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Current Diabetes Reports

Erschienen in:

01.04.2015 | Diabetes, Other Diseases, and New Complications: Emerging Associations (JJ Nolan, Section Editor)

Diabetes and Epilepsy in Children and Adolescents

verfasst von: M. Loredana Marcovecchio, Marianna Immacolata Petrosino, Francesco Chiarelli

Erschienen in: Current Diabetes Reports | Ausgabe 4/2015

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Abstract

Over the last years, there has been an increasing interest in the potential association between type 1 diabetes (T1D) and epilepsy. Both T1D and epilepsy are common conditions in children and adolescents, and therefore, their association might represent simply a coincidence or be related to common underlying mechanisms with a potential causal relationship. Few epidemiological studies have been performed in the pediatric population, and they have reached discordant conclusions, with some studies reporting an increased prevalence of epilepsy in children and adolescents with T1D, whereas others have not confirmed this finding. Several mechanisms could explain the occurrence of epilepsy in young people with T1D, such as metabolic abnormalities (hypo/hyperglycemia) and autoantibodies, along with a genetic predisposition and the presence of brain lesions/damage. Further studies are required to better define whether there is a causal relationship between the two conditions and to understand the underlying mechanisms.

American Diabetes Association. Diagnosis and classification of diabetes mellitus. Diabetes Care. 2014;37 Suppl 1:S81–90.CrossRef

2.••

Atkinson MA, Eisenbarth GS, Michels AW. Type 1 diabetes. Lancet. 2014;383:69–82. Recent high-quality review offering an update on type 1 diabetes. CrossRefPubMed

(IDF) IDF. 21 June 2014. Available from: http://www.idf.org/sites/default/files/EN_6E_Atlas_Full_0.pdf.

Kordonouri O, Klingensmith G, Knip M, Holl RW, Menon PSN, Aanstoot HJ, et al. Other complications and diabetes-associated conditions in children and adolescents. Pediatr Diabetes. 2014;15 Suppl 20:270–8.CrossRefPubMed

5.••

Moshè SL, Perucca E, Ryvlin P, Tomson T. Epilepsy: new advances. Lancet. 2014. Recent review on new advances on epilepsy.

6.••

Fisher RS, Acevedo C, Arzimanoglou A, et al. ILAE official report: a practical clinical definition of epilepsy. Epilepsia. 2014;55(4):475–82. Recent article reporting updated definition for epilepsy.CrossRefPubMed

Martinez C, Sullivan T, Hauser WA. Prevalence of acute repetitive seizures (ARS) in the United Kingdom. Epilepsy Res. 2009;87:137–43.CrossRefPubMed

Ottman R, Lipton RB, Ettinger AB, et al. Comorbidities of epilepsy: results from the Epilepsy Comorbidities and Health (EPIC) survey. Epilepsia. 2011;52:308–15.PubMed

Banerjee PN, Filippi D, Allen Hauser W. The descriptive epidemiology of epilepsy—a review. Epilepsy Res. 2009;85:31–45.CrossRefPubMedCentralPubMed

10.

Waaler PE, Blom BH, Skeidsvoll H, Mykletum A. Prevalence, classification and severity of epilepsy in children in Western Norway. Epilepsia. 2000;41:802–10.CrossRefPubMed

11.

Larsson K, Eeg-Olofsson O. A population based study of epilepsy in children from a Swedish county. Eur J Paediatr Neurol. 2006;10:107–13.CrossRefPubMed

12.

Luengo A, Parra J, Colas J, et al. Prevalence of epilepsy in northeast Madrid. J Neurol. 2001;248:762–7.CrossRefPubMed

13.

Rocca WA, Savettiere G, Andreson DW, et al. Door to door prevalence survey of epilepsy in three Sicilian municipalities. Neuroepidemiology. 2001;20:237–41.CrossRefPubMed

14.

Cowan LD. The epidemiology of the epilepsies in children. Ment Retard Dev Disabil Res Rev. 2002;8:171–81.CrossRefPubMed

15.

Hanly JG, Urowitz MB, Su L, et al. Seizure disorders in systemic lupus erythematosus results from an international, prospective, inception cohort study. Ann Rheum Dis. 2012;71:1502–9.CrossRefPubMed

16.

