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Metabolic Brain Disease

Erschienen in:

01.02.2015 | Review Article

PET and MR imaging of neuroinflammation in hepatic encephalopathy

verfasst von: Yun Yan Su, Gui Fen Yang, Guang Ming Lu, Shawn Wu, Long Jiang Zhang

Erschienen in: Metabolic Brain Disease | Ausgabe 1/2015

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Abstract

Neurological or psychiatric abnormalities associated with hepatic encephalopathy (HE) range from subclinical findings to coma. HE is commonly accompanied with the accumulation of toxic substances in bloodstream. The toxicity effect of hyperammonemia on astrocyte, such as the alteration in neurotransmission, oxidative stress, astrocyte swelling, is considered as an important factor in the pathogenesis of HE. Besides, neuroinflammation has captured more attention in the process of HE, but the mechanism of neuroinflammation leading to HE remains unclear. Molecular imaging techniques such as positron emission tomography (PET) and magnetic resonance imaging (MRI) targeting activated microglia and/ or other mediators appear to be promising noninvasive approaches to assess HE. This review focuses on novel imaging and therapy strategies of neuroinflammation in HE.

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Titel: PET and MR imaging of neuroinflammation in hepatic encephalopathy
verfasst von: Yun Yan Su
Gui Fen Yang
Guang Ming Lu
Shawn Wu
Long Jiang Zhang
Publikationsdatum: 01.02.2015
Verlag: Springer US
Erschienen in: Metabolic Brain Disease / Ausgabe 1/2015
Print ISSN: 0885-7490
Elektronische ISSN: 1573-7365
DOI: https://doi.org/10.1007/s11011-014-9633-1

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PET and MR imaging of neuroinflammation in hepatic encephalopathy

Abstract

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Niedriger diastolischer Blutdruck erhöht Risiko für schwere kardiovaskuläre Komplikationen

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