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European Journal of Clinical Microbiology & Infectious Diseases

Erschienen in:

01.09.2010 | Article

Clinical characteristics of viral intestinal infection in preterm and term neonates

verfasst von: S. Bagci, A. M. Eis-Hübinger, A. F. Yassin, A. Simon, P. Bartmann, A. R. Franz, A. Mueller

Erschienen in: European Journal of Clinical Microbiology & Infectious Diseases | Ausgabe 9/2010

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Abstract

The clinical presentation of the viral enteric pathogens in newborn infants has not been adequately examined. The aim of this study was to evaluate the clinical characteristics of viral intestinal infections in newborn infants. Clinical data of all term and preterm infants admitted to our tertiary neonatal intensive care unit from 1998 to 2007 with clinical signs of gastroenteritis (GE) or necrotizing enterocolitis (NEC) were retrospectively reviewed and compared between infants with different viral enteric pathogens in stool specimens. In 34 infants with signs of GE or NEC, enteropathogenic viruses were found in stool specimens. Rotavirus was detected in 12 cases, of which two infants had NEC. Compared with infants with rotavirus or norovirus, infants with astrovirus more frequently suffered from NEC (p<0.05). In addition, an acute systemic inflammatory response was significantly more common in patients with astrovirus infection (astrovirus vs. rotavirus and astrovirus vs. norovirus, p < 0.01 and p < 0.05, respectively). Of eight children infected with norovirus, one infant had a systemic acute inflammatory response and NEC. This study demonstrates that in newborn infants, intestinal rotavirus, norovirus, and astrovirus infections may be associated with severe illness such as hemorrhagic enteritis resulting in bloody diarrhea or even NEC.

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Titel: Clinical characteristics of viral intestinal infection in preterm and term neonates
verfasst von: S. Bagci
A. M. Eis-Hübinger
A. F. Yassin
A. Simon
P. Bartmann
A. R. Franz
A. Mueller
Publikationsdatum: 01.09.2010
Verlag: Springer-Verlag
Erschienen in: European Journal of Clinical Microbiology & Infectious Diseases / Ausgabe 9/2010
Print ISSN: 0934-9723
Elektronische ISSN: 1435-4373
DOI: https://doi.org/10.1007/s10096-010-0965-4

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