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Digestive Diseases and Sciences

Erschienen in:

01.09.2007 | Original Paper

Prokinetic Effects of a New Ghrelin Receptor Agonist TZP-101 in a Rat Model of Postoperative Ileus

verfasst von: Kalina Venkova, Graeme Fraser, Hamid R. Hoveyda, Beverley Greenwood-Van Meerveld

Erschienen in: Digestive Diseases and Sciences | Ausgabe 9/2007

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Abstract

Postoperative ileus (POI) is a major cause of postoperative complications and prolonged hospitalization. Ghrelin, which is the endogenous ligand for the growth hormone secretagogue receptor, has been found to stimulate gastric motility and accelerate gastric emptying. The present study investigates whether TZP-101 (0.03–1 mg/kg i.v.), a synthetic ghrelin-receptor agonist, could improve gastrointestinal transit in rats with POI. Since the main factors for the development of POI are the surgical manipulation and the gastrointestinal effects of opioid-receptor agonists used for pain management, the effect of TZP-101 was investigated in rats subjected to surgery, to morphine treatment (3 mg/kg s.c.), or to a combination of both. The results showed that TZP-101 is equally effective against the delayed gastrointestinal transit induced by surgery, by morphine, or by the combination of both interventions. The prokinetic action of TZP-101 was more pronounced in the stomach compared to the small intestine.

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Titel: Prokinetic Effects of a New Ghrelin Receptor Agonist TZP-101 in a Rat Model of Postoperative Ileus
verfasst von: Kalina Venkova
Graeme Fraser
Hamid R. Hoveyda
Beverley Greenwood-Van Meerveld
Publikationsdatum: 01.09.2007
Verlag: Springer US
Erschienen in: Digestive Diseases and Sciences / Ausgabe 9/2007
Print ISSN: 0163-2116
Elektronische ISSN: 1573-2568
DOI: https://doi.org/10.1007/s10620-007-9783-7

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