nach oben

Journal of Thrombosis and Thrombolysis

Erschienen in:

09.11.2017

Medicinal plants with antithrombotic property in Persian medicine: a mechanistic review

verfasst von: Zahra Memariani, Reihaneh Moeini, Shokooh Sadat Hamedi, Narjes Gorji, Seyyed Ali Mozaffarpur

Erschienen in: Journal of Thrombosis and Thrombolysis | Ausgabe 1/2018

Einloggen, um Zugang zu erhalten

Abstract

Thrombosis is one of the major causes of morbidity and mortality in a wide range of vessels diseases. Due to the high prevalence of thromboembolic disorders investigations are being carried out on new antithrombotic agents with limited adverse side effects in which herbal medicines are considered as alternative remedies. Persian medicine (PM) as a traditional medicine has a good potential for pharmacotherapy based on its own principles and development of drugs via investigating PM literature. In PM manuscripts there are some concepts that express the management of blood clots and antithrombotic properties. This study reviewed the pharmacological effects of medicinal plants mentioned in PM literature for blood clot management in light of current knowledge. Plants mentioned in PM for management of blood clot belong to 12 families in which Apiaceae, Lamiaceae and Compositae were the most repeated ones. Among the proposed plants Allium sativum, Rosmarinus officinalis, Boswellia serrata, Sesamum indicum, Matricaria chamomilla and Carthamus tinctorius have been the most researched plants in modern antithrombotic studies while for some plants such as Helichrysum stoechas, Dracocephalum kotschi, Carum carvi, Bunium persicum and Lagoecia cuminoides no evidence could be found. One of the interesting notes in clot management in PM texts was introducing the target organ for some of the recommended herbs like Carum carvi and Bunium persicum for dissolving blood clot in stomach and Commiphora mukul for thrombosed hemorrhoid. It seems review of PM recommendations can help to design future researches for antithrombotic drugs discovering with more effectiveness and safety.

Kitchens CS, Konkle BA, Kessler CM (2013) Consultative hemostasis and thrombosis. Elsevier, New York

Rosendaal FR, Raskob GE (2014) On world thrombosis day. Lancet 384(9955):1653–1654CrossRef

Raskob GE, Angchaisuksiri P, Blanco AN, Büller H, Gallus A, Hunt BJ et al (2014) (eds) Thrombosis: a major contributor to global disease burden. Seminars in thrombosis and hemostasis. Thieme Medical Publishers, Stuttgart

Tognolini M, Barocelli E, Ballabeni V, Bruni R, Bianchi A, Chiavarini M et al (2006) Comparative screening of plant essential oils: phenylpropanoid moiety as basic core for antiplatelet activity. Life Sci 78(13):1419–1432PubMedCrossRef

Saluk-Juszczak J, Pawlaczyk I, Olas B, Kołodziejczyk J, Ponczek M, Nowak P et al (2010) The effect of polyphenolic-polysaccharide conjugates from selected medicinal plants of Asteraceae family on the peroxynitrite-induced changes in blood platelet proteins. Int J Biol Macromol 47(5):700–705PubMedCrossRef

Mekhfi H, El Haouari M, Legssyer A, Bnouham M, Aziz M, Atmani F et al (2004) Platelet anti-aggregant property of some Moroccan medicinal plants. J Ethnopharmacol 94(2):317–322PubMedCrossRef

Kwon E-K, Kim Y-E, Lee C-H, Kim H-Y (2006) Screening of nine herbs with biological activities on ACE inhibition, HMG-CoA reductase inhibition, and fibrinolysis. Korean J Food Sci Technol 38:691–698

Kontogiorgis C, Nicolotti O, Mangiatordi GF, Tognolini M, Karalaki F, Giorgio C et al (2015) Studies on the antiplatelet and antithrombotic profile of anti-inflammatory coumarin derivatives. J Enzyme Inhibition Med Chem 30(6):925–933CrossRef

Lee W, Lee J, Kulkarni R, Kim M-A, Hwang JS, Na M et al (2016) Antithrombotic and antiplatelet activities of small-molecule alkaloids from Scolopendra subspinipes mutilans. Sci Rep 6:21956PubMedPubMedCentralCrossRef

10.

Seo EJ, Ngoc TM, Lee S-M, Kim YS, Jung Y-S (2012) Chrysophanol-8-O-glucoside, an anthraquinone derivative in rhubarb, has antiplatelet and anticoagulant activities. J Pharmacol Sci 118(2):245–254PubMedCrossRef

11.

