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Erschienen in: Pediatric Nephrology 7/2010

01.07.2010 | Review

Catheter-free methods for vesicoureteric reflux detection: our experience and a critical appraisal of existing data

verfasst von: Damjana Ključevšek, Tomaž Ključevšek, Tanja Kersnik Levart, Gregor Novljan, Rajko B. Kenda

Erschienen in: Pediatric Nephrology | Ausgabe 7/2010

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Abstract

In recent years, the exact role of vesicoureteric reflux (VUR) in general has become controversial, though in some groups of children the knowledge of the existence or non-existence of VUR is still a very important issue. The number of techniques available for the assessment of VUR is increasing, and a new classification taking into account their real characteristics (direct/indirect, catheter-using/catheter-free, radiation-giving/radiation-free) has been proposed. The purpose of the following review is to evaluate the currently available evidence supporting the use of various catheter-free methods for VUR detection. We believe that as the clinical role of VUR has been questioned, it is even more important for the method of its detection to be user-friendly as regards catheterisation, radiation and availability. There is still no evidence supporting the assertion that any of the catheter-free methods of VUR detection might be the optimal one for any child. However, there are some groups of children who would benefit from using them. New studies using new, catheter-free methods of VUR detection or a combination of two or more of the methods described may prove useful in improving sensitivity and providing additional data on this important issue.
Literatur
1.
Zurück zum Zitat Venhola M, Uhari M (2009) Vesicoureteral reflux, a benign condition. Pediatr Nephrol 24:223–226CrossRefPubMed Venhola M, Uhari M (2009) Vesicoureteral reflux, a benign condition. Pediatr Nephrol 24:223–226CrossRefPubMed
2.
Zurück zum Zitat Coulthard MG (2009) Vesicoureteric reflux is not a benign condition. Pediatr Nephrol 24:227–232CrossRefPubMed Coulthard MG (2009) Vesicoureteric reflux is not a benign condition. Pediatr Nephrol 24:227–232CrossRefPubMed
3.
Zurück zum Zitat Arat BS (1991) Vesicoureteric reflux and renal injury. Am J Kidney Dis 17:491–511 Arat BS (1991) Vesicoureteric reflux and renal injury. Am J Kidney Dis 17:491–511
4.
Zurück zum Zitat Smellie JM, Normand IC (1975) Bacteriuria, reflux, and renal scarring. Arch Dis Child 50:581–585CrossRefPubMed Smellie JM, Normand IC (1975) Bacteriuria, reflux, and renal scarring. Arch Dis Child 50:581–585CrossRefPubMed
5.
Zurück zum Zitat Mannhardt W, Schofer O, Schulte-Wissermann H (1986) Pathogenic factors in recurrent urinary tract infections and renal scar formation in children. Eur J Paediatr 145:330–336CrossRef Mannhardt W, Schofer O, Schulte-Wissermann H (1986) Pathogenic factors in recurrent urinary tract infections and renal scar formation in children. Eur J Paediatr 145:330–336CrossRef
7.
Zurück zum Zitat Marra G, Oppezzo C, Ardissino G, Dacco V, Testa S, Avolio L, Taiolio E, Sereni F (2004) Severe vesicoureteral reflux and chronic renal failure: a condition peculiar to male gender? Data from the ItalKid Project. J Pediatr 144:677–681CrossRefPubMed Marra G, Oppezzo C, Ardissino G, Dacco V, Testa S, Avolio L, Taiolio E, Sereni F (2004) Severe vesicoureteral reflux and chronic renal failure: a condition peculiar to male gender? Data from the ItalKid Project. J Pediatr 144:677–681CrossRefPubMed
8.
Zurück zum Zitat Wheeler D, Vimalachandra D, Hodson EM, Roy LP, Smith G, Craig JC (2003) Antibiotics and surgery for vesicoureteric reflux: a meta-analysis of randomized controlled trials. Arch Dis Child 88:688–694CrossRefPubMed Wheeler D, Vimalachandra D, Hodson EM, Roy LP, Smith G, Craig JC (2003) Antibiotics and surgery for vesicoureteric reflux: a meta-analysis of randomized controlled trials. Arch Dis Child 88:688–694CrossRefPubMed
9.
