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Archives of Virology

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01.01.2015 | Brief Review

Three-dimensional structure of foot-and-mouth disease virus and its biological functions

verfasst von: Shi-Chong Han, Hui-Chen Guo, Shi-Qi Sun

Erschienen in: Archives of Virology | Ausgabe 1/2015

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Abstract

Foot-and-mouth disease (FMD), an acute, violent, infectious disease of cloven-hoofed animals, remains widespread in most parts of the world. It can lead to a major plague of livestock and an economical catastrophe. Structural studies of FMD virus (FMDV) have greatly contributed to our understanding of the virus life cycle and provided new horizons for the control and eradication of FMDV. To examine host-FMDV interactions and viral pathogenesis from a structural perspective, the structures of viral structural and non-structural proteins are reviewed in the context of their relevance for virus assembly and dissociation, formation of capsid-like particles and virus-receptor complexes, and viral penetration and uncoating. Moreover, possibilities for devising novel antiviral treatments are discussed.

Acharya R, Fry E, Stuart D, Fox G, Rowlands D, Brown F (1989) The three-dimensional structure of foot-and-mouth disease virus at 2.9 A resolution. Nature 337:709–716PubMed

Agudo R, Ferrer-Orta C, Arias A, de la Higuera I, Perales C, Perez-Luque R, Verdaguer N, Domingo E (2010) A multi-step process of viral adaptation to a mutagenic nucleoside analogue by modulation of transition types leads to extinction-escape. PLoS Pathog 6:e1001072PubMedCentralPubMed

Allaire M, Chernaia MM, Malcolm BA, James MN (1994) Picornaviral 3C cysteine proteinases have a fold similar to chymotrypsin-like serine proteinases. Nature 369:72–76PubMed

Arnold E, Luo M, Vriend G, Rossmann MG, Palmenberg AC, Parks GD, Nicklin MJ, Wimmer E (1987) Implications of the picornavirus capsid structure for polyprotein processing. Proc Natl Acad Sci USA 84:21–25PubMedCentralPubMed

Ashcroft AE, Lago H, Macedo JM, Horn WT, Stonehouse NJ, Stockley PG (2005) Engineering thermal stability in RNA phage capsids via disulphide bonds. J Nanosci Nanotechnol 5:2034–2041PubMed

Azuma H, Yoneda S (2009) Structure and dynamics of the GH loop of the foot-and-mouth disease virus capsid. J Mol Graph Model 28:278–286PubMed

Banerjee R, Dasgupta A (2001) Interaction of picornavirus 2C polypeptide with the viral negative-strand RNA. J Gen Virol 82:2621–2627PubMed

Baranowski E, Ruiz-Jarabo CM, Sevilla N, Andreu D, Beck E, Domingo E (2000) Cell recognition by foot-and-mouth disease virus that lacks the RGD integrin-binding motif: flexibility in aphthovirus receptor usage. J Virol 74:1641–1647PubMedCentralPubMed

Basavappa R, Syed R, Flore O, Icenogle JP, Filman DJ, Hogle JM (1994) Role and mechanism of the maturation cleavage of VP0 in poliovirus assembly: structure of the empty capsid assembly intermediate at 2.9 A resolution. Protein Sci 3:1651–1669PubMedCentralPubMed

10.

Beales LP, Holzenburg A, Rowlands DJ (2003) Viral internal ribosome entry site structures segregate into two distinct morphologies. J Virol 77:6574–6579PubMedCentralPubMed

11.

Belnap DM, Filman DJ, Trus BL, Cheng N, Booy FP, Conway JF, Curry S, Hiremath CN, Tsang SK, Steven AC, Hogle JM (2000) Molecular tectonic model of virus structural transitions: the putative cell entry states of poliovirus. J Virol 74:1342–1354PubMedCentralPubMed

12.

Belser JA, Lu X, Szretter KJ, Jin X, Aschenbrenner LM, Lee A, Hawley S, Kim do H, Malakhov MP, Yu M, Fang F, Katz JM (2007) DAS181, a novel sialidase fusion protein, protects mice from lethal avian influenza H5N1 virus infection. The Journal of infectious diseases 196:1493–1499PubMed

13.

Belsham G, Martinez-Salas E, Sobrino F, Domingo E (2004) Genome organization, translation and replication of foot-and-mouth disease virus RNA. Foot and mouth disease: current perspectives, pp 19–52

14.

Belsham GJ, McInerney GM, Ross-Smith N (2000) Foot-and-mouth disease virus 3C protease induces cleavage of translation initiation factors eIF4A and eIF4G within infected cells. J Virol 74:272–280PubMedCentralPubMed

15.

Belsham GJ (2005) Translation and replication of FMDV RNA. Curr Top Microbiol Immunol 288:43–70PubMed

16.

Bentham M, Holmes K, Forrest S, Rowlands DJ, Stonehouse NJ (2012) Formation of higher-order foot-and-mouth disease virus 3D(pol) complexes is dependent on elongation activity. J Virol 86:2371–2374PubMedCentralPubMed

17.

Berka U, Khan A, Blaas D, Fuchs R (2009) Human rhinovirus type 2 uncoating at the plasma membrane is not affected by a pH gradient but is affected by the membrane potential. J Virol 83:3778–3787PubMedCentralPubMed

18.