Yoo H, Ku S-K, Lee W, Kwak S, Baek Y-D, Min B-W et al (2014) Antiplatelet, anticoagulant, and profibrinolytic activities of cudratricusxanthone A. Arch Pharm Res 37(8):1069–1078PubMedCrossRef

12.

Giordanetto F, Wållberg A, Ghosal S, Iliefski T, Cassel J, Yuan Z-Q et al (2012) Discovery of phosphoinositide 3-kinases (PI3K) p110β isoform inhibitor 4-[2-hydroxyethyl (1-naphthylmethyl) amino]-6-[(2S)-2-methylmorpholin-4-yl]-1H-pyrimidin-2-one, an effective antithrombotic agent without associated bleeding and insulin resistance. Bioorg Med Chem Lett 22(21):6671–6676PubMedCrossRef

13.

Yang N-Y, Tao W-W, Duan J-A (2010) Antithrombotic flavonoids from the faeces of Trogopterus xanthipes. Nat Prod Res 24(19):1843–1849PubMedCrossRef

14.

Messina F, Guglielmini G, Curini M, Orsini S, Gresele P, Marcotullio MC (2015) Effect of substituted stilbenes on platelet function. Fitoterapia 105:228–233PubMedCrossRef

15.

Moeini R, Memariani Z, Pasalar P, Gorji N (2017) Historical root of precision medicine: an ancient concept concordant with the modern pharmacotherapy. DARU J Pharm Sci 25(1):7CrossRef

16.

Moeini R, Gorji N, Ghods R, Mozaffarpur S (2017) Quantitative and qualitative assessment of persian medicine articles indexed in pubmed by the end of 2015. JBUMS 19(1):21–26

17.

Aghili Shirazi SMH (1992) Makhzan-ol-Advieh [Storehouse of medicaments]. Intisharat va Amoozesh Enghelab Islami Press, Tehran

18.

Avicenna (2010) Qanoon fi al Tib [Canon of Medicine]. Ehyaol Toras al-Arabi Press, Beirut

19.

Jorjani S-H (2010) Zakhire Kharazmshahi [Treasure of Kharazm]. Moaseseh Ehyae Tebe Tabiei, Qom

20.

Razes AH (2001) Al Havi [Liber continent]. Ehyaol Toras al-Arabi, Beiruot

21.

Arzani M (2008) Teb-e-Akbari [Akbari’s medicine]. Ehya Teb e Tabiee, Tehran

22.

Bordia A, Arora S, Kothari L, Jain K, Rathore B, Rathore A et al (1975) The protective action of essential oils of onion and garlic in cholesterol-fed rabbits. Atherosclerosis 22(1):103–109PubMedCrossRef

23.

Ali M, Mohammed SY (1986) Selective suppression of platelet thromboxane formation with sparing of vascular prostacyclin synthesis by aqueous extract of garlic in rabbits. Prostaglandin Leukotr Med 25(2):139–146CrossRef

24.

El-Sabban F, Fahim M, Radwan G, Zaghloul S, Singh S (1996) Garlic preserves patency and delays hyperthermia-induced thrombosis in pial microcirculation. Int J Hyperth 12(4):513–525CrossRef

25.

Ali M (1995) Mechanism by which garlic (Allium sativum) inhibits cyclooxygenase activity. Effect of raw versus boiled garlic extract on the synthesis of prostanoids. Prostaglandin Leukotr Essent Fatty Acids 53(6):397–400CrossRef

26.

Setorki M, Rafieian-Kopaei M, Merikhi A, Heidarian E, Shahinfard N, Ansari R et al (2013) Suppressive impact of anethum graveolens consumption on biochemical risk factors of atherosclerosis in hypercholesterolemic rabbits. Int J Prevent Med 4(8)

27.

Olajide OA (1999) Investigation of the effects of selected medicinal plants on experimental thrombosis. Phytother Res 13(3):231–232PubMedCrossRef

28.

Tawfik MK (2016) Anti-aggregatory effect of boswellic acid in high-fat fed rats: involvement of redox and inflammatory cascades. Arch Med Sci 12(6):1354PubMedPubMedCentralCrossRef

29.

Pan Y-N, Liang X-X, Niu L-Y, Wang Y-N, Tong X, Hua H-M et al (2015) Comparative studies of pharmacokinetics and anticoagulatory effect in rats after oral administration of Frankincense and its processed products. J Ethnopharmacol 172:118–123PubMedCrossRef

30.

Ding T-b, Jian L-g, Zhao J-t, Liu S-c, Zhang J-y, Wu SH (2015) Ethanol extract of Carthamus tinctorius L. shows anti-thrombosis activity in rats. Afr J Tradl Complement Altern Med (AJTCAM) 12(3):120–124CrossRef

31.

