Skip to main content
Erschienen in: Pituitary 1/2007

01.03.2007 | Case Report

Temozolomide in the treatment of an invasive prolactinoma resistant to dopamine agonists

verfasst von: Lisa M. Neff, Michelle Weil, Alan Cole, Thomas R. Hedges, William Shucart, Donald Lawrence, Jay-Jiguang Zhu, Arthur S. Tischler, Ronald M. Lechan

Erschienen in: Pituitary | Ausgabe 1/2007

Einloggen, um Zugang zu erhalten

Abstract

Prolactinomas are common tumors of the anterior pituitary gland. While conventional therapies, including dopamine agonists, transsphenoidal surgery and radiotherapy, are usually effective in controlling tumor growth, some patients develop treatment-resistant tumors. In this report, we describe a patient with an invasive prolactinoma resistant to conventional therapy that responded to the administration of the alkylating agent, temozolomide.
Literatur
1.
Zurück zum Zitat Gillam M, Molitch M, Lombardi G, Colao A (2006) Advances in the treatment of prolactinomas. Endocrine Rev 27:485–534CrossRef Gillam M, Molitch M, Lombardi G, Colao A (2006) Advances in the treatment of prolactinomas. Endocrine Rev 27:485–534CrossRef
2.
3.
Zurück zum Zitat Saeger W, Farrell WE, Horvath E, Lloyd RV, Kovacs K, Watson RE Jr, Lindell EP (2004) Proloctin secreting adenoma. In: DeLellis R, Lloyd R, Heitz P (eds) WHO classification of tumours, pathology & genetics, tumours of endocrine organs. IARC Press, Lyon, pp 20–23 Saeger W, Farrell WE, Horvath E, Lloyd RV, Kovacs K, Watson RE Jr, Lindell EP (2004) Proloctin secreting adenoma. In: DeLellis R, Lloyd R, Heitz P (eds) WHO classification of tumours, pathology & genetics, tumours of endocrine organs. IARC Press, Lyon, pp 20–23
4.
Zurück zum Zitat Riss D, Jin L, Qian X, Bayliss J, Scheithauer B, Young WJ, Vidal S, Kovacs K, Raz A, Lloyd R (2003) Differential expression of galectin-3 in pituitary tumors. Cancer Res 63:2251–2255PubMed Riss D, Jin L, Qian X, Bayliss J, Scheithauer B, Young WJ, Vidal S, Kovacs K, Raz A, Lloyd R (2003) Differential expression of galectin-3 in pituitary tumors. Cancer Res 63:2251–2255PubMed
5.
Zurück zum Zitat Zhu Y, Shahinian H, Bonert V, Lim S, Heaney A (2004) OR 43–5 Temodar: novel treatment for pituitary carcinoma. In The Endocrine Society Annual Meeting Zhu Y, Shahinian H, Bonert V, Lim S, Heaney A (2004) OR 43–5 Temodar: novel treatment for pituitary carcinoma. In The Endocrine Society Annual Meeting
6.
Zurück zum Zitat Lim S, Shahinian H, Maya M, Yong W, Heaney A (2006) Temodar: novel treatment for pituitary carcinoma. Lancet Oncol 7:518–520PubMedCrossRef Lim S, Shahinian H, Maya M, Yong W, Heaney A (2006) Temodar: novel treatment for pituitary carcinoma. Lancet Oncol 7:518–520PubMedCrossRef
7.
Zurück zum Zitat Tsagarakis S, Grossman A, Plowman P, Jones A, Touzel R, Rees L, Wass J, Besser G (1991) Megavoltage pituitary irradiation in the management of prolactinomas: long-term follow-up. Clin Endocrinol 34:399–406 Tsagarakis S, Grossman A, Plowman P, Jones A, Touzel R, Rees L, Wass J, Besser G (1991) Megavoltage pituitary irradiation in the management of prolactinomas: long-term follow-up. Clin Endocrinol 34:399–406
8.
Zurück zum Zitat Tsang R, Brierley J, Panzarella T, Gospodarowicz M, Sutcliffe S, Simpson W (1996) Role of radiation therapy in clinical hormonally-active pituitary adenomas. Radiother Oncol 41:45–53PubMedCrossRef Tsang R, Brierley J, Panzarella T, Gospodarowicz M, Sutcliffe S, Simpson W (1996) Role of radiation therapy in clinical hormonally-active pituitary adenomas. Radiother Oncol 41:45–53PubMedCrossRef
9.
