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Cancer and Metastasis Reviews
Erschienen in: Cancer and Metastasis Reviews 2/2010

01.06.2010

Inflammation-mediated promotion of invasion and metastasis

verfasst von: Graziella Solinas, Federica Marchesi, Cecilia Garlanda, Alberto Mantovani, Paola Allavena

Erschienen in: Cancer and Metastasis Reviews | Ausgabe 2/2010

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Abstract

Inflammation has been suggested to represent the seventh hallmark of cancer. Myelomonocytic cells are a key component of cancer-related inflammation. Tumor-associated macrophages and their mediators affect key elements in the multistep process of invasion and metastasis, from interaction with the extracellular matrix to the construction of a pre-metastatic niche. Evidence indicating that inflammatory mediators affect genetic stability and cause persistent epigenetic alterations suggests that inflammatory components of the tumor microenvironment impacts on fundamental mechanisms responsible for the generation of metastatic variants. These results provide impetus for efforts aimed at translating cancer-related inflammation into diagnostic–prognostic markers and innovative therapeutic strategies.
Literatur
1.
Balkwill, F., & Mantovani, A. (2001). Inflammation and cancer: back to Virchow? Lancet, 357, 539–545.CrossRefPubMed
2.
3.
Mantovani, A., Allavena, P., Sica, A., & Balkwill, F. (2008). Cancer-related inflammation. Nature, 454, 436–444.CrossRefPubMed
4.
5.
De Palma, M., Murdoch, C., Venneri, M. A., Naldini, L., & Lewis, C. E. (2007). Tie2-expressing monocytes: regulation of tumor angiogenesis and therapeutic implications. Trends Immunol, 28, 519–524.CrossRefPubMed
6.
Mantovani, A., & Sica, A. (2010). Macrophages, innate immunity and cancer: balance, tolerance, and diversity. Curr Opin Immunol, 22, 231–237.
7.
Pollard, J. W. (2009). Trophic macrophages in development and disease. Nat Rev Immunol, 9, 259–270.CrossRefPubMed
8.
Bollrath, J., & Greten, F. R. (2009). IKK/NF-kappaB and STAT3 pathways: central signalling hubs in inflammation-mediated tumour promotion and metastasis. EMBO Rep, 10, 1314–1319.CrossRefPubMed
9.
Wang, D., Dubois, R. N., & Richmond, A. (2009). The role of chemokines in intestinal inflammation and cancer. Curr Opin Pharmacol, 9, 688–696.CrossRefPubMed
10.
Wels, J., Kaplan, R. N., Rafii, S., & Lyden, D. (2008). Migratory neighbors and distant invaders: tumor-associated niche cells. Genes Dev, 22, 559–574.CrossRefPubMed
11.
Yu, H., Pardoll, D., & Jove, R. (2009). STATs in cancer inflammation and immunity: a leading role for STAT3. Nat Rev Cancer, 9, 798–809.CrossRefPubMed
12.
Karin, M. (2006). Nuclear factor-kappaB in cancer development and progression. Nature, 441, 431–436.CrossRefPubMed
13.
14.
Giavazzi, R., Garofalo, A., Bani, M. R., Abbate, M., Ghezzi, P., Boraschi, D., et al. (1990). Interleukin 1-induced augmentation of experimental metastases from a human melanoma in nude mice. Cancer Res, 50, 4771–4775.PubMed
15.
Colotta, F., Allavena, P., Sica, A., Garlanda, C., & Mantovani, A. (2009). Cancer-related inflammation, the seventh hallmark of cancer: links to genetic instability. Carcinogenesis, 30, 1073–1081.CrossRefPubMed
16.
Niwa, T., Tsukamoto, T., Toyoda, T., Mori, A., Tanaka, H., Maekita, T., et al. (2010). Inflammatory processes triggered by Helicobacter pylori infection cause aberrant DNA methylation in gastric epithelial cells. Cancer Res, 70, 1430–1440.CrossRefPubMed
17.
Barash, H., Gross, E., Edrei, Y., Ella, E., Israel, A., Cohen, I., et al. (2010). Accelerated carcinogenesis following liver regeneration is associated with chronic inflammation-induced double-strand DNA breaks. Proc Natl Acad Sci U S A, 107, 2207–2212.CrossRefPubMed
