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Erschienen in: Journal of Gastroenterology 8/2010

01.08.2010 | Review

Gastroesophageal reflux disease

verfasst von: Kwong Ming Fock, Choo Hean Poh

Erschienen in: Journal of Gastroenterology | Ausgabe 8/2010

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Abstract

GERD is a common chronic gastrointestinal disorder, and its prevalence in Asia is increasing. Classical symptoms of heartburn and regurgitation are common presentations. There is no standard criterion for the diagnosis of GERD, and 24-h pH monitoring lacks sensitivity in NERD. Furthermore, diagnostic studies for gastroesophageal reflux disease have several limitations. A short course of PPI is often used in clinical practice as a diagnostic test for gastroesophageal reflux disease. Elderly patients with GERD usually present with atypical manifestations, and they tend to develop more severe disease. PPI remains the mainstay of treatment for GERD. In a subset of patients who wish to discontinue maintenance treatment, anti-reflux surgery is a therapeutic option.
Literatur
1.
Zurück zum Zitat Dent J, El Serag H, Wallender M, Johansson S. Epidemiology of gastroesophageal reflux disease: a systematic review. Gut. 2005;54:710–7.CrossRefPubMed Dent J, El Serag H, Wallender M, Johansson S. Epidemiology of gastroesophageal reflux disease: a systematic review. Gut. 2005;54:710–7.CrossRefPubMed
2.
Zurück zum Zitat Camilleri M, Dubois D, Coulie B, Jones M, Kahrilas PJ, Rentz AM, et al. Prevalence and socioeconomic impact of upper gastrointestinal disorders in the United States: results of the US Upper Gastrointestinal Study. Clin Gastroenterol Hepatol. 2005;3:543–52.CrossRefPubMed Camilleri M, Dubois D, Coulie B, Jones M, Kahrilas PJ, Rentz AM, et al. Prevalence and socioeconomic impact of upper gastrointestinal disorders in the United States: results of the US Upper Gastrointestinal Study. Clin Gastroenterol Hepatol. 2005;3:543–52.CrossRefPubMed
3.
Zurück zum Zitat Fock KM, Talley NJ, Hunt R, Fass R, Nandurkar S, Lam SK, et al. Report of the Asia-Pacific consensus on the management of gastroesophageal reflux disease. J Gastroenterol Hepatol. 2004;19:357–67.CrossRefPubMed Fock KM, Talley NJ, Hunt R, Fass R, Nandurkar S, Lam SK, et al. Report of the Asia-Pacific consensus on the management of gastroesophageal reflux disease. J Gastroenterol Hepatol. 2004;19:357–67.CrossRefPubMed
4.
Zurück zum Zitat Fock KM, Talley NJ, Fass R, Goh KL, Katelaris P, Hung R, et al. Asia-Pacific consensus on the management of gastroesophageal reflux disease: update. J Gastroenterol Hepatol. 2008;23:8–22.CrossRefPubMed Fock KM, Talley NJ, Fass R, Goh KL, Katelaris P, Hung R, et al. Asia-Pacific consensus on the management of gastroesophageal reflux disease: update. J Gastroenterol Hepatol. 2008;23:8–22.CrossRefPubMed
5.
Zurück zum Zitat Nimish V, Sander V, Kahrilas P, Dent J, Jones R, Global Consensus Group. The montreal definition and classification of gastroesophageal reflux disease: a global evidence-based consensus. Am J Gastroenterol. 2006;101:1900–20.CrossRef Nimish V, Sander V, Kahrilas P, Dent J, Jones R, Global Consensus Group. The montreal definition and classification of gastroesophageal reflux disease: a global evidence-based consensus. Am J Gastroenterol. 2006;101:1900–20.CrossRef
6.
Zurück zum Zitat Tack J, Fass R. Review article: approaches to endoscopic-negative reflux disease: part of the GERD spectrum or a unique acid-related disorder? Aliment Pharmacol Ther. 2004;19(Suppl 1):28–34.CrossRefPubMed Tack J, Fass R. Review article: approaches to endoscopic-negative reflux disease: part of the GERD spectrum or a unique acid-related disorder? Aliment Pharmacol Ther. 2004;19(Suppl 1):28–34.CrossRefPubMed
7.
