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Erschienen in: Pediatric Nephrology 7/2013

01.07.2013 | Educational Review

The changing face of pediatric hypertension in the era of the childhood obesity epidemic

verfasst von: Joseph Flynn

Erschienen in: Pediatric Nephrology | Ausgabe 7/2013

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Abstract

Historically, hypertension in childhood was thought to be an uncommon diagnosis, usually related to an underlying condition, most often parenchymal renal disease. Primary hypertension in childhood was felt to be quite rare. However, the worldwide childhood obesity epidemic has had a profound impact on the frequency of hypertension and other obesity-related conditions with the result that primary hypertension should now be viewed as one of the most common health conditions in the young. This review will present updated data on the prevalence of hypertension in children and adolescents, the impact of the childhood obesity epidemic on hypertension prevalence and blood pressure levels, shifts in how often primary hypertension is being diagnosed in childhood, and an overview of the pathophysiology of obesity-related hypertension. It is hoped that improved understanding of the significance of these issues will lead to improved recognition and treatment, which will be the key to averting an epidemic of cardiovascular disease in adulthood.
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Literatur
2.
Zurück zum Zitat Lazzeri G, Rossi S, Pammolli A, Pilato V, Pozzi T, Giacchi MV (2008) Underweight and overweight among children and adolescents in Tuscany (Italy). Prevalence and short-term trends. Prev Med Hyg 49:13–21 Lazzeri G, Rossi S, Pammolli A, Pilato V, Pozzi T, Giacchi MV (2008) Underweight and overweight among children and adolescents in Tuscany (Italy). Prevalence and short-term trends. Prev Med Hyg 49:13–21
3.
Zurück zum Zitat Valdés Pizarro J, Royo-Bordonada MA (2012) Prevalence of childhood obesity in Spain: National Health Survey 2006–2007. Nutr Hosp 27:154–160PubMed Valdés Pizarro J, Royo-Bordonada MA (2012) Prevalence of childhood obesity in Spain: National Health Survey 2006–2007. Nutr Hosp 27:154–160PubMed
4.
Zurück zum Zitat Kollias A, Skliros E, Stergiou GS, Leotsakos N, Saridi M, Garifallos D (2011) Obesity and associated cardiovascular risk factors among schoolchildren in Greece: a cross-sectional study and review of the literature. J Pediatr Endocrinol Metab 24:929–938PubMedCrossRef Kollias A, Skliros E, Stergiou GS, Leotsakos N, Saridi M, Garifallos D (2011) Obesity and associated cardiovascular risk factors among schoolchildren in Greece: a cross-sectional study and review of the literature. J Pediatr Endocrinol Metab 24:929–938PubMedCrossRef
5.
Zurück zum Zitat Midha T, Nath B, Kumari R, Rao YK, Pandey U (2012) Childhood obesity in India: a meta-analysis. Indian J Pediatr 79:945–948PubMedCrossRef Midha T, Nath B, Kumari R, Rao YK, Pandey U (2012) Childhood obesity in India: a meta-analysis. Indian J Pediatr 79:945–948PubMedCrossRef
6.
Zurück zum Zitat Marwaha RK, Tandon N, Singh Y, Aggarwal R, Grewal K, Mani K (2006) A study of growth parameters and prevalence of overweight and obesity in school children from Delhi. Indian Pediatr 43:943–952PubMed Marwaha RK, Tandon N, Singh Y, Aggarwal R, Grewal K, Mani K (2006) A study of growth parameters and prevalence of overweight and obesity in school children from Delhi. Indian Pediatr 43:943–952PubMed
7.
Zurück zum Zitat Okafor CI (2012) The metabolic syndrome in Africa: current trends. Indian J Endocrinol Metab 16:56–66PubMedCrossRef Okafor CI (2012) The metabolic syndrome in Africa: current trends. Indian J Endocrinol Metab 16:56–66PubMedCrossRef
8.
Zurück zum Zitat Wang Y, Lobstein T (2006) Worldwide trends in childhood overweight and obesity. Int J Pediatr Obes 1:11–25PubMedCrossRef Wang Y, Lobstein T (2006) Worldwide trends in childhood overweight and obesity. Int J Pediatr Obes 1:11–25PubMedCrossRef
9.