Appenzeller S, Cendes F, Costallat LT. Epileptic seizures in systemic lupus erythematosus. Neurology. 2004;63:1808–12.CrossRefPubMed

17.

Andrade RM, Alarcón GS, González LA, et al. Seizures in patients with systemic lupus erythematosus: data from LUMINA, a multiethnic cohort (LUMINA LIV). Ann Rheum Dis. 2008;67:829–34.CrossRefPubMedCentralPubMed

18.

Shoenfeld Y, Lev S, Blatt I, Blank M, et al. Features associated with epilepsy in the antiphospholipid syndrome. J Rheumatol. 2004;31:1344–8.PubMed

19.

Cervera R, Piette JC, Font J, et al. Antiphospholipid syndrome: clinical and immunologic manifestations and patterns of disease expression in a cohort of 1,000 patients. Arthritis Rheum. 2002;46:1019–27.CrossRefPubMed

20.••

Vincent A, Irani SR, Lang B. Potentially pathogenic autoantibodies associated with epilepsy and encephalitis in children and adults. Epilepsia. 2011;52 Suppl 8:8–11. This paper highlights that some autoantibodies are increasingly found in different forms of epilepsy and detection of these antibodies can help to identify forms of epilepsy that may respond to immunotherapies. CrossRefPubMed

21.••

Ong MS, Kohane IS, Cai T, Gorman MP, Mandl KD. Population-level evidence for an autoimmune etiology of epilepsy. JAMA Neurol. 2014;71:569–74. This is an important population-level study investigating the relationship between epilepsy and several common autoimmune diseases, including type 1 diabetes mellitus. CrossRefPubMed

22.

Vincent A, Crino PB. Systemic and neurologic autoimmune disorders associated with seizures or epilepsy. Epilepsia. 2011;52 Suppl 3:12–7.CrossRefPubMed

23.

McCorry D, Nicolson A, Smith D, Marson A, Feltbower RG, Chadwick DW. An association between type 1 diabetes and idiopathic generalized epilepsy. Ann Neurol. 2006;59:204–6.CrossRefPubMed

24.

O’Connell MA, Harvey AS, Mackay MT, Cameron FJ. Does epilepsy occur more frequently in children with type 1 diabetes. J Paediatr Child Health. 2008;44:586–9.CrossRefPubMed

25.••

Schober E, Otto KP, Dost A, Jorch N, Holl R. German/Austrian DPV, initiative and the BMBF competence network diabetes. Association of epilepsy and type 1 diabetes mellitus in children and adolescents: is there an increased risk for diabetic ketoacidosis? J Pediatr. 2012;160:662–6. Important observational cohort study showing that children and adolescents with diabetes mellitus have increased prevalence of epilepsy and there is an association between epilepsy and diabetic ketoacidosis in the same patients. CrossRefPubMed

26.••

Ramakrishnan R, Appleton R. Study of prevalence of epilepsy in children with type 1 diabetes mellitus. Seizure. 2012;21:292–4. Recent study showing that epilepsy appears to occur more frequently in children with type 1 diabetes than in the general paediatric population.CrossRefPubMed

27.

Maccario M, Messis CP, Vastola EF. Focal seizures as a manifestation of hyperglycemia without ketoacidosis. A report of seven cases with review of the literature. Neurology. 1965;15:195–206.CrossRefPubMed

28.

Whiting S, Camfield P, Arab D, Salisbury S. Insulin-dependent diabetes mellitus presenting in children as frequent, medically unresponsive, partial seizures. J Child Neurol. 1997;12:178–80.CrossRefPubMed

29.

Sabharwal RK, Gupta M, Sharma D, Puri V. Juvenile diabetes manifesting as epilepsia partialis continua. J Assoc Physicians India. 1989;37:603–4.PubMed

30.

Olson JA, Olson DM, Sandborg C, Alexander S, Buckingham B. Type 1 diabetes mellitus and epilepsy partialis continua in a 6-year-old boy with elevated anti-GAD65 antibodies. Pediatrics. 2002;109:E50.

31.

