Introduction
Case report
History and clinical examination
Neuroimaging studies
Pituitary surgery, pathology and postoperative course
Radiation therapy and follow-up
Methods and results
Recognition of pituitary antigens by immunofluorescence
Recognition of pituitary and systemic antigens by immunoblotting
Spot | Tryptic peptide(s) | Protein name | ID | MW (kDa)a
| Protein location | Protein function |
---|---|---|---|---|---|---|
1 | FDTNSHNDDALLK | Growth hormone 1 | NP_000506 | 25 | Cytosol and granules | Promotes linear growth, influences protein, lipid, and sugar metabolism |
2 | KSAIDLEEMASGLNKR | Signal recognition particle 54 kDa | NP_003127 | 54 | Cytosol | Binds to the signal sequence of a secretory protein, like prolactin, as it emerges from the ribosome |
2,4 | MAENGDNEKMAALEAK | La autoantigen (Sjögren syndrome antigen B, SSB) | NP_003133 | 47 | Nucleus | Involved in RNA metabolism |
2 | IGSSLYALGTQDSTDICKF | Sorting nexin 6 | NP_689419 NP_067072 | 48 34 | Mainly in cytosol but also in nucleus upon signaling | Associates with the cytosolic face of endosomes and mediates retrograde transport of transmembrane cargo from endosomes to the trans-Golgi network. |
3 | TEAASDPQHPAASEGAAAAAASPPLLR | Vesicle amine transport protein 1 | NP_065978 | 42 | Membrane protein | Involved in vesicular transport |
4 | KDATNVGDEGGFAPNILENKE and KVVIGMDVAASEFFRS | Enolase 1, (alpha) | NP_001419 | 47 | Cytosol | Catalyzes the reversible dehydration of 2-phosphoglycerate into phosphoenolpyruvate, as part of glycolysis and gluconeogenesis |
5 | KPDTIEVQQMK and AQMVQEDLEK | Moesin | NP_002435 | 68 | Cytosol | Act as a cross-linker between plasma membranes and actin-based cytoskeletons |
6 | LALASLGYEK, LANQAADYFGDAFK, and LLDEEEATDNDLR | Programmed cell death 6 interacting protein | NP_037506 | 96 | Cytosol | Participates in programmed cell death |