Zurück zum Zitat Rerksuppaphol S, Rerksuppaphol L (2011) Prevalence of dyslipidemia in Thai schoolchildren. J Med Assoc Thai 94:710–715PubMed Rerksuppaphol S, Rerksuppaphol L (2011) Prevalence of dyslipidemia in Thai schoolchildren. J Med Assoc Thai 94:710–715PubMed
10.
Zurück zum Zitat Raj M (2011) Obesity and cardiovascular risk in children and adolescents. Indian J Endocrinol Metab 16:13–19CrossRef Raj M (2011) Obesity and cardiovascular risk in children and adolescents. Indian J Endocrinol Metab 16:13–19CrossRef
11.
Zurück zum Zitat Bhardwaj S, Misra A, Khurana L, Gulati S, Shah P, Vikram NK (2008) Childhood obesity in Asian Indians: a burgeoning cause of insulin resistance, diabetes and subclinical inflammation. Asia Pac J Clin Nutr 17 [Suppl 1]:172–175PubMed Bhardwaj S, Misra A, Khurana L, Gulati S, Shah P, Vikram NK (2008) Childhood obesity in Asian Indians: a burgeoning cause of insulin resistance, diabetes and subclinical inflammation. Asia Pac J Clin Nutr 17 [Suppl 1]:172–175PubMed
12.
Zurück zum Zitat May AL, Kuklina EV, Yoon PW (2012) Prevalence of cardiovascular disease risk factors among US adolescents, 1999–2008. Pediatrics 129:1035–1041PubMedCrossRef May AL, Kuklina EV, Yoon PW (2012) Prevalence of cardiovascular disease risk factors among US adolescents, 1999–2008. Pediatrics 129:1035–1041PubMedCrossRef
13.
Zurück zum Zitat National High Blood Pressure Education Program Working Group on High Blood Pressure in Children and Adolescents (2004) The fourth report on the diagnosis, evaluation, and treatment of high blood pressure in children and adolescents. Pediatrics 114:555–576CrossRef National High Blood Pressure Education Program Working Group on High Blood Pressure in Children and Adolescents (2004) The fourth report on the diagnosis, evaluation, and treatment of high blood pressure in children and adolescents. Pediatrics 114:555–576CrossRef
14.
Zurück zum Zitat Silverberg DS, Nostrand CV, Juchli B, Smith ES, Dorsser EV (1975) Screening for hypertension in a high school population. Can Med Assoc J 113:103–108PubMed Silverberg DS, Nostrand CV, Juchli B, Smith ES, Dorsser EV (1975) Screening for hypertension in a high school population. Can Med Assoc J 113:103–108PubMed
15.
Zurück zum Zitat Kilcoyne MM, Richter RW, Alsup PA (1974) Adolescent hypertension. I. Detection and prevalence. Circulation 50:758–764PubMedCrossRef Kilcoyne MM, Richter RW, Alsup PA (1974) Adolescent hypertension. I. Detection and prevalence. Circulation 50:758–764PubMedCrossRef
16.
Zurück zum Zitat Fixler DE, Laird WP, Fitzgerald V, Stead S, Adams R (1979) Hypertension screening in schools: results of the Dallas study. Pediatrics 63:32–36PubMed Fixler DE, Laird WP, Fitzgerald V, Stead S, Adams R (1979) Hypertension screening in schools: results of the Dallas study. Pediatrics 63:32–36PubMed
17.
Zurück zum Zitat Sinaiko AR, Gomez-Marin O, Prineas RJ (1989) Prevalence of “significant” hypertension in junior high school-aged children: the children and adolescent blood pressure program. J Pediatr 114:664–669PubMedCrossRef Sinaiko AR, Gomez-Marin O, Prineas RJ (1989) Prevalence of “significant” hypertension in junior high school-aged children: the children and adolescent blood pressure program. J Pediatr 114:664–669PubMedCrossRef
18.