Berryman S, Clark S, Monaghan P, Jackson T (2005) Early events in integrin alphavbeta6-mediated cell entry of foot-and-mouth disease virus. J Virol 79:8519–8534PubMedCentralPubMed

19.

Berryman S, Clark S, Kakker NK, Silk R, Seago J, Wadsworth J, Chamberlain K, Knowles NJ, Jackson T (2013) Positively charged residues at the five-fold symmetry axis of cell culture-adapted foot-and-mouth disease virus permit novel receptor interactions. J Virol 87:8735–8744PubMedCentralPubMed

20.

Bienz K, Egger D, Troxler M, Pasamontes L (1990) Structural organization of poliovirus RNA replication is mediated by viral proteins of the P2 genomic region. J Virol 64:1156–1163PubMedCentralPubMed

21.

Birtley JR, Curry S (2005) Crystallization of foot-and-mouth disease virus 3C protease: surface mutagenesis and a novel crystal-optimization strategy. Acta Crystallogr Sect D Biol Crystallogr 61:646–650

22.

Birtley JR, Knox SR, Jaulent AM, Brick P, Leatherbarrow RJ, Curry S (2005) Crystal structure of foot-and-mouth disease virus 3C protease. New insights into catalytic mechanism and cleavage specificity. J Biol Chem 280:11520–11527PubMed

23.

Bjorndahl TC, Andrew LC, Semenchenko V, Wishart DS (2007) NMR solution structures of the apo and peptide-inhibited human rhinovirus 3C protease (Serotype 14): structural and dynamic comparison. Biochemistry 46:12945–12958PubMed

24.

Blom N, Hansen J, Blaas D, Brunak S (1996) Cleavage site analysis in picornaviral polyproteins: discovering cellular targets by neural networks. Protein Sci 5:2203–2216PubMedCentralPubMed

25.

Brabec M, Baravalle G, Blaas D, Fuchs R (2003) Conformational changes, plasma membrane penetration, and infection by human rhinovirus type 2: role of receptors and low pH. J Virol 77:5370–5377PubMedCentralPubMed

26.

Brown F, Cartwright B (1961) Dissociation of foot-and-mouth disease virus into its nucleic acid and protein components. Nature 192:1163–1164PubMed

27.

Bubeck D, Filman DJ, Cheng N, Steven AC, Hogle JM, Belnap DM (2005) The structure of the poliovirus 135S cell entry intermediate at 10-angstrom resolution reveals the location of an externalized polypeptide that binds to membranes. J Virol 79:7745–7755PubMedCentralPubMed

28.

Burman A, Clark S, Abrescia NG, Fry EE, Stuart DI, Jackson T (2006) Specificity of the VP1 GH loop of foot-and-mouth disease virus for alphav integrins. J Virol 80:9798–9810PubMedCentralPubMed

29.

Butan C, Filman DJ, Hogle JM (2014) Cryo-electron microscopy reconstruction shows poliovirus 135S particles poised for membrane interaction and RNA release. J Virol 88:1758–1770PubMedCentralPubMed

30.

Cao Y, Lu Z, Sun J, Bai X, Sun P, Bao H, Chen Y, Guo J, Li D, Liu X, Liu Z (2009) Synthesis of empty capsid-like particles of Asia I foot-and-mouth disease virus in insect cells and their immunogenicity in guinea pigs. Veterinary Microbiol 137:10–17

31.

Cartwright B, Chapman WG, Brown F (1980) Serological and immunological relations between the 146S and 12S particles of foot-and-mouth disease virus. J Gen Virol 50:369–375PubMed

32.

Cencic R, Mayer C, Juliano MA, Juliano L, Konrat R, Kontaxis G, Skern T (2007) Investigating the substrate specificity and oligomerisation of the leader protease of foot and mouth disease virus using NMR. J Mol Biol 373:1071–1087PubMed

33.

Clarke BE, Sangar DV (1988) Processing and assembly of foot-and-mouth disease virus proteins using subgenomic RNA. J Gen Virol 69(Pt 9):2313–2325PubMed

34.

Curry S, Abrams CC, Fry E, Crowther JC, Belsham GJ, Stuart DI, King AM (1995) Viral RNA modulates the acid sensitivity of foot-and-mouth disease virus capsids. J Virol 69:430–438PubMedCentralPubMed

35.

Curry S, Fry E, Blakemore W, Abu-Ghazaleh R, Jackson T, King A, Lea S, Newman J, Rowlands D, Stuart D (1996) Perturbations in the surface structure of A22 Iraq foot-and-mouth disease virus accompanying coupled changes in host cell specificity and antigenicity. Structure 4:135–145PubMed

36.

Curry S, Fry E, Blakemore W, Abu-Ghazaleh R, Jackson T, King A, Lea S, Newman J, Stuart D (1997) Dissecting the roles of VP0 cleavage and RNA packaging in picornavirus capsid stabilization: the structure of empty capsids of foot-and-mouth disease virus. J Virol 71:9743–9752PubMedCentralPubMed

37.

