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Erschienen in: Journal of Thrombosis and Thrombolysis 3/2020

03.09.2020 | COVID-19 | Editorial Zur Zeit gratis

Anticipating the long-term cardiovascular effects of COVID-19

verfasst von: Richard C. Becker

Erschienen in: Journal of Thrombosis and Thrombolysis | Ausgabe 3/2020

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Excerpt

SARS-CoV2 infection can impact all organs structurally and functionally. Persisting symptoms in patients recovering from coronavirus disease 2019 (COVID-19) are common and with close follow-up can be detected in nearly 90% of patients 60 days from the original diagnosis [1]. The most common symptoms are fatigue, dyspnea, joint pain, chest pain, cough, insomnia and headache. Given the well-documented involvement of the circulatory system in COVID-19, including small, moderate and large-sized veins and arteries, coupled with robust immune and resulting local and systemic inflammatory responses, one would anticipate a prolonged recovery period and potentially long-term cardiovascular effects. The following editorial review summarizes the pathogenesis of structural, functional and metabolic abnormalities associated with COVID-19 and postulates long-term cardiovascular effects and management strategies under a broad clinical umbrella referred to as post-COVID-19 syndrome. …
Literatur
3.
Zurück zum Zitat Wichmann D, Sperhake JP, Lütgehetmann M, Steurer S, Edler C, Heinemann A, Heinrich F, Mushumba H, Kniep I, Schröder AS, Burdelski C, de Heer G, Nierhaus A, Frings D, Pfefferle S, Becker H, Bredereke-Wiedling H, de Weerth A, Paschen HR, Sheikhzadeh-Eggers S, Stang A, Schmiedel S, Bokemeyer C, Addo MM, Aepfelbacher M, Püschel K, Kluge S (2020) Autopsy findings and venous thromboembolism in patients with COVID-19: a prospective cohort study. Ann Intern Med 173:268–277PubMedCrossRef Wichmann D, Sperhake JP, Lütgehetmann M, Steurer S, Edler C, Heinemann A, Heinrich F, Mushumba H, Kniep I, Schröder AS, Burdelski C, de Heer G, Nierhaus A, Frings D, Pfefferle S, Becker H, Bredereke-Wiedling H, de Weerth A, Paschen HR, Sheikhzadeh-Eggers S, Stang A, Schmiedel S, Bokemeyer C, Addo MM, Aepfelbacher M, Püschel K, Kluge S (2020) Autopsy findings and venous thromboembolism in patients with COVID-19: a prospective cohort study. Ann Intern Med 173:268–277PubMedCrossRef
4.
Zurück zum Zitat Bompard F, Monnier H, Saab I, Tordjman M, Abdoul H, Fournier L, Sanchez O, Lorut C, Chassagnon G, Revel M-P (2020) Pulmonary embolism in patients with COVID-19 pneumonia. Eur Respir J 56:2001365PubMedPubMedCentralCrossRef Bompard F, Monnier H, Saab I, Tordjman M, Abdoul H, Fournier L, Sanchez O, Lorut C, Chassagnon G, Revel M-P (2020) Pulmonary embolism in patients with COVID-19 pneumonia. Eur Respir J 56:2001365PubMedPubMedCentralCrossRef
8.
Zurück zum Zitat Ebinger JE, Achamallah N, Ji H, Claggett BL, Sun N, Botting P, Nguyen TT, Luong E, Kim EH, Park E, Liu Y, Rosenberry R, Matusov Y, Zhao S, Pedraza I, Zaman T, Thompson M, Raedschelders K, Berg AH, Grein JD, Noble PW, Chugh SS, Bairey Merz CN, Marbán E, Van Eyk JE, Solomon SD, Albert CM, Chen P, Cheng S (2020) Pre-existing traits associated with Covid-19 illness severity. PLoS ONE 15:e0236240PubMedPubMedCentralCrossRef Ebinger JE, Achamallah N, Ji H, Claggett BL, Sun N, Botting P, Nguyen TT, Luong E, Kim EH, Park E, Liu Y, Rosenberry R, Matusov Y, Zhao S, Pedraza I, Zaman T, Thompson M, Raedschelders K, Berg AH, Grein JD, Noble PW, Chugh SS, Bairey Merz CN, Marbán E, Van Eyk JE, Solomon SD, Albert CM, Chen P, Cheng S (2020) Pre-existing traits associated with Covid-19 illness severity. PLoS ONE 15:e0236240PubMedPubMedCentralCrossRef
9.