Zurück zum Zitat Brada M, Ajithkumar T, Minniti G (2004) Radiosurgery for pituitary adenomas. Clin Endocrinol 61:531–543CrossRef Brada M, Ajithkumar T, Minniti G (2004) Radiosurgery for pituitary adenomas. Clin Endocrinol 61:531–543CrossRef
10.
Zurück zum Zitat Garcia M, Kapcala L (1995) Growth of a microprolactinoma to a macroprolactinoma during estrogen therapy. J Endocrinol Invest 18:450–455PubMed Garcia M, Kapcala L (1995) Growth of a microprolactinoma to a macroprolactinoma during estrogen therapy. J Endocrinol Invest 18:450–455PubMed
11.
Zurück zum Zitat Molitch M (2002) Medical management of prolactin-secreting pituitary adenomas. Pituitary 5:55–65PubMedCrossRef Molitch M (2002) Medical management of prolactin-secreting pituitary adenomas. Pituitary 5:55–65PubMedCrossRef
13.
Zurück zum Zitat Karumakaran S, Page R, Wass J (2001) The effect of the menopause on prolactin levels in patients with hyperprolactinaemia. Clin Endocrinol 54:295–300CrossRef Karumakaran S, Page R, Wass J (2001) The effect of the menopause on prolactin levels in patients with hyperprolactinaemia. Clin Endocrinol 54:295–300CrossRef
14.
Zurück zum Zitat Kaptain G, Simmons N, Alden T, Lopes M, Vance M, Laws E (1999) Estrogen receptors in prolactinomas: a clinico-pathological study. Pituitary 1:91–98PubMedCrossRef Kaptain G, Simmons N, Alden T, Lopes M, Vance M, Laws E (1999) Estrogen receptors in prolactinomas: a clinico-pathological study. Pituitary 1:91–98PubMedCrossRef
15.
Zurück zum Zitat Lamberts S, Verleun T, Hofland L, Oosterom R (1986) Differences in the interaction between dopamine and estradiol on prolactin release by cultured normal and tumorous human pituitary cells. J Clin Endocrinol Metab 63:1342–1347PubMedCrossRef Lamberts S, Verleun T, Hofland L, Oosterom R (1986) Differences in the interaction between dopamine and estradiol on prolactin release by cultured normal and tumorous human pituitary cells. J Clin Endocrinol Metab 63:1342–1347PubMedCrossRef
16.
Zurück zum Zitat Volker W, Gehring W, Berning R, Schmidt R, Schneider J, von zur Muhlen A (1982) Impaired pituitary response to bromocriptine suppression: reversal after bromocriptine plus tamoxifen. Acta Endocrinol 101:491–500PubMed Volker W, Gehring W, Berning R, Schmidt R, Schneider J, von zur Muhlen A (1982) Impaired pituitary response to bromocriptine suppression: reversal after bromocriptine plus tamoxifen. Acta Endocrinol 101:491–500PubMed
17.
Zurück zum Zitat Lamberts S, Verleun T, Oosterom R (1982) Effect of tamoxifen administration on prolactin release by invasive prolactin-secreting pituitary adenomas. Neuroendocrinol 34:339–342 Lamberts S, Verleun T, Oosterom R (1982) Effect of tamoxifen administration on prolactin release by invasive prolactin-secreting pituitary adenomas. Neuroendocrinol 34:339–342
18.
Zurück zum Zitat Mouridsen H, Gershanovich M, Sun Y, Perez-Carrion R, Boni C, Monnier A, Apffelstaedt J, Smith R, Sleeboom H, Jaenicke F, Pluzanska A, Dank M, Becquart D, Bapsy P, Salminen E, Snyder R, Chaudri-Ross H, Lang R, Wyld P, Bhatnagar A (2004) Phase III study of letrozole versus tamoxifen as first-line therapy of advanced breast cancer in postmenopausal women: analysis of survival and update of efficacy from the International Letrozole Breast Cancer Group. J Clin Oncol 21:2101–2109CrossRef Mouridsen H, Gershanovich M, Sun Y, Perez-Carrion R, Boni C, Monnier A, Apffelstaedt J, Smith R, Sleeboom H, Jaenicke F, Pluzanska A, Dank M, Becquart D, Bapsy P, Salminen E, Snyder R, Chaudri-Ross H, Lang R, Wyld P, Bhatnagar A (2004) Phase III study of letrozole versus tamoxifen as first-line therapy of advanced breast cancer in postmenopausal women: analysis of survival and update of efficacy from the International Letrozole Breast Cancer Group. J Clin Oncol 21:2101–2109CrossRef
