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Erschienen in: Neurosurgical Review 2/2020

29.07.2018 | Review

Neurosurgical management of patients with brain metastasis

verfasst von: Mustafa Aziz Hatiboglu, Kerime Akdur, Raymond Sawaya

Erschienen in: Neurosurgical Review | Ausgabe 2/2020

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Abstract

Brain metastasis is a serious complication in patients with systemic cancer. The main goal of the treatment in patients with brain metastasis is to control the disease in the brain, to prevent death from neurological disease and provide a satisfactory quality of life. Management of a patient with brain metastasis is important and sometimes demanding, and several factors such as tumor histology, status of primary disease, number of brain lesions, size of lesions, and performance status may influence the decision making process. We reviewed the neurosurgical treatment modalities in patients with metastatic brain tumor and suggested a treatment paradigm for different clinical conditions. The PubMed database was searched using combinations of search terms and synonyms for “management of brain metastasis,” “stereotactic radiosurgery for brain metastasis,” and “surgery for brain metastasis” between January 1, 1990, and January 1, 2018. This review would guide physicians to solve challenging problems in the treatment of patients with brain metastasis. In summary, local aggressive treatments such as surgical resection and stereotactic radiosurgery are reasonable in patients with limited intracranial disease, controlled primary disease, and high performance status. Besides, WBRT is still the standard treatment in patients with low performance score and leptomeningeal dissemination of cancer.
Literatur
1.
Zurück zum Zitat Walker AE, Robins M, Weinfeld FD (1985) Epidemiology of brain tumors: the national survey of intracranial neoplasms. Neurology 35:219–226PubMedCrossRef Walker AE, Robins M, Weinfeld FD (1985) Epidemiology of brain tumors: the national survey of intracranial neoplasms. Neurology 35:219–226PubMedCrossRef
2.
3.
Zurück zum Zitat Soffietti R, Ruda R, Trevisan E (2008) Brain metastases: current management and new developments. Curr Opin Oncol 20:676–684PubMedCrossRef Soffietti R, Ruda R, Trevisan E (2008) Brain metastases: current management and new developments. Curr Opin Oncol 20:676–684PubMedCrossRef
4.
Zurück zum Zitat Mandell L, Hilaris B, Sullivan M, Sundaresan N, Nori D, Kim JH, Martini N, Fuks Z (1986) The treatment of single brain metastasis from non-oat cell lung carcinoma. Surgery and radiation versus radiation therapy alone. Cancer 58:641–649PubMed Mandell L, Hilaris B, Sullivan M, Sundaresan N, Nori D, Kim JH, Martini N, Fuks Z (1986) The treatment of single brain metastasis from non-oat cell lung carcinoma. Surgery and radiation versus radiation therapy alone. Cancer 58:641–649PubMed
5.
Zurück zum Zitat Sundaresan N, Galicich JH, Beattie EJ Jr (1983) Surgical treatment of brain metastases from lung cancer. J Neurosurg 58:666–671PubMedCrossRef Sundaresan N, Galicich JH, Beattie EJ Jr (1983) Surgical treatment of brain metastases from lung cancer. J Neurosurg 58:666–671PubMedCrossRef
6.
Zurück zum Zitat Hatiboglu MA, Tuzgen S, Akdur K, Chang EL (2016) Treatment of high numbers of brain metastases with Gamma Knife radiosurgery: a review. Acta Neurochir 158:625–634PubMedCrossRef Hatiboglu MA, Tuzgen S, Akdur K, Chang EL (2016) Treatment of high numbers of brain metastases with Gamma Knife radiosurgery: a review. Acta Neurochir 158:625–634PubMedCrossRef
7.
Zurück zum Zitat Johnson BE, Grayson J, Makuch RW, Linnoila RI, Anderson MJ, Cohen MH, Glatstein E, Minna JD, Ihde DC (1990) Ten-year survival of patients with small-cell lung cancer treated with combination chemotherapy with or without irradiation. J Clin Oncol 8:396–401PubMedCrossRef Johnson BE, Grayson J, Makuch RW, Linnoila RI, Anderson MJ, Cohen MH, Glatstein E, Minna JD, Ihde DC (1990) Ten-year survival of patients with small-cell lung cancer treated with combination chemotherapy with or without irradiation. J Clin Oncol 8:396–401PubMedCrossRef
8.
Zurück zum Zitat Auperin A, Arriagada R, Pignon JP, Le Pechoux C, Gregor A, Stephens RJ, Kristjansen PE, Johnson BE, Ueoka H, Wagner H, Aisner J (1999) Prophylactic cranial irradiation for patients with small-cell lung cancer in complete remission. Prophylactic Cranial Irradiation Overview Collaborative Group. N Engl J Med 341:476–484PubMedCrossRef Auperin A, Arriagada R, Pignon JP, Le Pechoux C, Gregor A, Stephens RJ, Kristjansen PE, Johnson BE, Ueoka H, Wagner H, Aisner J (1999) Prophylactic cranial irradiation for patients with small-cell lung cancer in complete remission. Prophylactic Cranial Irradiation Overview Collaborative Group. N Engl J Med 341:476–484PubMedCrossRef
9.
Zurück zum Zitat Gaspar LE, Mehta MP, Patchell RA, Burri SH, Robinson PD, Morris RE, Ammirati M, Andrews DW, Asher AL, Cobbs CS, Kondziolka D, Linskey ME, Loeffler JS, McDermott M, Mikkelsen T, Olson JJ, Paleologos NA, Ryken TC, Kalkanis SN (2010) The role of whole brain radiation therapy in the management of newly diagnosed brain metastases: a systematic review and evidence-based clinical practice guideline. J Neuro-Oncol 96:17–32CrossRef Gaspar LE, Mehta MP, Patchell RA, Burri SH, Robinson PD, Morris RE, Ammirati M, Andrews DW, Asher AL, Cobbs CS, Kondziolka D, Linskey ME, Loeffler JS, McDermott M, Mikkelsen T, Olson JJ, Paleologos NA, Ryken TC, Kalkanis SN (2010) The role of whole brain radiation therapy in the management of newly diagnosed brain metastases: a systematic review and evidence-based clinical practice guideline. J Neuro-Oncol 96:17–32CrossRef
10.
Zurück zum Zitat Aoyama H, Shirato H, Tago M, Nakagawa K, Toyoda T, Hatano K, Kenjyo M, Oya N, Hirota S, Shioura H, Kunieda E, Inomata T, Hayakawa K, Katoh N, Kobashi G (2006) Stereotactic radiosurgery plus whole-brain radiation therapy vs stereotactic radiosurgery alone for treatment of brain metastases: a randomized controlled trial. JAMA 295:2483–2491PubMedCrossRef Aoyama H, Shirato H, Tago M, Nakagawa K, Toyoda T, Hatano K, Kenjyo M, Oya N, Hirota S, Shioura H, Kunieda E, Inomata T, Hayakawa K, Katoh N, Kobashi G (2006) Stereotactic radiosurgery plus whole-brain radiation therapy vs stereotactic radiosurgery alone for treatment of brain metastases: a randomized controlled trial. JAMA 295:2483–2491PubMedCrossRef
11.
Zurück zum Zitat Armstrong JG, Wronski M, Galicich J, Arbit E, Leibel SA, Burt M (1994) Postoperative radiation for lung cancer metastatic to the brain. J Clin Oncol 12:2340–2344PubMedCrossRef Armstrong JG, Wronski M, Galicich J, Arbit E, Leibel SA, Burt M (1994) Postoperative radiation for lung cancer metastatic to the brain. J Clin Oncol 12:2340–2344PubMedCrossRef
12.