Curry S, Roque-Rosell N, Sweeney TR, Zunszain PA, Leatherbarrow RJ (2007) Structural analysis of foot-and-mouth disease virus 3C protease: a viable target for antiviral drugs? Biochem Soc Trans 35:594–598PubMed

38.

Curry S, Roque-Rosell N, Zunszain PA, Leatherbarrow RJ (2007) Foot-and-mouth disease virus 3C protease: recent structural and functional insights into an antiviral target. Int J Biochem Cell Biol 39:1–6PubMed

39.

de Chassey B, Meyniel-Schicklin L, Aublin-Gex A, Andre P, Lotteau V (2012) New horizons for antiviral drug discovery from virus–host protein interaction networks. Curr Opin Virol 2:606–613PubMed

40.

de Los Santos T, de Avila Botton S, Weiblen R, Grubman MJ (2006) The leader proteinase of foot-and-mouth disease virus inhibits the induction of beta interferon mRNA and blocks the host innate immune response. J Virol 80:1906–1914PubMedCentral

41.

DeLano W (2002) The PyMOL Molecular Graphics System. DeLano Scientific, Palo Alto

42.

Devaney MA, Vakharia VN, Lloyd RE, Ehrenfeld E, Grubman MJ (1988) Leader protein of foot-and-mouth disease virus is required for cleavage of the p220 component of the cap-binding protein complex. J Virol 62:4407–4409PubMedCentralPubMed

43.

DiCara D, Rapisarda C, Sutcliffe JL, Violette SM, Weinreb PH, Hart IR, Howard MJ, Marshall JF (2007) Structure-function analysis of Arg-Gly-Asp helix motifs in alpha v beta 6 integrin ligands. J Biol Chem 282:9657–9665PubMed

44.

Dicara D, Burman A, Clark S, Berryman S, Howard MJ, Hart IR, Marshall JF, Jackson T (2008) Foot-and-mouth disease virus forms a highly stable, EDTA-resistant complex with its principal receptor, integrin alphavbeta6: implications for infectiousness. J Virol 82:1537–1546PubMedCentralPubMed

45.

Domingo E, Escarmis C, Baranowski E, Ruiz-Jarabo CM, Carrillo E, Nunez JI, Sobrino F (2003) Evolution of foot-and-mouth disease virus. Virus Res 91:47–63PubMed

46.

Ellard FM, Drew J, Blakemore WE, Stuart DI, King AM (1999) Evidence for the role of His-142 of protein 1C in the acid-induced disassembly of foot-and-mouth disease virus capsids. J Gen Virol 80(Pt 8):1911–1918PubMed

47.

Fernandez N, Garcia-Sacristan A, Ramajo J, Briones C, Martinez-Salas E (2011) Structural analysis provides insights into the modular organization of picornavirus IRES. Virology 409:251–261PubMed

48.

Ferrer-Orta C, Arias A, Perez-Luque R, Escarmis C, Domingo E, Verdaguer N (2004) Structure of foot-and-mouth disease virus RNA-dependent RNA polymerase and its complex with a template-primer RNA. J Biol Chem 279:47212–47221PubMed

49.

Ferrer-Orta C, Arias A, Agudo R, Perez-Luque R, Escarmis C, Domingo E, Verdaguer N (2006) The structure of a protein primer-polymerase complex in the initiation of genome replication. EMBO J 25:880–888PubMedCentralPubMed

50.

Ferrer-Orta C, Arias A, Escarmis C, Verdaguer N (2006) A comparison of viral RNA-dependent RNA polymerases. Curr Opin Struct Biol 16:27–34PubMed

51.

Ferrer-Orta C, Arias A, Perez-Luque R, Escarmis C, Domingo E, Verdaguer N (2007) Sequential structures provide insights into the fidelity of RNA replication. Proc Natl Acad Sci USA 104:9463–9468PubMedCentralPubMed

52.

Ferrer-Orta C, Agudo R, Domingo E, Verdaguer N (2009) Structural insights into replication initiation and elongation processes by the FMDV RNA-dependent RNA polymerase. Curr Opin Struct Biol 19:752–758PubMed

53.

Ferrer-Orta C, Sierra M, Agudo R, de la Higuera I, Arias A, Perez-Luque R, Escarmis C, Domingo E, Verdaguer N (2010) Structure of foot-and-mouth disease virus mutant polymerases with reduced sensitivity to ribavirin. J Virol 84:6188–6199PubMedCentralPubMed

54.

Foeger N, Kuehnel E, Cencic R, Skern T (2005) The binding of foot-and-mouth disease virus leader proteinase to eIF4GI involves conserved ionic interactions. FEBS J 272:2602–2611PubMed

55.

Fry EE, Lea SM, Jackson T, Newman JW, Ellard FM, Blakemore WE, Abu-Ghazaleh R, Samuel A, King AM, Stuart DI (1999) The structure and function of a foot-and-mouth disease virus-oligosaccharide receptor complex. EMBO J 18:543–554PubMedCentralPubMed

56.

Fry EE, Newman JW, Curry S, Najjam S, Jackson T, Blakemore W, Lea SM, Miller L, Burman A, King AM, Stuart DI (2005) Structure of Foot-and-mouth disease virus serotype A10 61 alone and complexed with oligosaccharide receptor: receptor conservation in the face of antigenic variation. J Gen Virol 86:1909–1920PubMed

57.