Zurück zum Zitat Razzaghi H, Wang Y, Lu H, Marshall KE, Dowling NF, Paz-Bailey G, Twentyman ER, Peacock G, Greenlund KJ (2020) Estimated county-level prevalence of selected underlying medical conditions associated with increased risk for severe COVID-19 illness–United States, 2018. MMWR Morb Mortal Wkly Rep 69:945–950PubMedPubMedCentralCrossRef Razzaghi H, Wang Y, Lu H, Marshall KE, Dowling NF, Paz-Bailey G, Twentyman ER, Peacock G, Greenlund KJ (2020) Estimated county-level prevalence of selected underlying medical conditions associated with increased risk for severe COVID-19 illness–United States, 2018. MMWR Morb Mortal Wkly Rep 69:945–950PubMedPubMedCentralCrossRef
10.
Zurück zum Zitat DeFilippis AP, Chapman AR, Mills NL, de Lemos JA, Arbab-Zadeh A, Newby LK, Morrow DA (2019) Assessment and treatment of patients with Type 2 myocardial infarction and acute nonischemic myocardial injury. Circulation 140:1661–1678PubMedPubMedCentralCrossRef DeFilippis AP, Chapman AR, Mills NL, de Lemos JA, Arbab-Zadeh A, Newby LK, Morrow DA (2019) Assessment and treatment of patients with Type 2 myocardial infarction and acute nonischemic myocardial injury. Circulation 140:1661–1678PubMedPubMedCentralCrossRef
12.
Zurück zum Zitat Jain SS, Liu Q, Raikhelkar J, Fried J, Elias P, Poterucha TJ, DeFilippis EM, Rosenblum H, Wang EY, Redfors B, Clerkin K, Griffin JM, Wan EY, Abdalla M, Bello NA, Hahn RT, Shimbo D, Weiner SD, Kirtane AJ, Kodali SK, Burkhoff D, Rabbani LE, Schwartz A, Leon MB, Homma S, Di Tullio MR, Sayer G, Uriel N, Anstey DE (2020) Indications for and findings on transthoracic echocardiography in COVID-19. J Am Soc Echocardiogr. https://doi.org/10.1016/j.echo.2020.06.009PubMedPubMedCentralCrossRef Jain SS, Liu Q, Raikhelkar J, Fried J, Elias P, Poterucha TJ, DeFilippis EM, Rosenblum H, Wang EY, Redfors B, Clerkin K, Griffin JM, Wan EY, Abdalla M, Bello NA, Hahn RT, Shimbo D, Weiner SD, Kirtane AJ, Kodali SK, Burkhoff D, Rabbani LE, Schwartz A, Leon MB, Homma S, Di Tullio MR, Sayer G, Uriel N, Anstey DE (2020) Indications for and findings on transthoracic echocardiography in COVID-19. J Am Soc Echocardiogr. https://​doi.​org/​10.​1016/​j.​echo.​2020.​06.​009PubMedPubMedCentralCrossRef
13.
Zurück zum Zitat Mall G, Klingel K, Albrecht M, Seemann M, Rieger P, Kandolf R (1991) Natural history of coxsackievirus B3-induced myocarditis in ACA/Sn mice: viral persistence demonstrated by quantitative in situ hybridization histochemistry. Eur Heart J 12:121–123PubMedCrossRef Mall G, Klingel K, Albrecht M, Seemann M, Rieger P, Kandolf R (1991) Natural history of coxsackievirus B3-induced myocarditis in ACA/Sn mice: viral persistence demonstrated by quantitative in situ hybridization histochemistry. Eur Heart J 12:121–123PubMedCrossRef
14.