Zurück zum Zitat Brown PD, Jaeckle K, Ballman KV, Farace E, Cerhan JH, Anderson SK, Carrero XW, Barker FG 2nd, Deming R, Burri SH, Menard C, Chung C, Stieber VW, Pollock BE, Galanis E, Buckner JC, Asher AL (2016) Effect of radiosurgery alone vs radiosurgery with whole brain radiation therapy on cognitive function in patients with 1 to 3 brain metastases: a randomized clinical trial. JAMA 316:401–409PubMedCrossRefPubMedCentral Brown PD, Jaeckle K, Ballman KV, Farace E, Cerhan JH, Anderson SK, Carrero XW, Barker FG 2nd, Deming R, Burri SH, Menard C, Chung C, Stieber VW, Pollock BE, Galanis E, Buckner JC, Asher AL (2016) Effect of radiosurgery alone vs radiosurgery with whole brain radiation therapy on cognitive function in patients with 1 to 3 brain metastases: a randomized clinical trial. JAMA 316:401–409PubMedCrossRefPubMedCentral
13.
Zurück zum Zitat Chang EL, Wefel JS, Hess KR, Allen PK, Lang FF, Kornguth DG, Arbuckle RB, Swint JM, Shiu AS, Maor MH, Meyers CA (2009) Neurocognition in patients with brain metastases treated with radiosurgery or radiosurgery plus whole-brain irradiation: a randomised controlled trial. Lancet Oncol 10:1037–1044PubMedCrossRef Chang EL, Wefel JS, Hess KR, Allen PK, Lang FF, Kornguth DG, Arbuckle RB, Swint JM, Shiu AS, Maor MH, Meyers CA (2009) Neurocognition in patients with brain metastases treated with radiosurgery or radiosurgery plus whole-brain irradiation: a randomised controlled trial. Lancet Oncol 10:1037–1044PubMedCrossRef
14.
Zurück zum Zitat Hagen NA, Cirrincione C, Thaler HT, DeAngelis LM (1990) The role of radiation therapy following resection of single brain metastasis from melanoma. Neurology 40:158–160PubMedCrossRef Hagen NA, Cirrincione C, Thaler HT, DeAngelis LM (1990) The role of radiation therapy following resection of single brain metastasis from melanoma. Neurology 40:158–160PubMedCrossRef
15.
Zurück zum Zitat Kocher M, Soffietti R, Abacioglu U, Villa S, Fauchon F, Baumert BG, Fariselli L, Tzuk-Shina T, Kortmann RD, Carrie C, Ben Hassel M, Kouri M, Valeinis E, van den Berge D, Collette S, Collette L, Mueller RP (2011) Adjuvant whole-brain radiotherapy versus observation after radiosurgery or surgical resection of one to three cerebral metastases: results of the EORTC 22952-26001 study. J Clin Oncol 29:134–141PubMedCrossRef Kocher M, Soffietti R, Abacioglu U, Villa S, Fauchon F, Baumert BG, Fariselli L, Tzuk-Shina T, Kortmann RD, Carrie C, Ben Hassel M, Kouri M, Valeinis E, van den Berge D, Collette S, Collette L, Mueller RP (2011) Adjuvant whole-brain radiotherapy versus observation after radiosurgery or surgical resection of one to three cerebral metastases: results of the EORTC 22952-26001 study. J Clin Oncol 29:134–141PubMedCrossRef
16.
Zurück zum Zitat Patchell RA, Tibbs PA, Regine WF, Dempsey RJ, Mohiuddin M, Kryscio RJ, Markesbery WR, Foon KA, Young B (1998) Postoperative radiotherapy in the treatment of single metastases to the brain: a randomized trial. JAMA 280:1485–1489PubMedCrossRef Patchell RA, Tibbs PA, Regine WF, Dempsey RJ, Mohiuddin M, Kryscio RJ, Markesbery WR, Foon KA, Young B (1998) Postoperative radiotherapy in the treatment of single metastases to the brain: a randomized trial. JAMA 280:1485–1489PubMedCrossRef
17.
Zurück zum Zitat Yamamoto M, Serizawa T, Shuto T, Akabane A, Higuchi Y, Kawagishi J, Yamanaka K, Sato Y, Jokura H, Yomo S, Nagano O, Kenai H, Moriki A, Suzuki S, Kida Y, Iwai Y, Hayashi M, Onishi H, Gondo M, Sato M, Akimitsu T, Kubo K, Kikuchi Y, Shibasaki T, Goto T, Takanashi M, Mori Y, Takakura K, Saeki N, Kunieda E, Aoyama H, Momoshima S, Tsuchiya K (2014) Stereotactic radiosurgery for patients with multiple brain metastases (JLGK0901): a multi-institutional prospective observational study. Lancet Oncol 15:387–395PubMedCrossRef Yamamoto M, Serizawa T, Shuto T, Akabane A, Higuchi Y, Kawagishi J, Yamanaka K, Sato Y, Jokura H, Yomo S, Nagano O, Kenai H, Moriki A, Suzuki S, Kida Y, Iwai Y, Hayashi M, Onishi H, Gondo M, Sato M, Akimitsu T, Kubo K, Kikuchi Y, Shibasaki T, Goto T, Takanashi M, Mori Y, Takakura K, Saeki N, Kunieda E, Aoyama H, Momoshima S, Tsuchiya K (2014) Stereotactic radiosurgery for patients with multiple brain metastases (JLGK0901): a multi-institutional prospective observational study. Lancet Oncol 15:387–395PubMedCrossRef
18.
Zurück zum Zitat Muacevic A, Kreth FW, Horstmann GA, Schmid-Elsaesser R, Wowra B, Steiger HJ, Reulen HJ (1999) Surgery and radiotherapy compared with gamma knife radiosurgery in the treatment of solitary cerebral metastases of small diameter. J Neurosurg 91:35–43PubMedCrossRef Muacevic A, Kreth FW, Horstmann GA, Schmid-Elsaesser R, Wowra B, Steiger HJ, Reulen HJ (1999) Surgery and radiotherapy compared with gamma knife radiosurgery in the treatment of solitary cerebral metastases of small diameter. J Neurosurg 91:35–43PubMedCrossRef
19.
Zurück zum Zitat Muacevic A, Wowra B, Siefert A, Tonn JC, Steiger HJ, Kreth FW (2008) Microsurgery plus whole brain irradiation versus Gamma Knife surgery alone for treatment of single metastases to the brain: a randomized controlled multicentre phase III trial. J Neuro-Oncol 87:299–307CrossRef Muacevic A, Wowra B, Siefert A, Tonn JC, Steiger HJ, Kreth FW (2008) Microsurgery plus whole brain irradiation versus Gamma Knife surgery alone for treatment of single metastases to the brain: a randomized controlled multicentre phase III trial. J Neuro-Oncol 87:299–307CrossRef
20.
Zurück zum Zitat O’Neill BP, Iturria NJ, Link MJ, Pollock BE, Ballman KV, O'Fallon JR (2003) A comparison of surgical resection and stereotactic radiosurgery in the treatment of solitary brain metastases. Int J Radiat Oncol Biol Phys 55:1169–1176PubMedCrossRef O’Neill BP, Iturria NJ, Link MJ, Pollock BE, Ballman KV, O'Fallon JR (2003) A comparison of surgical resection and stereotactic radiosurgery in the treatment of solitary brain metastases. Int J Radiat Oncol Biol Phys 55:1169–1176PubMedCrossRef
21.
