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Journal of Assisted Reproduction and Genetics
Erschienen in: Journal of Assisted Reproduction and Genetics 9/2012

01.09.2012 | Assisted Reproduction Technologies

Outcomes of day 3 embryo transfer with vitrification using Cryoleaf: a 3-year follow-up study

verfasst von: Xing-ling Wang, Xiao Zhang, Yao-qin Qin, Da-yong Hao, Hui-rong Shi

Erschienen in: Journal of Assisted Reproduction and Genetics | Ausgabe 9/2012

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Abstract

Objective

To compare success rates of vitrified-warmed with fresh and frozen-thawed ETs

Design

Retrospective.

Setting

Public fertility center.

Patient(s)

Cryopreserved- thawed/warmed ETs were included in this study. Fresh cycles, in which supernumerary embryos were cryopreserved, were set as the fresh control group.

Intervention(s)

Supernumerary day 3 embryos were cryopreserved by slow-freezing or vitrification and transferred after thawing or warming.

Main Outcome Measure(s)

Comparison of two cryopreservation techniques with respect to post-thaw survival of embryos, implantation and pregnancy rates, neonatal outcome, and congenital birth defects.

Results

A total of 962 fresh, 151 freezing-thawed and 300 vitrified-warmed cycles were included in this study. The survival and intact cell rates in the vitrification group were significantly higher compared with those in the slow freezing group (88.5 % vs 74.5 % and 86.6 % vs 64.0 %). The implantation, clinical pregnancy and live birth rates of the vitrification group were similar to the fresh and significant higher than slow freezing group. There were no significant differences in mean gestational age, birth weight, stillbirth, birth defects and the prevalence of neonatal diseases among three groups.

Conclusion

Vitrified-warmed ETs yield comparable outcomes with fresh ETs and is superior to frozen-thawed ETs regarding the survival rate and clinical outcomes.
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Metadaten
Titel
Outcomes of day 3 embryo transfer with vitrification using Cryoleaf: a 3-year follow-up study
verfasst von
Xing-ling Wang
Xiao Zhang
Yao-qin Qin
Da-yong Hao
Hui-rong Shi
Publikationsdatum
01.09.2012
Verlag
Springer US
Erschienen in
Journal of Assisted Reproduction and Genetics / Ausgabe 9/2012
Print ISSN: 1058-0468
Elektronische ISSN: 1573-7330
DOI
https://doi.org/10.1007/s10815-012-9814-y

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