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11.02.2016 | Original Article

Increase of kisspeptin-positive cells in the hypothalamus of a rat model of polycystic ovary syndrome

verfasst von: Mika Kondo, Satoko Osuka, Akira Iwase, Tatsuo Nakahara, Ai Saito, Bayasula, Tomoko Nakamura, Maki Goto, Tomomi Kotani, Fumitaka Kikkawa

Erschienen in: Metabolic Brain Disease | Ausgabe 3/2016

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Abstract

Kisspeptin, a hypothalamic neuropeptide, is expressed in the arcuate nucleus (ARC) that is considered as the center of the gonadotropin-releasing hormone (GnRH)-pulse generator. We hypothesized that kisspeptin expressed in the ARC is implicated in the disturbance of the hypothalamus−pituitary−ovary axis observed in polycystic ovary syndrome (PCOS). To test this hypothesis, we evaluated the hormonal profiles, luteinizing hormone (LH) pulse, and ARC kisspeptin immunoreactivity in a PCOS rat model using the anti-progestin RU486. We found an alteration of the LH pulse, including a trend towards an increased mean LH concentration and area under the curve, and a significant upregulation of the mean LH pulse amplitude. Additionally, a higher number of kisspeptin-positive cells was observed in the ARC of RU486-treated rats than in the ARC of intact rats. These results suggest the possible involvement of hypothalamic kisspeptin in the hypothalamus−pituitary−ovary axis and therefore, in PCOS pathophysiology.

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Titel: Increase of kisspeptin-positive cells in the hypothalamus of a rat model of polycystic ovary syndrome
verfasst von: Mika Kondo
Satoko Osuka
Akira Iwase
Tatsuo Nakahara
Ai Saito
Bayasula
Tomoko Nakamura
Maki Goto
Tomomi Kotani
Fumitaka Kikkawa
Publikationsdatum: 11.02.2016
Verlag: Springer US
Erschienen in: Metabolic Brain Disease / Ausgabe 3/2016
Print ISSN: 0885-7490
Elektronische ISSN: 1573-7365
DOI: https://doi.org/10.1007/s11011-016-9807-0

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