Zurück zum Zitat Rades D, Bohlen G, Pluemer A, Veninga T, Hanssens P, Dunst J, Schild SE (2007) Stereotactic radiosurgery alone versus resection plus whole-brain radiotherapy for 1 or 2 brain metastases in recursive partitioning analysis class 1 and 2 patients. Cancer 109:2515–2521PubMedCrossRef Rades D, Bohlen G, Pluemer A, Veninga T, Hanssens P, Dunst J, Schild SE (2007) Stereotactic radiosurgery alone versus resection plus whole-brain radiotherapy for 1 or 2 brain metastases in recursive partitioning analysis class 1 and 2 patients. Cancer 109:2515–2521PubMedCrossRef
22.
Zurück zum Zitat Schoggl A, Kitz K, Reddy M, Wolfsberger S, Schneider B, Dieckmann K, Ungersbock K (2000) Defining the role of stereotactic radiosurgery versus microsurgery in the treatment of single brain metastases. Acta Neurochir 142:621–626PubMedCrossRef Schoggl A, Kitz K, Reddy M, Wolfsberger S, Schneider B, Dieckmann K, Ungersbock K (2000) Defining the role of stereotactic radiosurgery versus microsurgery in the treatment of single brain metastases. Acta Neurochir 142:621–626PubMedCrossRef
23.
Zurück zum Zitat Andrews DW, Scott CB, Sperduto PW, Flanders AE, Gaspar LE, Schell MC, Werner-Wasik M, Demas W, Ryu J, Bahary JP, Souhami L, Rotman M, Mehta MP, Curran WJ Jr (2004) Whole brain radiation therapy with or without stereotactic radiosurgery boost for patients with one to three brain metastases: phase III results of the RTOG 9508 randomised trial. Lancet 363:1665–1672PubMedCrossRef Andrews DW, Scott CB, Sperduto PW, Flanders AE, Gaspar LE, Schell MC, Werner-Wasik M, Demas W, Ryu J, Bahary JP, Souhami L, Rotman M, Mehta MP, Curran WJ Jr (2004) Whole brain radiation therapy with or without stereotactic radiosurgery boost for patients with one to three brain metastases: phase III results of the RTOG 9508 randomised trial. Lancet 363:1665–1672PubMedCrossRef
24.
Zurück zum Zitat El Gantery MM, Abd El Baky HM, El Hossieny HA, Mahmoud M, Youssef O (2014) Management of brain metastases with stereotactic radiosurgery alone versus whole brain irradiation alone versus both. Radiat Oncol 9:116PubMedCrossRefPubMedCentral El Gantery MM, Abd El Baky HM, El Hossieny HA, Mahmoud M, Youssef O (2014) Management of brain metastases with stereotactic radiosurgery alone versus whole brain irradiation alone versus both. Radiat Oncol 9:116PubMedCrossRefPubMedCentral
25.
Zurück zum Zitat Kondziolka D, Patel A, Lunsford LD, Kassam A, Flickinger JC (1999) Stereotactic radiosurgery plus whole brain radiotherapy versus radiotherapy alone for patients with multiple brain metastases. Int J Radiat Oncol Biol Phys 45:427–434PubMedCrossRef Kondziolka D, Patel A, Lunsford LD, Kassam A, Flickinger JC (1999) Stereotactic radiosurgery plus whole brain radiotherapy versus radiotherapy alone for patients with multiple brain metastases. Int J Radiat Oncol Biol Phys 45:427–434PubMedCrossRef
26.
Zurück zum Zitat Mahajan A, Ahmed S, McAleer MF, Weinberg JS, Li J, Brown P, Settle S, Prabhu SS, Lang FF, Levine N, McGovern S, Sulman E, McCutcheon IE, Azeem S, Cahill D, Tatsui C, Heimberger AB, Ferguson S, Ghia A, Demonte F, Raza S, Guha-Thakurta N, Yang J, Sawaya R, Hess KR, Rao G (2017) Post-operative stereotactic radiosurgery versus observation for completely resected brain metastases: a single-centre, randomised, controlled, phase 3 trial. Lancet Oncol 18:1040–1048PubMedCrossRefPubMedCentral Mahajan A, Ahmed S, McAleer MF, Weinberg JS, Li J, Brown P, Settle S, Prabhu SS, Lang FF, Levine N, McGovern S, Sulman E, McCutcheon IE, Azeem S, Cahill D, Tatsui C, Heimberger AB, Ferguson S, Ghia A, Demonte F, Raza S, Guha-Thakurta N, Yang J, Sawaya R, Hess KR, Rao G (2017) Post-operative stereotactic radiosurgery versus observation for completely resected brain metastases: a single-centre, randomised, controlled, phase 3 trial. Lancet Oncol 18:1040–1048PubMedCrossRefPubMedCentral
27.
Zurück zum Zitat Mintz AH, Kestle J, Rathbone MP, Gaspar L, Hugenholtz H, Fisher B, Duncan G, Skingley P, Foster G, Levine M (1996) A randomized trial to assess the efficacy of surgery in addition to radiotherapy in patients with a single cerebral metastasis. Cancer 78:1470–1476PubMedCrossRef Mintz AH, Kestle J, Rathbone MP, Gaspar L, Hugenholtz H, Fisher B, Duncan G, Skingley P, Foster G, Levine M (1996) A randomized trial to assess the efficacy of surgery in addition to radiotherapy in patients with a single cerebral metastasis. Cancer 78:1470–1476PubMedCrossRef
28.
Zurück zum Zitat Patchell RA, Tibbs PA, Walsh JW, Dempsey RJ, Maruyama Y, Kryscio RJ, Markesbery WR, Macdonald JS, Young B (1990) A randomized trial of surgery in the treatment of single metastases to the brain. N Engl J Med 322:494–500PubMedCrossRef Patchell RA, Tibbs PA, Walsh JW, Dempsey RJ, Maruyama Y, Kryscio RJ, Markesbery WR, Macdonald JS, Young B (1990) A randomized trial of surgery in the treatment of single metastases to the brain. N Engl J Med 322:494–500PubMedCrossRef
29.
Zurück zum Zitat Vecht CJ, Haaxma-Reiche H, Noordijk EM, Padberg GW, Voormolen JH, Hoekstra FH, Tans JT, Lambooij N, Metsaars JA, Wattendorff AR et al (1993) Treatment of single brain metastasis: radiotherapy alone or combined with neurosurgery? Ann Neurol 33:583–590PubMedCrossRef Vecht CJ, Haaxma-Reiche H, Noordijk EM, Padberg GW, Voormolen JH, Hoekstra FH, Tans JT, Lambooij N, Metsaars JA, Wattendorff AR et al (1993) Treatment of single brain metastasis: radiotherapy alone or combined with neurosurgery? Ann Neurol 33:583–590PubMedCrossRef
30.
