]. A nationwide prevalence study showed that the age distribution of inguinal hernia repair is bimodal peaking at early childhood and old age (75–80 years) [5]. The cumulative incidence of inguinal hernia in the USA varies according to the patients’ age: 25- to 39-year-old patients show an incidence of 7.3, 14.8 % at the age of 40–59 years and 22.8 % at the age of more than 60 years [6].
Anzeige
The main goals of elective hernia surgery are symptomatic improvement and prevention of acute surgical emergencies such as incarceration or strangulation. Emergency repair is known to carry significantly higher rates of morbidity and mortality, especially among the elderly [7, 8]. However, there remains a lack of clarity about the appropriateness of intervention in elderly patients with comorbidity in whom symptoms may be minimal and elective repair carries risk [9]. Although a period of watchful waiting has been advocated by some authors for young fit patients, for older patients with comorbidity early elective repair has been advocated [10, 11].
Outcome studies demonstrate that morbidity and mortality are increased following surgery in the elderly as compared with the younger population [12].
In the Swedish Hernia Registry, there was a significant and substantial increase in risk of a postoperative complication with laparoscopic and open preperitoneal procedures in older patient (age > 65 years) [13]. In the Danish Hernia Registry, complications after groin hernia repair were more frequent in patient >65 years (4.5 %), compared with younger patients (2.7 %) (p = 0.001) [14].
In the National Surgical Quality Improvement Program (NSQIP) of the American College of Surgeons, the risk of onset of perioperative complications in patients >65 years is expressed with a significant higher odds ratio of 1.418 [1.206–1.666] [15].
Anzeige
Cardiac events occur in 1–5 % of patients undergoing non-cardiac surgery and pulmonary complications in 2.1–10.2 % of elderly patients [4].
The use of a low-pressure pneumoperitoneum and of alternative gases to the CO2 pneumoperitoneum is under discussion in order to reduce the cardiopulmonary complications associated with laparoscopic/endoscopic surgery [16, 17]. Other authors exclude older patients with important comorbidities such as severe chronic obstructive pulmonary disease (COPD) from laparoscopic/endoscopic surgical procedures [18].
In the prospective randomized Veterans Affairs Cooperative Study, it was not possible to identify any link between the patient’s age and onset of short-term complications following laparoscopic/endoscopic inguinal hernia surgery (n = 989 patients) [19]. In a retrospective comparative study with 185 patients, no difference was discerned in the perioperative complication rates between patients >65 and ≤65 years [18].
In retrospective comparative studies with 104 and 81 patients, no significant difference was seen in the perioperative outcome of patients aged ≥80 years between open and laparoscopic/endoscopic inguinal hernia repair [20, 21].
In an effort to minimize elective operative morbidity and enhance postoperative recovery, laparoscopic repair has been suggested as an appropriate technique to inguinal hernia repair [8, 22, 23].
Existing guidelines do not make any age-specific recommendations on optimal surgical approach in inguinal hernia surgery. There remains a lack of clarity about the safety of laparoscopic repair in an aging population [20, 21].
This study therefore aimed to clarify the impact of age on postoperative outcome after endoscopic repair of primary inguinal hernia, as well as attempting to identify other influence factors that impacted the perioperative outcome and a cutoff age at which laparoscopic repair should no longer be advocated.
Patients and methods
Herniamed is a multicenter, internet-based hernia registry [24] in which 358 participating clinics and surgeons in private practice from Germany, Austria and Switzerland (Status: April 15, 2013) have prospectively registered their patients who had undergone hernia operations [14]. This present analysis now examines the prospective data of all patients who had undergone laparoscopic/endoscopic inguinal hernia repair in transabdominal preperitoneal patch plasty (TAPP) or total extraperitoneal patch plasty (TEP) between September 1, 2009, and April 15, 2013. The inclusion criteria were a minimum age of 16 years, primary inguinal hernia and uni- or bilateral operation. In total, 24,571 patients were enrolled (Table 1). These comprised 17,214 patients aged ≤65 years (70.1 %) and 7357 patients aged >65 years (29.9 %) (Table 1).
Table 1
Classification of patients into age groups
Age
n
%
≤65 years
17,214
70.06
>65 years
7357
29.94
Overall
24,571
100.00
Anzeige
The groups were formed by dichotomizing the continuous variable ‘age’ into ‘≤65 years’ and ‘>65 years.’ In addition, the relationship of age to the categories of variables of interest is presented and discussed.
The demographic and surgery-related parameters included sex (m/f), ASA classification (I–IV), risk factors, previous operations and hernia defect sizes based on EHS classification (grade I–III), proportion of scrotal hernias, type of anesthesia, elective or emergency and inpatient vs outpatient treatment. The outcome variables defined were the intra- and postoperative as well as general complication rates, reoperation rate, duration of operation and length of hospital stay. Categorical data are presented as absolute and relative frequencies; continuous variables are displayed as mean, median, standard deviation, quantiles and ranges. In the case of skewed distributions as seen for durations, data were log-transformed. For the bilateral patient group, data on the variables given for both sides operated on were aggregated. For inguinal hernia defects of different sizes, the side with the larger defect is given. Classification as scrotal hernia was based on the presence of at least one scrotal hernia for bilateral inguinal hernia. Intra- and postoperative complications were recorded if a complication presented on at least one side. The same method was used to present details of any reoperation.
All analyses were performed with the software SAS 9.2 (SAS Institute Inc. Cary, NY, USA) and deliberately reviewed to the full level of significance. Each p value ≤0.05 thus represents a statistically significant result.