Zurück zum Zitat Pollack A, Kontorovich AR, Fuster V, Dec GW (2015) Viral myocarditis–diagnosis, treatment options, and current controversies. Nat Rev Cardiol 12:670–680PubMedCrossRef Pollack A, Kontorovich AR, Fuster V, Dec GW (2015) Viral myocarditis–diagnosis, treatment options, and current controversies. Nat Rev Cardiol 12:670–680PubMedCrossRef
15.
17.
Zurück zum Zitat Fujinami RS, von Herrath MG, Christen U, Whitton JL (2006) Molecular mimicry, bystander activation, or viral persistence: infections and autoimmune disease. Clin Microbiol Rev 19:80–94PubMedPubMedCentralCrossRef Fujinami RS, von Herrath MG, Christen U, Whitton JL (2006) Molecular mimicry, bystander activation, or viral persistence: infections and autoimmune disease. Clin Microbiol Rev 19:80–94PubMedPubMedCentralCrossRef
20.
Zurück zum Zitat Herskowitz A, Campbell S, Deckers J, Kasper EK, Boehmer J, Hadian D, Neumann DA, Baughman KL (1993) Demographic features and prevalence of idiopathic myocarditis in patients undergoing endomyocardial biopsy. Am J Cardiol 71:982–986PubMedCrossRef Herskowitz A, Campbell S, Deckers J, Kasper EK, Boehmer J, Hadian D, Neumann DA, Baughman KL (1993) Demographic features and prevalence of idiopathic myocarditis in patients undergoing endomyocardial biopsy. Am J Cardiol 71:982–986PubMedCrossRef
21.
Zurück zum Zitat Maron BJ, Udelson JE, Bonow RO, Nishimura RA, Ackerman MJ, Estes NA 3rd, Cooper LT Jr, Link MS, Maron MS (2015) Eligibility and disqualification recommendations for competitive athletes with cardiovascular abnormalities: task force 3—hypertrophic cardiomyopathy, arrhythmogenic right ventricular cardiomyopathy and other cardiomyopathies, and myocarditis—a scientific statement from the American heart association and American college of cardiology. Circulation 132:e273–e280PubMed Maron BJ, Udelson JE, Bonow RO, Nishimura RA, Ackerman MJ, Estes NA 3rd, Cooper LT Jr, Link MS, Maron MS (2015) Eligibility and disqualification recommendations for competitive athletes with cardiovascular abnormalities: task force 3—hypertrophic cardiomyopathy, arrhythmogenic right ventricular cardiomyopathy and other cardiomyopathies, and myocarditis—a scientific statement from the American heart association and American college of cardiology. Circulation 132:e273–e280PubMed
23.
Zurück zum Zitat Su H, Yang M, Wan C, Yi LX, Tang F, Zhu HY, Yi F, Yang HC, Fogo AB, Nie X, Zhang C (2020) Renal histopathological analysis of 26 postmortem findings of patients with COVID-19 in China. Kidney Int 98:219–227PubMedPubMedCentralCrossRef Su H, Yang M, Wan C, Yi LX, Tang F, Zhu HY, Yi F, Yang HC, Fogo AB, Nie X, Zhang C (2020) Renal histopathological analysis of 26 postmortem findings of patients with COVID-19 in China. Kidney Int 98:219–227PubMedPubMedCentralCrossRef
24.
Zurück zum Zitat Peleg Y, Kudose S, D'Agati V, Siddall E, Ahmad S, Kisselev S, Gharavi A, Canetta P (2020) Acute kidney injury due to collapsing glomerulopathy following COVID-19 infection. Kidney Int Rep 5:940–945CrossRefPubMedPubMedCentral Peleg Y, Kudose S, D'Agati V, Siddall E, Ahmad S, Kisselev S, Gharavi A, Canetta P (2020) Acute kidney injury due to collapsing glomerulopathy following COVID-19 infection. Kidney Int Rep 5:940–945CrossRefPubMedPubMedCentral
26.