Zurück zum Zitat Linskey ME, Andrews DW, Asher AL, Burri SH, Kondziolka D, Robinson PD, Ammirati M, Cobbs CS, Gaspar LE, Loeffler JS, McDermott M, Mehta MP, Mikkelsen T, Olson JJ, Paleologos NA, Patchell RA, Ryken TC, Kalkanis SN (2010) The role of stereotactic radiosurgery in the management of patients with newly diagnosed brain metastases: a systematic review and evidence-based clinical practice guideline. J Neuro-Oncol 96:45–68CrossRef Linskey ME, Andrews DW, Asher AL, Burri SH, Kondziolka D, Robinson PD, Ammirati M, Cobbs CS, Gaspar LE, Loeffler JS, McDermott M, Mehta MP, Mikkelsen T, Olson JJ, Paleologos NA, Patchell RA, Ryken TC, Kalkanis SN (2010) The role of stereotactic radiosurgery in the management of patients with newly diagnosed brain metastases: a systematic review and evidence-based clinical practice guideline. J Neuro-Oncol 96:45–68CrossRef
31.
Zurück zum Zitat Hatiboglu MA, Wildrick DM, Sawaya R (2013) The role of surgical resection in patients with brain metastases. Ecancermedicalscience 7:308PubMedPubMedCentral Hatiboglu MA, Wildrick DM, Sawaya R (2013) The role of surgical resection in patients with brain metastases. Ecancermedicalscience 7:308PubMedPubMedCentral
32.
Zurück zum Zitat Baumert BG, Rutten I, Dehing-Oberije C, Twijnstra A, Dirx MJ, Debougnoux-Huppertz RM, Lambin P, Kubat B (2006) A pathology-based substrate for target definition in radiosurgery of brain metastases. Int J Radiat Oncol Biol Phys 66:187–194PubMedCrossRef Baumert BG, Rutten I, Dehing-Oberije C, Twijnstra A, Dirx MJ, Debougnoux-Huppertz RM, Lambin P, Kubat B (2006) A pathology-based substrate for target definition in radiosurgery of brain metastases. Int J Radiat Oncol Biol Phys 66:187–194PubMedCrossRef
33.
Zurück zum Zitat Hatiboglu MA, Chang EL, Suki D, Sawaya R, Wildrick DM, Weinberg JS (2011) Outcomes and prognostic factors for patients with brainstem metastases undergoing stereotactic radiosurgery. Neurosurgery 69:796–806; discussion 806 Hatiboglu MA, Chang EL, Suki D, Sawaya R, Wildrick DM, Weinberg JS (2011) Outcomes and prognostic factors for patients with brainstem metastases undergoing stereotactic radiosurgery. Neurosurgery 69:796–806; discussion 806
34.
Zurück zum Zitat Li B, Yu J, Suntharalingam M, Kennedy AS, Amin PP, Chen Z, Yin R, Guo S, Han T, Wang Y, Yu N, Song G, Wang L (2000) Comparison of three treatment options for single brain metastasis from lung cancer. Int J Cancer 90:37–45PubMedCrossRef Li B, Yu J, Suntharalingam M, Kennedy AS, Amin PP, Chen Z, Yin R, Guo S, Han T, Wang Y, Yu N, Song G, Wang L (2000) Comparison of three treatment options for single brain metastasis from lung cancer. Int J Cancer 90:37–45PubMedCrossRef
35.
Zurück zum Zitat Hoffman R, Sneed PK, McDermott MW, Chang S, Lamborn KR, Park E, Wara WM, Larson DA (2001) Radiosurgery for brain metastases from primary lung carcinoma. Cancer J 7:121–131PubMed Hoffman R, Sneed PK, McDermott MW, Chang S, Lamborn KR, Park E, Wara WM, Larson DA (2001) Radiosurgery for brain metastases from primary lung carcinoma. Cancer J 7:121–131PubMed
36.
Zurück zum Zitat Minniti G, Clarke E, Lanzetta G, Osti MF, Trasimeni G, Bozzao A, Romano A, Enrici RM (2011) Stereotactic radiosurgery for brain metastases: analysis of outcome and risk of brain radionecrosis. Radiat Oncol 6:48PubMedCrossRefPubMedCentral Minniti G, Clarke E, Lanzetta G, Osti MF, Trasimeni G, Bozzao A, Romano A, Enrici RM (2011) Stereotactic radiosurgery for brain metastases: analysis of outcome and risk of brain radionecrosis. Radiat Oncol 6:48PubMedCrossRefPubMedCentral
37.
Zurück zum Zitat Sanghavi SN, Miranpuri SS, Chappell R, Buatti JM, Sneed PK, Suh JH, Regine WF, Weltman E, King VJ, Goetsch SJ, Breneman JC, Sperduto PW, Scott C, Mabanta S, Mehta MP (2001) Radiosurgery for patients with brain metastases: a multi-institutional analysis, stratified by the RTOG recursive partitioning analysis method. Int J Radiat Oncol Biol Phys 51:426–434PubMedCrossRef Sanghavi SN, Miranpuri SS, Chappell R, Buatti JM, Sneed PK, Suh JH, Regine WF, Weltman E, King VJ, Goetsch SJ, Breneman JC, Sperduto PW, Scott C, Mabanta S, Mehta MP (2001) Radiosurgery for patients with brain metastases: a multi-institutional analysis, stratified by the RTOG recursive partitioning analysis method. Int J Radiat Oncol Biol Phys 51:426–434PubMedCrossRef
38.
Zurück zum Zitat Sneed PK, Lamborn KR, Forstner JM, McDermott MW, Chang S, Park E, Gutin PH, Phillips TL, Wara WM, Larson DA (1999) Radiosurgery for brain metastases: is whole brain radiotherapy necessary? Int J Radiat Oncol Biol Phys 43:549–558PubMedCrossRef Sneed PK, Lamborn KR, Forstner JM, McDermott MW, Chang S, Park E, Gutin PH, Phillips TL, Wara WM, Larson DA (1999) Radiosurgery for brain metastases: is whole brain radiotherapy necessary? Int J Radiat Oncol Biol Phys 43:549–558PubMedCrossRef
39.
Zurück zum Zitat Sneed PK, Suh JH, Goetsch SJ, Sanghavi SN, Chappell R, Buatti JM, Regine WF, Weltman E, King VJ, Breneman JC, Sperduto PW, Mehta MP (2002) A multi-institutional review of radiosurgery alone vs. radiosurgery with whole brain radiotherapy as the initial management of brain metastases. Int J Radiat Oncol Biol Phys 53:519–526PubMedCrossRef Sneed PK, Suh JH, Goetsch SJ, Sanghavi SN, Chappell R, Buatti JM, Regine WF, Weltman E, King VJ, Breneman JC, Sperduto PW, Mehta MP (2002) A multi-institutional review of radiosurgery alone vs. radiosurgery with whole brain radiotherapy as the initial management of brain metastases. Int J Radiat Oncol Biol Phys 53:519–526PubMedCrossRef
40.
Zurück zum Zitat Varlotto JM, Flickinger JC, Niranjan A, Bhatnagar A, Kondziolka D, Lunsford LD (2005) The impact of whole-brain radiation therapy on the long-term control and morbidity of patients surviving more than one year after gamma knife radiosurgery for brain metastases. Int J Radiat Oncol Biol Phys 62:1125–1132PubMedCrossRef Varlotto JM, Flickinger JC, Niranjan A, Bhatnagar A, Kondziolka D, Lunsford LD (2005) The impact of whole-brain radiation therapy on the long-term control and morbidity of patients surviving more than one year after gamma knife radiosurgery for brain metastases. Int J Radiat Oncol Biol Phys 62:1125–1132PubMedCrossRef
41.