Fry EE, Stuart DI, Rowlands DJ (2005) The structure of foot-and-mouth disease virus. Curr Top Microbiol Immunol 288:71–101PubMed

58.

Fuchs R, Blaas D (2010) Uncoating of human rhinoviruses. Rev Med Virol 20:281–297PubMed

59.

Garriga D, Pickl-Herk A, Luque D, Wruss J, Caston JR, Blaas D, Verdaguer N (2012) Insights into minor group rhinovirus uncoating: the X-ray structure of the HRV2 empty capsid. PLoS Pathog 8:e1002473PubMedCentralPubMed

60.

Glaser W, Cencic R, Skern T (2001) Foot-and-mouth disease virus leader proteinase: involvement of C-terminal residues in self-processing and cleavage of eIF4GI. J Biol Chem 276:35473–35481PubMed

61.

Goodwin S, Tuthill TJ, Arias A, Killington RA, Rowlands DJ (2009) Foot-and-mouth disease virus assembly: processing of recombinant capsid precursor by exogenous protease induces self-assembly of pentamers in vitro in a myristoylation-dependent manner. J Virol 83:11275–11282PubMedCentralPubMed

62.

Graci JD, Cameron CE (2006) Mechanisms of action of ribavirin against distinct viruses. Rev Med Virol 16:37–48PubMed

63.

Gradi A, Foeger N, Strong R, Svitkin YV, Sonenberg N, Skern T, Belsham GJ (2004) Cleavage of eukaryotic translation initiation factor 4GII within foot-and-mouth disease virus-infected cells: identification of the L-protease cleavage site in vitro. J Virol 78:3271–3278PubMedCentralPubMed

64.

Grubman MJ, Baxt B (2004) Foot-and-mouth disease. Clin Microbiol Rev 17:465–493PubMedCentralPubMed

65.

Guarne A, Tormo J, Kirchweger R, Pfistermueller D, Fita I, Skern T (1998) Structure of the foot-and-mouth disease virus leader protease: a papain-like fold adapted for self-processing and eIF4G recognition. EMBO J 17:7469–7479PubMedCentralPubMed

66.

Guarne A, Hampoelz B, Glaser W, Carpena X, Tormo J, Fita I, Skern T (2000) Structural and biochemical features distinguish the foot-and-mouth disease virus leader proteinase from other papain-like enzymes. J Mol Biol 302:1227–1240PubMed

67.

Guex N, Peitsch MC (1996) Swiss-PdbViewer: a fast and easy-to-use PDB viewer for Macintosh and PC. Protein Data Bank Quarterly Newsletter 77

68.

Gullberg M, Muszynski B, Organtini LJ, Ashley RE, Hafenstein SL, Belsham GJ, Polacek C (2013) Assembly and characterization of foot-and-mouth disease virus empty capsid particles expressed within mammalian cells. J Gen Virol 94:1769–1779PubMed

69.

Guo HC, Sun SQ, Jin Y, Yang SL, Wei YQ, Sun DH, Yin SH, Ma JW, Liu ZX, Guo JH, Luo JX, Yin H, Liu XT, Liu DX (2013) Foot-and-mouth disease virus-like particles produced by a SUMO fusion protein system in Escherichia coli induce potent protective immune responses in guinea pigs, swine and cattle. Veterinary Res 44:48

70.

Hedstrom L (2002) Serine protease mechanism and specificity. Chem Rev 102:4501–4524PubMed

71.

Hendry E, Hatanaka H, Fry E, Smyth M, Tate J, Stanway G, Santti J, Maaronen M, Hyypia T, Stuart D (1999) The crystal structure of coxsackievirus A9: new insights into the uncoating mechanisms of enteroviruses. Structure 7:1527–1538PubMed

72.

Hewat EA, Verdaguer N, Fita I, Blakemore W, Brookes S, King A, Newman J, Domingo E, Mateu MG, Stuart DI (1997) Structure of the complex of an Fab fragment of a neutralizing antibody with foot-and-mouth disease virus: positioning of a highly mobile antigenic loop. EMBO J 16:1492–1500PubMedCentralPubMed

73.

Jackson T, Blakemore W, Newman JW, Knowles NJ, Mould AP, Humphries MJ, King AM (2000) Foot-and-mouth disease virus is a ligand for the high-affinity binding conformation of integrin alpha5beta1: influence of the leucine residue within the RGDL motif on selectivity of integrin binding. J Gen Virol 81:1383–1391PubMed

74.

Jackson T, Sheppard D, Denyer M, Blakemore W, King AM (2000) The epithelial integrin alphavbeta6 is a receptor for foot-and-mouth disease virus. J Virol 74:4949–4956PubMedCentralPubMed

75.

Jackson T, Mould AP, Sheppard D, King AM (2002) Integrin alphavbeta1 is a receptor for foot-and-mouth disease virus. J Virol 76:935–941PubMedCentralPubMed

76.