Zurück zum Zitat O’Quin M, Sharma BB, Miller KA, Tomsovic JP (1992) Adolescent blood pressure survey: Tulsa, Oklahoma, 1987 to 1989. South Med J 85:487–490PubMedCrossRef O’Quin M, Sharma BB, Miller KA, Tomsovic JP (1992) Adolescent blood pressure survey: Tulsa, Oklahoma, 1987 to 1989. South Med J 85:487–490PubMedCrossRef
19.
Zurück zum Zitat Adrogue HE, Sinaiko AR (2001) Prevalence of hypertension in junior high school-aged children: effect of new recommendations in the 1996 Updated Task Force Report. Am J Hypertens 14:412–414PubMedCrossRef Adrogue HE, Sinaiko AR (2001) Prevalence of hypertension in junior high school-aged children: effect of new recommendations in the 1996 Updated Task Force Report. Am J Hypertens 14:412–414PubMedCrossRef
20.
Zurück zum Zitat Sorof JM, Lai D, Turner J, Poffenbarger T, Portman RJ (2004) Overweight, ethnicity, and the prevalence of hypertension in school-aged children. Pediatrics 113:475–482PubMedCrossRef Sorof JM, Lai D, Turner J, Poffenbarger T, Portman RJ (2004) Overweight, ethnicity, and the prevalence of hypertension in school-aged children. Pediatrics 113:475–482PubMedCrossRef
21.
Zurück zum Zitat McNiece KL, Poffenbarger TS, Turner JL, Franco KD, Sorof JM, Portman RJ (2007) Prevalence of hypertension and pre-hypertension among adolescents. J Pediatr 150:640–644PubMedCrossRef McNiece KL, Poffenbarger TS, Turner JL, Franco KD, Sorof JM, Portman RJ (2007) Prevalence of hypertension and pre-hypertension among adolescents. J Pediatr 150:640–644PubMedCrossRef
22.
Zurück zum Zitat Steinthorsdottir SD, Eliasdottir SB, Indridason OS, Agustsdottir IM, Palsson R, Edvardsson VO (2011) Prevalence of hypertension in 9- to 10-year-old Icelandic school children. J Clin Hypertens (Greenwich) 13:774–779CrossRef Steinthorsdottir SD, Eliasdottir SB, Indridason OS, Agustsdottir IM, Palsson R, Edvardsson VO (2011) Prevalence of hypertension in 9- to 10-year-old Icelandic school children. J Clin Hypertens (Greenwich) 13:774–779CrossRef
23.
Zurück zum Zitat Cao Z-Q, Zhu L, Zhang T, Wu L, Wang Y (2012) Blood pressure and obesity among adolescents: a school-based population study in China. Am J Hypertens 25:576–582PubMedCrossRef Cao Z-Q, Zhu L, Zhang T, Wu L, Wang Y (2012) Blood pressure and obesity among adolescents: a school-based population study in China. Am J Hypertens 25:576–582PubMedCrossRef
24.
Zurück zum Zitat Task Force on Blood Pressure Control in Children (1987) Report of the second task force on blood pressure control in children—1987. National heart, lung, and blood institute, Bethesda, Maryland. Pediatrics 79:1–25 Task Force on Blood Pressure Control in Children (1987) Report of the second task force on blood pressure control in children—1987. National heart, lung, and blood institute, Bethesda, Maryland. Pediatrics 79:1–25
25.
Zurück zum Zitat National High Blood Pressure Education Program Working Group on Hypertension Control in Children and Adolescents (1996) Update on the 1987 task force report on high blood pressure in children and adolescents: a working group report from the National High Blood Pressure Education Program. Pediatrics 98:649–658 National High Blood Pressure Education Program Working Group on Hypertension Control in Children and Adolescents (1996) Update on the 1987 task force report on high blood pressure in children and adolescents: a working group report from the National High Blood Pressure Education Program. Pediatrics 98:649–658
26.