Zurück zum Zitat Chang WS, Kim HY, Chang JW, Park YG, Chang JH (2010) Analysis of radiosurgical results in patients with brain metastases according to the number of brain lesions: is stereotactic radiosurgery effective for multiple brain metastases? J Neurosurg 113(Suppl):73–78PubMedCrossRef Chang WS, Kim HY, Chang JW, Park YG, Chang JH (2010) Analysis of radiosurgical results in patients with brain metastases according to the number of brain lesions: is stereotactic radiosurgery effective for multiple brain metastases? J Neurosurg 113(Suppl):73–78PubMedCrossRef
42.
Zurück zum Zitat Brown PD, Ballman KV, Cerhan JH, Anderson SK, Carrero XW, Whitton AC, Greenspoon J, Parney IF, Laack NNI, Ashman JB, Bahary JP, Hadjipanayis CG, Urbanic JJ, Barker FG 2nd, Farace E, Khuntia D, Giannini C, Buckner JC, Galanis E, Roberge D (2017) Postoperative stereotactic radiosurgery compared with whole brain radiotherapy for resected metastatic brain disease (NCCTG N107C/CEC.3): a multicentre, randomised, controlled, phase 3 trial. Lancet Oncol 18:1049–1060PubMedCrossRefPubMedCentral Brown PD, Ballman KV, Cerhan JH, Anderson SK, Carrero XW, Whitton AC, Greenspoon J, Parney IF, Laack NNI, Ashman JB, Bahary JP, Hadjipanayis CG, Urbanic JJ, Barker FG 2nd, Farace E, Khuntia D, Giannini C, Buckner JC, Galanis E, Roberge D (2017) Postoperative stereotactic radiosurgery compared with whole brain radiotherapy for resected metastatic brain disease (NCCTG N107C/CEC.3): a multicentre, randomised, controlled, phase 3 trial. Lancet Oncol 18:1049–1060PubMedCrossRefPubMedCentral
43.
Zurück zum Zitat Molenaar R, Wiggenraad R, Verbeek-de Kanter A, Walchenbach R, Vecht C (2009) Relationship between volume, dose and local control in stereotactic radiosurgery of brain metastasis. Br J Neurosurg 23:170–178PubMedCrossRef Molenaar R, Wiggenraad R, Verbeek-de Kanter A, Walchenbach R, Vecht C (2009) Relationship between volume, dose and local control in stereotactic radiosurgery of brain metastasis. Br J Neurosurg 23:170–178PubMedCrossRef
44.
Zurück zum Zitat Ernst-Stecken A, Ganslandt O, Lambrecht U, Sauer R, Grabenbauer G (2006) Phase II trial of hypofractionated stereotactic radiotherapy for brain metastases: results and toxicity. Radiother Oncol 81:18–24PubMedCrossRef Ernst-Stecken A, Ganslandt O, Lambrecht U, Sauer R, Grabenbauer G (2006) Phase II trial of hypofractionated stereotactic radiotherapy for brain metastases: results and toxicity. Radiother Oncol 81:18–24PubMedCrossRef
45.
Zurück zum Zitat Jiang XS, Xiao JP, Zhang Y, Xu YJ, Li XP, Chen XJ, Huang XD, Yi JL, Gao L, Li YX (2012) Hypofractionated stereotactic radiotherapy for brain metastases larger than three centimeters. Radiat Oncol 7(36):36PubMedCrossRefPubMedCentral Jiang XS, Xiao JP, Zhang Y, Xu YJ, Li XP, Chen XJ, Huang XD, Yi JL, Gao L, Li YX (2012) Hypofractionated stereotactic radiotherapy for brain metastases larger than three centimeters. Radiat Oncol 7(36):36PubMedCrossRefPubMedCentral
46.
Zurück zum Zitat Lindvall P, Bergstrom P, Lofroth PO, Henriksson R, Bergenheim AT (2005) Hypofractionated conformal stereotactic radiotherapy alone or in combination with whole-brain radiotherapy in patients with cerebral metastases. Int J Radiat Oncol Biol Phys 61:1460–1466PubMedCrossRef Lindvall P, Bergstrom P, Lofroth PO, Henriksson R, Bergenheim AT (2005) Hypofractionated conformal stereotactic radiotherapy alone or in combination with whole-brain radiotherapy in patients with cerebral metastases. Int J Radiat Oncol Biol Phys 61:1460–1466PubMedCrossRef
47.
Zurück zum Zitat Narayana A, Chang J, Yenice K, Chan K, Lymberis S, Brennan C, Gutin PH (2007) Hypofractionated stereotactic radiotherapy using intensity-modulated radiotherapy in patients with one or two brain metastases. Stereotact Funct Neurosurg 85:82–87PubMedCrossRef Narayana A, Chang J, Yenice K, Chan K, Lymberis S, Brennan C, Gutin PH (2007) Hypofractionated stereotactic radiotherapy using intensity-modulated radiotherapy in patients with one or two brain metastases. Stereotact Funct Neurosurg 85:82–87PubMedCrossRef
48.
Zurück zum Zitat Oermann EK, Kress MA, Todd JV, Collins BT, Hoffman R, Chaudhry H, Collins SP, Morris D, Ewend MG (2013) The impact of radiosurgery fractionation and tumor radiobiology on the local control of brain metastases. J Neurosurg 119:1131–1138PubMedCrossRef Oermann EK, Kress MA, Todd JV, Collins BT, Hoffman R, Chaudhry H, Collins SP, Morris D, Ewend MG (2013) The impact of radiosurgery fractionation and tumor radiobiology on the local control of brain metastases. J Neurosurg 119:1131–1138PubMedCrossRef
49.
Zurück zum Zitat Prabhu RS, Press RH, Patel KR, Boselli DM, Symanowski JT, Lankford SP, McCammon RJ, Moeller BJ, Heinzerling JH, Fasola CE, Asher AL, Sumrall AL, Buchwald ZS, Curran WJ Jr, Shu HG, Crocker I, Burri SH (2017) Single-fraction stereotactic radiosurgery (SRS) alone versus surgical resection and SRS for large brain metastases: a multi-institutional analysis. Int J Radiat Oncol Biol Phys 99:459–467PubMedCrossRef Prabhu RS, Press RH, Patel KR, Boselli DM, Symanowski JT, Lankford SP, McCammon RJ, Moeller BJ, Heinzerling JH, Fasola CE, Asher AL, Sumrall AL, Buchwald ZS, Curran WJ Jr, Shu HG, Crocker I, Burri SH (2017) Single-fraction stereotactic radiosurgery (SRS) alone versus surgical resection and SRS for large brain metastases: a multi-institutional analysis. Int J Radiat Oncol Biol Phys 99:459–467PubMedCrossRef
50.
Zurück zum Zitat Rades D, Kieckebusch S, Haatanen T, Lohynska R, Dunst J, Schild SE (2008) Surgical resection followed by whole brain radiotherapy versus whole brain radiotherapy alone for single brain metastasis. Int J Radiat Oncol Biol Phys 70:1319–1324PubMedCrossRef Rades D, Kieckebusch S, Haatanen T, Lohynska R, Dunst J, Schild SE (2008) Surgical resection followed by whole brain radiotherapy versus whole brain radiotherapy alone for single brain metastasis. Int J Radiat Oncol Biol Phys 70:1319–1324PubMedCrossRef
51.