19.
Zurück zum Zitat Thurlimann B, Keshaviah A, Coates A, Mouridsen H, Mauriac L, Forbes J, Paridaens R, Castiglione-Gertsch M, Gelber R, Rabaglio M, Smith I, Wardly A, Price K, Goldhirsch A (2005) A comparison of letrozole and tamoxifen in postmenopausal women with early breast cancer. New Engl J Med 353:2747–2757PubMedCrossRef Thurlimann B, Keshaviah A, Coates A, Mouridsen H, Mauriac L, Forbes J, Paridaens R, Castiglione-Gertsch M, Gelber R, Rabaglio M, Smith I, Wardly A, Price K, Goldhirsch A (2005) A comparison of letrozole and tamoxifen in postmenopausal women with early breast cancer. New Engl J Med 353:2747–2757PubMedCrossRef
20.
Zurück zum Zitat Gilliam M, Middler S, Freed D, Molitch M (2002) The novel use of very high doses of cabergoline and a combination of testosterone and an aromatase inhibitor in the treatment of a giant prolactinoma. J Clin Endocrinol Metab 87:4447–4451CrossRef Gilliam M, Middler S, Freed D, Molitch M (2002) The novel use of very high doses of cabergoline and a combination of testosterone and an aromatase inhibitor in the treatment of a giant prolactinoma. J Clin Endocrinol Metab 87:4447–4451CrossRef
21.
22.
Zurück zum Zitat Lamberts S, Zweens M, Klijn J, van Vroonhoven C, Stefanko S, Del Pozo E (1986) The sensitivity of growth hormone and prolactin secretion to the somatostatin analogue SMS 201–995 in patients with prolactinomas and acromegaly. Clin Endocrinol 25:201–212 Lamberts S, Zweens M, Klijn J, van Vroonhoven C, Stefanko S, Del Pozo E (1986) The sensitivity of growth hormone and prolactin secretion to the somatostatin analogue SMS 201–995 in patients with prolactinomas and acromegaly. Clin Endocrinol 25:201–212
23.
Zurück zum Zitat Jaquet P, Ouafik L, Saveanu A, Gunz G, Fina F, Dufour H, Culler M, Moreau J (1999) Quantitative and functional expression of somatostatin receptor subtypes in human prolactinomas. J Clin Endocrinol Metab 84:3268–3276PubMedCrossRef Jaquet P, Ouafik L, Saveanu A, Gunz G, Fina F, Dufour H, Culler M, Moreau J (1999) Quantitative and functional expression of somatostatin receptor subtypes in human prolactinomas. J Clin Endocrinol Metab 84:3268–3276PubMedCrossRef
24.
Zurück zum Zitat Shimon I, Yan X, Taylor J, Weiss M, Culler M, Melmed S (1997) Somatostatin receptor (SSTR) subtype-selective analogues differentially suppress in vitro growth hormone and prolactin in human pituitary adenomas. Novel potential therapy for functional pituitary tumors. J Clin Invest 100:2386–2392 Shimon I, Yan X, Taylor J, Weiss M, Culler M, Melmed S (1997) Somatostatin receptor (SSTR) subtype-selective analogues differentially suppress in vitro growth hormone and prolactin in human pituitary adenomas. Novel potential therapy for functional pituitary tumors. J Clin Invest 100:2386–2392
25.
Zurück zum Zitat Hofland L, van der Hoek J, van Koetsveld P, de Herder W, Waaijers M, Sprij-Mooij D, Bruns C, Weckbecker G, Feelders R, van der Lely A, Beckers A, Lamberts S (2004) The novel somatostatin analog SOM230 is a potent inhibitor of hormone release by growth hormone- and prolactin-secreting pituitary adenomas in vitro. J Clin Endocrinol Metab 89:1577–1585PubMedCrossRef Hofland L, van der Hoek J, van Koetsveld P, de Herder W, Waaijers M, Sprij-Mooij D, Bruns C, Weckbecker G, Feelders R, van der Lely A, Beckers A, Lamberts S (2004) The novel somatostatin analog SOM230 is a potent inhibitor of hormone release by growth hormone- and prolactin-secreting pituitary adenomas in vitro. J Clin Endocrinol Metab 89:1577–1585PubMedCrossRef