Li H-X, Han S-Y, Wang X-W, Ma X, Zhang K, Wang L et al (2009) Effect of the carthamins yellow from Carthamus tinctorius L. on hemorheological disorders of blood stasis in rats. Food Chem Toxicol 47(8):1797–1802PubMedCrossRef

32.

Wu SH, Zheng CP, Chen SY, Cai XP, Shi YJ, Liu Z et al (2014) Anti-thrombotic effect of Carthamus tinctorius linn extracts in rats. Trop J Pharm Res 13(10):1637–1640CrossRef

33.

Gebhard C, Stämpfli SF, Gebhard CE, Akhmedov A, Breitenstein A, Camici GG et al (2009) Guggulsterone, an anti-inflammatory phytosterol, inhibits tissue factor and arterial thrombosis. Basic Res Cardiol 104(3):285–294PubMedCrossRef

34.

Yamamoto J, Naemura A, Ijiri Y, Ogawa K, Suzuki T, Shimada Y et al (2008) The antithrombotic effects of carrot filtrates in rats and mice. Blood Coagul Fibrinol 19(8):785–792CrossRef

35.

Potey L, Kannao S, Kosalge S (2015) Evaluation of coagulant and anti coagulant activity of some spices. Am J Pharm Res 5(01)

36.

Zhang L, Du JR, Wang J, Yu DK, Chen YS, He Y et al (2009) Z-ligustilide extracted from Radix Angelica Sinensis decreased platelet aggregation induced by ADP ex vivo and arterio-venous shunt thrombosis in vivo in rats. J Pharm Soc Japn 129(7):855–859CrossRef

37.

Zhong J, Pollastro F, Prenen J, Zhu Z, Appendino G, Nilius B (2011) Ligustilide: a novel TRPA1 modulator. Eur J Physiol 462(6):841–849CrossRef

38.

Choi JH, Kim YS, Shin CH, Lee HJ, Kim S (2015) Antithrombotic activities of luteolin in vitro and in vivo. J Biochem Mol Toxicol 29(12):552–558PubMedCrossRef

39.

Makino T, Ono T, Liu N, Nakamura T, Muso E, Honda G (2002) Suppressive effects of rosmarinic acid on mesangioproliferative glomerulonephritis in rats. Nephron 92(4):898–904PubMedCrossRef

40.

Naemura A, Ura M, Yamashita T, Arai R, Yamamoto J (2008) Long-term intake of rosemary and common thyme herbs inhibits experimental thrombosis without prolongation of bleeding time. Thromb Res 122(4):517–522PubMedCrossRef

41.

Yamamoto J, Yamada K, Naemura A, Yamashita T, Arai R (2005) Testing various herbs for antithrombotic effect. Nutrition 21(5):580–587PubMedCrossRef

42.

Kinugasa C, Naemura A, Hyodo K, Nakai Y, Katsuta M, Yamamoto J (2011) Experimental antithrombotic effects of sesame seed whole grains and extracts. Blood Coagul Fibrinol 22(6):526–531CrossRef

43.

Rajput MA, Khan RA, Qazi N, Feroz Z (2012) Effect of methanol extract of ajwain (Trachyspermum ammi L.) on blood coagulation in rats. J Liaquat Univ Med Health Sci 11(2):105–108

44.

Ansari F, Naderi G, Sadegh Sabet M, Karimi A (2012) Study of garlic effect on fibrinolytic activity of the blood clot in vitro. Iran J Pediatr Hematol Oncol 2(1)

45.

Gaffen J, Tavares I, Bennett A (1984) The effect of garlic extracts on contractions of rat gastric fundus and human platelet aggregation. J Pharm Pharmacol 36(4):272–274PubMedCrossRef

46.

Ali M, Bordia T, Mustafa T (1999) Effect of raw versus boiled aqueous extract of garlic and onion on platelet aggregation. Prostaglandin Leukotr Essent Fatty Acids (PLEFA) 60(1):43–47CrossRef

47.

Rahman K, Lowe GM (2006) Garlic and cardiovascular disease: a critical review. J Nutr 136(3):736S-40S

48.

Mohammad SF, Woodward SC (1986) Characterization of a potent inhibitor of platelet aggregation and release reaction isolated from Allium sativum (garlic). Thromb Res 44(6):793–806PubMedCrossRef

49.

Konić-Ristić A, Srdić-Rajić T, Kardum N, Aleksić-Veličković V, Kroon PA, Hollands WJ et al (2013) Effects of bioactive-rich extracts of pomegranate, persimmon, nettle, dill, kale and Sideritis and isolated bioactives on arachidonic acid induced markers of platelet activation and aggregation. J Sci Food Agric 93(14):3581–3587PubMedCrossRef

50.

