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European Journal of Clinical Microbiology & Infectious Diseases

Erschienen in:

01.07.2009 | Article

Nontuberculous mycobacterial infections among patients suspected of pulmonary tuberculosis

verfasst von: H. Grubek-Jaworska, R. Walkiewicz, A. Safianowska, M. Nowacka-Mazurek, R. Krenke, T. Przybyłowski, R. Chazan

Erschienen in: European Journal of Clinical Microbiology & Infectious Diseases | Ausgabe 7/2009

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Abstract

The purpose of this study was to present a retrospective analysis of the frequency of nontuberculous mycobacteria (NTM)-related pulmonary infections among the AFB-positive and/or culture-positive patients in the Warsaw region who were suspected of tuberculosis (TB) and hospitalized in the university hospital between 1999 and 2005. All the AFB-positive pulmonary samples were examined with a molecular method using the Amplicor MTB test (Roche) for detection of Mycobacterium tuberculosis complex, and all mycobacterial isolates were speciated by high performance liquid chromatography (HPLC) analysis of mycolic acids. Patients who met clinical, radiological, and bacteriological criteria of mycobacteriosis were classified according to the American Thoracic Society (ATS) guidelines for diagnosis of NTM related disease. Among the 445 smear-positive or/and culture-positive patients, 142 subjects (31.9%) were found to be infected with M. tuberculosis. Among 303 non-TB patients, mycobacteriosis was found in 27 (8.9%) subjects. The frequency of NTM-related lung disease as compared to the bacteriologically-confirmed lung TB was estimated at 1:5. The rapid, precise methods of NTM speciation are necessary for progress in diagnostics of NTM related diseases.

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Titel: Nontuberculous mycobacterial infections among patients suspected of pulmonary tuberculosis
verfasst von: H. Grubek-Jaworska
R. Walkiewicz
A. Safianowska
M. Nowacka-Mazurek
R. Krenke
T. Przybyłowski
R. Chazan
Publikationsdatum: 01.07.2009
Verlag: Springer-Verlag
Erschienen in: European Journal of Clinical Microbiology & Infectious Diseases / Ausgabe 7/2009
Print ISSN: 0934-9723
Elektronische ISSN: 1435-4373
DOI: https://doi.org/10.1007/s10096-008-0694-0

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