Zurück zum Zitat Craig JC, Irwig LM, Knight JF, Roy LP (2000) Does treatment of vesicoureteric reflux in childhood prevent end-stage renal disease attributable to reflux nephropathy? Pediatrics 105:1236–1241CrossRefPubMed Craig JC, Irwig LM, Knight JF, Roy LP (2000) Does treatment of vesicoureteric reflux in childhood prevent end-stage renal disease attributable to reflux nephropathy? Pediatrics 105:1236–1241CrossRefPubMed
10.
Zurück zum Zitat Moorthy I, Easty M, McHugh K, Ridout D, Biassoni L, Gordon I (2005) The presence of vesicoureteric reflux does not identify a population risk for renal scarring following a first urinary tract infection. Arch Dis Child 90:733–736CrossRefPubMed Moorthy I, Easty M, McHugh K, Ridout D, Biassoni L, Gordon I (2005) The presence of vesicoureteric reflux does not identify a population risk for renal scarring following a first urinary tract infection. Arch Dis Child 90:733–736CrossRefPubMed
11.
Zurück zum Zitat Benador D, Benador N, Slosman D, Mermillod B, Girardin E (1997) Are younger children at highest risk of renal sequelae after pyelonephritis? Lancet 4:17–19CrossRef Benador D, Benador N, Slosman D, Mermillod B, Girardin E (1997) Are younger children at highest risk of renal sequelae after pyelonephritis? Lancet 4:17–19CrossRef
12.
Zurück zum Zitat Martinell J, Claesson I, Lidin-Janson G, Jodal U (1995) Urinary infection, reflux and renal scarring in females continuously followed for 13–38 years. Pediatr Nephrol 9:131–136CrossRefPubMed Martinell J, Claesson I, Lidin-Janson G, Jodal U (1995) Urinary infection, reflux and renal scarring in females continuously followed for 13–38 years. Pediatr Nephrol 9:131–136CrossRefPubMed
13.
Zurück zum Zitat Jacobson SH, Eklof O, Eriksson CG, Lins LE, Tidgren B, Winberg J (1989) Development of hypertension and uraemia after pyelonephritis in childhood: 27 year follow-up. BMJ 299:703–706CrossRefPubMed Jacobson SH, Eklof O, Eriksson CG, Lins LE, Tidgren B, Winberg J (1989) Development of hypertension and uraemia after pyelonephritis in childhood: 27 year follow-up. BMJ 299:703–706CrossRefPubMed
14.
Zurück zum Zitat El-Khatib MT, Becker GJ, Kincaid-Smith PS (1990) Reflux nephropathy and primary vesicoureteral reflux in adults. Q J Med 77:1241–1253PubMed El-Khatib MT, Becker GJ, Kincaid-Smith PS (1990) Reflux nephropathy and primary vesicoureteral reflux in adults. Q J Med 77:1241–1253PubMed
15.
Zurück zum Zitat Gordon I, Barkovics M, Pidoria S, Cole TJ, Woolf AS (2003) Primary vesicoureteric reflux as a predictor of renal damage in children hospitalized with urinary tract infection: a systematic review and meta-analysis. J Am Soc Nephrol 14:739–744CrossRefPubMed Gordon I, Barkovics M, Pidoria S, Cole TJ, Woolf AS (2003) Primary vesicoureteric reflux as a predictor of renal damage in children hospitalized with urinary tract infection: a systematic review and meta-analysis. J Am Soc Nephrol 14:739–744CrossRefPubMed
16.
Zurück zum Zitat Riccabona M, Avni FE, Blickman JG, Dacher JN, Darge K, Lobo ML, Willi U (2008) Imaging recommendations in paediatric uroradiology: minutes of the ESPR workgroup session on urinary tract infection, fetal hydronephrosis, urinary tract ultrasonography and voiding cystourethrography, Barcelona, Spain, June 2007. Pediatr Radiol 38:138–145CrossRefPubMed Riccabona M, Avni FE, Blickman JG, Dacher JN, Darge K, Lobo ML, Willi U (2008) Imaging recommendations in paediatric uroradiology: minutes of the ESPR workgroup session on urinary tract infection, fetal hydronephrosis, urinary tract ultrasonography and voiding cystourethrography, Barcelona, Spain, June 2007. Pediatr Radiol 38:138–145CrossRefPubMed
17.
Zurück zum Zitat Stefanidis CJ, Siomou E (2007) Imaging strategies for vesicoureteral reflux diagnosis. Pediatr Nephrol 22:937–947CrossRefPubMed Stefanidis CJ, Siomou E (2007) Imaging strategies for vesicoureteral reflux diagnosis. Pediatr Nephrol 22:937–947CrossRefPubMed
18.
