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01.03.2016 | Original Article

Vitamin D in incident nephrotic syndrome: a Midwest Pediatric Nephrology Consortium study

verfasst von: David T. Selewski, Ashton Chen, Ibrahim F. Shatat, Priya Pais, Larry A. Greenbaum, Pavel Geier, Raoul D. Nelson, Stefan G. Kiessling, Patrick D. Brophy, Alejandro Quiroga, Michael E. Seifert, Caroline E. Straatmann, John D. Mahan, Maria E. Ferris, Jonathan P. Troost, Debbie S. Gipson

Erschienen in: Pediatric Nephrology | Ausgabe 3/2016

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Abstract

Background

Cross-sectional studies of children with prevalent nephrotic syndrome (NS) have shown 25-vitamin D (25(OH)D) deficiency rates of 20–100 %. Information on 25(OH)D status in incident patients or following remission is limited. This study aimed to assess 25(OH)D status of incident idiopathic NS children at presentation and longitudinally with short-term observation.

Methods

Multicenter longitudinal study of children (2–18 years old) from 14 centers across the Midwest Pediatric Nephrology Consortium with incident idiopathic NS. 25(OH)D levels were assessed at diagnosis and 3 months later.

Results

Sixty-one children, median age 5 (3, 11) years, completed baseline visit and 51 completed second visit labs. All 61 (100 %) had 25(OH)D < 20 ng/ml at diagnosis. Twenty-seven (53 %) had 25(OH)D < 20 ng/ml at follow-up. Fourteen (28 %) children were steroid resistant. Univariate analysis showed that children prescribed vitamin D supplements were less likely to have 25(OH)D deficiency at follow-up (OR 0.2, 95 % CI 0.04, 0.6). Steroid response, age, and season did not predict 25(OH)D deficiency. Multivariable linear regression modeling showed higher 25(OH)D levels at follow-up by 13.2 ng/ml (SE 4.6, p < 0.01) in children supplemented with vitamin D.

Conclusions

In this incident idiopathic NS cohort, all children at diagnosis had 25(OH)D deficiency and the majority continued to have a deficiency at 2–4 months. Supplemental vitamin D decreased the odds of 25(OH)D deficiency at follow-up, supporting a role for supplementation in incident NS.

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Titel: Vitamin D in incident nephrotic syndrome: a Midwest Pediatric Nephrology Consortium study
verfasst von: David T. Selewski
Ashton Chen
Ibrahim F. Shatat
Priya Pais
Larry A. Greenbaum
Pavel Geier
Raoul D. Nelson
Stefan G. Kiessling
Patrick D. Brophy
Alejandro Quiroga
Michael E. Seifert
Caroline E. Straatmann
John D. Mahan
Maria E. Ferris
Jonathan P. Troost
Debbie S. Gipson
Publikationsdatum: 01.03.2016
Verlag: Springer Berlin Heidelberg
Erschienen in: Pediatric Nephrology / Ausgabe 3/2016
Print ISSN: 0931-041X
Elektronische ISSN: 1432-198X
DOI: https://doi.org/10.1007/s00467-015-3236-x

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Vitamin D in incident nephrotic syndrome: a Midwest Pediatric Nephrology Consortium study