Zurück zum Zitat Yap SC, Lee HT (2012) Acute kidney injury and extrarenal organ dysfunction: new concepts and experimental evidence. Anesthesiology 116:1139–1148PubMedCrossRef Yap SC, Lee HT (2012) Acute kidney injury and extrarenal organ dysfunction: new concepts and experimental evidence. Anesthesiology 116:1139–1148PubMedCrossRef
27.
Zurück zum Zitat Vergaro G, Prud’homme M, Fazal L, Merval R, Passino C, Emdin M, Samuel J-L, Solal AC and Delcayre C. (2016) Inhibition of galectin-3 pathway prevents isoproterenol-induced left ventricular dysfunction and fibrosis in mice. Hypertension 67:606–612PubMedCrossRef Vergaro G, Prud’homme M, Fazal L, Merval R, Passino C, Emdin M, Samuel J-L, Solal AC and Delcayre C. (2016) Inhibition of galectin-3 pathway prevents isoproterenol-induced left ventricular dysfunction and fibrosis in mice. Hypertension 67:606–612PubMedCrossRef
28.
Zurück zum Zitat Di Lullo L, Reeves PB, Bellasi A, Ronco C (2019) Cardiorenal syndrome in acute kidney injury. Semin Nephrol 39:31–40PubMedCrossRef Di Lullo L, Reeves PB, Bellasi A, Ronco C (2019) Cardiorenal syndrome in acute kidney injury. Semin Nephrol 39:31–40PubMedCrossRef
30.
Zurück zum Zitat Ronco C, Haapio M, House AA, Anavekar N, Bellomo R (2008) Cardiorenal syndrome. J Am Coll Cardiol 52:1527–1539PubMedCrossRef Ronco C, Haapio M, House AA, Anavekar N, Bellomo R (2008) Cardiorenal syndrome. J Am Coll Cardiol 52:1527–1539PubMedCrossRef
35.
Zurück zum Zitat Robles-Cabrera A, Michel-Chávez A, Callejas-Rojas RC, Malamud-Kessler C, Delgado G, Estañol-Vidal B (2014) The cardiovagal, cardiosympathetic and vasosympathetic arterial baroreflexes and the neural control of short-term blood pressure. Revista de Neurologia. 59:508–516PubMedCrossRef Robles-Cabrera A, Michel-Chávez A, Callejas-Rojas RC, Malamud-Kessler C, Delgado G, Estañol-Vidal B (2014) The cardiovagal, cardiosympathetic and vasosympathetic arterial baroreflexes and the neural control of short-term blood pressure. Revista de Neurologia. 59:508–516PubMedCrossRef
36.
39.
Zurück zum Zitat Braun J, Loyal L, Frentsch M, Wendisch D, Georg P, Kurth F, Hippenstiel S, Dingeldey M, Kruse B, Fauchere F, Baysal E, Mangold M, Henze L, Lauster R, Mall MA, Beyer K, Röhmel J, Voigt S, Schmitz J, Miltenyi S, Demuth I, Müller MA, Hocke A, Witzenrath M, Suttorp N, Kern F, Reimer U, Wenschuh H, Drosten C, Corman VM, Giesecke-Thiel C, Sander LE, Thiel A (2020) SARS-CoV-2-reactive T cells in healthy donors and patients with COVID-19. Nature. https://doi.org/10.1038/s41586-020-2598-9PubMedCrossRefPubMedCentral Braun J, Loyal L, Frentsch M, Wendisch D, Georg P, Kurth F, Hippenstiel S, Dingeldey M, Kruse B, Fauchere F, Baysal E, Mangold M, Henze L, Lauster R, Mall MA, Beyer K, Röhmel J, Voigt S, Schmitz J, Miltenyi S, Demuth I, Müller MA, Hocke A, Witzenrath M, Suttorp N, Kern F, Reimer U, Wenschuh H, Drosten C, Corman VM, Giesecke-Thiel C, Sander LE, Thiel A (2020) SARS-CoV-2-reactive T cells in healthy donors and patients with COVID-19. Nature. https://​doi.​org/​10.​1038/​s41586-020-2598-9PubMedCrossRefPubMedCentral
40.