Zurück zum Zitat Fuller BG, Kaplan ID, Adler J, Cox RS, Bagshaw MA (1992) Stereotaxic radiosurgery for brain metastases: the importance of adjuvant whole brain irradiation. Int J Radiat Oncol Biol Phys 23:413–418PubMedCrossRef Fuller BG, Kaplan ID, Adler J, Cox RS, Bagshaw MA (1992) Stereotaxic radiosurgery for brain metastases: the importance of adjuvant whole brain irradiation. Int J Radiat Oncol Biol Phys 23:413–418PubMedCrossRef
52.
Zurück zum Zitat Kalkanis SN, Kondziolka D, Gaspar LE, Burri SH, Asher AL, Cobbs CS, Ammirati M, Robinson PD, Andrews DW, Loeffler JS, McDermott M, Mehta MP, Mikkelsen T, Olson JJ, Paleologos NA, Patchell RA, Ryken TC, Linskey ME (2010) The role of surgical resection in the management of newly diagnosed brain metastases: a systematic review and evidence-based clinical practice guideline. J Neuro-Oncol 96:33–43CrossRef Kalkanis SN, Kondziolka D, Gaspar LE, Burri SH, Asher AL, Cobbs CS, Ammirati M, Robinson PD, Andrews DW, Loeffler JS, McDermott M, Mehta MP, Mikkelsen T, Olson JJ, Paleologos NA, Patchell RA, Ryken TC, Linskey ME (2010) The role of surgical resection in the management of newly diagnosed brain metastases: a systematic review and evidence-based clinical practice guideline. J Neuro-Oncol 96:33–43CrossRef
53.
Zurück zum Zitat Sause WT, Crowley JJ, Morantz R, Rotman M, Mowry PA, Bouzaglou A, Borst JR, Selin H (1990) Solitary brain metastasis: results of an RTOG/SWOG protocol evaluation surgery + RT versus RT alone. Am J Clin Oncol 13:427–432PubMedCrossRef Sause WT, Crowley JJ, Morantz R, Rotman M, Mowry PA, Bouzaglou A, Borst JR, Selin H (1990) Solitary brain metastasis: results of an RTOG/SWOG protocol evaluation surgery + RT versus RT alone. Am J Clin Oncol 13:427–432PubMedCrossRef
54.
Zurück zum Zitat Skibber JM, Soong SJ, Austin L, Balch CM, Sawaya RE (1996) Cranial irradiation after surgical excision of brain metastases in melanoma patients. Ann Surg Oncol 3:118–123PubMedCrossRef Skibber JM, Soong SJ, Austin L, Balch CM, Sawaya RE (1996) Cranial irradiation after surgical excision of brain metastases in melanoma patients. Ann Surg Oncol 3:118–123PubMedCrossRef
55.
Zurück zum Zitat Wang LG, Guo Y, Zhang X, Song SJ, Xia JL, Fan FY, Shi M, Wei LC (2002) Brain metastasis: experience of the Xi-Jing hospital. Stereotact Funct Neurosurg 78:70–83PubMedCrossRef Wang LG, Guo Y, Zhang X, Song SJ, Xia JL, Fan FY, Shi M, Wei LC (2002) Brain metastasis: experience of the Xi-Jing hospital. Stereotact Funct Neurosurg 78:70–83PubMedCrossRef
56.
Zurück zum Zitat Soffietti R, Ruda R, Mutani R (2002) Management of brain metastases. J Neurol 249:1357–1369PubMedCrossRef Soffietti R, Ruda R, Mutani R (2002) Management of brain metastases. J Neurol 249:1357–1369PubMedCrossRef
57.
Zurück zum Zitat Suh JH (2010) Stereotactic radiosurgery for the management of brain metastases. N Engl J Med 362:1119–1127PubMedCrossRef Suh JH (2010) Stereotactic radiosurgery for the management of brain metastases. N Engl J Med 362:1119–1127PubMedCrossRef
58.
Zurück zum Zitat Rades D, Kueter JD, Meyners T, Pluemer A, Veninga T, Gliemroth J, Schild SE (2012) Single brain metastasis: resection followed by whole-brain irradiation and a boost to the metastatic site compared to whole-brain irradiation plus radiosurgery. Clin Neurol Neurosurg 114:326–330PubMedCrossRef Rades D, Kueter JD, Meyners T, Pluemer A, Veninga T, Gliemroth J, Schild SE (2012) Single brain metastasis: resection followed by whole-brain irradiation and a boost to the metastatic site compared to whole-brain irradiation plus radiosurgery. Clin Neurol Neurosurg 114:326–330PubMedCrossRef
59.
Zurück zum Zitat Suki D, Hatiboglu MA, Patel AJ, Weinberg JS, Groves MD, Mahajan A, Sawaya R (2009) Comparative risk of leptomeningeal dissemination of cancer after surgery or stereotactic radiosurgery for a single supratentorial solid tumor metastasis. Neurosurgery 64:664–674 discussion 674–666PubMedCrossRef Suki D, Hatiboglu MA, Patel AJ, Weinberg JS, Groves MD, Mahajan A, Sawaya R (2009) Comparative risk of leptomeningeal dissemination of cancer after surgery or stereotactic radiosurgery for a single supratentorial solid tumor metastasis. Neurosurgery 64:664–674 discussion 674–666PubMedCrossRef
60.
Zurück zum Zitat Patel AJ, Suki D, Hatiboglu MA, Abouassi H, Shi W, Wildrick DM, Lang FF, Sawaya R (2010) Factors influencing the risk of local recurrence after resection of a single brain metastasis. J Neurosurg 113:181–189PubMedCrossRef Patel AJ, Suki D, Hatiboglu MA, Abouassi H, Shi W, Wildrick DM, Lang FF, Sawaya R (2010) Factors influencing the risk of local recurrence after resection of a single brain metastasis. J Neurosurg 113:181–189PubMedCrossRef
61.
Zurück zum Zitat Bindal AK, Bindal RK, Hess KR, Shiu A, Hassenbusch SJ, Shi WM, Sawaya R (1996) Surgery versus radiosurgery in the treatment of brain metastasis. J Neurosurg 84:748–754PubMedCrossRef Bindal AK, Bindal RK, Hess KR, Shiu A, Hassenbusch SJ, Shi WM, Sawaya R (1996) Surgery versus radiosurgery in the treatment of brain metastasis. J Neurosurg 84:748–754PubMedCrossRef
62.
Zurück zum Zitat Paek SH, Audu PB, Sperling MR, Cho J, Andrews DW (2005) Reevaluation of surgery for the treatment of brain metastases: review of 208 patients with single or multiple brain metastases treated at one institution with modern neurosurgical techniques. Neurosurgery 56:1021–1034 discussion 1021–1034PubMed Paek SH, Audu PB, Sperling MR, Cho J, Andrews DW (2005) Reevaluation of surgery for the treatment of brain metastases: review of 208 patients with single or multiple brain metastases treated at one institution with modern neurosurgical techniques. Neurosurgery 56:1021–1034 discussion 1021–1034PubMed
63.
Zurück zum Zitat Chidel MA, Suh JH, Reddy CA, Chao ST, Lundbeck MF, Barnett GH (2000) Application of recursive partitioning analysis and evaluation of the use of whole brain radiation among patients treated with stereotactic radiosurgery for newly diagnosed brain metastases. Int J Radiat Oncol Biol Phys 47:993–999PubMedCrossRef Chidel MA, Suh JH, Reddy CA, Chao ST, Lundbeck MF, Barnett GH (2000) Application of recursive partitioning analysis and evaluation of the use of whole brain radiation among patients treated with stereotactic radiosurgery for newly diagnosed brain metastases. Int J Radiat Oncol Biol Phys 47:993–999PubMedCrossRef
64.
