nach oben

Erschienen in:

01.12.2014

Reducing Aggression and Impulsivity Through School-Based Prevention Programs: A Gene by Intervention Interaction

verfasst von: Rashelle J. Musci, Catherine P. Bradshaw, Brion Maher, George R. Uhl, Sheppard G. Kellam, Nicholas S. Ialongo

Erschienen in: Prevention Science | Ausgabe 6/2014

Einloggen, um Zugang zu erhalten

Abstract

A variety of school-based, universal preventive interventions have been developed to address behavioral and mental health problems. Unfortunately, few have been evaluated within the context of randomized controlled trials with long-term follow-up. Even fewer still have examined the potential genetic factors that may drive differential impact of the intervention. In the present analysis, we examine the extent to which the longitudinal effects of two elementary school-based interventions were moderated by the brain-derived neurotrophic factor (BDNF) gene, which has been linked with aggression and impulsive behaviors. The sample included 678 urban, primarily African American children who were randomly assigned along with their teachers to one of three first grade classroom conditions: classroom-centered (CC) intervention, Family School Partnership (FSP), or a control condition. The teacher ratings of the youth's aggressive and impulsive behavior were obtained at baseline and in grades 6–12. Single-nucleotide polymorphisms (SNPs) from the BDNF gene were extracted from the genome-wide data. Longitudinal latent trait–state–error models indicated a significant interaction between a particular profile of the BDNF SNP cluster (46 % of sample) and CC intervention on impulsivity (β = −.27, p < .05). A similar interaction was observed for the BDNF SNP cluster and the CC intervention on aggression (β = −.14, p < .05). The results suggest that the impacts of preventive interventions in early elementary school on late adolescent outcomes of impulsivity and aggression can be potentially modified by genetic factors, such as BDNF. However, replication of these results is necessary before firm conclusions can be drawn.

Nur mit Berechtigung zugänglich

Baron, R. M., & Kenny, D. A. (1986). The moderator–mediator variable distinction in social psychological research: Conceptual, strategic, and statistical considerations. Journal of Personality and Social Psychology, 51, 1173–1182. doi:10.1037/0022-3514.51.6.1173.CrossRefPubMed

Barrish, H. H., Saunders, M., & Wolf, M. M. (1969). Good behavior game: Effects of individual contingencies for group consequences on disruptive behavior in a classroom. Journal of Applied Behavior Analysis, 2, 119–124. doi:10.1901/jaba.1969.2-119.PubMedCentralCrossRefPubMed

Bradshaw, C. P., Zmuda, J. H., Kellam, S. G., & Ialongo, N. S. (2009). Longitudinal impact of two universal preventive interventions in first grade on educational outcomes in high school. Journal of Educational Psychology, 101, 926–937. doi:10.1037/a0016586.PubMedCentralCrossRefPubMed

Bradshaw, C. P., Schaeffer, C. M., Petras, H., & Ialongo, N. (2010). Predicting negative life outcomes from early aggressive-disruptive behavior trajectories: Gender differences in maladaptation across life domains. Journal of Youth and Adolescence, 39, 953–966. doi:10.1007/s10964-009-9442-8.CrossRefPubMed

Bradshaw, C. P., Goldweber, A., Fishbein, D., & Greenberg, M. T. (2012). Infusing developmental neuroscience into school-based preventive interventions: Implications and future directions. Journal of Adolescent Health, 51, S41–S47. doi:10.1016/j.jadohealth.2012.04.020.CrossRefPubMed

Brody, G. H., Beach, S. R. H., Philibert, R. A., Chen, Y., & Murry, V. M. (2009). Prevention effects moderate the association of 5-HTTLPR and youth risk behavior initiation: Gene × environment hypotheses tested via a randomized prevention design. Child Development, 80, 645–661. doi:10.1111/j.1467-8624.2009.01288.x.CrossRefPubMed

Canter, L., & Canter, M. (1991). Parents on your side: A comprehensive parent involvement program for teachers. Santa Monica: Lee Center.