After investigating dependency of outcome variables (intra- and postoperative as well as general complications, reoperation rate, duration of operation and length of postoperative hospital stay) on individual factors (age and other characteristics of patients as well as operation) in unadjusted, univariable analyses (Chi-square test, t test), multivariable models (continuously scaled outcome: general linear models, binary-scaled outcome: generalized linear models with logit link function) were applied, thus making it possible to analyze the influence of age adjusted by other possible influencing variables. The parameters of models and their corresponding 95 % confidence intervals are reported as results—odds ratios in case of logistic regression and beta estimates in case of general linear models.
Anzeige
The validity of the logistic models was investigated by means of LOESS regression allowing visualization of the relationship between influencing variable and outcome. Only if a monotone increasing or decreasing relationship is seen is the model valid.
Results
Unadjusted results
Unadjusted analyses of the influence exerted by patient classification into age groups on patient characteristic variables (Table 2) showed that the patients in the two age groups differed significantly from each other with regard to the majority of the variables analyzed. For example, the proportion of women in the age group over 65 years was significantly greater (p < 0.001). Likewise, in that age group, there were significantly more higher ASA classifications, larger hernia defects and more emergency operations (in each case p < 0.001). However, it must be borne in mind that due to the large number of cases even small, possibly clinically irrelevant, differences are identified as being significant.
Table 2
Demographic data
≤65 years
>65 years
p
n
%
n
%
Sex
Male
15,481
89.93
6351
86.33
<0.001
Female
1733
10.07
1006
13.67
ASA score
I
7578
44.02
797
10.83
<0.001
II
8659
50.30
4523
61.48
III
968
5.62
1997
27.14
IV
9
0.05
40
0.54
Defect size (EHS)
I (<1.5 cm)
3300
19.17
711
9.66
<0.001
II (1.5–3 cm)
10,883
63.22
4396
59.75
III (>3 cm)
3031
17.61
2250
30.58
Scrotal hernia (EHS)
No
16,851
97.89
7110
96.64
<0.001
Yes
363
2.11
247
3.36
Anesthesia
Local
14
0.08
6
0.08
1.000
Spinal
34
0.20
14
0.19
General
17,166
99.72
7337
99.73
Inpatient/outpatient
Outpatient
1020
5.93
194
2.64
<0.001
Inpatient
16,194
94.07
7163
97.36
Degree of urgency
Elective
17,061
99.11
7213
98.04
<0.001
Emergency
153
0.89
144
1.96
Operation technique
TEP
6636
38.55
2759
37.50
0.122
TAPP
10578
61.45
4598
62.50
Unilateral/bilateral
Unilateral
12,276
71.31
5311
72.19
0.165
Bilateral
4938
28.69
2046
27.81
A pronounced significant difference was found in the risk factors as well as in the rate of previous operations (Table 3). In the age group up to and including 65 years, 21.74 % of patients had at least one risk factor, whereas in the age group older than 65 years that applied for almost one-third of patients (p < 0.001). Analysis of individual risk factors revealed that, apart from nicotine abuse, all risk factors were represented more commonly in the higher age group. As expected, that was also the case for the rate of previous operations. At 36.66 %, the rate of previous operations was significantly lower in the younger age group compared with the >65 year olds, where more than one out of every two patients had had at least one previous operation (p < 0.001).
The unadjusted tests of the influence of age groups on the outcome parameters (Tables 4, 5) showed a significant difference in all perioperative complication rates, reoperation rate as well as in the duration of operation and the length of postoperative hospital stay.
Table 3
Risk factors
≤65 years
>65 years
p
n
%
n
%
Risk factors
Overall
No
13,471
78.26
4970
67.55
<0.001
Yes
3743
21.74
2387
32.45
Aortic aneurysm
No
17,196
99.90
7313
99.40
<0.001
Yes
18
0.10
44
0.60
Antiplatelet medication
No
16,732
97.20
6402
87.02
Yes
482
2.80
955
12.98
<0.001
COPD
No
16,524
95.99
6784
92.21
Yes
690
4.01
573
7.79
<0.001
Corticoids
No
17,104
99.36
7270
98.82
Yes
110
0.64
87
1.18
<0.001
Diabetes
No
16,752
97.32
6821
92.71
Yes
462
2.68
536
7.29
<0.001
Coagulopathy
No
17,098
99.33
7207
97.96
Yes
116
0.67
150
2.04
<0.001
Immunosuppression
No
17,135
99.54
7303
99.27
Yes
79
0.46
54
0.73
0.010
Anticoagulation therapy
No
17,140
99.57
7077
96.19
Yes
74
0.43
280
3.81
<0.001
Smoking
No
14,836
86.19
6988
94.98
Yes
2378
13.81
369
5.02
<0.001
Table 4
Unadjusted analysis of duration of operation and postoperative hospital stay
≤65 years
>65 years
p
Mean-STD
Mean
Mean + STD
Mean-STD
MW
Mean + STD
Duration of operation [min]
33.1
51.0
78.6
33.6
52.2
81.2
<0.001
Post-op. hospital stay [days]
1.0
1.6
2.6
1.1
1.8
3.1
<0.001
Table 5
Unadjusted analysis of perioperative complications and reoperations
≤65 years
>65 years
p
n
%
n
%
Intraoperative complications
Overall
Yes
205
1.19
118
1.60
No
17,009
98.81
7239
98.40
0.010
Bleeding
Yes
138
0.80
75
1.02
No
17,076
99.20
7282
98.98
0.098
Injuries
Overall
Yes
116
0.67
65
0.88
No
17,098
99.33
7292
99.12
0.078
Vascular
Yes
53
0.31
19
0.26
No
17,161
99.69
7338
99.74
0.606
