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Japanese Journal of Radiology

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01.10.2015 | Original Article

Correlating Parkinson’s disease motor symptoms with three-dimensional [¹⁸F]FP-CIT PET

Erschienen in: Japanese Journal of Radiology | Ausgabe 10/2015

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Abstract

Purpose

To investigate the correlation between the striatal three-dimensional location and the Unified Parkinson’s Disease Rating Scale (UPDRS) motor score in the context of idiopathic Parkinson’s disease (PD) through radiolabeled N-(3-fluoropropyl)-2β-carboxymethoxy-3β-(4-iodophenyl) nortropane positron emission tomography/computed tomography (FP-CIT PET/CT).

Materials and methods

In this cross-sectional study, we assessed the UPDRS motor score and performed FP-CIT PET/CT in patients with PD. Thirty-eight patients with idiopathic PD [average 70 years of age (range 49–86); male:female ratio 12:26] were enrolled. The correlation between FP-CIT PET/CT and the UPDRS III scores was investigated after the transformation of PET images by an alternative method using MATLAB.

Results

Left caudate nucleus uptake negatively correlated with UPDRS items 18, 20 (face), 22 (right arm and leg), 23, 24 (right side), 26 (right side), 27, 30, and 31, while right caudate nucleus uptake positively correlated with items 18, 22 (left arm), 26, and 29. Putamen uptake correlated with items 22 and 25. Left caudate nucleus uptake positively correlated with axial and akinetic-rigidity symptoms.

Conclusions

FP-CIT uptake in specific basal ganglia structures strongly correlated with the UPDRS III motor score. Among these, the left caudate nucleus exhibited the strongest relationship with axial and akinetic-rigidity PD symptoms.

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Titel: Correlating Parkinson’s disease motor symptoms with three-dimensional [18F]FP-CIT PET
Publikationsdatum: 01.10.2015
Erschienen in: Japanese Journal of Radiology / Ausgabe 10/2015
Print ISSN: 1867-1071
Elektronische ISSN: 1867-108X
DOI: https://doi.org/10.1007/s11604-015-0427-0

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Correlating Parkinson’s disease motor symptoms with three-dimensional [¹⁸F]FP-CIT PET

Abstract

Purpose

Materials and methods

Results

Conclusions

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Springer Medizin

Abstract

Purpose

Materials and methods

Results

Conclusions

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