Introduction
Materials and methods
Study design
Randomized controlled trial (RCT)
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Group A—97 embryos vitrified with Kitazato and warmed with Kitazato
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Group B—84 embryos vitrified with Kitazato and warmed with Sage
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Group C—62 embryos vitrified with Sage and warmed with Kitazato
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Group D—72 embryos vitrified with Sage and warmed with Sage
Cohort study (CS)
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Group KK—56 embryos vitrified with Kitazato and warmed with Kitazato
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Group KS—13 embryos vitrified with Kitazato and warmed with Sage
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Group SK—81 embryos vitrified with Sage and warmed with Kitazato
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Group SS—179 embryos vitrified with Sage and warmed with Sage
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Group SH—41 embryos vitrified with Sage and warmed with in-house kit
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Group HK—21 embryos vitrified with in-house kit and warmed with Kitazato
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Group HS—188 embryos vitrified with in-house kit and warmed with Sage
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Group HH—268 embryos vitrified with in-house kit and warmed with in-house kit
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Group eKK—91 embryos vitrified with Kitazato and warmed with Kitazato
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Group eKS—61 embryos vitrified with Kitazato and warmed with Sage
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Group eSK—26 embryos vitrified with Sage and warmed with Kitazato
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Group eSS—30 embryos vitrified with Sage and warmed with Sage
Controlled ovarian stimulation, oocyte retrieval, ICSI, and embryo culture
Donor oocytes
Vitrification/warming kits
Universal Vitrification procedure
Universal warming procedure
Endometrial preparation and embryo transfer
Statistical analysis
Results
Group A | Group B | Group C | Group D | |
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Mean female age (± SD) at freezing | 35.5 ± 4.3 | 35.9 ± 3.8 | 36.3 ± 4.4 | 35.5 ± 4.6 |
No. of surviving embryos/warmed embryos (%) | 96/97 (99.0) | 83/84 (98.8) | 61/62 (98.4) | 71/72 (98.6) |
No. of embryos implanted/embryos transferred (%) | 18/96 (18.8) | 15/83 (18.1) | 11/61 (18.0) | 16/71 (22.5) |
Group KK | Group KS | Group SK | Group SS | Group SH | Group HK | Group HS | Group HH | |
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Mean female age (± SD) at freezing | 36.0 ± 5.4 | 35.0 ± 5.1 | 37.4 ± 3.9 | 36.6 ± 4.5 | 36.3 ± 4.6 | 37.4 ± 3.9 | 37.0 ± 4.2 | 36.5 ± 4.3 |
No. of surviving embryos/warmed embryos (%) | 54/56 (96.4) | 13/13 (100) | 80/81 (98.8) | 174/179 (97.2) | 40/41 (97.6) | 20/21 (95.2) | 187/188 (99.5) | 261/268 (97.4) |
No. of embryos implanted/embryos transferred (%) | 11/54 (20.4) | 6/13 (46.2) | 14/80 (17.5) | 24/163 (14.7) | 12/40 (30.0) | 3/20 (15.0) | 26/179 (14.5) | 45/260 (17.3) |
Group eKK | Group eKS | Group eSK | Group eSS | |
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Mean female age (± SD) at freezing | 42.5 ± 5.5 | 38.8 ± 6.3 | 41.3 ± 4.8 | 39.5 ± 5.8 |
No. of surviving embryos/warmed embryos (%) | 91/91 (100) | 60/61 (98.4) | 26/26 (100) | 29/30 (96.7) |
No. of embryos implanted/transferred (%) | 13/91 (14.3) | 10/58 (17.2) | 4/26 (15.4) | 5/29 (17.2) |