Bowel
Yes
11
0.06
14
0.19
No
17,203
99.94
7343
99.81
0.007
Bladder
Yes
16
0.09
13
0.18
No
17,198
99.91
7344
99.82
0.103
Nerve
Yes
1
0.01
0
0.00
No
17,213
99.99
7357
100.0
1.000
Postoperative complications
Overall
Yes
468
2.72
338
4.59
No
16,746
97.28
7019
95.41
<0.001
Bleeding
Yes
121
0.70
110
1.50
No
17,093
99.30
7247
98.50
<0.001
Bowel injury/anastomotic leakage
Yes
6
0.03
3
0.04
No
17,208
99.97
7354
99.96
0.733
SSI
Yes
19
0.11
4
0.05
No
17,195
99.89
7353
99.95
0.255
Seroma
Yes
319
1.85
224
3.04
No
16,895
98.15
7133
96.96
<0.001
Mesh infection
Yes
10
0.06
1
0.01
No
17,204
99.94
7356
99.99
0.191
Ileus
Yes
13
0.08
8
0.11
No
17,201
99.92
7349
99.89
0.475
Reoperation
Yes
184
1.07
101
1.37
No
17,030
98.93
7256
98.63
0.044
General complications
Overall
Yes
147
0.85
146
1.98
No
17,067
99.15
7211
98.02
<0.001
Urinary tract infection
Yes
14
0.08
7
0.10
No
17,200
99.92
7350
99.90
0.812
Thrombosis
Yes
4
0.02
3
0.04
No
17,210
99.98
7354
99.96
0.434
Pulmonary embolism (PAE)
Yes
2
0.01
3
0.04
No
17,212
99.99
7354
99.96
0.162
Pneumonia
Yes
3
0.02
9
0.12
No
17,211
99.98
7348
99.88
0.002
COPD
Yes
8
0.05
9
0.12
No
17,206
99.95
7348
99.88
0.059
Myocardial infarction
Yes
3
0.02
11
0.15
No
17211
99.98
7346
99.85
<0.001
Renal failure
Yes
2
0.01
11
0.15
No
17212
99.99
7346
99.85
<0.001
Death
Yes
1
0.01
4
0.05
No
17213
99.99
7353
99.95
0.031
Anzeige
While the median length of hospital stay (Table 4) in both age groups was 2 days, a significant difference of 0.2 days was identified for the mean value, which was more favorable in the younger age category (p < 0.001). The significant difference in the duration of operation, which was on average 1.2 min, was accordingly small.
Overall, there were 0.41 % more intraoperative complications in the >65 years age group (p = 0.010), which was largely due a higher rate of intestinal injuries and bleeding (Table 5). The difference in postoperative complications at 2.72 versus 4.59 % was even more pronounced to the disadvantage of the >65 years age group (p < 0.001). That was imputable in particular to the higher rate of secondary bleeding and of seromas. There was also a difference of 0.3 % in the reoperation rate, again to the disadvantage of the >65 years age group (p = 0.044). There were twice as many general complications in the >65 years age group (0.85 vs 1.98 %, p < 0.001). The main complications seen were coronary heart disease, myocardial infarction, renal and cardiac failure, pleural effusion and pneumonia, and these occurred more often in the >65 years age group.
Multivariable results
Because of the differences in the patient characteristics between the two groups, and in particular due to the potential influence exerted by these variables on the outcome variables, unadjusted analysis of the complication rates with respect to age groups can lead to distortions. The results were verified using multivariable models.
Model fit of intraoperative complications, which reflects the suitability of the influence parameters for explaining the values of the outcome variables, was not significant (p = 0.199). Therefore, it was not possible to find any evidence that individual variables had a significant influence on onset of intraoperative complications.
The results of analysis of the postoperative complications are illustrated in Table 6 (model fit: p < 0.001). The postoperative complication rate is impacted primarily by an advanced hernia disease and the general condition of the patient. Scrotal EHS classification also resulted in an increased complication risk (OR 2.738 [2.078; 3.609]). Likewise, a larger hernia defect significantly increased the postoperative complication risk (p < 0,001; II vs I: OR 1.677 [1.285; 2.187]; III vs I: OR 2.471 [1.855; 3.292]). Equally, the overall complication risk was significantly increased by the use of transabdominal preperitoneal patch plasty (TAPP) (OR 2.461 [2.066; 2.931]). With regard to the postoperative complications, as demonstrated by unadjusted analysis, a significantly lower complication risk was identified in the ≤65 years age group (p < 0.001; OR 0.718 [0.612; 0.841]). Low ASA classifications (p = 0.037; II vs I: OR 1.161 [0.976; 1.381]; III vs I: OR 1.362 [1.071; 1.732]; IV vs I: OR 2.559 [0.891; 7.346]) and a unilateral operation (p = 0.041; OR 1.173 [1.007; 1.366]) also significantly reduced occurrence of a postoperative complication.
Table 6
Multivariable analysis of postoperative complications
Parameter
p value
Variables
OR
95 % CI
Operation technique
<0.001
TAPP vs TEP
2.461
2.066
2.931
Scrotal hernia (EHS)
<0.001
Yes vs No
2.738
2.078
3.609
Defect size (EHS)
<0.001
II (1.5–3 cm) vs I (<1.5 cm)
1.677
1.285
2.187
III (>3 cm) vs I (<1.5 cm)
2.471
1.855
3.292
Age
<0.001
≤65 vs >65 years
0.718
0.612
0.841
ASA score
0.037
II vs I
1.161
0.976
1.381
III vs I
1.362
1.071
1.732
IV vs I
2.559
0.891
7.346
Bilateral/unilateral
0.041
Bilateral vs unilateral
1.173
1.007
1.366
Sex
0.304
Male vs female
0.884
0.699
1.118
With a prevalence of 3.28 %, that corresponds to 28 postoperative complications for every 1,000 patients from the ≤65 years age group compared with 38 complications for the >65 years age group.