18.
Ishii, M., Wen, H., Corsa, C. A., Liu, T., Coelho, A. L., Allen, R. M., et al. (2009). Epigenetic regulation of the alternatively activated macrophage phenotype. Blood, 114, 3244–3254.CrossRefPubMed
19.
Mantovani, A., & Locati, M. (2009). Orchestration of macrophage polarization. Blood, 114, 3135–3136.CrossRefPubMed
20.
Iliopoulos, D., Hirsch, H. A., & Struhl, K. (2009). An epigenetic switch involving NF-kappaB, Lin28, Let-7 MicroRNA, and IL6 links inflammation to cell transformation. Cell, 139, 693–706.CrossRefPubMed
21.
Fidler, I. J. (2003). The pathogenesis of cancer metastasis: the ‘seed and soil’ hypothesis revisited. Nat Rev Cancer, 3, 453–458.CrossRefPubMed
22.
Torroella-Kouri, M., Silvera, R., Rodriguez, D., Caso, R., Shatry, A., Opiela, S., et al. (2009). Identification of a subpopulation of macrophages in mammary tumor-bearing mice that are neither M1 nor M2 and are less differentiated. Cancer Res, 69, 4800–4809.CrossRefPubMed
23.
Mantovani, A., Sozzani, S., Locati, M., Allavena, P., & Sica, A. (2002). Macrophage polarization: tumor-associated macrophages as a paradigm for polarized M2 mononuclear phagocytes. Trends Immunol, 23, 549–555.CrossRefPubMed
24.
Martinez, F. O., Helming, L., & Gordon, S. (2009). Alternative activation of macrophages: an immunologic functional perspective. Annu Rev Immunol, 27, 451–483.CrossRefPubMed
25.
Ojalvo, L. S., Whittaker, C. A., Condeelis, J. S., & Pollard, J. W. (2010). Gene expression analysis of macrophages that facilitate tumor invasion supports a role for Wnt-signaling in mediating their activity in primary mammary tumors. J Immunol, 184, 702–712.CrossRefPubMed
26.
Wilcox, R. A., Wada, D. A., Ziesmer, S. C., Elsawa, S. F., Comfere, N. I., Dietz, A. B., et al. (2009). Monocytes promote tumor cell survival in T-cell lymphoproliferative disorders and are impaired in their ability to differentiate into mature dendritic cells. Blood, 114, 2936–2944.CrossRefPubMed
27.
Zheng, Y., Cai, Z., Wang, S., Zhang, X., Qian, J., Hong, S., et al. (2009). Macrophages are an abundant component of myeloma microenvironment and protect myeloma cells from chemotherapy drug-induced apoptosis. Blood, 114, 3625–3628.CrossRefPubMed
28.
Jaiswal, S., Jamieson, C. H., Pang, W. W., Park, C. Y., Chao, M. P., Majeti, R., et al. (2009). CD47 is upregulated on circulating hematopoietic stem cells and leukemia cells to avoid phagocytosis. Cell, 138, 271–285.CrossRefPubMed
29.
Erler, J. T., Bennewith, K. L., Cox, T. R., Lang, G., Bird, D., Koong, A., et al. (2009). Hypoxia-induced lysyl oxidase is a critical mediator of bone marrow cell recruitment to form the premetastatic niche. Cancer Cell, 15, 35–44.CrossRefPubMed
30.
Hagemann, T., Wilson, J., Burke, F., Kulbe, H., Li, N. F., Pluddemann, A., et al. (2006). Ovarian cancer cells polarize macrophages toward a tumor-associated phenotype. J Immunol, 176, 5023–5032.PubMed
31.
Kim, S., Takahashi, H., Lin, W.-W., Descargues, P., Grivennikov, S., Kim, Y., et al. (2009). Carcinoma produced factors activate myeloid cells via TLR2 to stimulate metastasis. Nature, 457, 102–106.CrossRefPubMed
32.
Kuang, D. M., Wu, Y., Chen, N., Cheng, J., Zhuang, S. M., & Zheng, L. (2007). Tumor-derived hyaluronan induces formation of immunosuppressive macrophages through transient early activation of monocytes. Blood, 110, 587–595.CrossRefPubMed
33.
Goswami, S., Sahai, E., Wyckoff, J. B., Cammer, M., Cox, D., Pixley, F. J., et al. (2005). Macrophages promote the invasion of breast carcinoma cells via a colony-stimulating factor-1/epidermal growth factor paracrine loop. Cancer Res, 65, 5278–5283.CrossRefPubMed