Sowbhagya H (2014) Chemistry, technology, and nutraceutical functions of celery (Apium graveolens L.): an overview. Crit Rev Food Sci Nutr 54(3):389–398PubMedCrossRef

51.

Khan IN, Habib MR, Rahman MM, Mannan A, Sarker MMI, Hawlader S (2011) Thrombolytic potential of Ocimum sanctum L., Curcuma longa L., Azadirachta indica L. and Anacardium occidentale L. J Basic Clin Pharm 2(3):125–127PubMedPubMedCentral

52.

Kokkiripati PK, Bhakshu LM, Marri S, Padmasree K, Row AT, Raghavendra AS et al (2011) Gum resin of Boswellia serrata inhibited human monocytic (THP-1) cell activation and platelet aggregation. J Ethnopharmacol 137(1):893–901PubMedCrossRef

53.

Wang M, Chen M, Ding Y, Zhu Z, Zhang Y, Wei P et al (2015) Pretreatment with β-boswellic acid improves blood stasis induced endothelial dysfunction: role of eNOS activation. Sci Rep 5

54.

Ruan J, Yan L, Zhang L, Tao L, Wang A-y, Chen W et al (2012) Comparative effects of Hirudo, Frankincense and Motherwort on the inhibition of blood platelet aggregation and P-selectin secretion. J Med Plants Res 6(13):2614–2621

55.

Levy J, Xie Z-f (1988) Effect of three Chinese herbal medicines (Ligustrazine, Chrysanthemum indicum, Salviae miltiorrhizae) on PAF and ADP-induced platelet aggregation in vitro. Prostaglandins 35(5):842CrossRef

56.

Zia-Ul-Haq M, Khan BA, Landa P, Kutil Z, Ahmed S, Qayum M et al (2011) Platelet aggregation and anti-inflammatory effects of garden pea, Desi chickpea and Kabuli chickpea. Acta Pol Pharm 69(4):707–711

57.

Marzouk B, Haloui E, Akremi N, Aouni M, Marzouk Z, Fenina N (2012) Antimicrobial and anticoagulant activities of Citrullus colocynthis Schrad. leaves from Tunisia (Medenine). Afr J Pharm Pharmacol 6(26):1982–1988

58.

Jantan I, Rafi I, Jalil J (2005) Platelet-activating factor (PAF) receptor-binding antagonist activity of Malaysian medicinal plants. Phytomedicine 12(1):88–92PubMedCrossRef

59.

Zhang L, Jun-Rong D, Jin W, Dong-Ke Y, Ya-Shu C, Yao H et al (2009) Z-ligustilide extracted from Radix Angelica Sinensis decreased platelet aggregation induced by ADP ex vivo and arterio-venous shunt thrombosis in vivo in rats. Yakugaku Zasshi 129(7):855–859PubMedCrossRef

60.

Pierre S, Crosbie L, Duttaroy AK (2005) Inhibitory effect of aqueous extracts of some herbs on human platelet aggregation in vitro. Platelets 16(8):469–473PubMedCrossRef

61.

Bijak M, Saluk J, Tsirigotis-Maniecka M, Komorowska H, Wachowicz B, Zaczyńska E et al (2013) The influence of conjugates isolated from Matricaria chamomilla L. on platelets activity and cytotoxicity. Int J Biol Macromol 61:218–229PubMedCrossRef

62.

Chistokhodova N, Nguyen C, Calvino T, Kachirskaia I, Cunningham G, Miles DH (2002) Antithrombin activity of medicinal plants from central Florida. J Ethnopharmacol 81(2):277–280PubMedCrossRef

63.

Yazdanparast R, Shahriyary L (2008) Comparative effects of Artemisia dracunculus, Satureja hortensis and Origanum majorana on inhibition of blood platelet adhesion, aggregation and secretion. Vasc Pharmacol 48(1):32–37CrossRef

64.

Goun E, Cunningham G, Solodnikov S, Krasnykch O, Miles H (2002) Antithrombin activity of some constituents from Origanum vulgare. Fitoterapia 73(7):692–694PubMedCrossRef

65.

Lee Y-S, Kwon K-J, Kim M-S, Sohn H-Y (2013) Antimicrobial, antioxidant and anticoagulation activities of Korean radish (Raphanus sativus L.) leaves. Microbiol Biotechnol Lett 41(2):228–235CrossRef

66.

Lee J-J, Jin Y-R, Lee J-H, Yu J-Y, Han X-H, Oh K-W et al (2007) Antiplatelet activity of carnosic acid, a phenolic diterpene from Rosmarinus officinalis. Plant Med 73(02):121–127CrossRef

67.