26.
Zurück zum Zitat Grottoli S, Gasco V, Broglio F, Baldelli R, Ragazzoni F, Gallenca F, Mainolfi A, Prodam F, Muccioli G, Ghigo E (2006) Cortistatin-17 and somatostatin-14 display the same effects on growth hormone, prolactin, and insulin secretion in patients with acromegaly or prolactinoma. J Clin Endocrinol Metab 91:1595–1599PubMedCrossRef Grottoli S, Gasco V, Broglio F, Baldelli R, Ragazzoni F, Gallenca F, Mainolfi A, Prodam F, Muccioli G, Ghigo E (2006) Cortistatin-17 and somatostatin-14 display the same effects on growth hormone, prolactin, and insulin secretion in patients with acromegaly or prolactinoma. J Clin Endocrinol Metab 91:1595–1599PubMedCrossRef
27.
Zurück zum Zitat Rocheville M, Lange D, Kumar U, Patel S, Patel R, Patel Y (2000) Receptors for dopamine and somatostatin: formation of hetero-oligomers with enhanced functional activity. Science 288:154–157PubMedCrossRef Rocheville M, Lange D, Kumar U, Patel S, Patel R, Patel Y (2000) Receptors for dopamine and somatostatin: formation of hetero-oligomers with enhanced functional activity. Science 288:154–157PubMedCrossRef
28.
Zurück zum Zitat Seveanu A, Lavaque E, Gunz G, Barlier A, Kim S, Taylor J, Culler M, Enjalbert A, Jaquet P (2002) Demonstration of enhanced potency of a chimeric somatostatin-dopamine molecule, BIM-23A387, in suppressing growth hormone and prolactin secretion from human pituitary somatotroph adenoma cells. J Clin Endocrinol Metab 87:5545–5552CrossRef Seveanu A, Lavaque E, Gunz G, Barlier A, Kim S, Taylor J, Culler M, Enjalbert A, Jaquet P (2002) Demonstration of enhanced potency of a chimeric somatostatin-dopamine molecule, BIM-23A387, in suppressing growth hormone and prolactin secretion from human pituitary somatotroph adenoma cells. J Clin Endocrinol Metab 87:5545–5552CrossRef
29.
Zurück zum Zitat Kaltsas G, Mukherjee J, Plowman P, Monson J, Grossman A, Besser G (1998) The role of cytotoxic chemotherapy in the management of aggressive and malignant pituitary tumors. J Clin Endocrinol Metab 83:4233–4238PubMedCrossRef Kaltsas G, Mukherjee J, Plowman P, Monson J, Grossman A, Besser G (1998) The role of cytotoxic chemotherapy in the management of aggressive and malignant pituitary tumors. J Clin Endocrinol Metab 83:4233–4238PubMedCrossRef
30.
Zurück zum Zitat Hurel S, Harris P, McNicol A, Foster S, Kelly W, Baylis P (1997) Metastatic prolactinoma: effect of octreotide, cabergoline, carboplatin, and etoposide: immunocytochemical analysis of proto-oncogene expression. J Clin Endocrinol Metab 82:2962–2965PubMedCrossRef Hurel S, Harris P, McNicol A, Foster S, Kelly W, Baylis P (1997) Metastatic prolactinoma: effect of octreotide, cabergoline, carboplatin, and etoposide: immunocytochemical analysis of proto-oncogene expression. J Clin Endocrinol Metab 82:2962–2965PubMedCrossRef
31.
Zurück zum Zitat Kulke M, Stuart K, Enzinger P, Ryan D, Clark J, Muzikansky A, Vincitore M, Michelini A, Fuchs C (2006) Phase II study of temozolomide and thalidomide in patients with metastatic neuroendocrine tumors. J Clin Oncol 24:401–406PubMedCrossRef Kulke M, Stuart K, Enzinger P, Ryan D, Clark J, Muzikansky A, Vincitore M, Michelini A, Fuchs C (2006) Phase II study of temozolomide and thalidomide in patients with metastatic neuroendocrine tumors. J Clin Oncol 24:401–406PubMedCrossRef
32.
