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01.06.2009 | Original Article

ICAM-1 (Lys469Glu) and PECAM-1 (Leu125Val) polymorphisms in diffuse astrocytomas

verfasst von: Regislaine Valéria Burim, Silvia Aparecida Teixeira, Benedicto Oscar Colli, Fernanda Maris Peria, Luis Fernando Tirapelli, Suely Kazue Nagahashi Marie, Suzana Maria Fleury Malheiros, Sueli Mieko Oba-Shinjo, Alberto Alain Gabbai, Paulo Andrade Lotufo, Carlos Gilberto Carlotti-Júnior

Erschienen in: Clinical and Experimental Medicine | Ausgabe 2/2009

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Abstract

Cell adhesion molecules such as intercellular adhesion molecule-1 (ICAM-1) and platelet-endothelial cell adhesion molecule-1 (PECAM-1) play an important role in glioma invasion and angiogenesis. The aim of this study was to investigate whether specific genetic polymorphisms of ICAM-1 and PECAM-1 could be associated with glioma development and progression. Single-nucleotide polymorphism in codon 469 of ICAM-1 and codon 125 of PECAM-1 were examined in 158 patients with astrocytomas and 162 controls using polymerase chain reaction and restriction enzyme analysis. The distribution of PECAM-1 polymorphic genotypes in astrocytomas did not show any significant difference. However, a specific ICAM-1 genotype (G/G, corresponding to Lys469Glu) exhibited higher frequency in grade II astrocytomas compared to controls, grade III, and grade IV astrocytomas; suggesting that this polymorphism could be involved in the development of grade II astrocytomas.

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Titel: ICAM-1 (Lys469Glu) and PECAM-1 (Leu125Val) polymorphisms in diffuse astrocytomas
verfasst von: Regislaine Valéria Burim
Silvia Aparecida Teixeira
Benedicto Oscar Colli
Fernanda Maris Peria
Luis Fernando Tirapelli
Suely Kazue Nagahashi Marie
Suzana Maria Fleury Malheiros
Sueli Mieko Oba-Shinjo
Alberto Alain Gabbai
Paulo Andrade Lotufo
Carlos Gilberto Carlotti-Júnior
Publikationsdatum: 01.06.2009
Verlag: Springer Milan
Erschienen in: Clinical and Experimental Medicine / Ausgabe 2/2009
Print ISSN: 1591-8890
Elektronische ISSN: 1591-9528
DOI: https://doi.org/10.1007/s10238-009-0040-6

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