Jackson T, Clark S, Berryman S, Burman A, Cambier S, Mu D, Nishimura S, King AM (2004) Integrin alphavbeta8 functions as a receptor for foot-and-mouth disease virus: role of the beta-chain cytodomain in integrin-mediated infection. J Virol 78:4533–4540PubMedCentralPubMed

77.

Jamal SM, Belsham GJ (2013) Foot-and-mouth disease: past, present and future. Veterinary Res 44:116

78.

Jennings GT, Bachmann MF (2008) The coming of age of virus-like particle vaccines. Biol Chem 389:521–536PubMed

79.

Johnson JE, Chiu W (2000) Structures of virus and virus-like particles. Curr Opin Struct Biol 10:229–235PubMed

80.

Jung S, Schlick T (2013) Candidate RNA structures for domain 3 of the foot-and-mouth-disease virus internal ribosome entry site. Nucleic Acids Res 41:1483–1495PubMedCentralPubMed

81.

Kjellen L, Lindahl U (1991) Proteoglycans: structures and interactions. Annu Rev Biochem 60:443–475PubMed

82.

Klein M, Eggers HJ, Nelsen-Salz B (1999) Echovirus 9 strain barty non-structural protein 2C has NTPase activity. Virus Res 65:155–160PubMed

83.

Lea S, Hernandez J, Blakemore W, Brocchi E, Curry S, Domingo E, Fry E, Abu-Ghazaleh R, King A, Newman J et al (1994) The structure and antigenicity of a type C foot-and-mouth disease virus. Structure 2:123–139PubMed

84.

Lea S, Abu-Ghazaleh R, Blakemore W, Curry S, Fry E, Jackson T, King A, Logan D, Newman J, Stuart D (1995) Structural comparison of two strains of foot-and-mouth disease virus subtype O1 and a laboratory antigenic variant, G67. Structure 3:571–580PubMed

85.

Li C, Wang JC, Taylor MW, Zlotnick A (2012) In vitro assembly of an empty picornavirus capsid follows a dodecahedral path. J Virol 86:13062–13069PubMedCentralPubMed

86.

Li W, Ross-Smith N, Proud CG, Belsham GJ (2001) Cleavage of translation initiation factor 4AI (eIF4AI) but not eIF4AII by foot-and-mouth disease virus 3C protease: identification of the eIF4AI cleavage site. FEBS Lett 507:1–5PubMed

87.

Li Z, Yin X, Yi Y, Li X, Li B, Lan X, Zhang Z, Liu J (2011) FMD subunit vaccine produced using a silkworm-baculovirus expression system: protective efficacy against two type Asia1 isolates in cattle. Veterinary Microbiol 149:99–103

88.

Lin JY, Chen TC, Weng KF, Chang SC, Chen LL, Shih SR (2009) Viral and host proteins involved in picornavirus life cycle. J Biomed Sci 16:103PubMedCentralPubMed

89.

Logan D, Abu-Ghazaleh R, Blakemore W, Curry S, Jackson T, King A, Lea S, Lewis R, Newman J, Parry N et al (1993) Structure of a major immunogenic site on foot-and-mouth disease virus. Nature 362:566–568PubMed

90.

Lopez de Quinto S, Saiz M, de la Morena D, Sobrino F, Martinez-Salas E (2002) IRES-driven translation is stimulated separately by the FMDV 3′-NCR and poly(A) sequences. Nucleic Acids Res 30:4398–4405PubMedCentralPubMed

91.

Lu G, Qi J, Chen Z, Xu X, Gao F, Lin D, Qian W, Liu H, Jiang H, Yan J, Gao GF (2011) Enterovirus 71 and coxsackievirus A16 3C proteases: binding to rupintrivir and their substrates and anti-hand, foot, and mouth disease virus drug design. J Virol 85:10319–10331PubMedCentralPubMed

92.

Lu Z, Bao H, Cao Y, Sun P, Guo J, Li P, Bai X, Chen Y, Xie B, Li D, Liu Z, Xie Q (2008) Protection of guinea pigs and swine by a recombinant adenovirus expressing O serotype of foot-and-mouth disease virus whole capsid and 3C protease. Vaccine 26(Suppl 6):G48–53PubMed

93.

Maree FF, Blignaut B, de Beer TA, Rieder E (2013) Analysis of SAT type foot-and-mouth disease virus capsid proteins and the identification of putative amino acid residues affecting virus stability. PLoS ONE 8:e61612PubMedCentralPubMed

94.

Martin-Acebes MA, Gonzalez-Magaldi M, Sandvig K, Sobrino F, Armas-Portela R (2007) Productive entry of type C foot-and-mouth disease virus into susceptible cultured cells requires clathrin and is dependent on the presence of plasma membrane cholesterol. Virology 369:105–118PubMed

95.

Martin-Acebes MA, Rincon V, Armas-Portela R, Mateu MG, Sobrino F (2010) A single amino acid substitution in the capsid of foot-and-mouth disease virus can increase acid lability and confer resistance to acid-dependent uncoating inhibition. J Virol 84:2902–2912PubMedCentralPubMed

96.

Martin-Acebes MA, Vazquez-Calvo A, Rincon V, Mateu MG, Sobrino F (2011) A single amino acid substitution in the capsid of foot-and-mouth disease virus can increase acid resistance. J Virol 85:2733–2740PubMedCentralPubMed

97.

