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Inflammation
Erschienen in: Inflammation 2/2018

04.12.2017 | ORIGINAL ARTICLE

Anti-inflammatory Effects of Rosmarinic Acid in Lipopolysaccharide-Induced Mastitis in Mice

verfasst von: Kangfeng Jiang, Xiaofei Ma, Shuai Guo, Tao Zhang, Gan Zhao, Haichong Wu, Xiaoyan Wang, Ganzhen Deng

Erschienen in: Inflammation | Ausgabe 2/2018

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Abstract

Rosmarinic acid (RA), a type of food additives mainly extracted from rosemary, has been reported to possess anti-inflammatory activities in some previous studies. However, the effects of RA on lipopolysaccharide (LPS)-induced mastitis have not been reported. Here, we investigated the anti-inflammatory effects of RA on LPS-induced mastitis in mice and elucidated the potential mechanisms in mouse mammary epithelial cells (mMECs). RA treatment significantly ameliorated the mammary structural damage, and reduced the activity of myeloperoxidase. ELISA and qPCR results indicated that RA dose-dependently decreased the expression of TNF-α, IL-1β, and IL-6 both in tissues and mMECs. Furthermore, RA remarkably suppressed the protein levels of TLR4, MyD88, IRAK1, TRAF6, and p-IKKβ. In addition, RA was also found to inhibit LPS-induced NF-κB signaling pathway activation. These results suggest that RA effectively attenuates LPS-induced mastitis by inhibiting the TLR4/MyD88/NF-κB signaling pathway.
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Metadaten
Titel
Anti-inflammatory Effects of Rosmarinic Acid in Lipopolysaccharide-Induced Mastitis in Mice
verfasst von
Kangfeng Jiang
Xiaofei Ma
Shuai Guo
Tao Zhang
Gan Zhao
Haichong Wu
Xiaoyan Wang
Ganzhen Deng
Publikationsdatum
04.12.2017
Verlag
Springer US
Erschienen in
Inflammation / Ausgabe 2/2018
Print ISSN: 0360-3997
Elektronische ISSN: 1573-2576
DOI
https://doi.org/10.1007/s10753-017-0700-8

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