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Emergency Radiology

Erschienen in:

01.10.2014 | Case Report

Atypical femoral fractures in association with bisphosphonate therapy: a case series

verfasst von: Matthew Rheinboldt, Derrick Harper, Michael Stone

Erschienen in: Emergency Radiology | Ausgabe 5/2014

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Abstract

Well-established clinically as frontline therapy in the management of osteoporosis, bisphosphonates have been shown in numerous trials to be highly effective in reducing the risk of both vertebral and hip fractures. More recently, however, in a multitude of exhaustive case reviews, attention has been raised to the small but by now well-established link between prolonged bisphosphonate usage and the risk for atypical subtrochanteric femoral stress fractures. We present herein a trio of illustrative cases highlighting both clinical presentation and characteristic radiological findings thereof, as well as a discussion of the background, management, and natural history of these oftentimes problematic injuries.

Lenart B, Neviaser A, Lyman S et al (2008) Association of low-energy femoral fractures with prolonged bisphosphonate use: a case control study. Osteoporos Int. doi:10.1007/s00198-008-0805-x PubMed

Giannini S, Chiarello E, Tedesco G et al (2013) Atypical femoral fractures. Clin Cases Miner Bone Metab 10(1):30–33PubMedPubMedCentral

Kang J, Won Y, Kim J, Min B et al (2014) Atypical femoral fractures after anti-osteoporotic medication: a Korean multicenter study. Int Orthop. doi:10.1007/s00264-013

Odvina C, Zerwekh J, Rao D et al (2005) Severely suppressed bone turnover: a potential complication of alendronate therapy. J Clin Endocrinol Metab 90(3):1294–1301PubMedCrossRef

Abrahamsen B, Eiken P, Eastell R (2010) Cumulative alendronate dose and the long-term absolute risk of subtrochanteric and diaphyseal femur fractures: a register-based national cohort analysis. J Clin Endocinol Metab 95(12):5258–5265CrossRef

Kim S, Scheeweiss S, Katz J et al (2011) Oral bisphosphonates and risk of subtrochanteric or diaphyseal femur fractures in a population-based cohort. J Bone Miner Res 26(5):993–1001PubMedCrossRefPubMedCentral

Shane E, Burr D, Abrahamsen B et al (2010) Atypical subtrochanteric and diaphyseal femoral fractures: second report of a task force of the American society for bone and mineral research. J Bone Miner Res. doi:10.1002/jbmr.1998

Bisonette L, April P, Dumais R et al (2013) Atypical fracture of the tibial diaphysis associated with bisphosphonate therapy: a case report. Bone 56(2):406–409CrossRef

Isaacs J, Shidiak L, Harris I et al (2010) Femoral insufficiency fractures associated with prolonged bisphosphonate therapy. Clin Orthop Relat Res 468(12):3384–3392PubMedCrossRefPubMedCentral

10.

Edwards B, Bunta A, Lane J et al (2013) Bisphosphonates and nonhealing femoral fractures: analysis of the FDA Adverse Event Reporting System (FAERS) and international safety efforts: a systematic review from the Research on Adverse Drug Events and Reports (RADAR) project. J Bone Joint Surg Am 95(4):297–307PubMedCrossRefPubMedCentral

11.

Rizzoli R, Akesson K, Kanis J et al (2011) Subtrochanteric fractures after long-term treatment with bisphosphonates: a European Society on Clinical and Economic Aspects of Osteoporosis and Osteoarthritis and International Osteoporosis Foundation Working Group project. Osteoporos Int 22(2):373–390PubMedCrossRefPubMedCentral

12.

Nieves J, Cosman F (2010) Atypical subtrochanteric and femoral shaft fractures and possible association with bisphosphonates. Curr Osteoporos Rep. doi:10.1007/s11914-010-0007-2 PubMed

13.

Dorne H, Lander P (1985) Spontaneous stress fractures of the femoral neck. AJR 144:343–347PubMedCrossRef

14.

Porrino J, Kohl C, Taljanovic M et al (2010) Clinical perspective. Diagnosis of proximal femoral insufficiency fractures in patients receiving bisphosphonate therapy. AJR 194:1061–1064PubMedCrossRef

Titel: Atypical femoral fractures in association with bisphosphonate therapy: a case series
verfasst von: Matthew Rheinboldt
Derrick Harper
Michael Stone
Publikationsdatum: 01.10.2014
Verlag: Springer Berlin Heidelberg
Erschienen in: Emergency Radiology / Ausgabe 5/2014
Print ISSN: 1070-3004
Elektronische ISSN: 1438-1435
DOI: https://doi.org/10.1007/s10140-014-1215-3

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Atypical femoral fractures in association with bisphosphonate therapy: a case series

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