Mukherjee V, Mukherjee A, Mukherjee A, Halder A. Type I diabetes mellitus in a child presenting with epilepsy partialis continua. J Indian Med Assoc. 2007;105:340–2.PubMed

32.

Baglietto MG, Mancardi MM, Giannattasio A, et al. Epilepsia partialis continua in type 1 diabetes: evolution into epileptic encephalopathy with continuous spike-waves during slow sleep. Neurol Sci. 2009;30:509–12.CrossRefPubMed

33.

Mancardi MM, Striano P, Giannattasio A, et al. Type I diabetes and epilepsy: more than a casual relationship? Epilepsia. 2010;51:320–1.CrossRefPubMed

34.

Shinnar S, Pellock JM. Update on the epidemiology and prognosis of pediatric epilepsy. J Child Neurol. 2002;17:S4–17.CrossRefPubMed

35.

Hung WL, Hsieh PF, Lee YC, Chang MH. Occipital lobe seizures related to marked elevation of hemoglobin A1C: report of two cases. Seizure. 2010;19:359–62.CrossRefPubMed

36.

Wang CP, Hsieh PF, Chen CC, et al. Hyperglycemia with occipital seizures: images and visual evoked potentials. Epilepsia. 2005;46:1140–4.CrossRefPubMed

37.

Tiras R, Mutlu A, Ozben S, Aydemir T, Ozer F. Forced eye closure-induced reflex seizure and non-ketotic hyperglycemia. Ann Saudi Med. 2009;29:313–5.CrossRefPubMedCentralPubMed

38.

Siddiqi ZA, VanLandingham KE, Husain AM. Reflex seizures and non-ketotic hyperglycemia: an unresolved issue. Seizure. 2002;11:63–6.CrossRefPubMed

39.

Caietta E, Halbert C, Lépine A, et al. Association of type 1 diabetes mellitus and epilepsy in children. A cohort of 10 cases. Arch Pediatr. 2012;19:9–16.CrossRefPubMed

40.

Cotellessa M, Barbieri P, Mazzella M, Bonassi S, Minicucci L, Lorini R. High incidence of childhood type 1 diabetes in Liguria, Italy, from 1989 to 1998. Diabetes Care. 2003;26:1786–9.CrossRefPubMed

41.

Duncan JS, Sander JW, Sisodiya SM, Walker MC. Adult epilepsy. Lancet. 2006;367:1087–100.CrossRefPubMed

42.

Hirsch LJ, Hauser WA. Can sudden unexplained death in epilepsy be prevented? Lancet. 2004;364:2157–8.CrossRefPubMed

43.•

Surges R, Thijs RD, Tan HL, Sander JW. Sudden unexpected death in epilepsy: risk factors and potential pathomechanisms. Nat Rev Neurol. 2009;5:492–504. Useful paper highlighting key concepts on sudden unexpected death in epilepsy. CrossRefPubMed

44.

Yun C, Xuefeng W. Association between seizures and diabetes mellitus: a comprehensive review of literature. Curr Diabetes Rev. 2013;9:350–4.CrossRefPubMed

45.•

Maheandiran M, Mylvaganam S, Wu C, et al. Severe hypoglycemia in a juvenile diabetic rat model: presence and severity of seizures are associated with mortality. PLoS One. 2013;8:e83168. This study clearly shows that severe hypoglycemia is a necessary precondition for seizures, and that the increased frequency of these seizures is associated with mortality. CrossRefPubMedCentralPubMed

46.

Schwechter EM, Velísková J, Velísek L. Correlation between extracellular glucose and seizure susceptibility in adult rats. Ann Neurol. 2003;53:91–101.CrossRefPubMed

47.

Kirchner A, Velísková J, Velísek L. Differential effects of low glucose concentrations on seizures and epileptiform activity in vivo and in vitro. Eur J Neurosci. 2006;23:1512–22.CrossRefPubMed

48.

Secrest AM, Becker DJ, Kelsey SF, Laporte RE, Orchard TJ. Cause-specific mortality trends in a large population-based cohort with long-standing childhood-onset type 1 diabetes. Diabetes. 2010;59:3216–22.CrossRefPubMedCentralPubMed

49.