Zurück zum Zitat Yang L, Liu S, Liu J, Zhang Z, Wan X, Huang B, Chen Y, Zhang Y (2020) COVID-19: immunopathogenesis and immunotherapeutics. Sig Transduct Target Ther 5:128CrossRef Yang L, Liu S, Liu J, Zhang Z, Wan X, Huang B, Chen Y, Zhang Y (2020) COVID-19: immunopathogenesis and immunotherapeutics. Sig Transduct Target Ther 5:128CrossRef
41.
Zurück zum Zitat Wen W, Su W, Tang H, Le W, Zhang X, Zheng Y, Liu X, Xie L, Li J, Ye J, Dong L, Cui X, Miao Y, Wang D, Dong J, Xiao C, Chen W, Wang H (2020) Immune cell profiling of COVID-19 patients in the recovery stageby single-cell sequencing. Cell Discov 6:31PubMedPubMedCentralCrossRef Wen W, Su W, Tang H, Le W, Zhang X, Zheng Y, Liu X, Xie L, Li J, Ye J, Dong L, Cui X, Miao Y, Wang D, Dong J, Xiao C, Chen W, Wang H (2020) Immune cell profiling of COVID-19 patients in the recovery stageby single-cell sequencing. Cell Discov 6:31PubMedPubMedCentralCrossRef
42.
Zurück zum Zitat Chua RL, Lukassen S, Trump S, Hennig BP, Wendisch D, Pott F, Debnath O, Thürmann L, Kurth F, Völker MT, Kazmierski J, Timmermann B, Twardziok S, Schneider S, Machleidt F, Müller-Redetzky H, Maier M, Krannich A, Schmidt S, Balzer F, Liebig J, Loske J, Suttorp N, Eils J, Ishaque N, Liebert UG, von Kalle C, Hocke A, Witzenrath M, Goffinet C, Drosten C, Laudi S, Lehmann I, Conrad C, Sander L-E, Eils R (2020) COVID-19 severity correlates with airway epithelium–immune cell interactions identified by single-cell analysis. Nat Biotechnol 38:970–979PubMedCrossRef Chua RL, Lukassen S, Trump S, Hennig BP, Wendisch D, Pott F, Debnath O, Thürmann L, Kurth F, Völker MT, Kazmierski J, Timmermann B, Twardziok S, Schneider S, Machleidt F, Müller-Redetzky H, Maier M, Krannich A, Schmidt S, Balzer F, Liebig J, Loske J, Suttorp N, Eils J, Ishaque N, Liebert UG, von Kalle C, Hocke A, Witzenrath M, Goffinet C, Drosten C, Laudi S, Lehmann I, Conrad C, Sander L-E, Eils R (2020) COVID-19 severity correlates with airway epithelium–immune cell interactions identified by single-cell analysis. Nat Biotechnol 38:970–979PubMedCrossRef
45.
Zurück zum Zitat Ali M, Girgis S, Hassan A, Rudick S, Becker RC (2018) Inflammation and coronary artery disease: from pathophysiology to Canakinumab Anti-Inflammatory Thrombosis Outcomes Study (CANTOS). Coron Artery Dis 29:429–437PubMedCrossRef Ali M, Girgis S, Hassan A, Rudick S, Becker RC (2018) Inflammation and coronary artery disease: from pathophysiology to Canakinumab Anti-Inflammatory Thrombosis Outcomes Study (CANTOS). Coron Artery Dis 29:429–437PubMedCrossRef
46.
Zurück zum Zitat D'Marco L, Puchades MJ, Romero-Parra M, Gimenez-Civera E, Soler MJ, Ortiz A, Gorriz JL (2020) Coronavirus disease 2019 in chronic kidney disease. Clin Kidney J 13:297–306PubMedPubMedCentral D'Marco L, Puchades MJ, Romero-Parra M, Gimenez-Civera E, Soler MJ, Ortiz A, Gorriz JL (2020) Coronavirus disease 2019 in chronic kidney disease. Clin Kidney J 13:297–306PubMedPubMedCentral
47.