Jafar S (2008) In vitro thrmobolyitc/fibrinolyitc effects of Rue aqueous distilled extract. J Al-Nahrain Univ 11:28–33

68.

Wu TS, Shi LS, Wang JJ, Iou SC, Chang HC, Chen YP et al (2003) Cytotoxic and antiplatelet aggregation principles of Ruta graveolens. J Chin Chem Soc 50(1):171–178CrossRef

69.

Khaleel AE-S, Gonaid MH, El-Bagry RI (2007) Chemical and biological study of the residual aerial parts of Sesamum indicum L. J Food Drug Anal 15(3)

70.

Thushara R, Hemshekhar M, Sunitha K, Kumar M, Naveen S, Kemparaju K et al (2013) Sesamol induces apoptosis in human platelets via reactive oxygen species-mediated mitochondrial damage. Biochimie 95(11):2060–2068PubMedCrossRef

71.

Chang C-C, Lu W-J, Ong E-T, Chiang C-W, Lin S-C, Huang S-Y et al (2011) A novel role of sesamol in inhibiting NF-κB-mediated signaling in platelet activation. J Biomed Sci 18(1):93PubMedPubMedCentralCrossRef

72.

Liu B-L, Chiang P-S (2008) Production of hydrolysate with antioxidative activity and functional properties by enzymatic hydrolysis of defatted sesame (Sesamum indicum L.). Int J Appl Sci Eng 6(2):73–83

73.

Chang CC, Lu WJ, Chiang CW, Jayakumar T, Ong ET, Hsiao G et al (2010) Potent antiplatelet activity of sesamol in an in vitro and in vivo model: pivotal roles of cyclic AMP and p38 mitogen-activated protein kinase. J Nutr Biochem 21(12):1214–1221PubMedCrossRef

74.

Chen P-R, Lee C-C, Chang H, Tsai CE (2005) Sesamol regulates plasminogen activator gene expression in cultured endothelial cells: a potential effect on the fibrinolytic system. J Nutr Biochem 16(1):59–64PubMedCrossRef

75.

Losche W, Mazurov A, Heptinstall S, Groenewegen W, Repin V, Till U (1987) An extract of feverfew inhibits interactions of human platelets with collagen substrates. Thromb Res 48(5):511–518PubMedCrossRef

76.

Groenewegen W, Heptinstall S (1990) A comparison of the effects of an extract of feverfew and parthenolide, a component of feverfew, on human platelet activity in-vitro. J Pharm Pharmacol 42(8):553–557PubMedCrossRef

77.

Srivastava K (1988) Extract of a spice—Omum (Trachyspermum ammi)-shows antiaggregatory effects and alters arachidonic acid metabolism in human platelets. Prostaglandins Leukot Essent Fatty Acids 33(1):1–6PubMedCrossRef

78.

Karkabounas S, Kostoula O, Daskalou T, Veltsistas P, Karamouzis M, Zelovitis I et al (2006) Anticarcinogenic and antiplatelet effects of carvacrol. Exp Oncol 28(2):121–125PubMed

79.

Okazaki K, Kawazoe K, Takaishi Y (2002) Human platelet aggregation inhibitors from thyme (Thymus vulgaris L.). Phytother Res 16(4):398–399PubMedCrossRef

80.

Fakhar H, Tayer AH (2012) Effect of the garlic pill in comparison with plavix on platelet aggregation and bleeding time. Iran J Pediatr Hematol Oncol 2(4):146

81.

Ali M, Thomson M (1995) Consumption of a garlic clove a day could be beneficial in preventing thrombosis. Prostaglandins Leukotr Essent Fatty Acids 53(3):211–212CrossRef

82.

Wojcikowski K, Myers S, Brooks L (2007) Effects of garlic oil on platelet aggregation: a double blind placebo controlled crossover study. Platelets 18(1):29–34PubMedCrossRef

83.

Steiner M, Li W (2001) Aged garlic extract, a modulator of cardiovascular risk factors: a dose-finding study on the effects of AGE on platelet functions. J Nutr 131(3):980S–984SPubMed

84.

Rahman K, Billington D (2000) Dietary supplementation with aged garlic extract inhibits ADP-induced platelet aggregation in humans. J Nutr 130(11):2662–2665PubMed

85.

Bordia A, Verma S, Srivastava K (1998) Effect of garlic (Allium sativum) on blood lipids, blood sugar, fibrinogen and fibrinolytic activity in patients with coronary artery disease. Prostaglandins Leukotr Essent Fatty Acids 58(4):257–263CrossRef

86.

