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01.06.2016 | COMPUTED TOMOGRAPHY

Indications and efficacy of O₂–O₃ intradiscal versus steroid intraforaminal injection in different types of disco vertebral pathologies: a prospective randomized double-blind trial with 517 patients

verfasst von: Marco Perri, Claudia Marsecano, Marco Varrassi, Aldo Victor Giordano, Alessandra Splendiani, Ernesto di Cesare, Carlo Masciocchi, Massimo Gallucci

Erschienen in: La radiologia medica | Ausgabe 6/2016

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Abstract

Objective

The aim of this study was to prospectively evaluate the clinical efficacy of perigangliar steroid and local anesthetic with intradiscal O₂–O₃ injection versus steroid and local anesthetic intraforaminal injection in different types of herniation and grade of disc degeneration.

Materials and methods

A total of 517 patients were randomly assigned to two groups. Control Group (159 men, 101 women; age range 25–89 years) underwent steroid and local anesthetic intraforaminal injection. Study Group (163 men, 94 women; age range 22–92 years) underwent the same treatment with addiction of O₂–O₃ intradiscal injection. Procedures were performed under computed tomographic guidance. Visual Analog Scale Questionnaire was administered before treatment and at intervals, the last at 6-month follow-up. Results were compared with Kruskal–Wallis and t test.

Results

After 6 months, O₂–O₃ discolysis was successful in 106 (41.24 %) Study Group patients with extrusions compared with 9 Control Group patients (3.5 %) (P < 0.001). In 89 (34.6 %) Study Group patients with protrusions, success rate was statistically significant compared with 5 Control Group patients (1.9 %). Significant difference was detected in the presence of Grade I, II, III of Degenerated Disc in 185 of Study Group patients (68.4 %) compared with 4 Control Group patients (1.5 %).

Conclusions

The addition of O₂–O₃ discolysis is more effective at 6 months than perigangliar steroid and local anesthetic injection, especially in cases of herniated or protruded discs and with a Grade of Disc Degeneration from mild to moderate range.

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Titel: Indications and efficacy of O2–O3 intradiscal versus steroid intraforaminal injection in different types of disco vertebral pathologies: a prospective randomized double-blind trial with 517 patients
verfasst von: Marco Perri
Claudia Marsecano
Marco Varrassi
Aldo Victor Giordano
Alessandra Splendiani
Ernesto di Cesare
Carlo Masciocchi
Massimo Gallucci
Publikationsdatum: 01.06.2016
Verlag: Springer Milan
Erschienen in: La radiologia medica / Ausgabe 6/2016
Print ISSN: 0033-8362
Elektronische ISSN: 1826-6983
DOI: https://doi.org/10.1007/s11547-015-0598-x

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Indications and efficacy of O₂–O₃ intradiscal versus steroid intraforaminal injection in different types of disco vertebral pathologies: a prospective randomized double-blind trial with 517 patients