Zurück zum Zitat Yang J, Brody EN, Murthy AC, Mehler RE, Weiss SJ, DeLisle RK, Ostroff R, Williams SA, Ganz P (2020) Impact of kidney function on the blood proteome and on protein cardiovascular risk biomarkers in patients with stable coronary heart disease. J Am Heart Assoc 9:e016463PubMedPubMedCentral Yang J, Brody EN, Murthy AC, Mehler RE, Weiss SJ, DeLisle RK, Ostroff R, Williams SA, Ganz P (2020) Impact of kidney function on the blood proteome and on protein cardiovascular risk biomarkers in patients with stable coronary heart disease. J Am Heart Assoc 9:e016463PubMedPubMedCentral
48.
Zurück zum Zitat Wang CH, Liu CY, Wan YL, Chou CL, Huang KH, Lin HC, Lin SM, Lin TY, Chung KF, Kuo HP (2005) Persistence of lung inflammation and lung cytokines with high-resolution CT abnormalities during recovery from SARS. Respir Res 6:42PubMedPubMedCentralCrossRef Wang CH, Liu CY, Wan YL, Chou CL, Huang KH, Lin HC, Lin SM, Lin TY, Chung KF, Kuo HP (2005) Persistence of lung inflammation and lung cytokines with high-resolution CT abnormalities during recovery from SARS. Respir Res 6:42PubMedPubMedCentralCrossRef
50.
Zurück zum Zitat Sasannejad C, Ely EW, Lahiri S (2019) Long-term cognitive impairment after acute respiratory distress syndrome: a review of clinical impact and pathophysiological mechanisms. Crit Care 23:352PubMedPubMedCentralCrossRef Sasannejad C, Ely EW, Lahiri S (2019) Long-term cognitive impairment after acute respiratory distress syndrome: a review of clinical impact and pathophysiological mechanisms. Crit Care 23:352PubMedPubMedCentralCrossRef
51.
Zurück zum Zitat Song JW, Lam SM, Fan X, Cao WJ, Wang SY, Tian H, Chua GH, Zhang C, Meng FP, Xu Z, Fu JL, Huang L, Xia P, Yang T, Zhang S, Li B, Jiang TJ, Wang R, Wang Z, Shi M, Zhang JY, Wang FS, Shui G (2020) Omics-driven systems interrogation of metabolic dysregulation in COVID-19 pathogenesis. Cell Metab 32(188–202):e5 Song JW, Lam SM, Fan X, Cao WJ, Wang SY, Tian H, Chua GH, Zhang C, Meng FP, Xu Z, Fu JL, Huang L, Xia P, Yang T, Zhang S, Li B, Jiang TJ, Wang R, Wang Z, Shi M, Zhang JY, Wang FS, Shui G (2020) Omics-driven systems interrogation of metabolic dysregulation in COVID-19 pathogenesis. Cell Metab 32(188–202):e5
54.
Zurück zum Zitat Ebinger JE (2020) Estimated County-Level Prevalence of Selected Underlying Medical Conditions Associated with Increased Risk for Severe COVID-19 Illness–United States, 2018. MMWR Morb Mortal Wkly Rep. 69:945–950CrossRef Ebinger JE (2020) Estimated County-Level Prevalence of Selected Underlying Medical Conditions Associated with Increased Risk for Severe COVID-19 Illness–United States, 2018. MMWR Morb Mortal Wkly Rep. 69:945–950CrossRef
Metadaten
Titel
Anticipating the long-term cardiovascular effects of COVID-19
verfasst von
Richard C. Becker
Publikationsdatum
03.09.2020
Verlag
Springer US
Schlagwort
COVID-19
Erschienen in
Journal of Thrombosis and Thrombolysis / Ausgabe 3/2020
Print ISSN: 0929-5305
Elektronische ISSN: 1573-742X
DOI
https://doi.org/10.1007/s11239-020-02266-6

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