Zurück zum Zitat Bafaloukos D, Tsoutsos D, Kalofonos H, Chalkidou S, Panagiotou P, Linardou E, Briassoulis E, Efstathiou E, Polyzos A, Fountzilas G, Christodoulou C, Kouroussis C, Iconomou T, Gogas H (2005) Temozolomide and cisplatin versus temozolomide in patients with advanced melanoma: a randomized phase II study of the Hellenic Cooperative Oncology Group. Ann Oncol 16:950–957PubMedCrossRef Bafaloukos D, Tsoutsos D, Kalofonos H, Chalkidou S, Panagiotou P, Linardou E, Briassoulis E, Efstathiou E, Polyzos A, Fountzilas G, Christodoulou C, Kouroussis C, Iconomou T, Gogas H (2005) Temozolomide and cisplatin versus temozolomide in patients with advanced melanoma: a randomized phase II study of the Hellenic Cooperative Oncology Group. Ann Oncol 16:950–957PubMedCrossRef
33.
Zurück zum Zitat Nagasubramanian R, Dolan M (2003) Temozolomide: realizing the promise and potential. Curr Opin Oncol 15:412–418PubMedCrossRef Nagasubramanian R, Dolan M (2003) Temozolomide: realizing the promise and potential. Curr Opin Oncol 15:412–418PubMedCrossRef
34.
Zurück zum Zitat Hegi M, Diserens A, Godard S, Dietrich P, Regli L, Ostermann S, Otten P, Van Melle G, de Tribolet N, Stupp R (2004) Clinical trial substantiates the predictive value of O-6-methylguanine-DNA methyltransferase promoter methylation in glioblastoma patients treated with temozolomide. Clin Cancer Res 10:1871–1874PubMedCrossRef Hegi M, Diserens A, Godard S, Dietrich P, Regli L, Ostermann S, Otten P, Van Melle G, de Tribolet N, Stupp R (2004) Clinical trial substantiates the predictive value of O-6-methylguanine-DNA methyltransferase promoter methylation in glioblastoma patients treated with temozolomide. Clin Cancer Res 10:1871–1874PubMedCrossRef
35.
Zurück zum Zitat Roos W, Batista L, Naumann S, Wick W, Weller M, Menck C, Kaina B (2006) Apoptosis in malignant glioma cells triggered by the temozolomide-induced DNA lesion O6-methylguanine. Oncogene (advance online publication). doi:10.1038/sj.onc.1209785 Roos W, Batista L, Naumann S, Wick W, Weller M, Menck C, Kaina B (2006) Apoptosis in malignant glioma cells triggered by the temozolomide-induced DNA lesion O6-methylguanine. Oncogene (advance online publication). doi:10.1038/sj.onc.1209785
36.
Zurück zum Zitat Esteller M, Hamilton S, Burger P, Baylin S, Herman J (1999) Inactivation of the DNA repair gene O6-methylguanine-DNA methyltransferase by promoter hypermethylation is a common event in primary human neoplasia. Cancer Res 59:793–797PubMed Esteller M, Hamilton S, Burger P, Baylin S, Herman J (1999) Inactivation of the DNA repair gene O6-methylguanine-DNA methyltransferase by promoter hypermethylation is a common event in primary human neoplasia. Cancer Res 59:793–797PubMed
37.
Zurück zum Zitat Hegi M, Diserens A, Gorlia T, Hamou M, de Tribolet N, Weller M, Kros J, Hainfellner J, Mason W, Mariani L, Bromberg J, Hau P, Mirimanoff R, Cairncross J, Janzer R, Stupp R (2005) MGMT gene silencing and benefit from temozolomide in glioblastoma. N Engl J Med 352:997–1003PubMedCrossRef Hegi M, Diserens A, Gorlia T, Hamou M, de Tribolet N, Weller M, Kros J, Hainfellner J, Mason W, Mariani L, Bromberg J, Hau P, Mirimanoff R, Cairncross J, Janzer R, Stupp R (2005) MGMT gene silencing and benefit from temozolomide in glioblastoma. N Engl J Med 352:997–1003PubMedCrossRef
Metadaten
Titel
Temozolomide in the treatment of an invasive prolactinoma resistant to dopamine agonists
verfasst von
Lisa M. Neff
Michelle Weil
Alan Cole
Thomas R. Hedges
William Shucart
Donald Lawrence
Jay-Jiguang Zhu
Arthur S. Tischler
Ronald M. Lechan
Publikationsdatum
01.03.2007
Erschienen in
Pituitary / Ausgabe 1/2007
Print ISSN: 1386-341X
Elektronische ISSN: 1573-7403
DOI
https://doi.org/10.1007/s11102-007-0014-1