Wagner VM, Rosenbauer J, Grabert M, Holl RW, German Initiative on Quality Control in Pediatric Diabetology. Severe hypoglycaemia, metabolic control and diabetes management in young children with type 1 diabetes using insulin analogs—a follow up report of a large multicenter database. Eur J Pediatr. 2008;167:241–2.CrossRefPubMed

50.

Katz ML, Volkening LK, Anderson BJ, Laffel LM. Contemporary rates of severe hypoglycaemia in youth with type 1 diabetes: variability by insulin regimen. Diabet Med. 2012;29:926–32.CrossRefPubMedCentralPubMed

51.

Lahat E, Barr J, Bistritzer T. Focal epileptic episodes associated with hypoglycemia in children with diabetes. Clin Neurol Neurosurg. 1995;97:314–6.CrossRefPubMed

52.

Wayne EA, Dean HJ, Booth F, Tenenbein M. Focal neurological deficits associated with hypoglycemia in children with diabetes. J Pediatr. 1990;117:575–7.CrossRefPubMed

53.

Heller SR. Abnormalities of the electrocardiogram during hypoglycaemia: the cause of the dead in bed syndrome? Int J Clin Pract Suppl. 2002;129:27–32.PubMed

54.

Tokizane T. Sites of origin of hypoglycemic seizures in the rabbit. AMA Arch Neurol Psychiatr. 1957;77:259–66.CrossRef

55.

Gruetter R. Glycogen: the forgotten cerebral energy store. J Neurosci Res. 2003;74:179–83.CrossRefPubMed

56.

McCall AL. Cerebral glucose metabolism in diabetes mellitus. Eur J Pharmacol. 2004;490:147–58.CrossRefPubMed

57.

Rakhade SN, Jensen FE. Epileptogenesis in the immature brain: emerging mechanisms. Nat Rev Neurol. 2009;5:380–91.CrossRefPubMedCentralPubMed

58.

Yamada KA, Rensing N, Izumi Y, et al. Repetitive hypoglycemia in young rats impairs hippocampal long-term potentiation. Pediatr Res. 2004;55:372–9.CrossRefPubMed

59.

Suh SW, Hamby AM, Swanson RA. Hypoglycemia, brain energetics, and hypoglycemic neuronal death. Glia. 2007;55:1280–6.CrossRefPubMed

60.

Wolfsdorf J, Glaser N, Sperling MA, Association American Diabetes. Diabetic ketoacidosis in infants, children, and adolescents: a consensus statement from the American Diabetes Association. Diabetes Care. 2006;29:1150–9.CrossRefPubMed

61.

Takeoka M, Holmes GL, Thiele E, Bourgeois BF, Helmers SL, Duffy FH, et al. Topiramate and metabolic acidosis in pediatric epilepsy. Epilepsia. 2001;42:387–92.CrossRefPubMed

62.

Ko CH, Kong CK. Topiramate-induced metabolic acidosis: report of two cases. Dev Med Child Neurol. 2001;43:701–4.CrossRefPubMed

63.

Groeper K, McCann ME. Topiramate and metabolic acidosis: a case series and review of the literature. Paediatr Anaesth. 2005;15:167–70.CrossRefPubMed

64.••

Bien CG, Scheffer IE. Autoantibodies and epilepsy. Epilepsia. 2011;52 Suppl 3:18–22. Important paper reviewing the role of autoantibodies in the pathogenesis of epilepsy. CrossRefPubMed

65.

Striano P, Errichiello L, Striano S. Autoantibodies to glutamic acid decarboxylase in patients with epilepsy: what is their clinical relevance? Epilepsy Behav. 2011;20:145.PubMed

66.

Errichiello L, Perruolo G, Pascarella A, et al. Autoantibodies to glutamic acid decarboxylase (GAD) in focal and generalized epilepsy: a study on 233 patients. J Neuroimmunol. 2009;211:120–3.CrossRefPubMed

67.

Stagg CJ, Lang B, Best JG, et al. Autoantibodies to glutamic acid decarboxylase in patients with epilepsy are associated with low cortical GABA levels. Epilepsia. 2010;51:1898–901.CrossRefPubMed

68.

