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01.05.2014 | Abdominal Radiology

Comparative evaluation of percutaneous laser and radiofrequency ablation in patients with HCC smaller than 4 cm

verfasst von: Antonio Orlacchio, Francesca Bolacchi, Fabrizio Chegai, Alberto Bergamini, Elisa Costanzo, Costantino Del Giudice, Mario Angelico, Giovanni Simonetti

Erschienen in: La radiologia medica | Ausgabe 5/2014

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Abstract

Objective

This study was done to compare percutaneous laser ablation (PLA) and radiofrequency thermoablation (RFA) for the treatment of hepatocellular carcinoma (HCC) ≤4 cm, in patients with liver cirrhosis.

Materials and methods

Thirty patients with single HCC ≤4 cm in diameter were randomly assigned to one of two treatments: 15 patients were treated with PLA, using a multifibre system connected to a neodymium yttrium–aluminium–garnet laser source; 15 patients were treated with RFA, using an expandable needle electrode. Patients were followed up for up to 12 months.

Results

A complete response was obtained in 87 % lesions treated with PLA and in 93 % lesions treated with RFA (p = ns). The overall local recurrence-free survival rates at 3, 6 and 12 months were comparable. However, a higher rate of recurrence was observed in the PLA group for lesions ≥21 mm (p = 0.0081). A postablation syndrome was documented in 13 patients (1 PLA; 12 RFA). Tumour necrosis factor-α was significantly higher in the RFA group (p < 0.05).

Conclusions

RFA is more effective in the treatment of HCC compared to PLA for lesions ≥21 mm. However, PLA should be considered a viable treatment option for HCC ≤20 mm, in view of the lower incidence of complications.

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Titel: Comparative evaluation of percutaneous laser and radiofrequency ablation in patients with HCC smaller than 4 cm
verfasst von: Antonio Orlacchio
Francesca Bolacchi
Fabrizio Chegai
Alberto Bergamini
Elisa Costanzo
Costantino Del Giudice
Mario Angelico
Giovanni Simonetti
Publikationsdatum: 01.05.2014
Verlag: Springer Milan
Erschienen in: La radiologia medica / Ausgabe 5/2014
Print ISSN: 0033-8362
Elektronische ISSN: 1826-6983
DOI: https://doi.org/10.1007/s11547-013-0339-y

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Comparative evaluation of percutaneous laser and radiofrequency ablation in patients with HCC smaller than 4 cm