34.
Priceman, S. J., Sung, J. L., Shaposhnik, Z., Burton, J. B., Torres-Collado, A. X., Moughon, D. L., et al. (2010). Targeting distinct tumor-infiltrating myeloid cells by inhibiting CSF-1 receptor: combating tumor evasion of antiangiogenic therapy. Blood, 115, 1461–1471.CrossRefPubMed
35.
Zhang, J., Patel, L., & Pienta, K. J. (2010). CC chemokine ligand 2 (CCL2) promotes prostate cancer tumorigenesis and metastasis. Cytokine Growth Factor Rev, 21, 41–48.CrossRefPubMed
36.
Dehmel, S., Wang, S., Schmidt, C., Kiss, E., Loewe, R. P., Chilla, S., et al. (2010). Chemokine receptor Ccr5 deficiency induces alternative macrophage activation and improves long-term renal allograft outcome. Eur J Immunol, 40, 267–278.CrossRefPubMed
37.
Roca, H., Varsos, Z. S., Sud, S., Craig, M. J., Ying, C., & Pienta, K. J. (2009). CCL2 and IL-6 promote survival of human CD11b+ peripheral blood mononuclear cells and induce M2-type macrophage polarization. J Biol Chem, 284, 34342–34354.CrossRefPubMed
38.
Balkwill, F., & Mantovani, A. (2010). Cancer and Inflammation: Implications for Pharmacology and Therapeutics. Clin Pharmacol Ther (in press).
39.
Aspord, C., Pedroza-Gonzalez, A., Gallegos, M., Tindle, S., Burton, E. C., Su, D., et al. (2007). Breast cancer instructs dendritic cells to prime interleukin 13-secreting CD4+ T cells that facilitate tumor development. J Exp Med, 204, 1037–1047.CrossRefPubMed
40.
DeNardo, D. G., Barreto, J. B., Andreu, P., Vasquez, L., Tawfik, D., Kolhatkar, N., et al. (2009). CD4(+) T cells regulate pulmonary metastasis of mammary carcinomas by enhancing protumor properties of macrophages. Cancer Cell, 16, 91–102.CrossRefPubMed
41.
de Visser, K. E., Korets, L. V., & Coussens, L. M. (2005). De novo carcinogenesis promoted by chronic inflammation is B lymphocyte dependent. Cancer Cell, 7, 411–423.CrossRefPubMed
42.
Andreu, P., Johansson, M., Affara, N. I., Pucci, F., Tan, T., Junankar, S., et al. (2010). FcRgamma activation regulates inflammation-associated squamous carcinogenesis. Cancer Cell, 17, 121–134.CrossRefPubMed
43.
Markiewski, M. M., DeAngelis, R. A., Benencia, F., Ricklin-Lichtsteiner, S. K., Koutoulaki, A., Gerard, C., et al. (2008). Modulation of the antitumor immune response by complement. Nat Immunol, 9, 1225–1235.CrossRefPubMed
44.
Erez, N., Truitt, M., Olson, P., & Hanahan, D. (2010). Cancer-associated fibroblasts are activated in incipient neoplasia to orchestrate tumor-promoting inflammation in an NF-kappaB-dependent manner. Cancer Cell, 17, 135–147.CrossRefPubMed
45.
Cassatella, M. A., Locati, M., & Mantovani, A. (2009). Never underestimate the power of a neutrophil. Immunity, 31, 698–700.CrossRefPubMed
46.
Mantovani, A. (2009). The yin-yang of tumor-associated neutrophils. Cancer Cell, 16, 173–174.CrossRefPubMed
47.
Zhang, X., Majlessi, L., Deriaud, E., Leclerc, C., & Lo-Man, R. (2009). Coactivation of Syk kinase and MyD88 adaptor protein pathways by bacteria promotes regulatory properties of neutrophils. Immunity, 31, 761–771.CrossRefPubMed
48.
Nozawa, H., Chiu, C., & Hanahan, D. (2006). Infiltrating neutrophils mediate the initial angiogenic switch in a mouse model of multistage carcinogenesis. Proc Natl Acad Sci U S A, 103, 12493–12498.CrossRefPubMed
49.
Pekarek, L. A., Starr, B. A., Toledano, A. Y., & Schreiber, H. (1995). Inhibition of tumor growth by elimination of granulocytes. J Exp Med, 181, 435–440.CrossRefPubMed
50.
Fridlender, Z. G., Sun, J., Kim, S., Kapoor, V., Cheng, G., Ling, L., et al. (2009). Polarization of tumor-associated neutrophil (TAN) phenotype by TGF-beta: “N1” versus “N2” TAN—a new paradigm? Cancer Cell, 16, 183–194.CrossRefPubMed