Martinez MA, Verdaguer N, Mateu MG, Domingo E (1997) Evolution subverting essentiality: dispensability of the cell attachment Arg-Gly-Asp motif in multiply passaged foot-and-mouth disease virus. Proc Natl Acad Sci USA 94:6798–6802PubMedCentralPubMed

98.

Mason PW, Rieder E, Baxt B (1994) RGD sequence of foot-and-mouth disease virus is essential for infecting cells via the natural receptor but can be bypassed by an antibody-dependent enhancement pathway. Proc Natl Acad Sci USA 91:1932–1936PubMedCentralPubMed

99.

Mason PW, Bezborodova SV, Henry TM (2002) Identification and characterization of a cis-acting replication element (cre) adjacent to the internal ribosome entry site of foot-and-mouth disease virus. J Virol 76:9686–9694PubMedCentralPubMed

100.

Mason PW, Grubman MJ, Baxt B (2003) Molecular basis of pathogenesis of FMDV. Virus Res 91:9–32PubMed

101.

Mateo R, Luna E, Rincon V, Mateu MG (2008) Engineering viable foot-and-mouth disease viruses with increased thermostability as a step in the development of improved vaccines. J Virol 82:12232–12240PubMedCentralPubMed

102.

Mateu MG, Valero ML, Andreu D, Domingo E (1996) Systematic replacement of amino acid residues within an Arg-Gly-Asp-containing loop of foot-and-mouth disease virus and effect on cell recognition. J Biol Chem 271:12814–12819PubMed

103.

Matthews DA, Dragovich PS, Webber SE, Fuhrman SA, Patick AK, Zalman LS, Hendrickson TF, Love RA, Prins TJ, Marakovits JT, Zhou R, Tikhe J, Ford CE, Meador JW, Ferre RA, Brown EL, Binford SL, Brothers MA, DeLisle DM, Worland ST (1999) Structure-assisted design of mechanism-based irreversible inhibitors of human rhinovirus 3C protease with potent antiviral activity against multiple rhinovirus serotypes. Proc Natl Acad Sci USA 96:11000–11007PubMedCentralPubMed

104.

Mayer C, Neubauer D, Nchinda AT, Cencic R, Trompf K, Skern T (2008) Residue L143 of the foot-and-mouth disease virus leader proteinase is a determinant of cleavage specificity. J Virol 82:4656–4659PubMedCentralPubMed

105.

Miller LC, Blakemore W, Sheppard D, Atakilit A, King AM, Jackson T (2001) Role of the cytoplasmic domain of the beta-subunit of integrin alpha(v)beta6 in infection by foot-and-mouth disease virus. J Virol 75:4158–4164PubMedCentralPubMed

106.

Moscufo N, Simons J, Chow M (1991) Myristoylation is important at multiple stages in poliovirus assembly. J Virol 65:2372–2380PubMedCentralPubMed

107.

Nayak A, Goodfellow IG, Woolaway KE, Birtley J, Curry S, Belsham GJ (2006) Role of RNA structure and RNA binding activity of foot-and-mouth disease virus 3C protein in VPg uridylylation and virus replication. J Virol 80:9865–9875PubMedCentralPubMed

108.

Neff S, Sa-Carvalho D, Rieder E, Mason PW, Blystone SD, Brown EJ, Baxt B (1998) Foot-and-mouth disease virus virulent for cattle utilizes the integrin alpha(v)beta3 as its receptor. J Virol 72:3587–3594PubMedCentralPubMed

109.

Norder H, De Palma AM, Selisko B, Costenaro L, Papageorgiou N, Arnan C, Coutard B, Lantez V, De Lamballerie X, Baronti C, Sola M, Tan J, Neyts J, Canard B, Coll M, Gorbalenya AE, Hilgenfeld R (2011) Picornavirus non-structural proteins as targets for new anti-virals with broad activity. Antiviral Res 89:204–218PubMed

110.

Nugent CI, Johnson KL, Sarnow P, Kirkegaard K (1999) Functional coupling between replication and packaging of poliovirus replicon RNA. J Virol 73:427–435PubMedCentralPubMed

111.

Nurani G, Lindqvist B, Casasnovas JM (2003) Receptor priming of major group human rhinoviruses for uncoating and entry at mild low-pH environments. J Virol 77:11985–11991PubMedCentralPubMed

112.

O’Donnell V, LaRocco M, Duque H, Baxt B (2005) Analysis of foot-and-mouth disease virus internalization events in cultured cells. J Virol 79:8506–8518PubMedCentralPubMed

113.

O’Donnell V, Larocco M, Baxt B (2008) Heparan sulfate-binding foot-and-mouth disease virus enters cells via caveola-mediated endocytosis. J Virol 82:9075–9085PubMedCentralPubMed

114.

Pacheco JM, Brum MC, Moraes MP, Golde WT, Grubman MJ (2005) Rapid protection of cattle from direct challenge with foot-and-mouth disease virus (FMDV) by a single inoculation with an adenovirus-vectored FMDV subunit vaccine. Virology 337:205–209PubMed

115.

Parker WB (2005) Metabolism and antiviral activity of ribavirin. Virus Res 107:165–171PubMed

116.

