Erschienen in:
01.05.2013 | Original Article
Predictors for Early Recurrence After Hepatectomy for Initially Unresectable Colorectal Liver Metastasis
verfasst von:
Shinichiro Takahashi, Masaru Konishi, Takahiro Kinoshita, Naoto Gotohda, Yuichiro Kato, Norio Saito, Masanori Sugito, Takayuki Yoshino
Erschienen in:
Journal of Gastrointestinal Surgery
|
Ausgabe 5/2013
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Abstract
Background
Early recurrence correlates with poor survival following various cancer surgeries and puts considerable stress on patients both physically and mentally. This retrospective study investigated the predictive factors for early recurrence after surgical resection for initially unresectable colorectal liver metastasis to elucidate indications for conversion strategies.
Methods
We retrospectively studied 46 patients who underwent hepatectomy after chemotherapy for initially unresectable colorectal liver metastasis from 1997 to 2010.
Results
Recurrences occurred within 6 months after hepatectomy in 13 patients (37 %). The median survival time of 21.2 months and the 5-year survival rate of 0 % after hepatectomy in patients with recurrence within 6 months were significantly worse than those in patients with recurrence more than 6 months after hepatectomy. Recurrence in less than 6 months was significantly correlated with impossibility of anticancer therapy for recurrence after hepatectomy (p = 0.01). Eight or more hepatic tumors after chemotherapy were the only predictor of recurrence within 6 months (p = 0.01; odds ratio 9.6; 95 % confidence interval 1.5–60.6).
Conclusion
Recurrence within 6 months was significantly correlated with a poorer outcome following surgery for initially unresectable colorectal liver metastasis. Surgical indication for initially unresectable colorectal liver metastasis with eight or more hepatic tumors after chemotherapy should be considered carefully in the light of mental and physical status, co-morbidity, and alternative treatment plans.