Zurück zum Zitat Klauser AG, Schindlbeck NE, Muller-Lissner SA. Symptoms in gastroesophageal reflux disease. Lancet. 1990;335:205–8.CrossRefPubMed Klauser AG, Schindlbeck NE, Muller-Lissner SA. Symptoms in gastroesophageal reflux disease. Lancet. 1990;335:205–8.CrossRefPubMed
8.
Zurück zum Zitat Carlsson R, Dent J, Bolling-Sternevald E, Johnsson F, Junghard O, Lauritsen K, et al. The usefulness of a structured questionnaire in the assessment of symptomatic gastroesophageal reflux disease. Scand J Gastroenterol. 1998;33:1023–9.CrossRefPubMed Carlsson R, Dent J, Bolling-Sternevald E, Johnsson F, Junghard O, Lauritsen K, et al. The usefulness of a structured questionnaire in the assessment of symptomatic gastroesophageal reflux disease. Scand J Gastroenterol. 1998;33:1023–9.CrossRefPubMed
9.
Zurück zum Zitat Ho KY, Gwee KA, Khor JL, Selamat DS, Yeoh KG. Validation of a graded response questionnaire for the diagnosis of gastroesophageal reflux disease in an Asian primary care population. J Clin Gastroenterol. 2008;42:680–6.CrossRefPubMed Ho KY, Gwee KA, Khor JL, Selamat DS, Yeoh KG. Validation of a graded response questionnaire for the diagnosis of gastroesophageal reflux disease in an Asian primary care population. J Clin Gastroenterol. 2008;42:680–6.CrossRefPubMed
10.
Zurück zum Zitat Wu W. Ancillary tests in the diagnosis of gastroesophageal reflux disease. Gastroenterol Clin North Am. 1990;19:671–82.PubMed Wu W. Ancillary tests in the diagnosis of gastroesophageal reflux disease. Gastroenterol Clin North Am. 1990;19:671–82.PubMed
11.
Zurück zum Zitat Dent J, Brun J, Fendrick AM, Fennerty MB, Janssens J, Kahrilas PJ, et al. An evidence-based appraisal of reflux disease management—the Geneval Workshop Report. Gut. 1999;44:S1–16.CrossRef Dent J, Brun J, Fendrick AM, Fennerty MB, Janssens J, Kahrilas PJ, et al. An evidence-based appraisal of reflux disease management—the Geneval Workshop Report. Gut. 1999;44:S1–16.CrossRef
12.
Zurück zum Zitat Yoshikawa I, Yamasaki M, Yamasaki T, Kume K, Otsuki M. Lugol chromoendoscopy as a diagnostic tool in so called endoscopy negative GERD. Gastrointest Endosc. 2005;62:698–703. (see also pp 752, 754).CrossRefPubMed Yoshikawa I, Yamasaki M, Yamasaki T, Kume K, Otsuki M. Lugol chromoendoscopy as a diagnostic tool in so called endoscopy negative GERD. Gastrointest Endosc. 2005;62:698–703. (see also pp 752, 754).CrossRefPubMed
13.
Zurück zum Zitat Sharma P, Wani S, Bansal A, Hall S, Puli S, Mathur S, Rastogi A. A feasibility trial of narrow band imaging endoscopy in patients with gastroesophageal reflux disease. Gastroenterology. 2007;133:454–64.CrossRefPubMed Sharma P, Wani S, Bansal A, Hall S, Puli S, Mathur S, Rastogi A. A feasibility trial of narrow band imaging endoscopy in patients with gastroesophageal reflux disease. Gastroenterology. 2007;133:454–64.CrossRefPubMed
14.
Zurück zum Zitat Fock KM, Teo EK, Ang TL, Tan JY, Law NM. The utility of narrow band imaging in improving the endoscopic diagnosis of gastroesophageal reflux disease. Clin Gastroenterol Hepatol. 2009;7:54–9.CrossRefPubMed Fock KM, Teo EK, Ang TL, Tan JY, Law NM. The utility of narrow band imaging in improving the endoscopic diagnosis of gastroesophageal reflux disease. Clin Gastroenterol Hepatol. 2009;7:54–9.CrossRefPubMed
15.
Zurück zum Zitat Dent J. Microscopic esophageal mucosal injury in nonerosive reflux disease. Clin Gastroenterol Hepatol. 2007;5:4–16.CrossRefPubMed Dent J. Microscopic esophageal mucosal injury in nonerosive reflux disease. Clin Gastroenterol Hepatol. 2007;5:4–16.CrossRefPubMed
16.