Patick AK, Binford SL, Brothers MA, Jackson RL, Ford CE, Diem MD, Maldonado F, Dragovich PS, Zhou R, Prins TJ, Fuhrman SA, Meador JW, Zalman LS, Matthews DA, Worland ST (1999) In vitro antiviral activity of AG7088, a potent inhibitor of human rhinovirus 3C protease. Antimicrob Agents Chemother 43:2444–2450PubMedCentralPubMed

117.

Pegna M, Molinari H, Zetta L, Gibbons WA, Brown F, Rowlands D, Siligardi G, Mascagni P (1996) The solution structure of the immunodominant and cell receptor binding regions of foot-and-mouth disease virus serotype A, variant A. J Peptide Sci 2:75–90

118.

Petit MC, Benkirane N, Guichard G, Du AP, Marraud M, Cung MT, Briand JP, Muller S (1999) Solution structure of a retro-inverso peptide analogue mimicking the foot-and-mouth disease virus major antigenic site. Structural basis for its antigenic cross-reactivity with the parent peptide. J Biol Chem 274:3686–3692PubMed

119.

Piccone ME, Pauszek S, Pacheco J, Rieder E, Kramer E, Rodriguez LL (2009) Molecular characterization of a foot-and-mouth disease virus containing a 57-nucleotide insertion in the 3′ untranslated region. Arch Virol 154:671–676PubMed

120.

Porta C, Kotecha A, Burman A, Jackson T, Ren J, Loureiro S, Jones IM, Fry EE, Stuart DI, Charleston B (2013) Rational engineering of recombinant picornavirus capsids to produce safe, protective vaccine antigen. PLoS Pathog 9:e1003255PubMedCentralPubMed

121.

Reeve R, Blignaut B, Esterhuysen JJ, Opperman P, Matthews L, Fry EE, de Beer TA, Theron J, Rieder E, Vosloo W, O’Neill HG, Haydon DT, Maree FF (2010) Sequence-based prediction for vaccine strain selection and identification of antigenic variability in foot-and-mouth disease virus. PLoS Comput Biol 6:e1001027PubMedCentralPubMed

122.

Reguera J, Carreira A, Riolobos L, Almendral JM, Mateu MG (2004) Role of interfacial amino acid residues in assembly, stability, and conformation of a spherical virus capsid. Proc Natl Acad Sci USA 101:2724–2729PubMedCentralPubMed

123.

Rieder E, Berinstein A, Baxt B, Kang A, Mason PW (1996) Propagation of an attenuated virus by design: engineering a novel receptor for a noninfectious foot-and-mouth disease virus. Proc Natl Acad Sci USA 93:10428–10433PubMedCentralPubMed

124.

Rodriguez PL, Carrasco L (1993) Poliovirus protein 2C has ATPase and GTPase activities. J Biol Chem 268:8105–8110PubMed

125.

Rodriguez Pulido M, Sobrino F, Borrego B, Saiz M (2009) Attenuated foot-and-mouth disease virus RNA carrying a deletion in the 3′ noncoding region can elicit immunity in swine. J Virol 83:3475–3485PubMedCentralPubMed

126.

Rueckert RR, Wimmer E (1984) Systematic nomenclature of picornavirus proteins. J Virol 50:957–959PubMedCentralPubMed

127.

Sa-Carvalho D, Rieder E, Baxt B, Rodarte R, Tanuri A, Mason PW (1997) Tissue culture adaptation of foot-and-mouth disease virus selects viruses that bind to heparin and are attenuated in cattle. J Virol 71:5115–5123PubMedCentralPubMed

128.

Saiz M, Gomez S, Martinez-Salas E, Sobrino F (2001) Deletion or substitution of the aphthovirus 3′ NCR abrogates infectivity and virus replication. J Gen Virol 82:93–101PubMed

129.

Samuilova O, Krogerus C, Fabrichniy I, Hyypia T (2006) ATP hydrolysis and AMP kinase activities of nonstructural protein 2C of human parechovirus 1. J Virol 80:1053–1058PubMedCentralPubMed

130.

Scotti N, Rybicki EP (2013) Virus-like particles produced in plants as potential vaccines. Expert Rev Vaccines 12:211–224PubMed

131.

Seipelt J, Guarne A, Bergmann E, James M, Sommergruber W, Fita I, Skern T (1999) The structures of picornaviral proteinases. Virus Res 62:159–168PubMed

132.

Serrano P, Pulido MR, Saiz M, Martinez-Salas E (2006) The 3′ end of the foot-and-mouth disease virus genome establishes two distinct long-range RNA-RNA interactions with the 5′ end region. J Gen Virol 87:3013–3022PubMed

133.

Singleton MR, Dillingham MS, Wigley DB (2007) Structure and mechanism of helicases and nucleic acid translocases. Annu Rev Biochem 76:23–50PubMed

134.

Sweeney TR, Roque-Rosell N, Birtley JR, Leatherbarrow RJ, Curry S (2007) Structural and mutagenic analysis of foot-and-mouth disease virus 3C protease reveals the role of the beta-ribbon in proteolysis. J Virol 81:115–124PubMedCentralPubMed

135.

