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Erschienen in:
10.11.2017 | Nephrology - Original Paper
Serum apolipoprotein B is inversely associated with eccentric left ventricular hypertrophy in peritoneal dialysis patients
Erschienen in: International Urology and Nephrology | Ausgabe 1/2018
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Objectives
The study aimed to examine the relationship of serum apolipoprotein B level with left ventricular (LV) structural and functional characteristics, in particular, LV remodeling parameters in peritoneal dialysis (PD) patients.
Methods
A total of 182 patients with end-stage renal disease (ESRD) receiving PD were identified. Conventional echocardiography was performed for each patient, and echocardiographic characteristics were analyzed according to apo B quartile groups. Multivariate linear regression models were used to determine the associations between serum apo B and LV remodeling indices.
Results
A high serum apo B level was significantly related to the reduction in left atrium dimension (r = − 0.20, P = 0.011), LV dimensions (end-diastolic: r = − 0.27, P = 0.001; end-systolic: r = − 0.24, P = 0.003), peak velocities of early filling divided by peak velocities of atrial filling (r = − 0.38, P < 0.001), and LV volumetric dimension (end-diastolic: r = − 0.27, P < 0.001; end-systolic: r = − 0.28, P < 0.001). After adjustment for clinical confounding factors, the effect of serum apo B on LV eccentric remodeling modestly weakened but remained statistically significant (P = 0.038), while other associations were not significant. In multivariate linear regression analysis, conventional lipid profiles were not significantly associated with LV eccentric remodeling, whereas serum apo B was an independent determinant of LV dilatation (β: − 42.10, 95% CI − 74.82 to − 9.38, P = 0.012).
Conclusions
Serum apo B was significantly and inversely associated with LV dilatation, independently of conventional lipids and other CV risk factors in our ESRD patients undergoing PD. It suggested that low serum apo B level could be a powerful risk marker for eccentric left ventricular geometry remodeling and could be potentially used to risk-stratify PD patients.