Zurück zum Zitat Tobey NA, Hosseini SS, Argote CM, Dobrucali AM, Awayda MS, Orlando RC. Dilated Intercellular spaces and shunt permeability in nonerosive acid-damaged esophageal epithelium. Am J Gastroenterol. 2004;99:13–22.CrossRefPubMed Tobey NA, Hosseini SS, Argote CM, Dobrucali AM, Awayda MS, Orlando RC. Dilated Intercellular spaces and shunt permeability in nonerosive acid-damaged esophageal epithelium. Am J Gastroenterol. 2004;99:13–22.CrossRefPubMed
17.
Zurück zum Zitat Armstrong D, Vieth M, Fiocca R, Deprez P, Kuipers E, Holmqinst L, et al. Are endoscopy negative GERD and reflux esophagitis different disease? Baseline histology in GERD patients off-therapy—the CHEER Study. Gastroenterology. 2003;124:A-416. Armstrong D, Vieth M, Fiocca R, Deprez P, Kuipers E, Holmqinst L, et al. Are endoscopy negative GERD and reflux esophagitis different disease? Baseline histology in GERD patients off-therapy—the CHEER Study. Gastroenterology. 2003;124:A-416.
18.
Zurück zum Zitat Vakil N. Review article: how valuable are proton-pump inhibitors in establishing a diagnosis of gastroesophageal reflux disease? Aliment Pharmacol Ther. 2005;22(Suppl 1):64–9.CrossRefPubMed Vakil N. Review article: how valuable are proton-pump inhibitors in establishing a diagnosis of gastroesophageal reflux disease? Aliment Pharmacol Ther. 2005;22(Suppl 1):64–9.CrossRefPubMed
19.
Zurück zum Zitat Gasiorowska A, Fass R. The proton pump inhibitor (PPI) test in GERD. Does it still have a role? J Clin Gastroenterol. 2008;42:867–74.CrossRefPubMed Gasiorowska A, Fass R. The proton pump inhibitor (PPI) test in GERD. Does it still have a role? J Clin Gastroenterol. 2008;42:867–74.CrossRefPubMed
20.
Zurück zum Zitat Fass R, Ofman J, Sampliner R, Camargo L, Wendel C, Fennerty MB. The omeprazole test is as sensitive as 24 hour esophageal pH monitoring in diagnosing gastroesophageal reflux disease in symptomatic patients with erosive esophagitis. Aliment Pharmacol Ther. 2000;14:389–96.CrossRefPubMed Fass R, Ofman J, Sampliner R, Camargo L, Wendel C, Fennerty MB. The omeprazole test is as sensitive as 24 hour esophageal pH monitoring in diagnosing gastroesophageal reflux disease in symptomatic patients with erosive esophagitis. Aliment Pharmacol Ther. 2000;14:389–96.CrossRefPubMed
21.
Zurück zum Zitat Euler A, Byrne W. Twenty-four hour esophageal intraluminal pH probe testing: a comparative analysis. Gastroenterology. 1981;80:957–61.PubMed Euler A, Byrne W. Twenty-four hour esophageal intraluminal pH probe testing: a comparative analysis. Gastroenterology. 1981;80:957–61.PubMed
22.
Zurück zum Zitat Fass R, Fennerty M, Ofman JJ, Gralnek IM, Johnson C, Camargo E, et al. The clinical and economic value of a short course of omeprazole in patients with non-cardiac chest pain. Gastroenterology. 1998;115:42–9.CrossRefPubMed Fass R, Fennerty M, Ofman JJ, Gralnek IM, Johnson C, Camargo E, et al. The clinical and economic value of a short course of omeprazole in patients with non-cardiac chest pain. Gastroenterology. 1998;115:42–9.CrossRefPubMed
23.
Zurück zum Zitat Martinez S, Malagon IB, Garewal HS, Cui H, Fass R. Non-erosive reflux disease (NERD)-acid reflux and symptom pattern. Aliment Pharmacol Ther. 2003;17:537–45.CrossRefPubMed Martinez S, Malagon IB, Garewal HS, Cui H, Fass R. Non-erosive reflux disease (NERD)-acid reflux and symptom pattern. Aliment Pharmacol Ther. 2003;17:537–45.CrossRefPubMed
24.