Piquer S, Belloni C, Lampasona V, et al. Humoral autoimmune responses to glutamic acid decarboxylase have similar target epitopes and subclass that show titer-dependent disease association. Clin Immunol. 2005;117:31–5.CrossRefPubMed

69.

Manto MU, Laute MA, Aguera M, Rogemond V, Pandolfo M, Honnorat J. Effects of anti-glutamic acid decarboxylase antibodies associated with neurological diseases. Ann Neurol. 2007;61:544–51.CrossRefPubMed

70.

Vianello M, Tavolato B, Giometto B. Glutamic acid decarboxylase autoantibodies and neurological disorders. Neurol Sci. 2002;23:145–51.CrossRefPubMed

71.

Vianello M, Bisson G, Dal Maschio M, et al. Increased spontaneous activity of a network of hippocampal neurons in culture caused by suppression of inhibitory potentials mediated by anti-gad antibodies. Autoimmunity. 2008;41:66–73.CrossRefPubMed

72.

Liimatainen S, Peltola M, Sabater L, et al. Clinical significance of glutamic acid decarboxylase antibodies in patients with epilepsy. Epilepsia. 2010;51:760–7.CrossRefPubMed

73.

Saiz A, Blanco Y, Sabater L, et al. Spectrum of neurological syndromes associated with glutamic acid decarboxylase antibodies: diagnostic clues for this association. Brain. 2008;131:2553–63.CrossRefPubMed

74.

Giometto B, Nicolao P, Macucci M, Tavolaro B, Foxon R, Bottazzo GF. Temporal-lobe epilepsy associated with glutamic-acid-decarboxylase autoantibodies. Lancet. 1998;8:457.CrossRef

75.

Kanter IC, Huttner HB, Staykov D, Biermann T, Struffert T, Kerling F, et al. Cyclophosphamide for anti-GAD antibody-positive refractory status epilepticus. Epilepsia. 2008;49:914–20.CrossRefPubMed

76.

Ito S, Oguni H. Ketogenic diet for intractable childhood epilepsy; as an early option as well as a last resort. Brain Nerve. 2011;63:393–400.PubMed

77.

Hartman AL, Gasior M, Vining EP, Rogawski MA. The neuropharmacology of the ketogenic diet. Pediatr Neurol. 2007;36:281–92.CrossRefPubMedCentralPubMed

78.

Keene DL. A systematic review of the use of the ketogenic diet in childhood epilepsy. Pediatr Neurol. 2006;35:1–5.CrossRefPubMed

79.

Levy R, Cooper P. Ketogenic diet for epilepsy. Cochrane Database Syst Rev. 2003;3, CD001903.PubMed

80.

Kossoff EH, Zupec-Kania BA, Amark PE, et al. Optimal clinical management of children receiving the ketogenic diet: recommendations of the International Ketogenic Diet Study Group. Epilepsia. 2009;50:304–17.CrossRefPubMed

81.

Henderson CB, Filloux FM, Alder SC, Lyon JL, Caplin DA. Efficacy of the ketogenic diet as a treatment option for epilepsy: meta-analysis. J Child Neurol. 2006;21:193–8.PubMed

82.•

Aguirre Castaneda RL, Mack KJ, Lteif A. Successful treatment of type 1 diabetes and seizures with combined ketogenic diet and insulin. Pediatrics. 2012;129:e511–4. This article shows the successful treatment of type 1 diabetes and seizures with combined ketogenic diet and insulin.CrossRefPubMed

83.•

Aylward NM, Shah N, Sellers EA. The ketogenic diet for the treatment of myoclonic astatic epilepsy in a child with type 1 diabetes mellitus. Can J Diabetes. 2014;38:223. This article reports the successful use of the ketogenic diet in a child with epilepsy and type 1 diabetes.CrossRefPubMed

Titel: Diabetes and Epilepsy in Children and Adolescents
verfasst von: M. Loredana Marcovecchio
Marianna Immacolata Petrosino
Francesco Chiarelli
Publikationsdatum: 01.04.2015
Verlag: Springer US
Erschienen in: Current Diabetes Reports / Ausgabe 4/2015
Print ISSN: 1534-4827
Elektronische ISSN: 1539-0829
DOI: https://doi.org/10.1007/s11892-015-0588-3

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