Zurück zum Zitat Riccabona M, Fotter R (2004) Urinary tract infection in infants and children: an update with special regard to the changing role of reflux. Eur Radiol 14:L78–L88CrossRefPubMed Riccabona M, Fotter R (2004) Urinary tract infection in infants and children: an update with special regard to the changing role of reflux. Eur Radiol 14:L78–L88CrossRefPubMed
19.
Zurück zum Zitat Riccabona M (2002) Cystography in infants and children: a critical appraisal of the many forms with special regard to voiding cystourethrography. Eur Radiol 12:2910–2918PubMed Riccabona M (2002) Cystography in infants and children: a critical appraisal of the many forms with special regard to voiding cystourethrography. Eur Radiol 12:2910–2918PubMed
20.
Zurück zum Zitat Gordon I, Colarinha P, Fettich JJ, Fischer S, Frökier J, Hahn K, Kabasakal L, Mitjavila M, Olivier P, Piepsz A, Porn U, Sixt R, van Velzen J (2001) Guidelines for indirect radionuclide cystography. Eur J Nucl Med 28:BP16–BP20PubMed Gordon I, Colarinha P, Fettich JJ, Fischer S, Frökier J, Hahn K, Kabasakal L, Mitjavila M, Olivier P, Piepsz A, Porn U, Sixt R, van Velzen J (2001) Guidelines for indirect radionuclide cystography. Eur J Nucl Med 28:BP16–BP20PubMed
21.
Zurück zum Zitat Evans ED, Meyer JS, Harty MP, Bellah RD (1999) Assessment of increase in renal pelvic size on post-void sonography as predictor of vesicoureteral reflux. Pediatr Radiol 29:291–294CrossRefPubMed Evans ED, Meyer JS, Harty MP, Bellah RD (1999) Assessment of increase in renal pelvic size on post-void sonography as predictor of vesicoureteral reflux. Pediatr Radiol 29:291–294CrossRefPubMed
22.
Zurück zum Zitat Hiraoka M, Hori C, Tsukahara H, Kasuga K, Ishihara Y, Kotsuji F, Mayumi M (1999) Vesicoureteral reflux in male and female neonates as detected by voiding ultrasonography. Kidney Int 55:1486–1490CrossRefPubMed Hiraoka M, Hori C, Tsukahara H, Kasuga K, Ishihara Y, Kotsuji F, Mayumi M (1999) Vesicoureteral reflux in male and female neonates as detected by voiding ultrasonography. Kidney Int 55:1486–1490CrossRefPubMed
23.
Zurück zum Zitat Hiraoka M, Kasuga K, Hori C, Sudo M (1994) Ultrasonic indicators of ureteric reflux in the newborn. Lancet 343:519–520CrossRefPubMed Hiraoka M, Kasuga K, Hori C, Sudo M (1994) Ultrasonic indicators of ureteric reflux in the newborn. Lancet 343:519–520CrossRefPubMed
24.
Zurück zum Zitat Hiraoka M, Hashimoto G, Hori C, Tsukahara H, Konishi Y, Sudo M (1997) Use of ultrasonography in the detection of ureteric reflux in children suspected of having urinary tract infection. J Clin Ultrasound 25:195–199CrossRefPubMed Hiraoka M, Hashimoto G, Hori C, Tsukahara H, Konishi Y, Sudo M (1997) Use of ultrasonography in the detection of ureteric reflux in children suspected of having urinary tract infection. J Clin Ultrasound 25:195–199CrossRefPubMed
25.
Zurück zum Zitat Kopač M, Kenig A, Ključevšek D, Kenda RB (2005) Indirect voiding urosonography for detecting vesicoureteral reflux in children. Pediatr Nephrol 20:1285–1287CrossRefPubMed Kopač M, Kenig A, Ključevšek D, Kenda RB (2005) Indirect voiding urosonography for detecting vesicoureteral reflux in children. Pediatr Nephrol 20:1285–1287CrossRefPubMed
26.
Zurück zum Zitat Marshall JL, Johnson ND, De Campo MP (1990) Vesicoureteric reflux in children: prediction with colour Doppler imaging. Radiology 175:355–358PubMed Marshall JL, Johnson ND, De Campo MP (1990) Vesicoureteric reflux in children: prediction with colour Doppler imaging. Radiology 175:355–358PubMed
27.
Zurück zum Zitat Nishizawa O, Ishida H, Sugaya K, Kohama T, Harada T, Tsuchida S (1989) Application of Doppler colour flow imaging method on the detection of vesicoureteric reflux. Tohoku J Exp Med 159:163–164CrossRefPubMed Nishizawa O, Ishida H, Sugaya K, Kohama T, Harada T, Tsuchida S (1989) Application of Doppler colour flow imaging method on the detection of vesicoureteric reflux. Tohoku J Exp Med 159:163–164CrossRefPubMed
28.