The results of analysis of the reoperation rate are given in Table 7 (model fit: p < 0.001). The reoperation rate was influenced primarily by bilaterality of the inguinal hernia operation (p < 0.001). Conduct of a bilateral surgical procedure led to significantly more reoperations (OR 2.154 [1.669; 2.730]). Likewise, high ASA classifications resulted significantly more often in reoperation (p = 0.004; II vs I: OR 1.058 [0.799; 1.401]; III vs I: OR 1.581; [1.074; 2.327]; IV vs I: OR 6.001 [1.786; 20.167]). The risk of reoperation also rose for scrotal inguinal hernias (p = 0.033; OR 1.807 [1.049; 3.111]). The same applied for a large hernia defect (p = 0.043: II vs I: OR 1.208 [0.819; 1.780]; III vs I: OR 1.614 [1.051; 2.478]).
Table 7
Multivariable analysis of reoperation
Parameter
p value
Variables
OR
95 % CI
Bilateral/unilateral
<0.001
Bilateral vs unilateral
2.154
1.699
2.730
ASA score
0.004
II vs I
1.058
0.799
1.401
III vs I
1.581
1.074
2.327
IV vs I
6.001
1.786
20.167
Scrotal hernia (EHS)
0.033
Yes vs No
1.807
1.049
3.111
Defect size (EHS)
0.043
II (1.5–3 cm) vs I (<1.5 cm)
1.208
0.819
1.780
III (>3 cm) vs I (<1.5 cm)
1.614
1.051
2.478
Operation technique
0.463
TAPP vs TEP
1.096
0.858
1.399
Age
0.695
≤65 vs >65 years
0.947
0.721
1.244
Sex
0.918
Male vs female
0.979
0.650
1.474
Conversely—and contrary to the findings of unadjusted analysis—the reoperation rate did not differ significantly between the two age groups investigated.
Table 8 gives the results of multivariable analysis of the influences impacting general complications (model fit: p < 0.001). The general complications were influenced primarily by ASA status (p < 0.001). In particular, ASA classification IV increased the complication risk (IV vs I: OR 6.355 [1.892; 21.345]). Onset of general complications was likewise significantly more common in the >65 years age group than in the ≤65 years age group (p < 0.001; OR 0.615 [0.473; 0.800]). The use of the TAPP operation method also favored onset of general complications (p = 0.005). The corresponding risk rose for a TAPP operation with an odds ratio of OR 1.432 [1.114; 1.841].
Table 8
Multivariable analysis of general complications
Parameter
p value
Variables
OR
95 % CI
ASA score
<0.001
II vs I
1.171
0.855
1.604
III vs I
3.419
2.381
4.911
IV vs I
6.355
1.892
21.345
Age
<0.001
≤65 years vs >65 years
0.615
0.473
0.800
Operation technique
0.005
TAPP vs TEP
1.432
1.114
1.841
Bilateral/unilateral
0.225
Bilateral vs unilateral
1.169
0.909
1.504
Defect size (EHS)
0.588
II (1.5–3 cm) vs I (<1.5 cm)
0.842
0.595
1.190
III (>3 cm) vs I (<1.5 cm)
0.906
0.608
1.352
Scrotal hernia (EHS)
0.665
Yes vs No
1.148
0.614
2.146
Sex
0.999
Male vs female
1.000
0.693
1.443
For an overall general complication rate of 1.19 %, that corresponds to occurrence of a complication in around 10 out of every 1000 patients undergoing surgery from the ≤65 years age group compared with 14 out of every 1000 patients for the >65 years age group.
Model fit of the duration of operation was also highly significant (p < 0.001). The highly significant impact of the age groups on the duration of operation, which was demonstrated in unadjusted analysis, could only be confirmed as a trend in the multivariable model (Table 9). In reality, a large hernia defect, the presence of a scrotal hernia, surgery for a male patient, the use of TAPP and bilateral operation (in each case p < 0.001) led to significant increase in the duration of operation.
Table 9
Multivariable analysis of duration of operation
Parameter
p value
Variables
Beta
95 % CI
Intercept
<0.001
3.717
3.603
3.831
Bilateral
<0.001
Bilateral
0.313
0.301
0.324
Operation technique
<0.001
TAPP
0.089
0.078
0.099
Defect size (EHS)
<0.001
I (<1.5 cm)
−0.113
−0.131
−0.096
Defect size (EHS)
<0.001
II (1.5–3 cm)
−0.097
−0.110
−0.084
Scrotal hernia (EHS)
<0.001
Yes
0.182
0.149
0.216
Sex
<0.001
Male
0.046
0.029
0.062
ASA score
I
0.115
0.002
0.229
ASA score
II
0.124
0.011
0.237
ASA score
0.024
III
0.108
−0.006
0.222
Age
0.072
≤65 Jahre
−0.011
−0.023
0.001
Table 10 shows the results of multivariable analysis of the factors influencing the postoperative length of hospital stay (model fit: p < 0.001). The postoperative length of hospital stay was significantly increased in the >65 years age group also, when concurrently looking at the other influencing variables (p < 0.001). All other influencing variables also had a significant impact on the length of stay. The length of hospital stay was increased in each case by the use of the TAPP operation method, bilaterality of operation as well as by a scrotal hernia. Besides, the postoperative stay was significantly longer for women than for men.