Zurück zum Zitat Des Varannes SB, Mion F, Ducrotte P, Zerbib F, Denis P, Ponchon T, et al. Simultaneous recording of esophageal acid exposure with conventional pH monitoring and a wireless system (Bravo). Gut. 2005;54:1682–6.CrossRefPubMed Des Varannes SB, Mion F, Ducrotte P, Zerbib F, Denis P, Ponchon T, et al. Simultaneous recording of esophageal acid exposure with conventional pH monitoring and a wireless system (Bravo). Gut. 2005;54:1682–6.CrossRefPubMed
25.
Zurück zum Zitat Sifrim D, Castell D, Dent J, Kahrilas PJ. Gastroesophageal reflux monitoring: review and consensus report on detection and definitions of acid, non acid and gas reflux. Gut. 2004;53:1024–31.CrossRefPubMed Sifrim D, Castell D, Dent J, Kahrilas PJ. Gastroesophageal reflux monitoring: review and consensus report on detection and definitions of acid, non acid and gas reflux. Gut. 2004;53:1024–31.CrossRefPubMed
26.
Zurück zum Zitat Bredenoord AJ, Weusten BLAM, Timmer R, Conchillo JM, Smout AJPM. Addition of esophageal impedance monitoring to pH monitoring increases the yield of symptom association analysis in patients off PPI therapy. Am J Gastroenterol. 2006;101:453–9.CrossRefPubMed Bredenoord AJ, Weusten BLAM, Timmer R, Conchillo JM, Smout AJPM. Addition of esophageal impedance monitoring to pH monitoring increases the yield of symptom association analysis in patients off PPI therapy. Am J Gastroenterol. 2006;101:453–9.CrossRefPubMed
27.
Zurück zum Zitat Lichtenstein DR, Cash BD, Davila R, Baron TH, Adler DG, Anderson MA, et al. Standards of Practice Committee. Role of endoscopy in the management of GERD. Gastrointest Endosc. 2007;66:219–24.CrossRefPubMed Lichtenstein DR, Cash BD, Davila R, Baron TH, Adler DG, Anderson MA, et al. Standards of Practice Committee. Role of endoscopy in the management of GERD. Gastrointest Endosc. 2007;66:219–24.CrossRefPubMed
28.
Zurück zum Zitat Poh CH, Gasiorowska A, Navarro-Rodriguez T, Willis MR, Hargadon D, Noelck N, et al. Upper GI tract findings in patients with heartburn in whom proton pump inhibitor treatment failed versus those not receiving antireflux treatment. Gastrointest Endosc. 2010;71:28–34.CrossRefPubMed Poh CH, Gasiorowska A, Navarro-Rodriguez T, Willis MR, Hargadon D, Noelck N, et al. Upper GI tract findings in patients with heartburn in whom proton pump inhibitor treatment failed versus those not receiving antireflux treatment. Gastrointest Endosc. 2010;71:28–34.CrossRefPubMed
29.
Zurück zum Zitat Kaltenbach T, Crockett S, Gerson LB. Are lifestyle measures effective in patients with gastroesophageal reflux disease? An evidence-based approach. Arch Intern Med. 2006;166:965–71.CrossRefPubMed Kaltenbach T, Crockett S, Gerson LB. Are lifestyle measures effective in patients with gastroesophageal reflux disease? An evidence-based approach. Arch Intern Med. 2006;166:965–71.CrossRefPubMed
30.
Zurück zum Zitat Weberg R, Berstad A. Symptomatic effect of a low-dose antacid regimen in reflux esophagitis. Scand J Gastroenterol. 1989;24:401–6.CrossRefPubMed Weberg R, Berstad A. Symptomatic effect of a low-dose antacid regimen in reflux esophagitis. Scand J Gastroenterol. 1989;24:401–6.CrossRefPubMed
31.
Zurück zum Zitat Carling L, Cronstedt J, Engqvist A, Kagevi I, Nyström B, Svedberg LE, et al. Sucralfate versus placebo in reflux esophagitis. A double-blind multicenter study. Scand J Gastroenterol. 1988;23:1117–24.CrossRefPubMed Carling L, Cronstedt J, Engqvist A, Kagevi I, Nyström B, Svedberg LE, et al. Sucralfate versus placebo in reflux esophagitis. A double-blind multicenter study. Scand J Gastroenterol. 1988;23:1117–24.CrossRefPubMed
32.