Zurück zum Zitat Oak SN, Kulkarni B, Chaubal N (1999) Colour flow Doppler sonography: a reliable alternative to voiding cystourethrogram in the diagnosis of vesicoureteral reflux in children. Urology 53:1211–1214CrossRefPubMed Oak SN, Kulkarni B, Chaubal N (1999) Colour flow Doppler sonography: a reliable alternative to voiding cystourethrogram in the diagnosis of vesicoureteral reflux in children. Urology 53:1211–1214CrossRefPubMed
29.
Zurück zum Zitat Salih M, Baltaci S, Kiliç S, Anafarta K, Bedük Y (1994) Colour flow Doppler sonography in the diagnosis of vesicoureteric reflux. Eur Urol 26:93–97PubMed Salih M, Baltaci S, Kiliç S, Anafarta K, Bedük Y (1994) Colour flow Doppler sonography in the diagnosis of vesicoureteric reflux. Eur Urol 26:93–97PubMed
30.
Zurück zum Zitat Koşar A, Yeşiladağ A, Oyar O, Perk H, Gǖlsoy U (2003) Detection of vesico-ureteric reflux in children by colour-flow Doppler ultrasonography. BJU Int 91:856–859CrossRefPubMed Koşar A, Yeşiladağ A, Oyar O, Perk H, Gǖlsoy U (2003) Detection of vesico-ureteric reflux in children by colour-flow Doppler ultrasonography. BJU Int 91:856–859CrossRefPubMed
31.
Zurück zum Zitat Heberlik A (1997) Detection of low-grade vesicoureteric reflux in children by colour Doppler imaging mode. Pediatr Surg Int 12:38–43CrossRef Heberlik A (1997) Detection of low-grade vesicoureteric reflux in children by colour Doppler imaging mode. Pediatr Surg Int 12:38–43CrossRef
32.
Zurück zum Zitat Leung VY, Chu W, Yeung CK, Metreweli C (2007) Doppler waveforms of the ureteric jet: an overview and implications for the presence of a functional sphincter at the vesicoureteric junction. Pediatr Radiol 37:417–425CrossRefPubMed Leung VY, Chu W, Yeung CK, Metreweli C (2007) Doppler waveforms of the ureteric jet: an overview and implications for the presence of a functional sphincter at the vesicoureteric junction. Pediatr Radiol 37:417–425CrossRefPubMed
33.
Zurück zum Zitat Leung VY, Metreweli C, Yeung CK (2002) The ureteric jet Doppler waveform as an indicator of vesicoureteric sphincter function in adults and children. An observational study. Ultrasound Med Biol 28:865–872CrossRefPubMed Leung VY, Metreweli C, Yeung CK (2002) The ureteric jet Doppler waveform as an indicator of vesicoureteric sphincter function in adults and children. An observational study. Ultrasound Med Biol 28:865–872CrossRefPubMed
34.
Zurück zum Zitat Leung VY, Metreweli C, Yeung CK (2002) Immature ureteric jet Doppler patterns and urinary tract infection and vesicoureteric reflux in children. Ultrasound Med Biol 28:873–878CrossRefPubMed Leung VY, Metreweli C, Yeung CK (2002) Immature ureteric jet Doppler patterns and urinary tract infection and vesicoureteric reflux in children. Ultrasound Med Biol 28:873–878CrossRefPubMed
35.
Zurück zum Zitat Ključevšek D, Ključevšek T, Kersnik Levart T, Kenda RB (2009) Ureteric jet Doppler waveform: is it a reliable predictor of vesicoureteric reflux in children? Pediatr Nephrol 24:313–318CrossRefPubMed Ključevšek D, Ključevšek T, Kersnik Levart T, Kenda RB (2009) Ureteric jet Doppler waveform: is it a reliable predictor of vesicoureteric reflux in children? Pediatr Nephrol 24:313–318CrossRefPubMed
36.
Zurück zum Zitat Riccabona M, Pilhatsch A, Haberlik A, Ring E (2008) Three-dimensional ultrasonography-based virtual cystoscopy of the pediatric urinary bladder. J Ultrasound Med 27:1453–1459PubMed Riccabona M, Pilhatsch A, Haberlik A, Ring E (2008) Three-dimensional ultrasonography-based virtual cystoscopy of the pediatric urinary bladder. J Ultrasound Med 27:1453–1459PubMed
Metadaten
Titel
Catheter-free methods for vesicoureteric reflux detection: our experience and a critical appraisal of existing data
verfasst von
Damjana Ključevšek
Tomaž Ključevšek
Tanja Kersnik Levart
Gregor Novljan
Rajko B. Kenda
Publikationsdatum
01.07.2010
Verlag
Springer-Verlag
Erschienen in
Pediatric Nephrology / Ausgabe 7/2010
Print ISSN: 0931-041X
Elektronische ISSN: 1432-198X
DOI
https://doi.org/10.1007/s00467-009-1391-7

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