Steiner M, Lin R (1998) Changes in platelet function and susceptibility of lipoproteins to oxidation associated with administration of aged garlic extract. J Cardiovasc Pharmacol 31(6):904–908PubMedCrossRef

87.

Legnani C, Frascaro M, Guazzaloca G, Ludovici S, Cesarano G, Coccheri S (1993) Effects of a dried garlic preparation on fibrinolysis and platelet aggregation in healthy subjects. Arzneimittelforschung 43(2):119–122PubMed

88.

Kiesewetter H, Jung F, Jung E, Mrowietz C, Koscielny J, Wenzel E (1993) Effect of garlic on platelet aggregation in patients with increased risk of juvenile ischaemic attack. Eur J Clin Pharmacol 45(4):333–336PubMedCrossRef

89.

Mansouri M, Nayebi N, Hasani-Ranjbar S, Taheri E, Larijani B (2012) The effect of 12 weeks Anethum graveolens (dill) on metabolic markers in patients with metabolic syndrome; a randomized double blind controlled trial. DARU J Pharm Sci 20(1):47CrossRef

90.

Paoletti A, Gallo E, Benemei S, Vietri M, Lapi F, Volpi R et al (2011) Interactions between natural health products and oral anticoagulants: spontaneous reports in the Italian Surveillance System of Natural Health Products. Evid Based Complement Alternat Med

91.

Segal R, Pilote L (2006) Warfarin interaction with Matricaria chamomilla. Can Med Assoc J 174(9):1281–1282CrossRef

92.

Mikaili P, Maadirad S, Moloudizargari M, Aghajanshakeri S, Sarahroodi S (2013) Therapeutic uses and pharmacological properties of garlic, shallot, and their biologically active compounds. Iran J Basic Med Sci 16(10):1031–1048PubMedPubMedCentral

93.

Khatua TN, Adela R, Banerjee SK (2013) Garlic and cardioprotection: insights into the molecular mechanisms. Can J Physiol Pharmacol 91(6):448–458PubMedCrossRef

94.

Chen P-R, Tsai CE, Chang H, Liu T-L, Lee C-C (2005) Sesamol induces nitric oxide release from human umbilical vein endothelial cells. Lipids 40(9):955–961PubMedCrossRef

95.

Zhou X, Tang L, Xu Y, Zhou G, Wang Z (2014) Towards a better understanding of medicinal uses of Carthamus tinctorius L. in traditional Chinese medicine: a phytochemical and pharmacological review. J Ethnopharmacol 151(1):27–43PubMedCrossRef

96.

Chen W, Jin M, Wu W, Li J, Yang S (1999) Inhibition of safflor yellow on rabbit platelet activation induced by platelet activating factor. Zhongguo yao xue za zhi (Zhongguo yao xue hui: 1989) 35(11):741–744

97.

Jin M, Wu W, Chen WM (2001) Inhibition of safflor yellow against the binding of platelet activating factor to its receptor in vitro. Chin Pharm J 36(3):167–169

98.

Zang B, Jin M, Si N, Zhang Y, Wu W, Piao Y (2002) Antagonistic effect of hydroxysafflor yellow A on the platelet activating factor receptor. Acta Pharm Sin 37(9):696–699

99.

Balunas MJ, Kinghorn AD (2005) Drug discovery from medicinal plants. Life Sci 78(5):431–441PubMedCrossRef

100.

Fabricant DS, Farnsworth NR (2001) The value of plants used in traditional medicine for drug discovery. Environm Health Perspect 109(Suppl 1):69CrossRef

101.

Chaudhari K, Hamad B, Syed BA (2014) Antithrombotic drugs market. Nat Rev Drug Discov 13(8):571–572PubMedCrossRef

102.

Deitelzweig S, Amin A, Jing Y, Makenbaeva D, Wiederkehr D, Lin J et al (2012) Medical cost reductions associated with the usage of novel oral anticoagulants vs warfarin among atrial fibrillation patients, based on the RE-LY, ROCKET-AF, and ARISTOTLE trials. J Med Econ 15(4):776–785PubMedCrossRef

103.

Patwardhan B, Mashelkar RA (2009) Traditional medicine-inspired approaches to drug discovery: can Ayurveda show the way forward? Drug Discov Today 14(15):804–811PubMedCrossRef

104.

Gurib-Fakim A (2006) Medicinal plants: traditions of yesterday and drugs of tomorrow. Mol Aspect Med 27(1):1–93CrossRef

105.