Cleynen, I., Mahachie, J. J. M., Henckaerts, L., Van Moerkerche, W., Rutgeerts, P., Van Steen, K., & Vermeire, S. (2010). Molecular reclassification of Crohn's disease by cluster analysis of genetic variants. PloS One, 5, e12952. doi:10.1371/journal.pone.0012952.PubMedCentralCrossRefPubMed

Cole, D. A., Martin, N. C., & Steiger, J. H. (2005). Empirical and conceptual problems with longitudinal trait-state models: Introducing a trait-state-occasion model. Psychological Methods, 10, 3–20. doi:10.1037/1082-989X.10.1.3.CrossRefPubMed

Cole, D. A., Nolen-Hoeksema, S., Girgus, J., & Paul, G. (2006). Stress exposure and stress generation in child and adolescent depression: A latent trait-state-error approach to longitudinal analyses. Journal of Abnormal Psychology, 115, 40–51. doi:10.1037/0021-843X.115.1.40.CrossRefPubMed

DeYoung, C. G., & Clark, R. (2012). The gene in its natural habitat: The importance of gene-trait interactions. Development and Psychopathology, 24, 1307–1318. doi:10.1017/S0954579412000727.CrossRefPubMed

Ensminger, M. E., Forrest, C. B., Riley, A. W., Kang, M., Green, B. F., & Starfield, B. (2000). The validity of measures of socioeconomic status of adolescents. Journal of Adolescent Research, 15, 392–419. doi:10.1177/0743558400153005.CrossRef

Gizer, I. R., Ficks, C., & Waldman, I. D. (2009). Candidate gene studies of ADHD: A meta-analytic review. Human Genetics, 126, 51–90. doi:10.1007/s00439-009-0694-x.CrossRefPubMed

Guillin, O., Diaz, J., Carroll, P., Griffon, N., Schwartz, J. C., & Sokoloff, P. (2001). BDNF controls dopamine D₃ receptor expression and triggers behavioral sensitization. Nature, 411, 86–89.CrossRefPubMed

Howe, G. W., Beach, S. R. H., & Brody, G. H. (2010). Microtrial methods for translating gene environment dynamics into preventive interventions. Prevention Science, 11, 343–354. doi:10.1007/s11121-010-0177-2.PubMedCentralCrossRefPubMed

Ialongo, N. S., Werthamer, L., Kellam, S. G., Brown, C. H., Wang, S., & Lin, Y. (1999). Proximal impact of two first-grade preventive interventions on the early risk behaviors for later substance abuse, depression, and antisocial behavior. American Journal of Community Psychology, 27, 599–641. doi:10.1023/A:1022137920532.CrossRefPubMed

Ialongo, N., Poduska, J., Werthamer, L., & Kellam, S. (2001). The distal impact of two first grade preventive interventions on conduct problems and disorder in early adolescence. Journal of Emotional and Behavioral Disorders, 9, 146–160. doi:10.1177/106342660100900301.CrossRef

Ialongo, N., Rogosch, F. A., Cicchetti, D., Toth, S. L., Buckley, J., Petras, H., & Neiderhiser, J. (2006). A developmental psychopathology approach to the prevention of mental health disorders. In D. Cicchetti & D. Cohen (Eds.), Developmental psychopathology (Theory and method 2nd ed., Vol. 1, pp. 968–1018). New York: Wiley Press.

Institute of Education Sciences. (2011). The Nation's Report Card: Trial Urban District Assessment Reading 2011. Retrieved from http://nces.ed.gov/pubsearch/pubsinfo.asp?pubid=2012455.

Institute of Education Sciences. (2012). Fast Facts. Retrieved from http://nces.ed.gov/fastfacts/display.asp?id=16.

Ito, W., Chehab, M., Thakur, S., Li, J., & Morozov, A. (2011). BDNF-restricted knockout mice as an animal model for aggression. Genes, Brain and Behavior, 10, 365–374. doi:10.1111/j.1601-183X.2010.00676.x.CrossRef

Jo, B. (2002). Model misspecification sensitivity analysis in estimating causal effects of interventions with non-compliance. Statistics in Medicine, 21, 3161–3181. doi:10.1002/sim.1267.CrossRefPubMed

Kellam, S. G., Brown, C. H., Poduska, J. M., Ialongo, N., Wang, W., Toyinbo, P., & Wilcox, H. C. (2008). Effects of a universal classroom behavior management program in first and second grades on young adult behavioral, psychiatric, and social outcomes. Drug and Alcohol Dependence, 95, S5–S28. doi:10.1016/j.drugalcdep.2008.01.004.PubMedCentralCrossRefPubMed

Kenny, D. A., & Zautra, A. (1995). The trait-state-error model for multiwave data. Journal of Consulting and Clinical Psychology, 63, 52–59. doi:10.1037/0022-006X.63.1.52.

