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Neurosurgical Review

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01.07.2009 | Review

Dendritic-cell- and peptide-based vaccination strategies for glioma

verfasst von: Ryuya Yamanaka

Erschienen in: Neurosurgical Review | Ausgabe 3/2009

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Abstract

Despite advances in radiation and chemotherapy along with surgical resectioning, the prognosis of patients with malignant glioma is poor. Therefore, the development of a new treatment modality is extremely important. There are increasing reports demonstrating that systemic immunotherapy using dendritic cells and peptide is capable of inducing an antiglioma response. This review highlights dendritic-cell- and peptide-based immunotherapy for glioma patients. Dendritic-cell- and peptide-based immunotherapy strategies appear promising as an approach to successfully induce an antitumor immune response and increase survival in patients with glioma. Dendritic cell- and peptide-based therapy of glioma seems to be safe and without major side effects. There are several types of glioma; so to achieve effective therapy, it may be necessary to evaluate the molecular genetic abnormalities in individual patient tumors and design novel immunotherapeutic strategies based on the pharmacogenomic findings. Here, in this review, recent advances in dendritic-cell- and peptide-based immunotherapy approaches for patients with gliomas are discussed.

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Titel: Dendritic-cell- and peptide-based vaccination strategies for glioma
verfasst von: Ryuya Yamanaka
Publikationsdatum: 01.07.2009
Verlag: Springer-Verlag
Erschienen in: Neurosurgical Review / Ausgabe 3/2009
Print ISSN: 0344-5607
Elektronische ISSN: 1437-2320
DOI: https://doi.org/10.1007/s10143-009-0189-1

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