Zurück zum Zitat Combs SE, Schulz-Ertner D, Thilmann C, Edler L, Debus J (2004) Treatment of cerebral metastases from breast cancer with stereotactic radiosurgery. Strahlenther Onkol 180:590–596PubMedCrossRef Combs SE, Schulz-Ertner D, Thilmann C, Edler L, Debus J (2004) Treatment of cerebral metastases from breast cancer with stereotactic radiosurgery. Strahlenther Onkol 180:590–596PubMedCrossRef
65.
Zurück zum Zitat Garell PCHP, Wen BC, Mellenberg DE, Torner J (1999) Stereotactic radisurgery versus microsurgicall resection for the initial treatment of metastatic cancer to the brain. J Radiosurg 2:1–5CrossRef Garell PCHP, Wen BC, Mellenberg DE, Torner J (1999) Stereotactic radisurgery versus microsurgicall resection for the initial treatment of metastatic cancer to the brain. J Radiosurg 2:1–5CrossRef
66.
Zurück zum Zitat Gaspar L, Scott C, Rotman M, Asbell S, Phillips T, Wasserman T, McKenna WG, Byhardt R (1997) Recursive partitioning analysis (RPA) of prognostic factors in three Radiation Therapy Oncology Group (RTOG) brain metastases trials. Int J Radiat Oncol Biol Phys 37:745–751PubMedCrossRef Gaspar L, Scott C, Rotman M, Asbell S, Phillips T, Wasserman T, McKenna WG, Byhardt R (1997) Recursive partitioning analysis (RPA) of prognostic factors in three Radiation Therapy Oncology Group (RTOG) brain metastases trials. Int J Radiat Oncol Biol Phys 37:745–751PubMedCrossRef
67.
Zurück zum Zitat Gaspar LE, Scott C, Murray K, Curran W (2000) Validation of the RTOG recursive partitioning analysis (RPA) classification for brain metastases. Int J Radiat Oncol Biol Phys 47:1001–1006PubMedCrossRef Gaspar LE, Scott C, Murray K, Curran W (2000) Validation of the RTOG recursive partitioning analysis (RPA) classification for brain metastases. Int J Radiat Oncol Biol Phys 47:1001–1006PubMedCrossRef
68.
Zurück zum Zitat Kocher M, Maarouf M, Bendel M, Voges J, Muller RP, Sturm V (2004) Linac radiosurgery versus whole brain radiotherapy for brain metastases. A survival comparison based on the RTOG recursive partitioning analysis. Strahlenther Onkol 180:263–267PubMedCrossRef Kocher M, Maarouf M, Bendel M, Voges J, Muller RP, Sturm V (2004) Linac radiosurgery versus whole brain radiotherapy for brain metastases. A survival comparison based on the RTOG recursive partitioning analysis. Strahlenther Onkol 180:263–267PubMedCrossRef
69.
Zurück zum Zitat Pirzkall A, Debus J, Lohr F, Fuss M, Rhein B, Engenhart-Cabillic R, Wannenmacher M (1998) Radiosurgery alone or in combination with whole-brain radiotherapy for brain metastases. J Clin Oncol 16:3563–3569PubMedCrossRef Pirzkall A, Debus J, Lohr F, Fuss M, Rhein B, Engenhart-Cabillic R, Wannenmacher M (1998) Radiosurgery alone or in combination with whole-brain radiotherapy for brain metastases. J Clin Oncol 16:3563–3569PubMedCrossRef
70.
Zurück zum Zitat Rades D, Pluemer A, Veninga T, Hanssens P, Dunst J, Schild SE (2007) Whole-brain radiotherapy versus stereotactic radiosurgery for patients in recursive partitioning analysis classes 1 and 2 with 1 to 3 brain metastases. Cancer 110:2285–2292PubMedCrossRef Rades D, Pluemer A, Veninga T, Hanssens P, Dunst J, Schild SE (2007) Whole-brain radiotherapy versus stereotactic radiosurgery for patients in recursive partitioning analysis classes 1 and 2 with 1 to 3 brain metastases. Cancer 110:2285–2292PubMedCrossRef
71.
Zurück zum Zitat Serizawa T, Iuchi T, Ono J, Saeki N, Osato K, Odaki M, Ushikubo O, Hirai S, Sato M, Matsuda S (2000) Gamma knife treatment for multiple metastatic brain tumors compared with whole-brain radiation therapy. J Neurosurg 93(Suppl 3):32–36PubMedCrossRef Serizawa T, Iuchi T, Ono J, Saeki N, Osato K, Odaki M, Ushikubo O, Hirai S, Sato M, Matsuda S (2000) Gamma knife treatment for multiple metastatic brain tumors compared with whole-brain radiation therapy. J Neurosurg 93(Suppl 3):32–36PubMedCrossRef
72.
Zurück zum Zitat Shinoura N, Yamada R, Okamoto K, Nakamura O, Shitara N (2002) Local recurrence of metastatic brain tumor after stereotactic radiosurgery or surgery plus radiation. J Neuro-Oncol 60:71–77CrossRef Shinoura N, Yamada R, Okamoto K, Nakamura O, Shitara N (2002) Local recurrence of metastatic brain tumor after stereotactic radiosurgery or surgery plus radiation. J Neuro-Oncol 60:71–77CrossRef
73.
Zurück zum Zitat Nabors LB, Portnow J, Ammirati M, Brem H, Brown P, Butowski N, Chamberlain MC, DeAngelis LM, Fenstermaker RA, Friedman A, Gilbert MR, Hattangadi-Gluth J, Hesser D, Holdhoff M, Junck L, Lawson R, Loeffler JS, Moots PL, Mrugala MM, Newton HB, Raizer JJ, Recht L, Shonka N, Shrieve DC, Sills AK Jr, Swinnen LJ, Tran D, Tran N, Vrionis FD, Wen PY, McMillian NR, Ho M (2014) Central nervous system cancers, version 2.2014. Featured updates to the NCCN Guidelines. J Natl Compr Cancer Netw 12:1517–1523CrossRef Nabors LB, Portnow J, Ammirati M, Brem H, Brown P, Butowski N, Chamberlain MC, DeAngelis LM, Fenstermaker RA, Friedman A, Gilbert MR, Hattangadi-Gluth J, Hesser D, Holdhoff M, Junck L, Lawson R, Loeffler JS, Moots PL, Mrugala MM, Newton HB, Raizer JJ, Recht L, Shonka N, Shrieve DC, Sills AK Jr, Swinnen LJ, Tran D, Tran N, Vrionis FD, Wen PY, McMillian NR, Ho M (2014) Central nervous system cancers, version 2.2014. Featured updates to the NCCN Guidelines. J Natl Compr Cancer Netw 12:1517–1523CrossRef
74.
Zurück zum Zitat Valery CA, Cornu P, Noel G, Duyme M, Boisserie G, Sakka LJ, Mazeron JJ, van Effenterre R (2003) Predictive factors of radiation necrosis after radiosurgery for cerebral metastases. Stereotact Funct Neurosurg 81:115–119PubMedCrossRef Valery CA, Cornu P, Noel G, Duyme M, Boisserie G, Sakka LJ, Mazeron JJ, van Effenterre R (2003) Predictive factors of radiation necrosis after radiosurgery for cerebral metastases. Stereotact Funct Neurosurg 81:115–119PubMedCrossRef
75.