Lasky-Su, J., Faraone, S. V., Lange, C., Tsuang, M. T., Doyle, A. E., Smoller, J. W., & Biederman, J. (2007). A study of how socioeconomic status moderates the relationship between SNPs encompassing BDNF and ADHD symptom counts in ADHD families. Behavior Genetics, 37, 487–497. doi:10.1007/s10519-006-9136-x.CrossRefPubMed

Lee, J., Laurin, N., Crosbie, J., Ickowicz, A., Pathare, T., Malone, M., & Carr, C. L. (2007). Association study of the brain-derived neurotropic factor (BDNF) gene in attention deficit hyperactivity disorder. American Journal of Medical Genetics, 144B, 976–981. doi:10.1002/ajmg.b.30437.CrossRefPubMed

Moffitt, T. E. (2006). Life-course persistent versus adolescent-limited antisocial behavior. In D. Cicchetti & D. Cohen (Eds.), Developmental psychopathology (Risk, disorder, and adaptation 2nd ed., Vol. 3, pp. 570–598). New York: Wiley Press.

Muthén, B. (2001). Second-generation structural equation modeling with a combination of categorical and continuous latent variables: New opportunities for latent class/latent growth modeling. In L. M. Collins & A. Sayer (Eds.), New methods for the analysis of change (pp. 291–322). Washington: American Psychological Association.CrossRef

Muthén, L. K., & Muthén, B. O. (1998–2011). Mplus user's guide (7th ed.). Los Angeles, CA: Author.

Muthén, B., & Shedden, K. (1999). Finite mixture modeling with mixture outcomes using the EM algorithm. Biometrics, 55, 463–469. doi:10.1111/j.0006-341X.1999.00463.x.CrossRefPubMed

Oades, R. D., Lasky-Su, J., Christiansen, H., Farone, S. V., Sonuga-Barke, E. J. S., Banaschewski, T., & Asherson, P. (2008). The influence of serotonin and other genes on impulsive behavioral aggression and cognitive impulsivity in children with attention-deficit/hyperactivity disorder (ADHD): Findings from a family-based association test (FBAT) analysis. Behavioral and Brain Functions, 4, 48. doi:10.1186/1744-9081-4-48.PubMedCentralCrossRefPubMed

Olatunji, B. O., & Cole, D. A. (2009). The longitudinal structure of general and specific anxiety dimensions in children: Testing a latent trait-state-occasion model. Psychological Assessment, 21, 412–424. doi:10.1037/a0016206.CrossRefPubMed

Patterson, G. R., Reid, J., & Dishion, T. (1992). A Social Learning Approach: IV. Antisocial Boys. Eugene: Castalia Press.

Perie, M., Grigg, W. S., Donahue, P. L. (2006). The Nation's Report Card: Reading 2005. Retrieved from http://nces.ed.gov/nationsreportcard/pubs/main2005/2006451.asp

Petras, H., Chilcoat, H. D., Leaf, P. J., Ialongo, N. S., & Kellam, S. G. (2004). Utility of TOCA-R scores during the elementary school years in identifying later violence among adolescent males. Journal of the American Academy of Child and Adolescent Psychiatry, 43, 88–96. doi:10.1097/00004583-200401000-00018.CrossRefPubMed

Petras, H., Masyn, K., & Ialongo, N. (2011). The developmental impact of two first grade preventive interventions on aggressive/disruptive behavior in childhood and adolescence: an application of latent transition growth mixture modeling. Prevention Science, 12, 300–313. doi:10.1007/s11121-011-0216-7.PubMedCentralCrossRefPubMed

Purcell, S., Neale, B., Todd-Brown, K., Thomas, L., Ferreira, M. A. R., Bender, D., & Sham, P. C. (2007). PLINK: A tool set for whole-genome association and population-based linkage analyses. American Journal of Human Genetics, 81, 559–575. doi:10.1086/519795.PubMedCentralCrossRefPubMed

Rutter, M. (1985). Resilience in the face of adversity: Protective factors and resistance to psychiatric disturbance. British Journal of Psychiatry, 147, 598–611. doi:10.1192/bjp.147.6.598.CrossRefPubMed

Schafer, J. L., & Graham, J. W. (2002). Missing data: Our view of the state of the art. Psychological Medicine, 7, 611–622. doi:10.1037//1082-989X.7.2.147.

