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Lasers in Medical Science
Erschienen in: Lasers in Medical Science 3/2020

16.09.2019 | Review Article

Tumor-derived extracellular vesicles: insights into bystander effects of exosomes after irradiation

verfasst von: Nasrollah Jabbari, Mohammad Karimipour, Majid Khaksar, Elinaz Akbariazar, Morteza Heidarzadeh, Behnam Mojarad, Hossein Aftab, Reza Rahbarghazi, Jafar Rezaie

Erschienen in: Lasers in Medical Science | Ausgabe 3/2020

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Abstract

This review article aims to address the kinetic of TDEs in cancer cells pre- and post-radiotherapy. Radiotherapy is traditionally used for the treatment of multiple cancer types; however, there is growing evidence to show that radiotherapy exerts NTEs on cells near to the irradiated cells. In tumor mass, irradiated cells can affect non-irradiated cells in different ways. Of note, exosomes are nano-scaled cell particles releasing from tumor cells and play key roles in survival, metastasis, and immunosuppression of tumor cells. Recent evidence indicated that irradiation has the potential to affect the dynamic of different signaling pathways such as exosome biogenesis. Indeed, exosomes act as intercellular mediators in various cell communication through transmitting bio-molecules. Due to their critical roles in cancer biology, exosomes are at the center of attention. TDEs contain an exclusive molecular signature that they may serve as tumor biomarker in the diagnosis of different cancers. Interestingly, radiotherapy and IR could also contribute to altering the dynamic of exosome secretion. Most probably, the content of exosomes in irradiated cells is different compared to exosomes originated from the non-irradiated BCs. Irradiated cells release exosomes with exclusive content that mediate NTEs in BCs. Considering variation in cell type, IR doses, and radio-resistance or radio-sensitivity of different cancers, there is, however, contradictions in the feature and activity of irradiated exosomes on neighboring cells.
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Metadaten
Titel
Tumor-derived extracellular vesicles: insights into bystander effects of exosomes after irradiation
verfasst von
Nasrollah Jabbari
Mohammad Karimipour
Majid Khaksar
Elinaz Akbariazar
Morteza Heidarzadeh
Behnam Mojarad
Hossein Aftab
Reza Rahbarghazi
Jafar Rezaie
Publikationsdatum
16.09.2019
Verlag
Springer London
Erschienen in
Lasers in Medical Science / Ausgabe 3/2020
Print ISSN: 0268-8921
Elektronische ISSN: 1435-604X
DOI
https://doi.org/10.1007/s10103-019-02880-8

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