Zurück zum Zitat Ma L, Petti P, Wang B, Descovich M, Chuang C, Barani IJ, Kunwar S, Shrieve DC, Sahgal A, Larson DA (2011) Apparatus dependence of normal brain tissue dose in stereotactic radiosurgery for multiple brain metastases. J Neurosurg 114:1580–1584PubMedCrossRef Ma L, Petti P, Wang B, Descovich M, Chuang C, Barani IJ, Kunwar S, Shrieve DC, Sahgal A, Larson DA (2011) Apparatus dependence of normal brain tissue dose in stereotactic radiosurgery for multiple brain metastases. J Neurosurg 114:1580–1584PubMedCrossRef
76.
Zurück zum Zitat Sahgal A, Barani IJ, Novotny J Jr, Zhang B, Petti P, Larson DA, Ma L (2010) Prescription dose guideline based on physical criterion for multiple metastatic brain tumors treated with stereotactic radiosurgery. Int J Radiat Oncol Biol Phys 78:605–608PubMedCrossRef Sahgal A, Barani IJ, Novotny J Jr, Zhang B, Petti P, Larson DA, Ma L (2010) Prescription dose guideline based on physical criterion for multiple metastatic brain tumors treated with stereotactic radiosurgery. Int J Radiat Oncol Biol Phys 78:605–608PubMedCrossRef
77.
Zurück zum Zitat Hatiboglu MA, Akdur K (2017) Evaluating critical brain radiation doses in the treatment of multiple brain lesions with Gamma Knife radiosurgery. Stereotact Funct Neurosurg 95:268–278PubMedCrossRef Hatiboglu MA, Akdur K (2017) Evaluating critical brain radiation doses in the treatment of multiple brain lesions with Gamma Knife radiosurgery. Stereotact Funct Neurosurg 95:268–278PubMedCrossRef
78.
Zurück zum Zitat Bindal RK, Sawaya R, Leavens ME, Lee JJ (1993) Surgical treatment of multiple brain metastases. J Neurosurg 79:210–216PubMedCrossRef Bindal RK, Sawaya R, Leavens ME, Lee JJ (1993) Surgical treatment of multiple brain metastases. J Neurosurg 79:210–216PubMedCrossRef
79.
Zurück zum Zitat Stark AM, Tscheslog H, Buhl R, Held-Feindt J, Mehdorn HM (2005) Surgical treatment for brain metastases: prognostic factors and survival in 177 patients. Neurosurg Rev 28:115–119PubMedCrossRef Stark AM, Tscheslog H, Buhl R, Held-Feindt J, Mehdorn HM (2005) Surgical treatment for brain metastases: prognostic factors and survival in 177 patients. Neurosurg Rev 28:115–119PubMedCrossRef
80.
Zurück zum Zitat Wronski M, Arbit E, McCormick B (1997) Surgical treatment of 70 patients with brain metastases from breast carcinoma. Cancer 80:1746–1754PubMedCrossRef Wronski M, Arbit E, McCormick B (1997) Surgical treatment of 70 patients with brain metastases from breast carcinoma. Cancer 80:1746–1754PubMedCrossRef
81.
Zurück zum Zitat Mintz A, Perry J, Spithoff K, Chambers A, Laperriere N (2007) Management of single brain metastasis: a practice guideline. Curr Oncol 14:131–143PubMedCrossRefPubMedCentral Mintz A, Perry J, Spithoff K, Chambers A, Laperriere N (2007) Management of single brain metastasis: a practice guideline. Curr Oncol 14:131–143PubMedCrossRefPubMedCentral
82.
Zurück zum Zitat Bindal RK, Sawaya R, Leavens ME, Hess KR, Taylor SH (1995) Reoperation for recurrent metastatic brain tumors. J Neurosurg 83:600–604PubMedCrossRef Bindal RK, Sawaya R, Leavens ME, Hess KR, Taylor SH (1995) Reoperation for recurrent metastatic brain tumors. J Neurosurg 83:600–604PubMedCrossRef
83.
84.
Zurück zum Zitat Kim DH, Schultheiss TE, Radany EH, Badie B, Pezner RD (2013) Clinical outcomes of patients treated with a second course of stereotactic radiosurgery for locally or regionally recurrent brain metastases after prior stereotactic radiosurgery. J Neuro-Oncol 115:37–43CrossRef Kim DH, Schultheiss TE, Radany EH, Badie B, Pezner RD (2013) Clinical outcomes of patients treated with a second course of stereotactic radiosurgery for locally or regionally recurrent brain metastases after prior stereotactic radiosurgery. J Neuro-Oncol 115:37–43CrossRef
85.
Zurück zum Zitat Koffer P, Chan J, Rava P, Gorovets D, Ebner D, Savir G, Kinsella T, Cielo D, Hepel JT (2017) Repeat stereotactic radiosurgery for locally recurrent brain metastases. World Neurosurg 104:589–593PubMedCrossRef Koffer P, Chan J, Rava P, Gorovets D, Ebner D, Savir G, Kinsella T, Cielo D, Hepel JT (2017) Repeat stereotactic radiosurgery for locally recurrent brain metastases. World Neurosurg 104:589–593PubMedCrossRef
86.
Zurück zum Zitat Lucas JT Jr, Colmer HG, White L, Fitzgerald N, Isom S, Bourland JD, Laxton AW, Tatter SB, Chan MD (2015) Competing risk analysis of neurologic versus nonneurologic death in patients undergoing radiosurgical salvage after whole-brain radiation therapy failure: who actually dies of their brain metastases? Int J Radiat Oncol Biol Phys 92:1008–1015PubMedCrossRefPubMedCentral Lucas JT Jr, Colmer HG, White L, Fitzgerald N, Isom S, Bourland JD, Laxton AW, Tatter SB, Chan MD (2015) Competing risk analysis of neurologic versus nonneurologic death in patients undergoing radiosurgical salvage after whole-brain radiation therapy failure: who actually dies of their brain metastases? Int J Radiat Oncol Biol Phys 92:1008–1015PubMedCrossRefPubMedCentral
87.
Zurück zum Zitat Kondziolka D, Kano H, Harrison GL, Yang HC, Liew DN, Niranjan A, Brufsky AM, Flickinger JC, Lunsford LD (2011) Stereotactic radiosurgery as primary and salvage treatment for brain metastases from breast cancer. Clinical article. J Neurosurg 114:792–800PubMedCrossRef Kondziolka D, Kano H, Harrison GL, Yang HC, Liew DN, Niranjan A, Brufsky AM, Flickinger JC, Lunsford LD (2011) Stereotactic radiosurgery as primary and salvage treatment for brain metastases from breast cancer. Clinical article. J Neurosurg 114:792–800PubMedCrossRef
Metadaten
Titel
Neurosurgical management of patients with brain metastasis
verfasst von
Mustafa Aziz Hatiboglu
Kerime Akdur
Raymond Sawaya
Publikationsdatum
29.07.2018
Verlag
Springer Berlin Heidelberg
Erschienen in
Neurosurgical Review / Ausgabe 2/2020
Print ISSN: 0344-5607
Elektronische ISSN: 1437-2320
DOI
https://doi.org/10.1007/s10143-018-1013-6

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