Spalletta, G., Morris, D. W., Angelucci, F., Rubino, I. A., Spoletini, I., Bria, P., & Corvin, A. P. (2009). BDNF Val66Met polymorphism is associated with aggressive behavior in schizophrenia. European Journal of Psychiatry, 25, 311–313. doi:10.1016/j.eurpsy.2009.10.008.CrossRef

Uhl, G. R., Walther, D., Musci, R., Fisher, C., Anthony, J. C., Storr, C. L., & Rose, J. E. (2012). Smoking quit success genotype score predicts quit success and distinct patterns of developmental involvement with common addictive substances. Molecular Psychiatry. doi:10.1038/mp.2012.155.PubMedCentralPubMed

Wagner, S., Baskaya, O., Dahmen, N., Lieb, K., & Tadić, A. (2010). Modulatory role of the brain-derived neurotrophic factor Val66Met polymorphism on the effects of serious life events on impulsive aggression in borderline personality disorder. Genes, Brain and Behavior, 9, 97–102. doi:10.1111/j.1601-183X.2009.00539.x.CrossRef

Webster-Stratton, C. (1984). Randomized trial of two parent-training programs for families with conduct-disordered children. Journal of Consulting and Clinical Psychology, 52, 666–678. doi:10.1037//0022-006X.52.4.666.CrossRefPubMed

Werthamer-Larsson, L., Kellam, S., & Wheeler, L. (1991). Effect of first-grade classroom environment on shy behavior, aggressive behavior, and concentration problems. American Journal of Community Psychology, 19, 585–602. doi:10.1007/BF00937993.CrossRefPubMed

Wilson, S. J., & Lipsey, M. W. (2007). School-based interventions for aggressive and disruptive behavior: Update of a meta-analysis. American Journal of Preventive Medicine, 33, S130–S143. doi:10.1016/j.amepre.2007.04.011.PubMedCentralCrossRefPubMed

Titel: Reducing Aggression and Impulsivity Through School-Based Prevention Programs: A Gene by Intervention Interaction
verfasst von: Rashelle J. Musci
Catherine P. Bradshaw
Brion Maher
George R. Uhl
Sheppard G. Kellam
Nicholas S. Ialongo
Publikationsdatum: 01.12.2014
Verlag: Springer US
Erschienen in: Prevention Science / Ausgabe 6/2014
Print ISSN: 1389-4986
Elektronische ISSN: 1573-6695
DOI: https://doi.org/10.1007/s11121-013-0441-3

Live-Webinar "Chronische Unterbauch- und Viszeralschmerzen in der Praxis managen"

Springer Medizin

Reducing Aggression and Impulsivity Through School-Based Prevention Programs: A Gene by Intervention Interaction

Abstract

Live-Webinar "Chronische Unterbauch- und Viszeralschmerzen in der Praxis managen"

Springer Medizin

Abstract

Bitte loggen Sie sich ein, um Zugang zu diesem Inhalt zu erhalten

Weitere Artikel der Ausgabe 6/2014

Analogue Study of Peer Influence on Risk-Taking Behavior in Older Adolescents

Fit for Purpose: A Form and Function-Based Taxonomy for Prevention is Arguably More Refined, Accurate, and Predictive

Commentary on Crowley et al.’s Research Priorities for Economic Analysis of Prevention

Understanding Proximal–Distal Economic Projections of the Benefits of Childhood Preventive Interventions

Preventing Internalizing Symptoms Among Hispanic Adolescents: A Synthesis Across Familias Unidas Trials

Erratum to: Reducing Aggression and Impulsivity Through School-Based Prevention Programs: A Gene by Intervention Interaction