Erschienen in:
01.07.2006 | Case Report
Treatment of therapy-resistant sarcoidosis with adalimumab
verfasst von:
José Luis Callejas-Rubio, Norberto Ortego-Centeno, Lourdes Lopez-Perez, Maria Nicolas Benticuaga
Erschienen in:
Clinical Rheumatology
|
Ausgabe 4/2006
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Abstract
A possible role of tumor necrosis factor alpha (TNFα) in the pathomechanism of sarcoidosis must be considered in the analysis of this disorder since elevated concentrations of this cytokine have been found. In addition, TNFα expression could be demonstrated in sarcoid granulomata [
1]. It is well known that TNFα plays a crucial role in granulomatous inflammation, e.g., in mycobacterial diseases [
2]. Therefore, TNFα blockade is a potential approach in the therapy for sarcoidosis. Up to now, various cases of therapy-resistant sarcoidosis treated with anti-TNFα (infliximab and etanercept) have been reported [
3‐
8]. Here, we describe successful treatment using adalimumab, a human recombinant immunoglobulin (Ig) G1 anti-TNF monoclonal antibody [
9].