De Caterina R, Husted S, Wallentin L, Andreotti F, Arnesen H, Bachmann F et al (2013) General mechanisms of coagulation and targets of anticoagulants (Section I). Thromb Haemost 109(2013):569–579PubMedCrossRef

106.

Mosa RA (2014) Some bioactivity of triterpenes from stem bark of Protorhus longifolia. University of Zululand, and their derivatives

107.

Kooti W, Ali-Akbari S, Asadi-Samani M, Ghadery H, Ashtary-Larky D (2015) A review on medicinal plant of Apium graveolens. Adv Herb Med 1(1):48–59

108.

Shukla S, Gupta S (2010) Apigenin: a promising molecule for cancer prevention. Pharma Res 27(6):962–978CrossRef

109.

Zhang XY, Qiao H, Shi YB (2014) HPLC method with fluorescence detection for the determination of ligustilide in rat plasma and its pharmacokinetics. Pharma Biol 52(1):21–30CrossRef

110.

Iranshahy M, Iranshahi M (2011) Traditional uses, phytochemistry and pharmacology of asafoetida (Ferula assa-foetida oleo-gum-resin): a review. J Ethnopharmacol 134(1):1–10PubMedCrossRef

111.

Navarro-Núñez L, Lozano M, Palomo M, Martinez C, Vicente V, Castillo J et al (2008) Apigenin inhibits platelet adhesion and thrombus formation and synergizes with aspirin in the suppression of the arachidonic acid pathway. J Agric Food Chem 56(9):2970–2976PubMedCrossRef

112.

Fukuda K, Murata K, TANIGUCHI M, SHIBANO M, SHIRATORI M, Tadato T et al (2009) Fibrinolytic activity of ligustilide and pharmaceutical comparison of Angelica acutiloba roots before and after processing in hot water. J Tradit Med 26(5+6):210–218

113.

Liu L, Ma H, Yang N, Tang Y, Guo J, Tao W et al (2010) A series of natural flavonoids as thrombin inhibitors: structure-activity relationships. Thromb Res 126(5):e365–e378PubMedCrossRef

114.

Siemoneit U, Tausch L, Poeckel D, Paul M, Northoff H, Koeberle A et al (2017) Defined structure-activity relationships of boswellic acids determine modulation of Ca²⁺ mobilization and aggregation of human platelets by Boswellia serrata extracts. Planta Med 83(12–13):1020–1027PubMed

115.

Aksu K, Donmez A, Keser G (2012) Inflammation-induced thrombosis: mechanisms, disease associations and management. Curr Pharm Design 18(11):1478–1493CrossRef

116.

Badimon L, Vilahur G (2014) Thrombosis formation on atherosclerotic lesions and plaque rupture. J Intern Med 276(6):618–632PubMedCrossRef

117.

Santhakumar AB, Bulmer AC, Singh I (2014) A review of the mechanisms and effectiveness of dietary polyphenols in reducing oxidative stress and thrombotic risk. J Hum Nutr Diet 27(1):1–21PubMedCrossRef

118.

Asgarpanah J, Kazemivash N (2013) Phytochemistry, pharmacology and medicinal properties of Carthamus tinctorius L. Chin J Integr Med 19(2):153–159PubMedCrossRef

119.

Ying Z, Kherada N, Kampfrath T, Mihai G, Simonetti O, Desikan R et al (2011) A modified sesamol derivative inhibits progression of atherosclerosis. Arterioscler Thromb Vasc Biol 31(3):536–542PubMedCrossRef

120.

Khan SS, Najam R, Anser H, Riaz B, Alam N (2014) Chamomile tea: herbal hypoglycemic alternative for conventional medicine. Pak J Pharm Sci 27(5):1509–1514PubMed

121.

Singh O, Khanam Z, Misra N, Srivastava MK (2011) Chamomile (Matricaria chamomilla L.): an overview. Pharmacogn Rev 5(9):82PubMedPubMedCentralCrossRef

122.

Choi S, Oh D-S, Jerng UM (2017) A systematic review of the pharmacokinetic and pharmacodynamic interactions of herbal medicine with warfarin. PLoS ONE 12(8):e0182794PubMedPubMedCentralCrossRef

123.

Izzo AA, Hoon-Kim S, Radhakrishnan R, Williamson EM (2016) A critical approach to evaluating clinical efficacy, adverse events and drug interactions of herbal remedies. Phytother Res 30(5):691–700PubMedCrossRef

124.

Bijak M, Saluk J, Tsirigotis-Maniecka M, Komorowska H, Wachowicz B, Zaczynska E et al (2013) The influence of conjugates isolated from Matricaria chamomilla L. on platelets activity and cytotoxicity. Int J Biol Macromol 61:218–229PubMedCrossRef

125.