Zurück zum Zitat Din-Dzietham R, Liu Y, Bielo MV, Shamsa F (2007) High blood pressure trends in children and adolescents in national surveys, 1963 to 2002. Circulation 116:1488–1496PubMedCrossRef Din-Dzietham R, Liu Y, Bielo MV, Shamsa F (2007) High blood pressure trends in children and adolescents in national surveys, 1963 to 2002. Circulation 116:1488–1496PubMedCrossRef
27.
Zurück zum Zitat Chiolero A, Bovet P, Paradis G, Paccaud F (2007) Has blood pressure increased in children in response to the obesity epidemic? Pediatrics 119:544–553PubMedCrossRef Chiolero A, Bovet P, Paradis G, Paccaud F (2007) Has blood pressure increased in children in response to the obesity epidemic? Pediatrics 119:544–553PubMedCrossRef
29.
Zurück zum Zitat de Rezende FD, Scarpelli RAB, de Souza GF, da Costa JO, Scarpelli AMB, Scarpelli PA, de Carvalho GB, D’Agostini HM, Pedrosa JC (2003) Prevalence of systemic hypertension in students aged 7 to 14 years in the municipality of Barbacena, in the state of Minas Gerais in 1999. Arq Bras Cardiol 81:381–386PubMedCrossRef de Rezende FD, Scarpelli RAB, de Souza GF, da Costa JO, Scarpelli AMB, Scarpelli PA, de Carvalho GB, D’Agostini HM, Pedrosa JC (2003) Prevalence of systemic hypertension in students aged 7 to 14 years in the municipality of Barbacena, in the state of Minas Gerais in 1999. Arq Bras Cardiol 81:381–386PubMedCrossRef
30.
Zurück zum Zitat Sharma A, Grover N, Kaushik S, Bhardwaj R, Sankhyan N (2010) Prevalence of hypertension among school children in Shimla. Indian Pediatr 47:873–876PubMedCrossRef Sharma A, Grover N, Kaushik S, Bhardwaj R, Sankhyan N (2010) Prevalence of hypertension among school children in Shimla. Indian Pediatr 47:873–876PubMedCrossRef
32.
Zurück zum Zitat Tu W, Eckert GJ, DiMeglio LA, Yu Z, Jung J, Pratt JH (2011) Intensified effect of adiposity on blood pressure in overweight and obese children. Hypertension 58:818–824PubMedCrossRef Tu W, Eckert GJ, DiMeglio LA, Yu Z, Jung J, Pratt JH (2011) Intensified effect of adiposity on blood pressure in overweight and obese children. Hypertension 58:818–824PubMedCrossRef
33.
Zurück zum Zitat Luepker RV, Jacobs DR, Prineas RJ, Sinaiko AR (1999) Secular trends of blood pressure and body size in a multi-ethnic adolescent population: 1986 to 1996. J Pediatr 134:668–674PubMedCrossRef Luepker RV, Jacobs DR, Prineas RJ, Sinaiko AR (1999) Secular trends of blood pressure and body size in a multi-ethnic adolescent population: 1986 to 1996. J Pediatr 134:668–674PubMedCrossRef
34.
Zurück zum Zitat Simonetti GD, Schwertz R, Klett M, Hoffmann GF, Schaefer F, Wühl E (2011) Determinants of blood pressure in preschool children: the role of parental smoking. Circulation 123:292–298PubMedCrossRef Simonetti GD, Schwertz R, Klett M, Hoffmann GF, Schaefer F, Wühl E (2011) Determinants of blood pressure in preschool children: the role of parental smoking. Circulation 123:292–298PubMedCrossRef
35.
Zurück zum Zitat Muntner P, He J, Cutler JA, Wildman RP, Whelton PK (2004) Trends in blood pressure among children and adolescents. JAMA 291:2107–2113PubMedCrossRef Muntner P, He J, Cutler JA, Wildman RP, Whelton PK (2004) Trends in blood pressure among children and adolescents. JAMA 291:2107–2113PubMedCrossRef
36.
Zurück zum Zitat Feld LG, Springate JE (1988) Hypertension in children. Curr Probl Pediatr 18:317–373PubMed Feld LG, Springate JE (1988) Hypertension in children. Curr Probl Pediatr 18:317–373PubMed
37.