Zurück zum Zitat Tytgat GNJ. Review article: treatment of mild and severe cases of GERD. Aliment Pharmacol Ther. 2002;16(Suppl 4):73–8.CrossRefPubMed Tytgat GNJ. Review article: treatment of mild and severe cases of GERD. Aliment Pharmacol Ther. 2002;16(Suppl 4):73–8.CrossRefPubMed
33.
Zurück zum Zitat Colin-Jones DG. The role and limitations of H2-receptor antagonists in the treatment of gastroesophageal reflux disease. Aliment Pharmacol Ther. 1995;9(Suppl 1):9–14.PubMed Colin-Jones DG. The role and limitations of H2-receptor antagonists in the treatment of gastroesophageal reflux disease. Aliment Pharmacol Ther. 1995;9(Suppl 1):9–14.PubMed
34.
Zurück zum Zitat Chiba N, De Gara CJ, Wilkinson JM, Hunt R. Speed of healing and symptom relief in grade II to IV gastroesophageal reflux disease: a meta-analysis. Gastroenterology. 1997;112:1798–810.CrossRefPubMed Chiba N, De Gara CJ, Wilkinson JM, Hunt R. Speed of healing and symptom relief in grade II to IV gastroesophageal reflux disease: a meta-analysis. Gastroenterology. 1997;112:1798–810.CrossRefPubMed
35.
Zurück zum Zitat DeVault KR, Castell DO. The Practice Parameters Committee of the American College of Gastroenterology. Updated guidelines for the diagnosis and treatment of gastroesophageal reflux disease. Am J Gastroenterol. 1999;94:1434–42.CrossRefPubMed DeVault KR, Castell DO. The Practice Parameters Committee of the American College of Gastroenterology. Updated guidelines for the diagnosis and treatment of gastroesophageal reflux disease. Am J Gastroenterol. 1999;94:1434–42.CrossRefPubMed
36.
Zurück zum Zitat Carlsson R, Dent J, Watts R, Riley S, Sheikh R, Hatlebakk J, et al. Gastroesophageal reflux disease in primary care: an international study of different treatment strategies with omeprazole. Eur J Gastroenterol Hepatol. 1998;10:119–24.CrossRefPubMed Carlsson R, Dent J, Watts R, Riley S, Sheikh R, Hatlebakk J, et al. Gastroesophageal reflux disease in primary care: an international study of different treatment strategies with omeprazole. Eur J Gastroenterol Hepatol. 1998;10:119–24.CrossRefPubMed
37.
Zurück zum Zitat Hallerback B, Unge P, Carling L, et al. Omeprazole or ranitidine in long term treatment of reflux esophagitis. Gastroenterology. 1994;107:1305–11.PubMed Hallerback B, Unge P, Carling L, et al. Omeprazole or ranitidine in long term treatment of reflux esophagitis. Gastroenterology. 1994;107:1305–11.PubMed
38.
Zurück zum Zitat Wilde MI, McTavish D. Omeprazole. An update of its pharmacology and therapeutic use in acid-related disorders. Drugs. 1994;48:91–132.CrossRefPubMed Wilde MI, McTavish D. Omeprazole. An update of its pharmacology and therapeutic use in acid-related disorders. Drugs. 1994;48:91–132.CrossRefPubMed
39.
Zurück zum Zitat Koury SI, Stone CK, La Charite DD. Omeprazole and the development of acute hepatitis. Eur J Emerg Med. 1998;5:467–9.CrossRefPubMed Koury SI, Stone CK, La Charite DD. Omeprazole and the development of acute hepatitis. Eur J Emerg Med. 1998;5:467–9.CrossRefPubMed
40.
Zurück zum Zitat Yip D, Kovac S, Jardine M, Horvath J, Findlay M. Omeprazole induced interstitial nephritis. J Clin Gastroenterol. 1997;25:450–2.CrossRefPubMed Yip D, Kovac S, Jardine M, Horvath J, Findlay M. Omeprazole induced interstitial nephritis. J Clin Gastroenterol. 1997;25:450–2.CrossRefPubMed
41.
Zurück zum Zitat Singh P, Indaram A, Greenberg R, Visvalingam V, Bank S. Long term omeprazole therapy for reflux esophagitis: follow up in serum gastrin levels, EC cell hyperplasia and neoplasia. World J Gastroenterol. 2000;6:789–92.PubMed Singh P, Indaram A, Greenberg R, Visvalingam V, Bank S. Long term omeprazole therapy for reflux esophagitis: follow up in serum gastrin levels, EC cell hyperplasia and neoplasia. World J Gastroenterol. 2000;6:789–92.PubMed
42.
