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Digestive Diseases and Sciences
Erschienen in: Digestive Diseases and Sciences 7/2015

01.07.2015 | Original Article

Impact of Radiofrequency Ablation on Malignant Biliary Strictures: Results of a Collaborative Registry

verfasst von: Reem Z. Sharaiha, Amrita Sethi, Kristen R. Weaver, Tamas A. Gonda, Raj J. Shah, Norio Fukami, Prashant Kedia, Nikhil A. Kumta, Carlos M. Rondon Clavo, Michael D. Saunders, Jorge Cerecedo-Rodriguez, Paola Figueroa Barojas, Jessica L. Widmer, Monica Gaidhane, William R. Brugge, Michel Kahaleh

Erschienen in: Digestive Diseases and Sciences | Ausgabe 7/2015

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Abstract

Background

Radiofrequency ablation of malignant biliary strictures has been offered for the last 3 years, but only limited data have been published.

Aim

To assess the safety, efficacy, and survival outcomes of patients receiving endoscopic radiofrequency ablation.

Methods

Between April 2010 and December 2013, 69 patients with unresectable neoplastic lesions and malignant biliary obstruction underwent 98 radiofrequency ablation sessions with stenting.

Results

A total of 69 patients (22 male, aged 66.1 ± 13.3) were included in the registry. The etiology of malignant biliary stricture included unresectable cholangiocarcinoma (n = 45), pancreatic cancer (n = 19), gallbladder cancer (n = 2), gastric cancer (n = 1), and liver metastasis from colon cancer (n = 3). Seventy-eight percentage of patients had prior chemotherapy. All strictures were stented post-radiofrequency ablation with either plastic stents or metal stents. The mean stricture length treated was 14.3 mm. There was a statistically significant improvement in stricture diameter post-ablation (p < 0.0001). The likelihood of stricture improvement was significantly greater in pancreatic cancer-associated strictures [RR 1.8 (95 % 1.03–5.38)]. Seven patients (10 %) had adverse events, not linked directly to radiofrequency ablation. Median survival was 11.46 months (6.2–25 months).

Conclusion

Radiofrequency ablation is effective and safe in malignant biliary obstruction and seems to be associated with improved survival.
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Metadaten
Titel
Impact of Radiofrequency Ablation on Malignant Biliary Strictures: Results of a Collaborative Registry
verfasst von
Reem Z. Sharaiha
Amrita Sethi
Kristen R. Weaver
Tamas A. Gonda
Raj J. Shah
Norio Fukami
Prashant Kedia
Nikhil A. Kumta
Carlos M. Rondon Clavo
Michael D. Saunders
Jorge Cerecedo-Rodriguez
Paola Figueroa Barojas
Jessica L. Widmer
Monica Gaidhane
William R. Brugge
Michel Kahaleh
Publikationsdatum
01.07.2015
Verlag
Springer US
Erschienen in
Digestive Diseases and Sciences / Ausgabe 7/2015
Print ISSN: 0163-2116
Elektronische ISSN: 1573-2568
DOI
https://doi.org/10.1007/s10620-015-3558-3

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