Zurück zum Zitat Arar MY, Hogg RJ, Arant BS Jr, Seikaly MG (1994) Etiology of sustained hypertension in children in the southwestern United States. Pediatr Nephrol 8:186–189PubMedCrossRef Arar MY, Hogg RJ, Arant BS Jr, Seikaly MG (1994) Etiology of sustained hypertension in children in the southwestern United States. Pediatr Nephrol 8:186–189PubMedCrossRef
38.
Zurück zum Zitat Flynn JT, Alderman MH (2005) Characteristics of children with primary hypertension seen at a referral center. Pediatr Nephrol 20:961–966PubMedCrossRef Flynn JT, Alderman MH (2005) Characteristics of children with primary hypertension seen at a referral center. Pediatr Nephrol 20:961–966PubMedCrossRef
39.
Zurück zum Zitat Croix B, Feig DI (2006) Childhood hypertension is not a silent disease. Pediatr Nephrol 21:527–532PubMedCrossRef Croix B, Feig DI (2006) Childhood hypertension is not a silent disease. Pediatr Nephrol 21:527–532PubMedCrossRef
40.
Zurück zum Zitat Kapur G, Ahmed M, Pan C, Mitsnefes M, Chiang M, Mattoo TK (2010) Secondary hypertension in overweight and stage 1 hypertensive children: a Midwest Pediatric Nephrology Consortium report. J Clin Hypertens (Greenwich) 12:34–39CrossRef Kapur G, Ahmed M, Pan C, Mitsnefes M, Chiang M, Mattoo TK (2010) Secondary hypertension in overweight and stage 1 hypertensive children: a Midwest Pediatric Nephrology Consortium report. J Clin Hypertens (Greenwich) 12:34–39CrossRef
41.
Zurück zum Zitat Flynn JT, Zhang Y, Solar-Yohay S, Shi V (2012) Clinical and demographic characteristics of children with hypertension. Hypertension 60:1047–1054PubMedCrossRef Flynn JT, Zhang Y, Solar-Yohay S, Shi V (2012) Clinical and demographic characteristics of children with hypertension. Hypertension 60:1047–1054PubMedCrossRef
42.
Zurück zum Zitat Welch WP, Yang W, Taylor-Zapata P, Flynn JT (2012) Antihypertensive drug use in children: are the drugs labeled and indicated? J Clin Hypertens (Greenwich) 14:388–395CrossRef Welch WP, Yang W, Taylor-Zapata P, Flynn JT (2012) Antihypertensive drug use in children: are the drugs labeled and indicated? J Clin Hypertens (Greenwich) 14:388–395CrossRef
44.
Zurück zum Zitat Kotsis V, Stabouli S, Papakatsika S, Rizos Z, Parati G (2010) Mechanisms of obesity-induced hypertension. Hypertens Res 33:386–393PubMedCrossRef Kotsis V, Stabouli S, Papakatsika S, Rizos Z, Parati G (2010) Mechanisms of obesity-induced hypertension. Hypertens Res 33:386–393PubMedCrossRef
45.
Zurück zum Zitat Rocchini AP (2011) Childhood obesity and blood pressure regulation. In: Flynn JT, Ingelfinger J, Portman R (eds) Pediatric hypertension, 2nd edn. Humana Press., New York, pp 301–328CrossRef Rocchini AP (2011) Childhood obesity and blood pressure regulation. In: Flynn JT, Ingelfinger J, Portman R (eds) Pediatric hypertension, 2nd edn. Humana Press., New York, pp 301–328CrossRef
46.
Zurück zum Zitat Grontved A, Steene-Johannessen J, Kynde I, Franks PW, Helge JW, Froberg K, Anderssen SA, Andersen LB (2011) Association between plasma leptin and blood pressure in two population-based samples of children and adolescents. J Hypertens 29:1093–1100PubMedCrossRef Grontved A, Steene-Johannessen J, Kynde I, Franks PW, Helge JW, Froberg K, Anderssen SA, Andersen LB (2011) Association between plasma leptin and blood pressure in two population-based samples of children and adolescents. J Hypertens 29:1093–1100PubMedCrossRef
47.