Zurück zum Zitat Juurlink DN, Gomes T, Ko DT, Szmitko PE, Austin PC, Tu JV, et al. A population-based study of the drug interaction between proton pump inhibitors and clopidrogrel. CMAJ. 2009;180:713–8.PubMed Juurlink DN, Gomes T, Ko DT, Szmitko PE, Austin PC, Tu JV, et al. A population-based study of the drug interaction between proton pump inhibitors and clopidrogrel. CMAJ. 2009;180:713–8.PubMed
43.
Zurück zum Zitat Futagami S, Iwakiri K, Shindo T, Kawagoe T, Horie A, Shimpuku M, et al. The prokinetic effect of mosapride citrate combined with omeprazole therapy improves clinical symptoms and gastric emptying in PPI-resistant NERD patients with delayed gastric emptying. J Gastroenterol. 2010;45:413–21.CrossRefPubMed Futagami S, Iwakiri K, Shindo T, Kawagoe T, Horie A, Shimpuku M, et al. The prokinetic effect of mosapride citrate combined with omeprazole therapy improves clinical symptoms and gastric emptying in PPI-resistant NERD patients with delayed gastric emptying. J Gastroenterol. 2010;45:413–21.CrossRefPubMed
44.
Zurück zum Zitat Kim YS, Kim TH, Choi CS, Shon YW, Kim SW, Seo GS, et al. Effect of itopride, a new prokinetic, in patients with mild GERD: a pilot study. World J Gastroenterol. 2005;11(27):4210–4.PubMed Kim YS, Kim TH, Choi CS, Shon YW, Kim SW, Seo GS, et al. Effect of itopride, a new prokinetic, in patients with mild GERD: a pilot study. World J Gastroenterol. 2005;11(27):4210–4.PubMed
45.
Zurück zum Zitat Dodds WJ, Dent J, Hogan WJ, Helm JF, Hauser R, Patel GK, et al. Mechanisms of gastroesophageal reflux in patients with reflux esophagitis. N Engl J Med. 1982;307:1547–52.CrossRefPubMed Dodds WJ, Dent J, Hogan WJ, Helm JF, Hauser R, Patel GK, et al. Mechanisms of gastroesophageal reflux in patients with reflux esophagitis. N Engl J Med. 1982;307:1547–52.CrossRefPubMed
46.
Zurück zum Zitat Vela MF, Tutuian R, Katz PO, Castell DO. Baclofen decreases acid and non-acid post prandial gastroesophageal reflux measured by combined multichannel intraluminal impedance and pH. Aliment Pharmacol Ther. 2003;17:243–51.CrossRefPubMed Vela MF, Tutuian R, Katz PO, Castell DO. Baclofen decreases acid and non-acid post prandial gastroesophageal reflux measured by combined multichannel intraluminal impedance and pH. Aliment Pharmacol Ther. 2003;17:243–51.CrossRefPubMed
47.
Zurück zum Zitat Lundell L, Miettinen P, Myrvold HE, Pedersen SA, Thor K, Lamm M, et al. Long term management of gastroesophageal reflux disease with omeprazole or open antireflux surgery: results of a prospective, randomized clinical trial. Eur J Gastroenterol Hepatol. 2000;12:879–87.CrossRefPubMed Lundell L, Miettinen P, Myrvold HE, Pedersen SA, Thor K, Lamm M, et al. Long term management of gastroesophageal reflux disease with omeprazole or open antireflux surgery: results of a prospective, randomized clinical trial. Eur J Gastroenterol Hepatol. 2000;12:879–87.CrossRefPubMed
48.
Zurück zum Zitat Lafullarde T, Watson D, Jamieson G, Meyers JC, Game PA, Devitt PG. Laparoscopic Nissen fundoplication. Arch Surg. 2001;136:180–4.CrossRefPubMed Lafullarde T, Watson D, Jamieson G, Meyers JC, Game PA, Devitt PG. Laparoscopic Nissen fundoplication. Arch Surg. 2001;136:180–4.CrossRefPubMed
49.
