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Pediatric Nephrology

01.04.2004 | Review

The post-transplant lymphoproliferative disorder—a literature review

verfasst von: Rokshana Shroff, Lesley Rees

Erschienen in: Pediatric Nephrology | Ausgabe 4/2004

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Abstract

The Epstein-Barr virus (EBV)-induced post-transplant lymphoproliferative disorder (PTLD) affects 1%–10% of all paediatric renal transplant recipients. This is a heterogeneous group of conditions characterised by EBV-driven proliferation of B-lymphocytes in the face of impaired T-cell immune surveillance. The risk factors predisposing to PTLD are becoming better understood, but its pathogenesis and myriad of clinical and histological features remain poorly defined. While new treatment modalities are being tried with variable success, regular EBV surveillance and carefully monitored reduction of immunosuppression remain the mainstay of treatment. In this review, we have presented the current knowledge of this increasingly common complication in renal transplant recipients.
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Metadaten
Titel
The post-transplant lymphoproliferative disorder—a literature review
verfasst von
Rokshana Shroff
Lesley Rees
Publikationsdatum
01.04.2004
Verlag
Springer-Verlag
Erschienen in
Pediatric Nephrology / Ausgabe 4/2004
Print ISSN: 0931-041X
Elektronische ISSN: 1432-198X
DOI
https://doi.org/10.1007/s00467-003-1392-x

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