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Digestive Diseases and Sciences
Erschienen in: Digestive Diseases and Sciences 3/2017

29.12.2016 | Original Article

Prevalence of Restless Legs Syndrome in Patients with Inflammatory Bowel Disease

verfasst von: Ikuko Takahara, Fuminao Takeshima, Tatsuki Ichikawa, Toshihisa Matsuzaki, Hidetaka Shibata, Satoshi Miuma, Yuko Akazawa, Hisamitsu Miyaaki, Naota Taura, Kazuhiko Nakao

Erschienen in: Digestive Diseases and Sciences | Ausgabe 3/2017

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Abstract

Background and Aim

There has been increased interest in sleep disorders in patients with inflammatory bowel disease (IBD). Studies in North America and Europe reported that the prevalence of restless legs syndrome (RLS) is much higher in patients with Crohn’s disease (CD) than in the general population. The aim of this study was to reveal the prevalence and clinical features of RLS in Japanese patients with IBD and investigate the influence of RLS on sleep quality and quality of life (QOL).

Methods

The study included 80 outpatients with IBD who visited Nagasaki University Hospital between December 2012 and July 2014. All patients completed the international RLS study group rating scale, a validated measure of the presence of RLS. Sleep quality was assessed using the Japanese version of the Pittsburgh Sleep Quality Index (PSQI), and health-related QOL was assessed using the Japanese version of the 36-item short form healthy profile (SF-36) version 2.

Results

The prevalence of RLS in patients with IBD was 20%, including rates of 21.7% in patients with ulcerative colitis (UC) and 17.6% in patients with CD. Among patients with CD, the proportion of women and serum level of CRP were higher in the RLS group than in the non-RLS group. Among those with UC, there were no differences in clinical characteristics between the RLS and non-RLS groups. Patients in the RLS group slept significantly less well than those in the non-RLS group (PSQI > 5; 62.5 vs. 34.4%, P < 0.05). No significant relationships were observed between QOL indices and the presence of RLS (SF-36 physical score, 46.8 vs. 50.1; mental score, 43.8 vs. 45.7; role/social score, 48.1 vs. 49.2).

Conclusions

RLS occurs frequently in Japanese patients with UC as well as CD. RLS affects sleep quality but not QOL, and it should be considered one of the causes of sleep disturbance in patients with IBD.
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Metadaten
Titel
Prevalence of Restless Legs Syndrome in Patients with Inflammatory Bowel Disease
verfasst von
Ikuko Takahara
Fuminao Takeshima
Tatsuki Ichikawa
Toshihisa Matsuzaki
Hidetaka Shibata
Satoshi Miuma
Yuko Akazawa
Hisamitsu Miyaaki
Naota Taura
Kazuhiko Nakao
Publikationsdatum
29.12.2016
Verlag
Springer US
Erschienen in
Digestive Diseases and Sciences / Ausgabe 3/2017
Print ISSN: 0163-2116
Elektronische ISSN: 1573-2568
DOI
https://doi.org/10.1007/s10620-016-4420-y

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