Sweeney TR, Cisnetto V, Bose D, Bailey M, Wilson JR, Zhang X, Belsham GJ, Curry S (2010) Foot-and-mouth disease virus 2C is a hexameric AAA+ protein with a coordinated ATP hydrolysis mechanism. J Biol Chem 285:24347–24359PubMedCentralPubMed

136.

Teterina NL, Gorbalenya AE, Egger D, Bienz K, Rinaudo MS, Ehrenfeld E (2006) Testing the modularity of the N-terminal amphipathic helix conserved in picornavirus 2C proteins and hepatitis C NS5A protein. Virology 344:453–467PubMed

137.

Thompson AA, Peersen OB (2004) Structural basis for proteolysis-dependent activation of the poliovirus RNA-dependent RNA polymerase. EMBO J 23:3462–3471PubMedCentralPubMed

138.

Tuthill TJ, Harlos K, Walter TS, Knowles NJ, Groppelli E, Rowlands DJ, Stuart DI, Fry EE (2009) Equine rhinitis A virus and its low pH empty particle: clues towards an aphthovirus entry mechanism? PLoS Pathog 5:e1000620PubMedCentralPubMed

139.

Vakharia VN, Devaney MA, Moore DM, Dunn JJ, Grubman MJ (1987) Proteolytic processing of foot-and-mouth disease virus polyproteins expressed in a cell-free system from clone-derived transcripts. J Virol 61:3199–3207PubMedCentralPubMed

140.

van Vlijmen HW, Curry S, Schaefer M, Karplus M (1998) Titration calculations of foot-and-mouth disease virus capsids and their stabilities as a function of pH. J Mol Biol 275:295–308PubMed

141.

Verdaguer N, Mateu MG, Andreu D, Giralt E, Domingo E, Fita I (1995) Structure of the major antigenic loop of foot-and-mouth disease virus complexed with a neutralizing antibody: direct involvement of the Arg-Gly-Asp motif in the interaction. EMBO J 14:1690–1696PubMedCentralPubMed

142.

Verdaguer N, Mateu MG, Bravo J, Domingo E, Fita I (1996) Induced pocket to accommodate the cell attachment Arg-Gly-Asp motif in a neutralizing antibody against foot-and-mouth-disease virus. J Mol Biol 256:364–376PubMed

143.

Verdaguer N, Sevilla N, Valero ML, Stuart D, Brocchi E, Andreu D, Giralt E, Domingo E, Mateu MG, Fita I (1998) A similar pattern of interaction for different antibodies with a major antigenic site of foot-and-mouth disease virus: implications for intratypic antigenic variation. J Virol 72:739–748PubMedCentralPubMed

144.

Verdaguer N, Schoehn G, Ochoa WF, Fita I, Brookes S, King A, Domingo E, Mateu MG, Stuart D, Hewat EA (1999) Flexibility of the major antigenic loop of foot-and-mouth disease virus bound to a Fab fragment of a neutralising antibody: structure and neutralisation. Virology 255:260–268PubMed

145.

Verlinden Y, Cuconati A, Wimmer E, Rombaut B (2000) Cell-free synthesis of poliovirus: 14S subunits are the key intermediates in the encapsidation of poliovirus RNA. J Gen Virol 81:2751–2754PubMed

146.

Witwer C, Rauscher S, Hofacker IL, Stadler PF (2001) Conserved RNA secondary structures in Picornaviridae genomes. Nucleic acids Res 29:5079–5089PubMedCentralPubMed

147.

Wu Y, Lou Z, Miao Y, Yu Y, Dong H, Peng W, Bartlam M, Li X, Rao Z (2010) Structures of EV71 RNA-dependent RNA polymerase in complex with substrate and analogue provide a drug target against the hand-foot-and-mouth disease pandemic in China. Protein Cell 1:491–500PubMed

148.

Xiong JP, Stehle T, Zhang R, Joachimiak A, Frech M, Goodman SL, Arnaout MA (2002) Crystal structure of the extracellular segment of integrin alpha Vbeta3 in complex with an Arg-Gly-Asp ligand. Science 296:151–155PubMed

149.

Ye Y, Yan G, Luo Y, Tong T, Liu X, Xin C, Liao M, Fan H (2013) Quantitative proteomics by amino acid labeling in foot-and-mouth disease virus (FMDV)-infected cells. J Proteome Res 12:363–377PubMed

150.

Zunszain PA, Knox SR, Sweeney TR, Yang J, Roque-Rosell N, Belsham GJ, Leatherbarrow RJ, Curry S (2010) Insights into cleavage specificity from the crystal structure of foot-and-mouth disease virus 3C protease complexed with a peptide substrate. J Mol Biol 395:375–389PubMed

Titel: Three-dimensional structure of foot-and-mouth disease virus and its biological functions
verfasst von: Shi-Chong Han
Hui-Chen Guo
Shi-Qi Sun
Publikationsdatum: 01.01.2015
Verlag: Springer Vienna
Erschienen in: Archives of Virology / Ausgabe 1/2015
Print ISSN: 0304-8608
Elektronische ISSN: 1432-8798
DOI: https://doi.org/10.1007/s00705-014-2278-x

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