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Clinical Rheumatology

Erschienen in:

02.07.2021 | Original Article

Genicular nerve block in rheumatoid arthritis: a randomized clinical trial

verfasst von: A. M. Elsaman, A. Maaty, A. Hamed

Erschienen in: Clinical Rheumatology | Ausgabe 11/2021

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Abstract

Objective

This study highlights the effect of a genicular nerve block (GNB) on pain, function, and inflammation outcome measures in rheumatoid arthritis (RA) knees.

Methods

A total of sixty-four patients diagnosed with RA using ACR/EULAR 2010 criteria with unilateral persistent knee arthritis were recruited to the study. They were randomly assigned into two groups: group 1 received GNB and group 2 received intra-articular triamcinolone. Both groups were examined by the SOLAR scoring system, visual analog scale (VAS), and Lysholm score at 0, 2, and 12 weeks. A semi-quantitative score was used to assess the tenderness and swelling at the same intervals.

Results

Function and inflammation improved significantly in group 2 at a 2-week interval as compared to group 1, whereas pain improved in both groups with non-significant differences. After 12 weeks, group 1 showed significant improvement as compared with group 2 for the three outcome measures. Neither the disease activity nor the current medication was related to the GNB effect. Disease duration was negatively related to GNB-induced improvement.

Conclusion

GNB is a new promising local therapy for RA to control pain, improve function, and alleviate inflammation of the knee joint. Although it has a relatively short-term effect, yet it has outperformed the steroid effect.

Key Points

• Knee monoarthritis treatment in rheumatoid arthritis is always challenging

• GNB has been approved for the treatment of pain in knee osteoarthritis

• GNB in this study was able to control active knee arthritis and this effect persisted longer thane intra-articular steroid injection

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Titel: Genicular nerve block in rheumatoid arthritis: a randomized clinical trial
verfasst von: A. M. Elsaman
A. Maaty
A. Hamed
Publikationsdatum: 02.07.2021
Verlag: Springer International Publishing
Erschienen in: Clinical Rheumatology / Ausgabe 11/2021
Print ISSN: 0770-3198
Elektronische ISSN: 1434-9949
DOI: https://doi.org/10.1007/s10067-021-05821-5

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