Zurück zum Zitat Shatat IF, Freeman KD, Vuguin PM, Dimartino-Nardi JR, Flynn JT (2009) Relationship between adiponectin and ambulatory blood pressure in obese adolescents. Pediatr Res 65:691–695PubMedCrossRef Shatat IF, Freeman KD, Vuguin PM, Dimartino-Nardi JR, Flynn JT (2009) Relationship between adiponectin and ambulatory blood pressure in obese adolescents. Pediatr Res 65:691–695PubMedCrossRef
48.
Zurück zum Zitat Mohamed-Ali V, Bulmer K, Clarke D, Goodrick S, Coppack SW, Pinkney JH (2000) Beta-adrenergic regulation of proinflammatory cytokines in humans. Int J Obes Relat Metab Disord 24 [Suppl 2]:S154–S155PubMedCrossRef Mohamed-Ali V, Bulmer K, Clarke D, Goodrick S, Coppack SW, Pinkney JH (2000) Beta-adrenergic regulation of proinflammatory cytokines in humans. Int J Obes Relat Metab Disord 24 [Suppl 2]:S154–S155PubMedCrossRef
49.
Zurück zum Zitat Jung RT, Shetty PS, Barrand M, Callingham BA, James WP (1979) Role of catecholamines in hypotensive response to dieting. Br Med J 6155:12–13CrossRef Jung RT, Shetty PS, Barrand M, Callingham BA, James WP (1979) Role of catecholamines in hypotensive response to dieting. Br Med J 6155:12–13CrossRef
50.
Zurück zum Zitat Chrousos GP (1995) The hypothalamic-pituitary-adrenal axis and immune-mediated inflammation. N Engl J Med 332:1351–1362PubMedCrossRef Chrousos GP (1995) The hypothalamic-pituitary-adrenal axis and immune-mediated inflammation. N Engl J Med 332:1351–1362PubMedCrossRef
51.
Zurück zum Zitat Aghamohammadzadeh R, Heagerty AM (2012) Obesity-related hypertension: epidemiology, pathophysiology, treatments, and the contribution of perivascular adipose tissue. Ann Med 44 [Suppl 1]:S74–S84PubMedCrossRef Aghamohammadzadeh R, Heagerty AM (2012) Obesity-related hypertension: epidemiology, pathophysiology, treatments, and the contribution of perivascular adipose tissue. Ann Med 44 [Suppl 1]:S74–S84PubMedCrossRef
52.
Zurück zum Zitat Shatat IF, Flynn JT (2011) Relationships between renin, aldosterone and 24-hour ambulatory blood pressure in obese adolescents. Pediatr Res 69:336–340PubMedCrossRef Shatat IF, Flynn JT (2011) Relationships between renin, aldosterone and 24-hour ambulatory blood pressure in obese adolescents. Pediatr Res 69:336–340PubMedCrossRef
53.
Zurück zum Zitat Daniels SR (1999) Is there an epidemic of cardiovascular disease on the horizon? J Pediatr 134:665–666PubMedCrossRef Daniels SR (1999) Is there an epidemic of cardiovascular disease on the horizon? J Pediatr 134:665–666PubMedCrossRef
54.
Zurück zum Zitat Bibbins-Domingo K, Coxson P, Pletcher MJ, Lightwood J, Goldman L (2007) Adolescent overweight and future adult coronary heart disease. N Engl J Med 357:2371–2379PubMedCrossRef Bibbins-Domingo K, Coxson P, Pletcher MJ, Lightwood J, Goldman L (2007) Adolescent overweight and future adult coronary heart disease. N Engl J Med 357:2371–2379PubMedCrossRef
Metadaten
Titel
The changing face of pediatric hypertension in the era of the childhood obesity epidemic
verfasst von
Joseph Flynn
Publikationsdatum
01.07.2013
Verlag
Springer-Verlag
Erschienen in
Pediatric Nephrology / Ausgabe 7/2013
Print ISSN: 0931-041X
Elektronische ISSN: 1432-198X
DOI
https://doi.org/10.1007/s00467-012-2344-0

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