Table 10
Multivariable analysis of hospital stay
Parameter
p value
Variables
Beta
95 % CI
Intercept
<0.001
1.107
0.967
1.246
ASA score
<0.001
I
−0.571
−0.709
−0.432
ASA score
<0.001
II
−0.524
−0.662
−0.386
ASA score
<0.001
III
−0.365
−0.504
−0.226
Bilateral
<0.001
Bilateral
0.111
0.097
0.125
Sex
<0.001
Male
−0.124
−0.145
−0.104
Scrotal hernia (EHS)
<0.001
YES
0.203
0.163
0.243
Age
<0.001
≤65 years
−0.056
−0.071
−0.041
Defect size (EHS)
<0.001
I (<1.5 cm)
0.014
−0.008
0.035
Defect size (EHS)
<0.001
II (1.5–3 cm)
0.039
0.023
0.055
Operation technique
0.020
TAPP
0.015
0.002
0.028
On the basis of the LOESS graphs, it can be seen that the proportion of higher ASA classifications and of risk factors rise almost linearly with increasing age (Fig. 1). The postoperative complications increase as from age 80 years (Fig. 1).
Fig. 1
Non-metric regression analysis (LOESS) of age for post-op. complication, cumulative risk factors and ASA score
×
Discussion
The registry study presented here investigated the influence of patient age >65 years on the perioperative outcome compared with that of patient age ≤65 years. In addition, other factors impacting onset of perioperative complications were identified and their relative influence on the results determined.
The patients in the two age groups differed significantly from each other with regard to the majority of the variables analyzed. For example, in the >65 years age group, the proportion of women, higher ASA classifications, larger hernia defects, emergency operations, risk factors and previous operations were significantly greater.
Unadjusted analyses revealed that patients in >65 years age group had significantly higher intraoperative, postoperative and general complication rates as well as a higher reoperation rate linked to these complications. In multivariable analysis, it was not possible to find any evidence that individual variables influenced onset of intraoperative complications. As regards the postoperative complications, multivariable analysis showed the risk identified for the ≤65 years age group was significantly lower. Likewise, there were significantly fewer postoperative complications when using TEP, for smaller hernia defects, unilateral operation and a lower ASA classification. Conversely, scrotal EHS classification had an unfavorable influence on occurrence of postoperative complications. However, as in the TAPP group, the percentage of patients with scrotal hernias or with larger hernia defects is significantly higher compared with TEP both minimal invasive techniques are hardly comparable and conclusions should be drawn with caution.
On the other hand, the reoperation rate did not differ significantly between the two age groups in multivariable analysis. The probability of reoperation was increased by bilateral operations, a higher ASA classification, larger hernia defects as well as by a scrotal hernia, but not by the operation technique.
General complications were also seen in multivariable analysis significantly more often in the >65 years age group than in the younger patients. The TAPP operation method and a higher ASA classification are other unfavorable influence factors.
The postoperative length of hospital stay was significantly increased in the >65 years age group, also when concurrently looking at the other influencing variables.
The higher rate of postoperative surgical and general complications in patients in the >65 years age group compared with in the ≤65 years age group thus concords with the findings of the Swedish Hernia Registry [13], Danish Hernia Registry [14] and of the National Surgical Quality Improvement Program of the American College of Surgeons [15]. However, the data presented here in this study additionally show that the age-related rise in postoperative surgical complications did not lead to an increased complication-related reoperation rate. Rather, it was more a bilateral operation, higher ASA classification, larger hernia defect and scrotal hernia which resulted in postoperative complications necessitating reoperation. These were also the influencing variables, in addition to TAPP, which apart from age >65 years gave rise to increased postoperative surgical complications, which could be treated conservatively. Accordingly, the higher perioperative complication rate associated with endoscopic/laparoscopic inguinal hernia surgery in patients >65 years compared with those ≤65 years is of multifactorial genesis. The same applies for the general postoperative complications, which in the >65 years age group were further negatively influenced by conduct of TAPP operation and the presence of a higher ASA classification. That, too, demonstrates the multifactorial influence exerted on the postoperative outcome of patients in the >65 years age group.
The age limit of 65 years is used as a rule for analysis of the influence of age on the postoperative outcome following surgical procedures because of the fact that this is the retirement age in many countries [13]. However, our own analyses based on LOESS graphs show that age 80 years tends to be the time point from which a marked rise is seen in postoperative complications.
In summary, it can be stated that the increase in perioperative complication and reoperation rates associated with laparoscopic/endoscopic inguinal hernia surgery is not only influenced by higher age but mainly by other factors. These include, in particular, bilateral operation, large hernia defect or scrotal hernia and a higher ASA classification and a multitude of risk factors. It can also be demonstrated that it is only as from age 80 years that a relevant rise in postoperative complication rates can be identified. As such, age >65 years in itself does not constitute a risk factor for conduct of laparoscopic/endoscopic inguinal hernia repair. If this is indicated, the focus should be more on the factors identified by the presented study and which have a significant influence on the outcome. In patients over the age of 80, laparoscopic hernia repair is possible, but preoperative analysis of risk factors and their correction if possible should be mandatory [25]. Moreover, careful intraoperative monitoring by the anesthesiologist is essential and the possibility to stay for some hours in an ICU should be provided.