Zurück zum Zitat Spechler S. Comparison of medical and surgical therapy for complicated gastroesophageal reflux disease in veterans. N Engl J Med. 1992;326:786–92.CrossRefPubMed Spechler S. Comparison of medical and surgical therapy for complicated gastroesophageal reflux disease in veterans. N Engl J Med. 1992;326:786–92.CrossRefPubMed
50.
Zurück zum Zitat Lundell L, Attwood S, Fiocca R, Galmiche JP, Hatlebakk J, Lind T, et al. Comparison laparoscopic antireflux surgery with esomeprazole in the management of patients with chronic gastroesophageal reflux disease: a 3-year interim analysis of the LOTUS trial. Gut. 2008;57:1207–13.CrossRefPubMed Lundell L, Attwood S, Fiocca R, Galmiche JP, Hatlebakk J, Lind T, et al. Comparison laparoscopic antireflux surgery with esomeprazole in the management of patients with chronic gastroesophageal reflux disease: a 3-year interim analysis of the LOTUS trial. Gut. 2008;57:1207–13.CrossRefPubMed
51.
Zurück zum Zitat Kozarek R, Low D, Raltz S. Complications associated with laparoscopic anti-reflux surgery: one multispecialty clinic’s experience. Gastrointest Endosc. 1997;46:527–31.CrossRefPubMed Kozarek R, Low D, Raltz S. Complications associated with laparoscopic anti-reflux surgery: one multispecialty clinic’s experience. Gastrointest Endosc. 1997;46:527–31.CrossRefPubMed
52.
Zurück zum Zitat Galmiche J, Zerbib F. Laparoscopic fundoplication is the treatment of choice for gastroesophageal reflux disease. Gut. 2002;51:472–4.CrossRefPubMed Galmiche J, Zerbib F. Laparoscopic fundoplication is the treatment of choice for gastroesophageal reflux disease. Gut. 2002;51:472–4.CrossRefPubMed
53.
Zurück zum Zitat Lundell L, Miettinen P, Myrvold HE, Hatlebakk JG, Wallin L, Malm A, et al. Seven-year follow-up of randomized clinical trial comparing proton pump inhibition with surgical therapy for reflux esophagitis. Br J Surg. 2007;94:198–203.CrossRefPubMed Lundell L, Miettinen P, Myrvold HE, Hatlebakk JG, Wallin L, Malm A, et al. Seven-year follow-up of randomized clinical trial comparing proton pump inhibition with surgical therapy for reflux esophagitis. Br J Surg. 2007;94:198–203.CrossRefPubMed
54.
Zurück zum Zitat Soot S, Eshraghi N, Farahmand M, Sheppard BC, Deveney CW. Transition from open to laparoscopic fundoplication: the learning curve. Arch Surg. 1999;134:278–81.CrossRefPubMed Soot S, Eshraghi N, Farahmand M, Sheppard BC, Deveney CW. Transition from open to laparoscopic fundoplication: the learning curve. Arch Surg. 1999;134:278–81.CrossRefPubMed
55.
Zurück zum Zitat DeMeester TR, Johnson LF, Joseph GJ, Toscano MS, Hall AW, Skinner DB. Patterns of gastroesophageal reflux in health and disease. Ann Surg. 1976;184:459–70.CrossRefPubMed DeMeester TR, Johnson LF, Joseph GJ, Toscano MS, Hall AW, Skinner DB. Patterns of gastroesophageal reflux in health and disease. Ann Surg. 1976;184:459–70.CrossRefPubMed
56.
Zurück zum Zitat Poh CH, Allen L, Gasiorowska A, Navarro-Rodriguez T, Quan SF, Malagon I, et al. Conscious awakening are commonly associated with acid-reflux events in patients with gastroesophageal reflux disease. Clin Gastroenterol Hepatol. 2010 (in press). Poh CH, Allen L, Gasiorowska A, Navarro-Rodriguez T, Quan SF, Malagon I, et al. Conscious awakening are commonly associated with acid-reflux events in patients with gastroesophageal reflux disease. Clin Gastroenterol Hepatol. 2010 (in press).
57.
Zurück zum Zitat Smith PM, Kerr GD, Cockel R, Ross BA, Bate CM, Brown P, et al. A comparison of omeprazole and ranitidine in the prevention of reoccurrence of benign esophageal stricture. Restore Investigator Group. Gastroenterology. 1994;107:1312–8.PubMed Smith PM, Kerr GD, Cockel R, Ross BA, Bate CM, Brown P, et al. A comparison of omeprazole and ranitidine in the prevention of reoccurrence of benign esophageal stricture. Restore Investigator Group. Gastroenterology. 1994;107:1312–8.PubMed
58.