Habib G (2014) Essential oils and drugs: interactions: uniwien.

126.

Di Minno A, Frigerio B, Spadarella G, Ravani A, Sansaro D, Amato M et al (2017) Old and new oral anticoagulants: food, herbal medicines and drug interactions. Blood Rev 31(4):193–203PubMedCrossRef

127.

Chua YT, Ang XL, Zhong XM, Khoo KS (2015) Interaction between warfarin and Chinese herbal medicines. Singap Med J 56(1):11–18CrossRef

128.

Segal R, Pilote L (2006) Warfarin interaction with Matricaria chamomilla. CMAJ 174(9):1281–1282PubMedPubMedCentralCrossRef

129.

Chua YT, Ang XL, Zhong XM, Khoo KS (2015) Interaction between warfarin and Chinese herbal medicines. Singap Med J 56(1):11CrossRef

130.

Mouly S, Lloret-Linares C, Sellier PO, Sene D, Bergmann JF (2017) Is the clinical relevance of drug-food and drug-herb interactions limited to grapefruit juice and Saint-John’s Wort? Pharmacol Res 118:82–92PubMedCrossRef

Titel: Medicinal plants with antithrombotic property in Persian medicine: a mechanistic review
verfasst von: Zahra Memariani
Reihaneh Moeini
Shokooh Sadat Hamedi
Narjes Gorji
Seyyed Ali Mozaffarpur
Publikationsdatum: 09.11.2017
Verlag: Springer US
Erschienen in: Journal of Thrombosis and Thrombolysis / Ausgabe 1/2018
Print ISSN: 0929-5305
Elektronische ISSN: 1573-742X
DOI: https://doi.org/10.1007/s11239-017-1580-3

Leitlinien kompakt für die Innere Medizin

Mit medbee Pocketcards sicher entscheiden.

^{Seit 2022 gehört die medbee GmbH zum Springer Medizin Verlag}

Kostenlos registrieren

Neu im Fachgebiet Innere Medizin

„Jeder Fall von plötzlichem Tod muss obduziert werden!“

17.05.2024 Plötzlicher Herztod Nachrichten

Ein signifikanter Anteil der Fälle von plötzlichem Herztod ist genetisch bedingt. Um ihre Verwandten vor diesem Schicksal zu bewahren, sollten jüngere Personen, die plötzlich unerwartet versterben, ausnahmslos einer Autopsie unterzogen werden.

Hirnblutung unter DOAK und VKA ähnlich bedrohlich

17.05.2024 Direkte orale Antikoagulanzien Nachrichten

Kommt es zu einer nichttraumatischen Hirnblutung, spielt es keine große Rolle, ob die Betroffenen zuvor direkt wirksame orale Antikoagulanzien oder Marcumar bekommen haben: Die Prognose ist ähnlich schlecht.

Schlechtere Vorhofflimmern-Prognose bei kleinem linken Ventrikel

17.05.2024 Vorhofflimmern Nachrichten

Nicht nur ein vergrößerter, sondern auch ein kleiner linker Ventrikel ist bei Vorhofflimmern mit einer erhöhten Komplikationsrate assoziiert. Der Zusammenhang besteht nach Daten aus China unabhängig von anderen Risikofaktoren.

Semaglutid bei Herzinsuffizienz: Wie erklärt sich die Wirksamkeit?

17.05.2024 Herzinsuffizienz Nachrichten

Bei adipösen Patienten mit Herzinsuffizienz des HFpEF-Phänotyps ist Semaglutid von symptomatischem Nutzen. Resultiert dieser Benefit allein aus der Gewichtsreduktion oder auch aus spezifischen Effekten auf die Herzinsuffizienz-Pathogenese? Eine neue Analyse gibt Aufschluss.

Update Innere Medizin

Bestellen Sie unseren Fach-Newsletter und bleiben Sie gut informiert.

Newsletter bestellen

Die Highlights vom Kongress des American College of Cardiology 2024

Springer Medizin

Abstract

Bitte loggen Sie sich ein, um Zugang zu diesem Inhalt zu erhalten

Weitere Artikel der Ausgabe 1/2018

Initial and long term impact of a multi-disciplinary task force in the diagnosis and management of heparin-induced thrombocytopenia

Cerebral venous sinus thrombosis complicated by seizures: a retrospective analysis of 69 cases

O blood type is a risk factor for upper gastrointestinal bleeding

Heparin, coumarin, protein C, antithrombin, fibrinolysis and other clotting related resistances: old and new concepts in blood coagulation

Systemic lupus erythematosus and the risk of perioperative major adverse cardiovascular events