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19.06.2021 | Review Article

Association between thyroid function and Alzheimer's disease: A systematic review

verfasst von: Paulina Belén Sepulveda Figueroa, Ana Flávia Fernandes Ferreira, Luiz Roberto Britto, Arlette Patricia Doussoulin, Andréa da Silva Torrão

Erschienen in: Metabolic Brain Disease | Ausgabe 7/2021

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Abstract

Alterations in metabolic parameters have been associated with an increased risk of dementia, among which thyroid function has gained great importance in Alzheimer's disease (AD) pathology in recent years. However, it remains unclear whether thyroid dysfunctions could influence and contribute to the beginning and/or progression of AD or if it results from AD. This systematic review was conducted to examine the association between thyroid hormone (TH) levels and AD. Medline, ISI Web of Science, EMBASE, Cochrane library, Scopus, Scielo, and LILACS were searched, from January 2010 to March 2020. A total of 17 articles were selected. The studies reported alterations in TH and circadian rhythm in AD patients. Behavior, cognition, cerebral blood flow, and glucose consumption were correlated with TH deficits in AD patients. Whether thyroid dysfunctions and AD have a cause-effect relationship was inconclusive, however, the literature was able to provide enough data to corroborate a relationship between TH and AD. Although further studies are needed in this field, the current systematic review provides information that could help future investigations.

Graphical abstract

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Titel: Association between thyroid function and Alzheimer's disease: A systematic review
verfasst von: Paulina Belén Sepulveda Figueroa
Ana Flávia Fernandes Ferreira
Luiz Roberto Britto
Arlette Patricia Doussoulin
Andréa da Silva Torrão
Publikationsdatum: 19.06.2021
Verlag: Springer US
Erschienen in: Metabolic Brain Disease / Ausgabe 7/2021
Print ISSN: 0885-7490
Elektronische ISSN: 1573-7365
DOI: https://doi.org/10.1007/s11011-021-00760-1

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Association between thyroid function and Alzheimer's disease: A systematic review

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