Zurück zum Zitat Raiha IJ, Imprivaara O, Seppala M, Sourander LB. Prevalence and characteristics of symptomatic gastroesophageal reflux disease in the elderly. J Am Geriatr Soc. 1992;40:1209–11.PubMed Raiha IJ, Imprivaara O, Seppala M, Sourander LB. Prevalence and characteristics of symptomatic gastroesophageal reflux disease in the elderly. J Am Geriatr Soc. 1992;40:1209–11.PubMed
59.
Zurück zum Zitat Zhu H, Pace F, Sangaletti O, Bianchi PG. Features of symptomatic gastroesophageal reflux in elderly patients. Scand J Gastroenterol. 1993;28:235–8.CrossRefPubMed Zhu H, Pace F, Sangaletti O, Bianchi PG. Features of symptomatic gastroesophageal reflux in elderly patients. Scand J Gastroenterol. 1993;28:235–8.CrossRefPubMed
60.
Zurück zum Zitat Plant RL. Anatomy and physiology of swallowing in adults and geriatrics. Otolaryngol Clin North Am. 1998;31:447–88. Plant RL. Anatomy and physiology of swallowing in adults and geriatrics. Otolaryngol Clin North Am. 1998;31:447–88.
61.
Zurück zum Zitat Raiha I, Hietanen E, Sourander L. Symptoms of gastro-esophageal reflux disease in elderly people. Age Ageing. 1991;20:365–70.CrossRefPubMed Raiha I, Hietanen E, Sourander L. Symptoms of gastro-esophageal reflux disease in elderly people. Age Ageing. 1991;20:365–70.CrossRefPubMed
62.
Zurück zum Zitat Mold JW, Reed LE, Davis AB, Allen ML, Decktor DL, Robinson M. Prevalence for gastroesophageal reflux in elderly patients in a primary care setting. Am J Gastroenterol. 1991;86:965–70.PubMed Mold JW, Reed LE, Davis AB, Allen ML, Decktor DL, Robinson M. Prevalence for gastroesophageal reflux in elderly patients in a primary care setting. Am J Gastroenterol. 1991;86:965–70.PubMed
63.
Zurück zum Zitat O’Connell MB, Madden DM, Murray AM, Heaney RP, Kerzner LJ. Effects of proton pump inhibitors on calcium carbonate absorption in women: a randomized crossover trial. Am J Med. 2005;118:778–81.CrossRefPubMed O’Connell MB, Madden DM, Murray AM, Heaney RP, Kerzner LJ. Effects of proton pump inhibitors on calcium carbonate absorption in women: a randomized crossover trial. Am J Med. 2005;118:778–81.CrossRefPubMed
64.
Zurück zum Zitat Yang YX, Lewis JD, Epstein S, Epstein S, Metz DC. Long-term proton pump inhibitor therapy and risk of hip fracture. JAMA. 2006;296:2947–53.CrossRefPubMed Yang YX, Lewis JD, Epstein S, Epstein S, Metz DC. Long-term proton pump inhibitor therapy and risk of hip fracture. JAMA. 2006;296:2947–53.CrossRefPubMed
65.
Zurück zum Zitat Laheij RJF, Stukenboom MCJM, Hassing RJ, Dieleman J, Stricker BHC, Jansen JBMJ. Risk of community-acquired pneumonia and use of gastric acid suppressive drugs. JAMA. 2004;292:1955–60.CrossRefPubMed Laheij RJF, Stukenboom MCJM, Hassing RJ, Dieleman J, Stricker BHC, Jansen JBMJ. Risk of community-acquired pneumonia and use of gastric acid suppressive drugs. JAMA. 2004;292:1955–60.CrossRefPubMed
Metadaten
Titel
Gastroesophageal reflux disease
verfasst von
Kwong Ming Fock
Choo Hean Poh
Publikationsdatum
01.08.2010
Verlag
Springer Japan
Erschienen in
Journal of Gastroenterology / Ausgabe 8/2010
Print ISSN: 0944-1174
Elektronische ISSN: 1435-5922
DOI
https://doi.org/10.1007/s00535-010-0274-9

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