Acknowledgments
Ferdinand Köckerling has got grants to fund the Herniamed Registry from Johnson&Johnson, Norderstedt, Karl Storz, Tutlingen, PFM Medical, Cologne, Dahlhausen, Cologne, B Braun, Tutlingen, MenkeMed, Munich and BARD, Karlsruhe.
Disclosures
F. Mayer, M. Lechner, D. Adolf, D. Öfner, G. Köhler, R, Fortelny, R. Bittner have no conflicts of interest or financial ties to disclose.
Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.
Mit der Zeitschrift Die Chirurgie erhalten Sie zusätzlich Online-Zugriff auf weitere 43 chirurgische Fachzeitschriften, CME-Fortbildungen, Webinare, Vorbereitungskursen zur Facharztprüfung und die digitale Enzyklopädie e.Medpedia.
Bis 30. April 2024 bestellen und im ersten Jahr nur 199 € zahlen!
Ahmetov, Azat (Saint-Petersburg); Alapatt, Terence Francis (Frankfurt/Main); Anders, Stefan (Berlin); Anderson, Jürina (Würzburg); Arndt, Anatoli (Elmshorn); Asperger, Walter (Halle); Avram, Iulian (Saarbrücken); Barkus; Jörg (Velbert); Becker, Matthias (Freital); Behrend, Matthias (Deggendorf); Beuleke, Andrea (Burgwedel); Berger, Dieter (Baden-Baden); Bittner, Reinhard (Rottenburg); Blumberg, Claus (Lübeck); Böckmann, Ulrich (Papenburg); Böhle, Arnd Steffen (Bremen); Böttger, Thomas Carsten (Fürth); Borchert, Erika (Grevenbroich); Born, Henry (Leipzig); Brabender, Jan (Köln); Breitenbuch von, Philipp (Radebeul); Brüggemann, Armin (Kassel); Brütting, Alfred (Erlangen); Budzier, Eckhard (Meldorf); Burghardt, Jens (Rüdersdorf); Carus, Thomas (Bremen); Cejnar, Stephan-Alexander (München); Chirikov, Ruslan (Dorsten); Comman, Andreas (Bogen); Crescenti, Fabio (Verden/Aller); Dapunt, Emanuela (Bruneck); Decker, Georg (Berlin); Demmel, Michael (Arnsberg); Descloux, Alexandre (Baden); Deusch, Klaus-Peter (Wiesbaden); Dick, Marcus (Neumünster); Dieterich, Klaus (Ditzingen); Dietz, Harald (Landshut); Dittmann, Michael (Northeim); Dornbusch, Jan (Herzberg/Elster); Drummer, Bernhard (Forchheim); Eckermann, Oliver (Luckenwalde); Eckhoff, Jörn /Hamburg); Elger, Karlheinz (Germersheim); Engelhardt, Thomas (Erfurt); Erichsen, Axel (Friedrichshafen); Eucker, Dietmar (Bruderholz); Fackeldey, Volker (Kitzingen); Farke, Stefan (Delmenhorst); Faust, Hendrik (Emden); Federmann, Georg (Seehausen); Feichter, Albert (Wien); Fiedler, Michael (Eisenberg); Fischer, Ines (Wiener Neustadt); Fortelny, René H. (Wien); Franczak, Andreas (Wien); Franke, Claus (Düsseldorf); Frankenberg von, Moritz (Salem); Frehner, Wolfgang (Ottobeuren); Friedhoff, Klaus (Andernach); Friedrich, Jürgen (Essen); Frings, Wolfram (Bonn); Fritsche, Ralf (Darmstadt); Frommhold, Klaus (Coesfeld); Frunder, Albrecht (Tübingen); Fuhrer, Günther (Reutlingen); Gassler, Harald (Villach); Gerdes, Martin (Ostercappeln); Gilg, Kai-Uwe (Hartmannsdorf); Glaubitz, Martin (Neumünster); Glutig, Holger (Meißen); Gmeiner, Dietmar (Bad Dürrnberg); Göring, Herbert (München); Grebe, Werner (Rheda-Wiedenbrück); Grothe, Dirk (Melle); Gürtler, Thomas (Zürich); Hache, Helmer (Löbau); Hämmerle, Alexander (Bad Pyrmont); Haffner, Eugen (Hamm); Hain, Hans-Jürgen (Groß-Umstadt); Hammans, Sebastian (Lingen); Hampe, Carsten (Garbsen); Harrer, Petra (Starnberg); Heinzmann, Bernd (Magdeburg); Heitland, Tim (München); Helbling, Christian (Rapperswil); Hempen, Hans-Günther (Cloppenburg); Henneking, Klaus-Wilhelm (Bayreuth); Hermes, Wolfgang (Weyhe); Herrgesell, Holger (Berlin); Herzing, Holger Höchstadt); Hessler, Christian (Bingen); Hildebrand, Christiaan (Langenfeld); Höferlin, Andreas (Mainz); Hoffmann, Michael (Kassel; Hofmann, Eva M. (Frankfurt/Main); Hopfer, Frank (Eggenfelden); Hornung, Frederic (Wolfratshausen); Hügel, Omar (Hannover); Hüttemann, Martin (Oberhausen); Huhn, Ulla (Berlin); Imdahl, Andreas (Heidenheim); Jacob, Dietmar (Bielefeld); Jenert, Burghard (Lichtenstein); Jugenheimer, Michael (Herrenberg); Junger, Marc (München); Käs, Stephan (Weiden); Kahraman, Orhan (Hamburg); Kaiser, Christian (Westerstede); Kaiser, Stefan (Kleinmachnow); Kapischke, Matthias (Hamburg); Karch, Matthias (Eichstätt); Keck, Heinrich (Wolfenbüttel); Keller, Hans W. (Bonn); Kienzle, Ulrich (Karlsruhe); Kipfmüller, Brigitte (Köthen); Kirsch, Ulrike (Oranienburg); Klammer, Frank (Ahlen); Klatt, Richard (Hagen); Kleemann, Nils (Perleberg); Klein, Karl-Hermann (Burbach); Kleist, Sven (Berlin); Klobusicky, Pavol (Bad Kissingen); Kneifel, Thomas (Datteln); Knoop, Michael (Frankfurt/Oder); Knotter, Bianca (Mannheim); Koch, Andreas (Cottbus); Köckerling, Ferdinand (Berlin); Köhler, Gernot (Linz); König, Oliver (Buchholz); Kornblum, Hans (Tübingen); Krämer, Dirk (Bad Zwischenahn); Kraft, Barbara (Stuttgart); Kreissl, Peter (Ebersberg); Krones, Carsten Johannes (Aachen); Kruse, Christinan (Aschaffenburg); Kube, Rainer (Cottbus); Kühlberg, Thomas (Berlin); Kuhn, Roger (Gifhorn); Kusch, Eduard (Gütersloh); Kuthe, Andreas (Hannover); Ladberg, Ralf (Bremen); Ladra, Jürgen (Düren); Lahr-Eigen, Rolf (Potsdam); Lainka, Martin (Wattenscheid); Lammers, Bernhard J. (Neuss); Lancee, Steffen (Alsfeld); Larusson, Hannes Jon (Pinneberg); Lauschke, Holger (Duisburg); Leher, Markus (Schärding); Leidl, Stefan (Waidhofen/Ybbs); Lenz, Stefan (Berlin); Lesch, Alexander (Kamp-Lintfort); Lienert, Mark (Duisburg); Limberger, Andreas (Schrobenhausen); Locher, Martin (Kiel); Loghmanieh, Siawasch (Viersen); Lorenz, Ralph (Berlin); Mallmann, Bernhard (Krefeld); Manger, Regina (Schwabmünchen); Maurer, Stephan (Münster); Mayer, Franz (Salzburg); Menzel, Ingo (Weimar); Meurer, Kirsten (Bochum); Meyer, Moritz (Ahaus); Mirow, Lutz (Kirchberg); Mittenzwey, Hans-Joachim (Berlin); Mörder-Köttgen, Anja (Freiburg); Moesta, Kurt Thomas (Hannover); Moldenhauer, Ingolf (Braunschweig); Morkramer, Rolf (Xanten); Mosa, Tawfik (Merseburg); Müller, Hannes (Schlanders); Münzberg, Gregor (Berlin); Mussack, Thomas (St. Gallen); Neumann, Jürgen (Haan); Niebuhr, Henning (Hamburg); Nölling, Anke (Burbach); Nostitz, Friedrich Zoltán (Mühlhausen); Obermaier, Straubing); Öz-Schmidt, Meryem (Hanau); Oldorf, Peter (Usingen); Olivieri, Manuel (Pforzheim); Pawelzik, Marek (Hamburg); Peiper, Christian (Hamm); Pertl, Alexander (Spittal/Drau); Philipp, Mark (Rostock); Pickart, Lutz (Bad Langensalza); Pizzera, Christian (Graz); Pöllath, Martin (Sulzbach-Rosenberg); Possin, Ulrich (Laatzen); Prenzel, Klaus (Bad Neuenahr-Ahrweiler); Pröve, Florian (Goslar); Pronnet, Thomas (Fürstenfeldbruck); Pross, Matthias (Berlin); Puff, Johannes (Dinkelsbühl); Rabl, Anton (Passau); Rapp, Martin (Neunkirchen); Reck, Thomas (Püttlingen); Reinpold, Wolfgang (Hamburg); Reuter, Christoph (Quakenbrück); Richter, Jörg (Winnenden); Riemann, Kerstin (Alzenau-Wasserlos); Rodehorst, Anette (Otterndorf); Roehr, Thomas (Rödental); Roncossek, Bremerhaven); Roth Hartmut (Nürnberg); Sardoschau, Nihad (Saarbrücken); Sauer, Gottfried (Rüsselsheim); Sauer, Jörg (Arnsberg); Seekamp, Axel (Freiburg); Seelig, Matthias (Bad Soden); Seiler, Christoph Michael (Warendorf); Seltmann, Cornelia (Hachenburg); Senkal, Metin (Witten); Shamiyeh, Andreas (Linz); Shang, Edward (München); Siemssen, Björn (Berlin); Sievers, Dörte (Hamburg); Silbernik, Daniel (Bonn); Simon, Thomas (Sinsheim); Sinn, Daniel (Olpe); Sinning, Frank (Nürnberg); Smaxwil, Constatin Aurel (Stuttgart); Schabel, Volker (Kirchheim/Teck); Schadd, Peter (Euskirchen); Schassen von, Christian (Hamburg); Schattenhofer, Thomas (Vilshofen); Scheidbach, Hubert (Neustadt/Saale); Schelp, Lothar (Wuppertal); Scherf, Alexander (Pforzheim); Scheyer, Mathias (Bludenz); Schimmelpenning, Hendrik (Neustadt in Holstein); Schinkel, Svenja (Kempten); Schmid, Michael (Gera); Schmid, Thomas (Innsbruck); Schmidt, Rainer (Paderborn); Schmidt, Sven-Christian (Berlin); Schmidt, Ulf (Mechernich); Schmitz, Heiner (Jena); Schmitz, Ronald (Altenburg); Schöche, Jan (Borna); Schoenen, Detlef (Schwandorf); Schrittwieser, Rudolf /Bruck an der Mur); Schroll, Andreas (München); Schultz, Christian (Bremen-Lesum); Schultz, Harald (Landstuhl); Schulze, Frank P. Mülheim an