Weitere Artikel der Ausgabe 1/2007

Pituitary 1/2007 Zur Ausgabe

Leitlinien kompakt für die Innere Medizin

Mit medbee Pocketcards sicher entscheiden.

Seit 2022 gehört die medbee GmbH zum Springer Medizin Verlag

Reizdarmsyndrom: Diäten wirksamer als Medikamente

29.04.2024 Reizdarmsyndrom Nachrichten

Bei Reizdarmsyndrom scheinen Diäten, wie etwa die FODMAP-arme oder die kohlenhydratreduzierte Ernährung, effektiver als eine medikamentöse Therapie zu sein. Das hat eine Studie aus Schweden ergeben, die die drei Therapieoptionen im direkten Vergleich analysierte.

Notfall-TEP der Hüfte ist auch bei 90-Jährigen machbar

26.04.2024 Hüft-TEP Nachrichten

Ob bei einer Notfalloperation nach Schenkelhalsfraktur eine Hemiarthroplastik oder eine totale Endoprothese (TEP) eingebaut wird, sollte nicht allein vom Alter der Patientinnen und Patienten abhängen. Auch über 90-Jährige können von der TEP profitieren.

Niedriger diastolischer Blutdruck erhöht Risiko für schwere kardiovaskuläre Komplikationen

25.04.2024 Hypotonie Nachrichten

Wenn unter einer medikamentösen Hochdrucktherapie der diastolische Blutdruck in den Keller geht, steigt das Risiko für schwere kardiovaskuläre Ereignisse: Darauf deutet eine Sekundäranalyse der SPRINT-Studie hin.

Bei schweren Reaktionen auf Insektenstiche empfiehlt sich eine spezifische Immuntherapie

Insektenstiche sind bei Erwachsenen die häufigsten Auslöser einer Anaphylaxie. Einen wirksamen Schutz vor schweren anaphylaktischen Reaktionen bietet die allergenspezifische Immuntherapie. Jedoch kommt sie noch viel zu selten zum Einsatz.

Update Innere Medizin

Bestellen Sie unseren Fach-Newsletter und bleiben Sie gut informiert.