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Current Diabetes Reports
Erschienen in: Current Diabetes Reports 10/2016

01.10.2016 | Pathogenesis of Type 1 Diabetes (A Pugliese, Section Editor)

Biomarkers of β-Cell Stress and Death in Type 1 Diabetes

verfasst von: Raghavendra G. Mirmira, Emily K. Sims, Farooq Syed, Carmella Evans-Molina

Erschienen in: Current Diabetes Reports | Ausgabe 10/2016

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Abstract

The hallmark of type 1 diabetes (T1D) is a decline in functional β-cell mass arising as a result of autoimmunity. Immunomodulatory interventions at disease onset have resulted in partial stabilization of β-cell function, but full recovery of insulin secretion has remained elusive. Revised efforts have focused on disease prevention through interventions administered at earlier disease stages. To support this paradigm, there is a parallel effort ongoing to identify circulating biomarkers that have the potential to identify stress and death of the islet β-cells. Whereas no definitive biomarker(s) have been fully validated, several approaches hold promise that T1D can be reliably identified in the pre-symptomatic phase, such that either β-cell preservation or immunomodulatory agents might be employed in at-risk populations. This review summarizes the most promising protein- and nucleic acid-based biomarkers discovered to date and reviews the context in which they have been studied.
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Metadaten
Titel
Biomarkers of β-Cell Stress and Death in Type 1 Diabetes
verfasst von
Raghavendra G. Mirmira
Emily K. Sims
Farooq Syed
Carmella Evans-Molina
Publikationsdatum
01.10.2016
Verlag
Springer US
Erschienen in
Current Diabetes Reports / Ausgabe 10/2016
Print ISSN: 1534-4827
Elektronische ISSN: 1539-0829
DOI
https://doi.org/10.1007/s11892-016-0783-x

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