51.
52.
Nguyen, D. X., Chiang, A. C., Zhang, X. H., Kim, J. Y., Kris, M. G., Ladanyi, M., et al. (2009). WNT/TCF signaling through LEF1 and HOXB9 mediates lung adenocarcinoma metastasis. Cell, 138, 51–62.CrossRefPubMed
53.
Hiratsuka, S., Watanabe, A., Aburatani, H., & Maru, Y. (2006). Tumour-mediated upregulation of chemoattractants and recruitment of myeloid cells predetermines lung metastasis. Nat Cell Biol, 8, 1369–1375.CrossRefPubMed
54.
Kaplan, R. N., Rafii, S., & Lyden, D. (2006). Preparing the “soil”: the premetastatic niche. Cancer Res, 66, 11089–11093.CrossRefPubMed
55.
Kaplan, R. N., Riba, R. D., Zacharoulis, S., Bramley, A. H., Vincent, L., Costa, C., et al. (2005). VEGFR1-positive haematopoietic bone marrow progenitors initiate the pre-metastatic niche. Nature, 438, 820–827.CrossRefPubMed
56.
Murdoch, C., Muthana, M., Coffelt, S. B., & Lewis, C. E. (2008). The role of myeloid cells in the promotion of tumour angiogenesis. Nat Rev Cancer, 8, 618–631.CrossRefPubMed
57.
Padua, D., Zhang, X. H., Wang, Q., Nadal, C., Gerald, W. L., Gomis, R. R., et al. (2008). TGFbeta primes breast tumors for lung metastasis seeding through angiopoietin-like 4. Cell, 133, 66–77.CrossRefPubMed
58.
Barleon, B., Sozzani, S., Zhou, D., Weich, H. A., Mantovani, A., & Marme, D. (1996). Migration of human monocytes in response to vascular endothelial growth factor (VEGF) is mediated via the VEGF receptor flt-1. Blood, 87, 3336–3343.PubMed
59.
Coussens, L. M., Tinkle, C. L., Hanahan, D., & Werb, Z. (2000). MMP-9 supplied by bone marrow-derived cells contributes to skin carcinogenesis. Cell, 103, 481–490.CrossRefPubMed
60.
Gocheva, V., Wang, H. W., Gadea, B. B., Shree, T., Hunter, K. E., Garfall, A. L., et al. (2010). IL-4 induces cathepsin protease activity in tumor-associated macrophages to promote cancer growth and invasion. Genes Dev, 24, 241–255.CrossRefPubMed
61.
Ding, T., Xu, J., Wang, F., Shi, M., Zhang, Y., Li, S. P., et al. (2009). High tumor-infiltrating macrophage density predicts poor prognosis in patients with primary hepatocellular carcinoma after resection. Hum Pathol, 40, 381–389.CrossRefPubMed
62.
Kuang, D. M., Zhao, Q., Peng, C., Xu, J., Zhang, J. P., Wu, C., et al. (2009). Activated monocytes in peritumoral stroma of hepatocellular carcinoma foster immune privilege and disease progression through PD-L1. J Exp Med, 206, 1327–1337.CrossRefPubMed
63.
Zhang, J. P., Yan, J., Xu, J., Pang, X. H., Chen, M. S., Li, L., et al. (2009). Increased intratumoral IL-17-producing cells correlate with poor survival in hepatocellular carcinoma patients. J Hepatol, 50, 980–989.CrossRefPubMed
64.
DeVita, V. T., Jr., & Costa, J. (2010). Toward a personalized treatment of Hodgkin's disease. N Engl J Med, 362, 942–943.CrossRefPubMed
65.
Steidl, C., Lee, T., Shah, S. P., Farinha, P., Han, G., Nayar, T., et al. (2010). Tumor-associated macrophages and survival in classic Hodgkin's lymphoma. N Engl J Med, 362, 875–885.CrossRefPubMed
66.
Chiodoni C, Colombo MP, Sangaletti S. Matricellular proteins: form homeostasis to inflammation, cancer and metastasis. Cancer Metastasis Reviews, in press (this issue).
Metadaten
Titel
Inflammation-mediated promotion of invasion and metastasis
verfasst von
Graziella Solinas
Federica Marchesi
Cecilia Garlanda
Alberto Mantovani
Paola Allavena
Publikationsdatum
01.06.2010
Verlag
Springer US
Erschienen in
Cancer and Metastasis Reviews / Ausgabe 2/2010
Print ISSN: 0167-7659
Elektronische ISSN: 1573-7233
DOI
https://doi.org/10.1007/s10555-010-9227-2

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