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01.07.2012 | Original paper

Plasma micronutrients, trace elements, and breast cancer in BRCA1 mutation carriers: an exploratory study

verfasst von: Joanne Kotsopoulos, Grzegorz Sukiennicki, Magdalena Muszyńska, Daniel Gackowski, Krzysztof Kąklewski, Katarzyna Durda, Katarzyna Jaworska, Tomasz Huzarski, Jacek Gronwald, Tomasz Byrski, Oleg Ashuryk, Tadeusz Dębniak, Aleksandra Tołoczko-Grabarek, Małgorzata Stawicka, Dariusz Godlewski, Ryszard Oliński, Anna Jakubowska, Steven A. Narod, Jan Lubinski

Erschienen in: Cancer Causes & Control | Ausgabe 7/2012

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Abstract

Purpose

Few studies have evaluated the role of micronutrients or trace elements in breast cancer development among BRCA1 mutation carriers. To investigate a possible role of dietary and environmental exposures on cancer risk, we undertook an exploratory study, using a matched case–control design (n = 48 cases and 96 controls), to evaluate the relationships between plasma levels of 14 micronutrients and breast cancer risk among BRCA1 mutation carriers in Poland.

Methods

We estimated the univariate odds ratios (OR) and 95 % confidence intervals (CI) for breast cancer associated with plasma levels for each of 14 micronutrients.

Results

Of the 14 analytes quantified, significant differences between cases and controls were seen for two (iron and retinol; p = 0.009 and p = 0.03, respectively). Women in the highest tertile of plasma iron had a 57 % lower risk, compared with those in the lowest quartile (OR = 0.43; 95 % CI 0.18–1.04; p for trend = 0.06). Increasing antimony levels were associated with an increased risk of breast cancer (p for trend = 0.05). Women in the highest tertile had a 2.43-fold increase in breast cancer risk compared with women in the lowest tertile (OR = 2.43; 95 % CI 1.00–5.91).

Conclusions

This study provides some preliminary evidence regarding a role of diet, specifically iron and antimony, in the etiology of BRCA1-associated breast cancer. Prospective studies are necessary to confirm these findings.

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Titel: Plasma micronutrients, trace elements, and breast cancer in BRCA1 mutation carriers: an exploratory study
verfasst von: Joanne Kotsopoulos
Grzegorz Sukiennicki
Magdalena Muszyńska
Daniel Gackowski
Krzysztof Kąklewski
Katarzyna Durda
Katarzyna Jaworska
Tomasz Huzarski
Jacek Gronwald
Tomasz Byrski
Oleg Ashuryk
Tadeusz Dębniak
Aleksandra Tołoczko-Grabarek
Małgorzata Stawicka
Dariusz Godlewski
Ryszard Oliński
Anna Jakubowska
Steven A. Narod
Jan Lubinski
Publikationsdatum: 01.07.2012
Verlag: Springer Netherlands
Erschienen in: Cancer Causes & Control / Ausgabe 7/2012
Print ISSN: 0957-5243
Elektronische ISSN: 1573-7225
DOI: https://doi.org/10.1007/s10552-012-9975-0

Springer Medizin

Plasma micronutrients, trace elements, and breast cancer in BRCA1 mutation carriers: an exploratory study