der Ruhr); Schumacher, Franz-Josef (Oberhausen); Schwab, Robert (Koblenz); Schwandner, Thilo (Lich); Schwarz, Jochen Günter (Rottenburg); Schymatzek, Ulrich (Radevormwald); Spangenberger, Wolfgang (Bergisch-Gladbach); Sperling, Peter (Montabaur); Staade, Katja (Düsseldorf); Staib, Ludger (Esslingen); Stamm, Ingrid (Heppenheim); Stark, Wolfgang (Roth); Stechemesser, Bernd (Köln); Steinhilper, Uz (München); Stern, Oliver (Hamburg); Stolte, Thomas (Mannheim); Stopinski, Jürgen (Schwalmstadt); Stubbe, Hendrik (Güstrow/); Stülzebach, Carsten (Friedrichroda); Tepel, Jürgen (Osnabrück); Terzić, Alexander (Wildeshausen); Teske, Ulrich (Essen); Thews, Andreas (Schönebeck); Tillenburg, Wolfgang (Marktheidenfeld); Timmermann, Wolfgang (Hagen); Train, Stefan H. (Gronau); Trauzettel, Uwe (Plettenberg); Triechelt, Uwe (Langenhagen); Ulcar, Heimo (Schwarzach im Pongau); Unger, Solveig (Chemnitz); Verweel, Rainer (Hürth); Vogel, Ulrike (Berlin); Voigt, Rigo (Altenburg); Voit, Gerhard (Fürth); Volkers, Hans-Uwe (Norden); Vossough, Alexander (Neuss); Wallasch, Andreas (Menden); Wallner, Axel (Lüdinghausen); Warscher, Manfred (Lienz); Warwas, Markus (Bonn); Weber, Jörg (Köln); Weiß, Johannes (Schwetzingen); Weißenbach, Peter (Neunkirchen); Werner, Uwe (Lübbecke-Rahden); Wessel, Ina (Duisburg); Weyhe, Dirk (Oldenburg); Wieber, Isabell (Köln); Wiesmann, Aloys (Rheine); Wiesner, Ingo (Halle); Woehe, Fritz (Sanderhausen); Wolf, Claudio (Neuwied); Yildirim, Selcuk (Berlin); Zarras, Konstantinos (Düsseldorf); Zeller, Johannes (Waldshut-Tiengen); Zhorzel, Sven (Agatharied); Zuz, Gerhard (Leipzig);
Nach PCI besteht ein erhöhtes Blutungsrisiko, wenn die Behandelten eine verminderte linksventrikuläre Ejektionsfraktion aufweisen. Das Risiko ist umso höher, je stärker die Pumpfunktion eingeschränkt ist.
In einer Leseranfrage in der Zeitschrift Journal of the American Academy of Dermatology möchte ein anonymer Dermatologe bzw. eine anonyme Dermatologin wissen, ob er oder sie einen Patienten behandeln muss, der eine rassistische Tätowierung trägt.
Der Einsatz von Wundprotektoren bei offenen Eingriffen am unteren Gastrointestinaltrakt schützt vor Infektionen im Op.-Gebiet – und dient darüber hinaus der besseren Sicht. Das bestätigt mit großer Robustheit eine randomisierte Studie im Fachblatt JAMA Surgery.
Der belastende Arbeitsalltag wirkt sich negativ auf die psychische Gesundheit der Angehörigen ärztlicher Berufsgruppen aus. Chirurginnen und Chirurgen bilden da keine Ausnahme, im Gegenteil.
Update Chirurgie
Bestellen Sie unseren Fach-Newsletterund bleiben Sie gut informiert.
Das Karpaltunnelsyndrom ist die häufigste Kompressionsneuropathie peripherer Nerven. Obwohl die Anamnese mit dem nächtlichen Einschlafen der Hand (Brachialgia parästhetica nocturna) sehr typisch ist, ist eine klinisch-neurologische Untersuchung und Elektroneurografie in manchen Fällen auch eine Neurosonografie erforderlich. Im Anfangsstadium sind konservative Maßnahmen (Handgelenksschiene, Ergotherapie) empfehlenswert. Bei nicht Ansprechen der konservativen Therapie oder Auftreten von neurologischen Ausfällen ist eine Dekompression des N. medianus am Karpaltunnel indiziert.
Das Webinar beschäftigt sich mit Fragen und Antworten zu Diagnostik und Klassifikation sowie Möglichkeiten des Ausschlusses von Zusatzverletzungen. Die Referenten erläutern, welche Frakturen konservativ behandelt werden können und wie. Das Webinar beantwortet die Frage nach aktuellen operativen Therapiekonzepten: Welcher Zugang, welches Osteosynthesematerial? Auf was muss bei der Nachbehandlung der distalen Radiusfraktur geachtet werden?
Inhalte des Webinars zur S1-Leitlinie „Empfehlungen zur Therapie der akuten Appendizitis bei Erwachsenen“ sind die Darstellung des Projektes und des Erstellungswegs zur S1-Leitlinie, die Erläuterung der klinischen Relevanz der Klassifikation EAES 2015, die wissenschaftliche Begründung der wichtigsten Empfehlungen und die Darstellung stadiengerechter Therapieoptionen.
