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Pediatric Nephrology

Erschienen in:

01.11.2014 | Brief Report

Eculizumab treatment for rescue of renal function in IgA nephropathy

verfasst von: Therese Rosenblad, Johan Rebetz, Martin Johansson, Zivile Békássy, Lisa Sartz, Diana Karpman

Erschienen in: Pediatric Nephrology | Ausgabe 11/2014

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Abstract

Background

Immunoglobulin A (IgA) nephropathy is a chronic glomerulonephritis with excessive glomerular deposition of IgA1, C3 and C5b-9, which may lead to renal failure.

Case Diagnosis/Treatment

We describe the clinical course of an adolescent with rapidly progressive disease leading to renal failure in spite of immunosuppressive treatment. Due to refractory disease the patient was treated with eculizumab (anti-C5) for 3 months in an attempt to rescue renal function. Treatment led to clinical improvement with stabilization of the glomerular filtration rate and reduced proteinuria. Discontinuation of treatment led to a rapid deterioration of renal function. This was followed by a single dose of eculizumab, which again reduced creatinine levels temporarily.

Conclusions

Early initiation of eculizumab therapy in patients with progressive IgA nephropathy may have a beneficial effect by blocking complement-mediated renal inflammation.

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Titel: Eculizumab treatment for rescue of renal function in IgA nephropathy
verfasst von: Therese Rosenblad
Johan Rebetz
Martin Johansson
Zivile Békássy
Lisa Sartz
Diana Karpman
Publikationsdatum: 01.11.2014
Verlag: Springer Berlin Heidelberg
Erschienen in: Pediatric Nephrology / Ausgabe 11/2014
Print ISSN: 0931-041X
Elektronische ISSN: 1432-198X
DOI: https://doi.org/10.1007/s00467-014-2863-y

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Springer Medizin

Eculizumab treatment for rescue of renal function in IgA nephropathy

Abstract

Background

Case Diagnosis/Treatment

Conclusions

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Springer Medizin

Abstract

Background

Case Diagnosis/Treatment

Conclusions

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